General Santos Doctors’ Medical School

Foundation, Inc.
Bulaong Subd., Brgy. West, General Santos City, Philippines
Tel No.: (083) 302-3507, Telefax No.: (083) 552-9793

Name: ____________________________________ Course: _________________ Score:

Date: _____________________________________ Group No: _______________

Activity No.10
ASSAY OF ASPIRIN
Materials:
 Aspirin (USP Grade)
 Standard NaOH Solution
 Standard HCl Solution
 phenolphthalein

Procedure
1. Weigh 1g of aspirin accurately in tared Erlenmeyer flask.
2. Run down 50ml of standard NaOH solution to the weighed sample of aspirin.
3. Cover with an inverted beaker and boil for 10minutes.
4. Allow to cool.
5. Add 2 drops of phenolphthalein.
6. Titrate the excess NaOH with standard HCl solution to the disappearance of pink color.
7. Perform a blank determination following the same procedure without a sample.

Formula

% C9H8O4 = (ml HCl B.T. – ml HCl A.T.) x NHCl x meq.wt C9H8O4 x 100
Wt. of sample
B.T. = Blank Test
A.T. = Actual Test
 General Santos Doctors’ Medical School
Foundation, Inc.
Bulaong Subd., Brgy. West, General Santos City, Philippines
Tel No.: (083) 302-3507, Telefax No.: (083) 552-9793

Name: ____________________________________ Course: __________________ Score:

Date: _____________________________________ Group No: ________________

Activity No.10
ASSAY OF ASPIRIN
A. Objectives (3)
1.
2.
3.

B. Data and Results

DATA BLANK ACTUAL
Weight of the sample, g
Final Reading-NaOH, ml
Initial Reading-NaOH,ml
Volume NaOH used
Normality of NaOH
Final Reading-HCl, ml
Initial Reading-HCl,ml
Volume HCl used
Normality of HCl
%C9H8O4

C. Write the chemical equation/s.

D. Calculations (Write all your solutions.)

 General Santos Doctors’ Medical School
Foundation, Inc.
Bulaong Subd., Brgy. West, General Santos City, Philippines
Tel No.: (083) 302-3507, Telefax No.: (083) 552-9793

E. Analysis

F. Conclusion
 General Santos Doctors’ Medical School
Foundation, Inc.
Bulaong Subd., Brgy. West, General Santos City, Philippines
Tel No.: (083) 302-3507, Telefax No.: (083) 552-9793