Professional Documents
Culture Documents
Robotics in Plastic Surgery It S Here.48
Robotics in Plastic Surgery It S Here.48
Robotics in Plastic Surgery It S Here.48
A
dvanced surgical robotics represent the The Automated Endoscopic System for
merger of surgical technique with sophis- Optimal Positioning (AESOP) robot, developed
ticated and intelligent technology. Novel by Computer Motion, Inc., was the first surgical
robotic technologies provide users with enhanced robot to gain U.S. Food and Drug Administration
precision, a greater degree of freedom in move- (FDA) approval, in 1994.1 The system was
ment, improved visual–spatial resolution, and designed to manipulate a laparoscopic surgical
tremor elimination while operating. Having the camera and possessed optical arms with seven
potential to confer dramatic improvements in degrees of freedom.2 This robot was ultimately
functional, aesthetic, and quality-of-life outcomes modified and renamed the Zeus Robotic Surgical
for patients, these innovations will expand the System (ZEUS), which included a separate oper-
breadth of operations that surgeons are able to ating console for the surgeon to sit comfortably
perform safely. during the operation. ZEUS was used for the
first transcontinental robot-assisted laparoscopic
cholecystectomy, famously known as “Operation
From the 1Hagey Laboratory for Pediatric Regenerative Lindbergh.”3
Medicine, Division of Plastic and Reconstructive Surgery, Today, the most popular robotic platform
Department of Surgery, Stanford University; 2Department of is the da Vinci surgical system, developed by
Plastic Surgery, University of Texas Southwestern Medical Intuitive Surgical, Inc. (Sunnyvale, CA), and
Center; 3Department of Surgery, University of Arizona; 4pri- approved by the FDA in 2000 (Fig. 1). The da
vate practice; 5Scottsdate Plastic Surgery LLC; 6Division Vinci system is the market leader, with more than
of Plastic Surgery, Department of Surgery, Mayo Clinic; 5 million reported surgical interventions across
7
Department of Plastic and Reconstructive Surgery, Johns
Hopkins University; 8St. John’s Pleasant Valley Hospital;
9
Division of Plastic and Reconstructive Surgery, Department
Disclosure statements are at the end of this article,
of Surgery, Washington University in St. Louis School of
Medicine. following the correspondence information.
Received for publication December 26, 2021; accepted
October 20, 2022.
The first two authors contributed equally. Related digital media are available in the full-text
Copyright © 2023 by the American Society of Plastic Surgeons version of the article on www.PRSJournal.com.
DOI: 10.1097/PRS.0000000000010270
www.PRSJournal.com 239
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2023
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
Fig. 1. (Above, left) Intraoperative use of the da Vinci surgical system. (Above, right) Surgeon remotely operating the da Vinci system
from the console. (Below, left) MUSA microsurgery robot (Microsure). (Below, right) Intraoperative use of the MUSA microsurgery
robot in a hand surgery case. Images used with permission from Intuitive Surgical, Inc., and Microsure.
the United States and 65 other countries. The around 1991,6 hysterectomy,7 and hip or knee
platform consists of three components: a sur- replacement.8
geon’s console; a patient trolley, which has mul- In plastic surgery, robotically assisted surgery
tiple articulating robotic arms; and an imaging has been used for transoral reconstruction of oro-
system capable of generating real-time three- pharyngeal defects, muscle and perforator flap
dimensional images.4 This system has undergone harvest, complex ventral hernia repair, and more
several modifications over the years to improve recently, microvascular anastomosis.9–11
ease of handling, increase the range of instru- Transoral robotic surgery was approved by
ment movements, and enhance image resolu- the FDA in 2009 as a minimally invasive approach
tion, leading to widespread adoption in many to resect oropharyngeal tumors.12 The recon-
disciplines, such as urology, gynecology, cardiac struction of these defects also can be performed
surgery, and general surgery.5 robotically, thus eliminating the need for mandib-
ulotomy and lip-split incision, allowing for a high
degree of precision and visualization within the
CURRENT APPLICATIONS OF ROBOTIC oropharynx.13–15 Robotic surgery has the poten-
SURGERY tial to be applied to other indications in cranio-
The introduction of robotic surgery into sur- facial surgery beyond oncologic reconstruction.
gical practice began with procedures addressing A preclinical study recently reported the develop-
anatomically uniform and easily reachable organs ment of a cleft palate simulator for robotic cleft
located at a safe distance from vital structures, palate surgery,16 providing superior visualization,
such as transurethral prostate resection beginning improved ergonomics, increased dexterity, and
240
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 152, Number 1 • Robotics in Plastic Surgery
greater instrument articulation within the intra- MUSA robot (Microsure) compared with conven-
oral space compared with standard instruments.17 tional anastomosis.
Indications for robotic muscle harvest include Dobbs et al.4 performed a systematic review
free flaps, as well as pedicled flaps for chest wall, on the use of robotics in plastic surgery in
pelvic, and breast reconstruction. Harvesting the 2017. In Tables, Supplemental Digital Content
rectus abdominis or latissimus dorsi flaps requires 1 through 3, we provide an updated overview
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
extensive skin incisions, which can result in poor of studies using robotic technologies published
cosmetic outcomes and significant donor-site between January of 2018 and March of 2022.
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
morbidity.18 The da Vinci surgical system can be The MEDLINE and PubMed Central databases
used to harvest rectus abdominis flaps without were queried. The Preferred Reporting Items for
violating the anterior rectus sheath, thus decreas- Systematic Reviews and Meta-Analyses (PRISMA)
ing incisional morbidity.19,20 Robotic latissimus flow diagram in Figure 2 summarizes our search
dorsi harvest has demonstrated benefits over tra- strategy using Medical Subject Heading (MeSH)
ditional open and endoscopic techniques, neces- terms.32 Identified studies were imported into
sitating only minimal donor-site incisions and EndNote X9 (Clarivate Analytics), and duplicates
leading to reduced postoperative pain and length were removed. Records were then uploaded to
of hospitalization.10,21,22 the Covidence platform (www.covidence.org) for
Early experience with robotic nipple-sparing screening by two independent reviewers (D.H.
mastectomy and implant-based reconstruction and S.M.) using inclusion and exclusion crite-
has demonstrated low rates of skin necrosis and ria (Fig. 2). (See Table, Supplemental Digital
a high degree of patient satisfaction. A transaxil- Content 1, which shows studies on breast surgery
lary approach through small incisions also may using robotic technologies published between
improve aesthetic outcomes.23,24 For autologous January of 2018 and March of 2022, http://links.
breast reconstruction, robotic pedicle dissection lww.com/PRS/F932. See Table, Supplemental
of the deep inferior epigastric perforator flap can Digital Content 2, which shows studies on cra-
be performed using a transabdominal approach niofacial surgery/head and neck reconstruction
from the posterior surface of the abdominal wall, using robotic technologies published between
thus reducing the length of the fascial incision of January of 2018 and March of 2022, http://links.
the anterior rectus sheath.9,25,26 lww.com/PRS/F933. See Table, Supplemental
Robotic surgery has allowed for improved Digital Content 3, which shows studies on recon-
visualization, precision, and flexibility in com- structive/flap surgery using robotic technologies
plex ventral hernia repairs compared with stan- published between January of 2018 and March of
dard laparoscopic approaches.27 Robot-assisted 2022, http://links.lww.com/PRS/F934.)
transabdominal preperitoneal surgery for large
ventral hernias allows for a dissection in three-
dimensional space and minimally invasive mesh IDENTIFIED NEEDS FOR ARTIFICIAL
placement.28 INTELLIGENCE ROBOTS IN PLASTIC
Robotic applications in microsurgery have the SURGERY
potential to revolutionize a field in which a high Although multiple indications for robotics in
degree of precision is critical for successful post- plastic surgery have been described, the adoption
operative outcomes.29 Several companies, such of robotic technology into clinical practice has
as Microsure (Eindhoven, Netherlands) (Fig. 1) been slow and is limited to some highly special-
and Medical MicroInstruments, Inc. (Calci, Italy), ized centers.10 Because most procedures in plastic
have developed robots specifically created for surgery involve surface anatomy and traditionally
microsurgical applications.30 These new systems rely on open surgical approaches, the benefits of
may be particularly useful for supermicrosur- robotically assisted surgery might not be immedi-
gery such as lymphovenous and perforator-to- ately evident to surgeons.
perforator anastomoses.30 Robotic surgery offers Another obstacle to routine implementation
important advantages, such as motion scaling for of robotics into clinical practice in plastic sur-
tremor elimination and enhanced precision and gery is the high cost of the existing systems on
stability during complex microvascular anastomo- the market, which can exceed $2 million for the
sis. Van Mulken et al.31 recently demonstrated a robot and $2000 to $6000 in consumables per 10
significantly shorter operative time in a case series procedures. The Microsure robotic system, for
of lymphovenous anastomosis for the treatment example, is in the same price bracket as many
of breast cancer–related lymphedema using the high-end microscopes, ranging between $400,000
241
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2023
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
Fig. 2. PRISMA flow diagram showing the search strategy and process for article retrieval and screening. MEDLINE and PubMed
Central databases were queried for studies on robotic technology in plastic surgery between January of 2019 and March of 2022.
and $650,000 for a fully loaded microsurgery stay associated with robotic surgery cannot be
robot and $3000 and $4000 in consumables.33 A immediately anticipated.10,36 Further obstacles
robot with Medical MicroInstrument’s Complete to widespread adoption of currently available
Symani System developed for microsurgery pro- robotic platforms are the small range of appropri-
cedures costs $1.06 million and $4000 to $5000 ate surgical instruments for robotic microsurgery
in consumables.34 A more well-known system, the and the lack of a structured robotic training cur-
da Vinci XI robot, costs ≈$2 million, with $3000 riculum for plastic surgeons.10,36 To improve sur-
to $6000 in consumables.35 Initial upfront costs gical education in robotics during plastic surgery
offer a deterrence to some health care systems to residency and fellowship training, standardized
adopt robotic procedures into practice, even with assessment tools have been tested and validated.37
stated patient benefits to microscopic robotic Novel robotic platforms, such as the Versius
surgery. CPT codes and diagnosis-related groups system (CMR Medical, Cambdridge, United
do not reflect the use of robotics and therefore Kingdom), which recently received CE approval
are coded as standard laparoscopic approaches. in the European Union and is being used clini-
The concern for inadequate reimbursement may cally in India, are addressing some of these limi-
prevent surgeons and hospital administrations tations by pursuing alternative strategies such
from engaging in robot-assisted surgery, because as operating with a system as a service business
the benefits of cost reduction attributable to model instead of a fixed high price to purchase
reduced operative times or duration of hospital the device and consumables, reducing the cost of
242
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 152, Number 1 • Robotics in Plastic Surgery
the lifetime operation of a robot for a hospital by Some common applications of neural networks
30% to 40%.38 This payment model would reduce include image or pattern recognition, self-
overall robot and consumable costs from $8 mil- driving vehicle trajectory prediction, and facial
lion to ~$6 million and may be prudent and more recognition.44
readily adopted by hospitals and clinics as it will Unsupervised learning, on the other hand,
mitigate substantial long-term costs for robotic does not use labeled training data.44 Instead, the
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
surgery systems. The continuous improvement of algorithms try to infer the relationship among the
robotic technologies and introduction of artificial data based on natural structures present within
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
intelligence (AI) have the potential to overcome the dataset (eg, color, shape). This type of learn-
the obstacles of robotics in clinical practice by ing categorizes an unlabeled dataset by identify-
making technology more user-friendly and allow- ing underlying undetected patters44 (Fig. 3).
ing for more competitive pricing because of stan-
dardized production pipelines.
Next-Generation Semiautonomous Robots
In robot-assisted surgery, most platforms are
APPLICATIONS OF AI ROBOTS semiautonomous. The robots are operated by
algorithms that use a form of supervised learn-
Principles of AI ing.45 Engineers train an algorithm on the correct
The use of AI within robotics is defined as a output task given a certain input, enabling the
concept of self-improving algorithms that enable robot to become efficient at performing special-
machines to recognize objects or words and orga- ized tasks without experiencing fatigue or tremor.
nize them into actionable patterns, which are Robot-assisted surgery has been refined to provide
then utilized to solve problems or make deci- surgeons with an immersive virtual experience
sions.39 The core feature of AI-driven software is that mimics the mechanics of an operative pro-
machine learning, that is, the incorporation of cedure, providing AI assistance to enhance the
algorithms whose performance improves as they user experience.46 With recent advancements in
are exposed to more data over time.40 Machine machine learning, robot-assisted surgery is mov-
learning is divided into two fields: supervised and ing toward a revolution that can enhance surgi-
unsupervised learning. The difference between cal environment perception, precision, safety, and
the two types of learning is that supervised learn- efficiency. Advanced robotic technologies being
ing is performed using a ground truth. A ground developed that incorporate multiple biosensors
truth refers to previous knowledge about the cor- as well as AI with a limited degree of autonomy
rect output value that is expected from an algo- will likely transform the way surgery is performed
rithm performing a certain computational task.41 in the future (Fig. 4, above).
Common supervised learning algorithms Physical touch of tissue traditionally has pro-
include logistic regression, support vector vided critical haptic feedback to the surgeon,
machines, naïve Bayes, and random forests, which information about pathologies, and guidance
are applied to a dataset to “learn” the correct about the appropriate amount of force to apply
label.41 Once a model is able to learn differences during a procedure. Robotic surgery interrupts
among data entities (eg, images, using such vari- the physical connection between the surgeon
ables as pixels, shapes, and color), the perfor- and the patient and in telerobotic surgery even
mance of the model can be evaluated on a test between the surgeon and the robot. This poses
dataset (data to which the algorithm has not been challenges that are being addressed by technolog-
exposed), allowing the operator to observe how ical advancements using AI. Soft-surface robots
well the “trained model” performs at accurately with large-area sensor arrays, called “e-skin,” are
classifying the data.41 being developed, which mimic the mechanical
The term “neural networks” recently has and haptic features of a surgeon’s hands, provid-
gained traction in supervised learning.42,43 These ing spatial resolution and thermal sensitivity.47
algorithms learn by receiving input from many Novel e-skin developments go beyond physical
labeled examples and decouple each example to properties of human skin and are able to perform
understand its underlying features.43 By decon- metabolic biosensing and transmit information
structing an input, the neural network is able to wirelessly to the user interface using Bluetooth
reconstruct it with a correct output. To achieve technology.48
greater neural network accuracy, a large num- A rapidly evolving area that aims to enhance
ber of diverse training examples are needed.43,44 the human–machine interface is the development
243
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2023
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
Fig. 3. Supervised learning algorithms (eg, artificial neural networks) infer a function from a set of labeled training examples (train-
ing dataset), which can then be used to map unknown datasets. By deconstructing an input, supervised algorithms are able to
reconstruct it with a correct output. Unsupervised learning does not use labeled training data; instead, the algorithms try to infer
the relationship among the data based on natural structures present within the dataset (eg, color, shape). This type of learning
categorizes an unlabeled dataset by identifying underlying undetected patterns.
of AI-powered enhanced intraoperative imaging. Incision, Omaha, NE), whose arms can enter
Near-infrared cameras incorporated into robotic body cavities through a single incision.53 Catheter-
systems enable surgeons to perform indocyanine like continuum robots also have been developed,
green fluorescence imaging intraoperatively,49 an which can reach surgical target sites along tor-
option currently being transformed into three- tuous anatomic paths.54 Combined mechanical
dimensional visualization.50 Multiphoton micros- refinement and miniaturization have generated a
copy enables the visualization of subcellular novel class of “microbots” that mimic and extend
structures, such as muscle-embedded nerve fibers, the range of endoscopic surgery toward devices
without contrast enhancing or labeling.51 Confocal autonomously navigating within body cavities and
laser endomicroscopy allows for real-time in vivo vessels, as exemplified for endovascular heart
histologic evaluation of tissues on a cellular level, valve repair.55,56
providing real-time intraoperative cellular-level Semiautonomous platforms currently in clin-
magnified images with up to 5 μm resolution.52 ical use, such as the latest generation of the da
Another pathway of technological develop- Vinci robot or the Mazor X Spine Assist robot,
ment is driven toward miniaturized devices, such employ AI algorithms and feedback sensors; how-
as the miniature in vivo robot (MIVR; Virtual ever, these devices are completely dependent on
244
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 152, Number 1 • Robotics in Plastic Surgery
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
Fig. 4. (Above) The development of artificially intelligent robots requires machine learning algorithms that integrate
multimodal training datasets. (Below) The development of autonomous surgical robots requires advanced biosensors
(positional, haptic, and optic sensors) that process and integrate data from the patient, the surgical environment, and
surgical tools.
human control. The next generation of surgical For a patient receiving robot-assisted surgery
robots will integrate greater amounts of auto- under the joint custodianship of a human surgeon
mation algorithms that could ultimately lead to and a robot, accountability for surgical complica-
autonomous surgical robots57 (Fig. 4, below). tions will have to be reassessed with respect to the
physician–robot–patient axis.60 Would blame for
an atypical cut be placed on the surgeon or on
LIMITATIONS the engineering team who designed the robot?
The transition of a robotic device that Who would be held accountable for a technical
depends on a human surgeon’s decisions toward malfunction, such as tissue damage caused by
a fully autonomous artificially intelligent robot mechanical failure of a robotic cutting tool: the
that makes unsupervised final decisions and surgeon for negligence, the clinic for improper
irreversible physical actions bears obvious ethi- maintenance, or the manufacturer for faulty
cal and legal challenges.58 With regard to the design? Legal analyses show that early adopters
development and application of AI software in of novel robotic techniques are at highest risk of
medicine, the FDA took a major step in April litigation.61,62 These substantial uncertainties are
of 2019 by proposing a regulatory framework an urgent call for authoritative guidelines to be
to ensure that safe and effective AI technology developed through a multidisciplinary consensus
reaches users, including patients and health care process,58 which should also scrutinize the modes
professionals.59 of credentialing surgeons for guiding robotic
245
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2023
and training of surgeons, nurses, and other staff crosurgery,31 novel AI-driven technologies could
members.65–69 advance the field further and reduce operative
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
246
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 152, Number 1 • Robotics in Plastic Surgery
DISCLOSURE
CALL FOR INNOVATION
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
247
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Plastic and Reconstructive Surgery • July 2023
18. Ascherman JA, Seruya M, Bartsich SA. Abdominal wall mor- system: experience at Galaxy Care Laparoscopy Institute. J
bidity following unilateral and bilateral breast reconstruc- Robot Surg. 2021;15:451–456.
tion with pedicled TRAM flaps: an outcomes analysis of 117 39. Hamet P, Tremblay J. Artificial intelligence in medicine.
consecutive patients. Plast Reconstr Surg. 2008;121:1–8. Metabolism 2017;69:S36–S40.
19. Pedersen J, Song DH, Selber JC. Robotic, intraperitoneal 40. Esteva A, Robicquet A, Ramsundar B, et al. A guide to deep
harvest of the rectus abdominis muscle. Plast Reconstr Surg. learning in healthcare. Nat Med. 2019;25:24–29.
2014;134:1057–1063. 41. Uddin S, Khan A, Hossain ME, Moni MA. Comparing dif-
Downloaded from http://journals.lww.com/plasreconsurg by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0
20. Asaad M, Pisters LL, Klein GT, et al. Robotic rectus abdomi- ferent supervised machine learning algorithms for disease
nis muscle flap following robotic extirpative surgery. Plast prediction. BMC Med Inform Decis Mak. 2019;19:281.
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
Reconstr Surg. 2021;148:1377–1381. 42. Hu Y, Zhang L, Li W, Yang G-Z. Robotic sewing and knot
21. Selber JC, Baumann DP, Holsinger FC. Robotic latissi- tying for personalized stent graft manufacturing. arXiv.
mus dorsi muscle harvest: a case series. Plast Reconstr Surg. Preprint posted online March 22, 2018.
2012;129:1305–1312. 43. Zhang Z. A gentle introduction to artificial neural networks.
22. Vourtsis SA, Paspala A, Lykoudis PM, et al. Robotic-assisted Ann Transl Med. 2016;4:370.
harvest of latissimus dorsi muscle flap for breast reconstruc- 44. Gris KV, Coutu JP, Gris D. Supervised and unsupervised
tion: review of the literature. J Robot Surg. 2022;16:15–19. learning technology in the study of rodent behavior. Front
23. Toesca A, Peradze N, Galimberti V, et al. Robotic nipple- Behav Neurosci. 2017;11:141.
sparing mastectomy and immediate breast reconstruction 45. Hashimoto DA, Rosman G, Rus D, Meireles OR. Artificial
with implant: first report of surgical technique. Ann Surg. intelligence in surgery: promises and perils. Ann Surg.
2017;266:e28–e30. 2018;268:70–76.
24. Selber JC. Robotic nipple-sparing mastectomy: the next step 46. Camarillo DB, Krummel TM, Salisbury JK Jr. Robotic tech-
in the evolution of minimally invasive breast surgery. Ann nology in surgery: past, present, and future. Am J Surg.
Surg Oncol. 2019;26:10–11. 2004;188:2S–15S.
25. Bishop SN, Asaad M, Liu J, et al. Robotic harvest of the deep 47. El Rassi I, El Rassi JM. A review of haptic feedback
inferior epigastric perforator flap for breast reconstruction: in tele-operated robotic surgery. J Med Eng Technol.
a case series. Plast Reconstr Surg. 2022;149:1073–1077. 2020;44:247–254.
26. Kurlander DE, Le-Petross HT, Shuck JW, Butler CE, Selber 48. Yu Y, Nassar J, Xu C, et al. Biofuel-powered soft electronic
JC. Robotic DIEP patient selection: analysis of CT angiogra- skin with multiplexed and wireless sensing for human-
phy. Plast Reconstr Surg Glob Open 2021;9:e3970. machine interfaces. Sci Robot. 2020;5:eaaz7946.
27. Fagermoen MS, Nygard AK. [Practice studies: what it can 49. Ferrari-Light D, Geraci TC, Sasankan P, Cerfolio RJ. The util-
and should be.] Sykepleien 1989;77:20–23. ity of near-infrared fluorescence and indocyanine green dur-
28. Bittner JG, Alrefai S, Vy M, Mabe M, Del Prado PAR, ing robotic pulmonary resection. Front Surg. 2019;6:47.
Clingempeel NL. Comparative analysis of open and robotic 50. Vizzielli G, Cosentino F, Raimondo D, et al. Real three-
transversus abdominis release for ventral hernia repair. Surg dimensional approach vs two-dimensional camera with and
Endosc. 2018;32:727–734. without real-time near-infrared imaging with indocyanine
29. Ibrahim AE, Sarhane KA, Selber JC. New frontiers in green for detection of endometriosis: a case-control study.
robotic-assisted microsurgical reconstruction. Clin Plast Surg. Acta Obstet Gynecol Scand. 2020;99:1330–1338.
2017;44:415–423. 51. Tewari AK, Shevchuk MM, Sterling J, et al. Multiphoton
30. van Mulken TJM, Boymans C, Schols RM, et al. Preclinical microscopy for structure identification in human prostate
experience using a new robotic system created for microsur- and periprostatic tissue: implications in prostate cancer sur-
gery. Plast Reconstr Surg. 2018;142:1367–1376. gery. BJU Int. 2011;108:1421–1429.
31. van Mulken TJM, Schols RM, Scharmga AMJ, et al; 52. Gudeloglu A, Brahmbhatt JV, Parekattil SJ. Robotic-assisted
MicroSurgical Robot Research Group. First-in-human microsurgery for an elective microsurgical practice. Semin
robotic supermicrosurgery using a dedicated microsurgical Plast Surg. 2014;28:11–19.
robot for treating breast cancer-related lymphedema: a ran- 53. Peters BS, Armijo PR, Krause C, Choudhury SA, Oleynikov
domized pilot trial. Nat Commun. 2020;11:757. D. Review of emerging surgical robotic technology. Surg
32. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 Endosc. 2018;32:1636–1655.
statement: an updated guideline for reporting systematic 54. Shi C, Luo X, Qi P, et al. Shape sensing techniques for con-
reviews. BMJ. 2021;372:n71. tinuum robots in minimally invasive surgery: a survey. IEEE
33. Microsure. Robot assisted microsurgery. Available at: Trans Biomed Eng. 2017;64:1665–1678.
https://microsure.nl. Accessed April 1, 2022. 55. Ashrafian H, Clancy O, Grover V, Darzi A. The evolution
34. MMI. Symani System Overview. Available at: https://www. of robotic surgery: surgical and anaesthetic aspects. Br J
mmimicro.com/symani-system-overview. Accessed April 1, Anaesth. 2017;119:i72–i84.
2022. 56. Fagogenis G, Mencattelli M, Machaidze Z, et al. Autonomous
35. van Dam P, Hauspy J, Verkinderen L, et al. Are costs of robot- robotic intracardiac catheter navigation using haptic vision.
assisted surgery warranted for gynecological procedures? Sci Robot. 2019;4:eaaw1977.
Obstet Gynecol Int. 2011;2011:973830. 57. Staub BN, Sadrameli SS. The use of robotics in minimally
36. Tan YPA, Liverneaux P, Wong JKF. Current limitations of invasive spine surgery. J Spine Surg. 2019;5:S31–S40.
surgical robotics in reconstructive plastic microsurgery. Front 58. O’Sullivan S, Nevejans N, Allen C, et al. Legal, regulatory,
Surg. 2018;5:22. and ethical frameworks for development of standards in arti-
37. Alrasheed T, Liu J, Hanasono MM, Butler CE, Selber ficial intelligence (AI) and autonomous robotic surgery. Int J
JC. Robotic microsurgery: validating an assessment Med Robot. 2019;15:e1968.
tool and plotting the learning curve. Plast Reconstr Surg. 59. Food and Drug Administration. Proposed Regulatory
2014;134:794–803. Framework for Modifications to Artificial Intelligence/
38. Puntambekar SP, Goel A, Chandak S, et al. Feasibility of Machine Learning (AI/ML)–Based Software as a Medical
robotic radical hysterectomy (RRH) with a new robotic Device (SaMD). Published June 3, 2019. Available at: https://
248
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.
Volume 152, Number 1 • Robotics in Plastic Surgery
trials. JAMA Surg. 2017;152:717–718. 71. Shademan A, Decker RS, Opfermann JD, Leonard S, Krieger
62. Nik-Ahd F, Souders CP, Zhao H, et al. Robotic urologic sur- A, Kim PC. Supervised autonomous robotic soft tissue sur-
hCywCX1AWnYQp/IlQrHD3i3D0OdRyi7TvSFl4Cf3VC4/OAVpDDa8K2+Ya6H515kE= on 08/17/2023
gery: trends in litigation over the last decade. J Robot Surg. gery. Sci Transl Med. 2016;8:337ra64.
2019;13:729–734. 72. Garas G, Cingolani I, Patel V, et al. Surgical innovation
63. Liu R, Wakabayashi G, Palanivelu C, et al. International con- in the era of global surgery: a network analysis. Ann Surg.
sensus statement on robotic pancreatic surgery. Hepatobiliary 2020;271:868–874.
Surg Nutr. 2019;8:345–360. 73. Haidegger T, Sandor J, Benyo Z. Surgery in space: the future
64. Lai HW, Toesca A, Sarfati B, et al. Consensus statement of robotic telesurgery. Surg Endosc. 2011;25:681–690.
on robotic mastectomy: expert panel from International 74. Grasso S, Dilday J, Yoon B, Walker A, Ahnfeldt E. Status of
Endoscopic and Robotic Breast Surgery Symposium (IERBS) robotic-assisted surgery (RAS) in the Department of Defense
2019. Ann Surg. 2020;271:1005–1012. (DoD). Mil Med. 2019;184:e412–e416.
65. Kockerling F, Sheen AJ, Berrevoet F, et al. The reality of gen- 75. Reichenbach M, Frederick T, Cubrich L, et al. Telesurgery
eral surgery training and increased complexity of abdominal with miniature robots to leverage surgical expertise
wall hernia surgery. Hernia 2019;23:1081–1091. in distributed expeditionary environments. Mil Med.
66. Soomro NA, Hashimoto DA, Porteous AJ, et al. Systematic 2017;182:316–321.
review of learning curves in robot-assisted surgery. BJS Open 76. Samalavicius NE, Siaulys R, Janusonis V, Klimasauskiene V,
2020;4:27–44. Dulskas A. Use of 4 robotic arms performing Senhance(R)
67. Chen R, Rodrigues Armijo P, Krause C, Force SRT, Siu KC, robotic surgery may reduce the risk of coronavirus infec-
Oleynikov D. A comprehensive review of robotic surgery cur- tion to medical professionals during COVID-19. Eur J Obstet
riculum and training for residents, fellows, and postgraduate Gynecol Reprod Biol. 2020;251:274–275.
surgical education. Surg Endosc. 2020;34:361–367. 77. Rosen MA, Lee BH, Sampson JB, et al. Failure mode and
68. Uslu Y, Altinbas Y, Ozercan T, van Giersbergen MY. The effects analysis applied to the maintenance and repair of
process of nurse adaptation to robotic surgery: a qualitative anesthetic equipment in an austere medical environment.
study. Int J Med Robot. 2019;15:e1996. Int J Qual Health Care 2014;26:404–410.
249
Copyright © 2023 American Society of Plastic Surgeons. Unauthorized reproduction of this article is prohibited.