Notification  of  adverse  effects  of  drugs  in  oncology  

 
(1) (1) (1) (2) (2)  (3) (1,2)
S.BENNIS ,  M.  BENABBES ,  M.ALAMI  CHENTOUFI ,  A.  SBAI ,,  W.  CHAOUKI ,,  Y.CHERRAH ,    B.MEDDAH  
1 : Pharmacie, Institut national d’oncologie, Centre hospitalier Ibn Sina, Rabat
2: Unité de Recherche Qualité et Communication, Institut national d’oncologie, Centre hospitalier Ibn Sina, Rabat
3 : Laboratoire de pharmacologie et toxicologie, faculté de médecine et de pharmacie de Rabat.
 

Abstract
Introduction

The cytotoxics adverse effects are numerous, frequent and severe; and
can even lead to a sustainable sometimes significant disability The
notification in oncology is, therefore, a necessity so as to permanently
evaluate the relation benefit/risk of every anti-cancer drug,
This study aims to present the most important side effects of anticancer
drug, to follow and to prevent their occurrence. Also, we will present the
case of reporting of adverse effects of chemotherapy at the National
Institute of Oncology of Rabat.

Patients and methods :

This is a descriptive study conducted at the National Institute of Oncology
in Rabat.
The register of notifications of adverse events to drugs and other health
products is used to notify and report anti-cancer drugs anomaly.

Results:
We found at the day hospital reserved for daily chemotherapy, various
adverse events were detected:
- oxaliplatin : Respiratory problems with a dry cough
- Oxaliplatin : skin reaction with facial redness and at arms.
- Bleomycin, etoposide, Cisplatin in association: Flagellate eryhtema
in all the body of the patient  
- Oxaliplatin : Tingling in the mouth and feet and loss of taste.
- Fluotouracile, irinotecan, bevacizumab, folinate : severe mucositis IV

Conclusion :
Notification of any defects such as it is, especially in oncology, is the only
strategy and solution to monitor the safety of cytotoxic and subsequently
improve patient health .