‫ارﺗﺒﺎط ﺑﻴﻦ ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ‪ ABO‬و ‪ Rh‬و اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ‬

‫‪٣‬‬ ‫‪٢‬‬ ‫‪١‬‬

‫ﻓﺘﺎﻧﻪ ﺗﻮﺳﻠﻴﺎن‪ ،1‬اﻟﻬﺎم ﻋﺒﺪاﻟﻬﻲ ‪ ،‬دﻛﺘﺮﻣﺤﻤﻮد وﻛﻴﻠﻲ ‪ ،‬ﻋﻠﻲ اﻣﻴﻨﻲ *‬

‫‪-1‬ﻛﺎرﺷﻨﺎس ارﺷﺪ اﻳﻤﻨﻮﻟﻮژي‪ ،‬داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ ﺷﻬﻴﺪ ﺻﺪوﻗﻲ ﻳﺰد‪ ،‬داﻧﺸﻜﺪه ﭘﺰﺷﻜﻲ‪،‬ﮔﺮوه اﻳﻤﻨﻮﻟﻮژي‬
‫‪-2‬دﻛﺘﺮاي ﭘﺰﺷﻜﻲ اﺟﺘﻤﺎﻋﻲ‪ ،‬داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ ﺷﻬﻴﺪ ﺻﺪوﻗﻲ ﻳﺰد‪ ،‬داﻧﺸﻜﺪه ﭘﺰﺷﻜﻲ‪،‬ﮔﺮوه ﭘﺰﺷﻜﻲ اﺟﺘﻤﺎﻋﻲ‬
‫‪-3‬ﻛﺎرﺷﻨﺎس ارﺷﺪ ﻫﻤﺎﺗﻮﻟﻮژي‪ ،‬داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ ﺷﻬﻴﺪ ﺻﺪوﻗﻲ ﻳﺰد‪ ،‬داﻧﺸﻜﺪه ﭘﺰﺷﻜﻲ‪،‬ﮔﺮوه ﻫﻤﺎﺗﻮﻟﻮژي‬

‫*ﻧﻮﻳﺴﻨﺪه ﻣﺴﺌﻮل‪ :‬ﻋﻠﻲ اﻣﻴﻨﻲ‪ -‬ﭘﺴﺖ اﻟﻜﺘﺮوﻧﻴﻜﻲ‪Tav.15600@gmail.com :‬‬

‫ﭼﻜﻴﺪه‬

‫ﻣﻘﺪﻣﻪ و ﻫﺪف‪ :‬دﻳﺎﺑﺖ‪ ،‬ﺑﻴﻤﺎري ﻣﺰﻣﻦ و ﭘﻴﺸﺮوﻧﺪهاي اﺳﺖ ﻛﻪ ﺑﺎﻋﺚ ﻧﺎﺗﻮاﻧﻲ و ﻣﺮگ و ﻣﻴﺮ زودرس ﻣﻲﺷﻮد‪ .‬ﻋﻠﺖﺷﻨﺎﺳﻲ‬

‫دﻳﺎﺑﺖ ﻣﻠﻴﺘﻮس ﭘﻴﭽﻴﺪه اﺳﺖ وﻟﻲ ﻋﻮاﻣﻠﻲ ﻣﺎﻧﻨﺪ ژﻧﺘﻴﻚ‪ ،‬اﻳﻤﻮﻧﻮﻟﻮژﻳﻚ و ﻣﺤﻴﻂ در آن دﺧﺎﻟﺖ دارﻧﺪ‪ .‬ﻫﺪف از اﻳﻦ ﭘﮋوﻫﺶ‬

‫ﺑﺮرﺳﻲ ارﺗﺒﺎط ﺑﻴﻦ اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ و ﻧﻮع ﮔﺮوه ﺧﻮﻧﻲ اﻓﺮاد ﺑﻮد‪.‬‬

‫ﻣﻮاد و روشﻫﺎ‪ :‬در اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ– ﻣﻘﻄﻌﻲ ﮔﺮوه ﺧﻮﻧﻲ ‪ 237‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ ﺑﺎ ﮔﺮوه ﺧﻮﻧﻲ ‪ 251‬ﻧﻔﺮ از‬

‫اﻓﺮاد ﻛﻨﺘﺮل ﻣﻘﺎﻳﺴﻪ ﮔﺮدﻳﺪ‪.‬‬

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‫ﻳﺎﻓﺘﻪﻫﺎ‪ :‬ﺗﻮزﻳﻊ ﮔﺮوهﺧﻮﻧﻲ‪ 237‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ ﺑﺼﻮرت ‪ 59‬ﻧﻔﺮ )‪ 56 ،A (%24.9‬ﻧﻔﺮ )‪15 ،B(%23.7‬‬

‫ﻧﻔﺮ)‪107 ،AB(%6.3‬ﻧﻔﺮ)‪ O(%45.1‬و ﺗﻮزﻳﻊ ﮔﺮوهﺧﻮﻧﻲ ‪ 251‬ﻓﺮد ﮔﺮوه ﻛﻨﺘﺮل ﺑﺼﻮرت ‪25‬ﻧﻔﺮ )‪69 ،A(%63‬ﻧﻔﺮ‬

‫)‪18 ،B(%25.6‬ﻧﻔﺮ )‪ AB (%6.8%‬و‪101‬ﻧﻔﺮ )‪ O (%42.6‬ﺑﻮدﻧﺪ‪.‬‬

‫ﺑﺤﺚ و ﻧﺘﻴﺠﻪﮔﻴﺮي‪ :‬در اﻳﻦ ﻣﻄﺎﻟﻌﻪ ارﺗﺒﺎط ﻣﻌﻨﻲداري ﺑﻴﻦ دﻳﺎﺑﺖ و ﮔﺮوه ﺧﻮﻧﻲ ﭘﻴﺪا ﻧﺸﺪ‪ .‬اﻟﺒﺘﻪ اﺧﺘﻼف دو ﮔﺮوه ﻣﻮرد‬

‫ﻣﻄﺎﻟﻌﻪ از ﻧﻈﺮ ﻧﻮع ‪ RH‬ﻣﻌﻨﻲدار ﺑﻮد)‪. (P<0.0001‬‬

‫واژهﻫﺎي ﻛﻠﻴﺪي‪ :‬دﻳﺎﺑﺖ‪ ،‬ﮔﺮوه ﺧﻮﻧﻲ‪ ،‬ﻋﺎﻣﻞ‪.RH‬‬

‫] ‪[ DOR: 20.1001.1.23455020.1393.2.1.4.7‬‬

‫‪٢٨‬‬
 ‫دوره ‪ –2‬ﺷﻤﺎره‪ -1‬ﺑﻬﺎر‪93‬‬ ‫ﻓﺼﻠﻨﺎﻣﻪ ﭘﺮﺳﺘﺎري دﻳﺎﺑﺖ داﻧﺸﻜﺪه ﭘﺮﺳﺘﺎري و ﻣﺎﻣﺎﻳﻲ زاﺑﻞ‬

‫ﻣﻘﺪﻣﻪ‬

‫ﻧﺎﭘﺬﻳﺮ‪ ،‬زﻣﻴﻨﻪﻫﺎي ژﻧﺘﻴﻜﻲ اﻓﺮاد ﻣﻲﺑﺎﺷﺪ )‪ .(6‬ﺷﻮاﻫﺪ ﺣﺎﻛﻲ از آن‬ ‫ﺑﻴﻤﺎري دﻳﺎﺑﺖ ﺷﺎﻳﻊﺗﺮﻳﻦ ﺑﻴﻤﺎري ﻧﺎﺷﻲ از اﺧﺘﻼﻻت ﻣﺘﺎﺑﻮﻟﻴﺴﻢ‬

‫اﺳﺖ ﻛﻪ وراﺛﺖ ﻧﻘﺶ ﻣﻬﻤﻲ در اﻳﺠﺎد اﻳﻦ ﺑﻴﻤﺎري دارد و ﺷﻴﻮع‬ ‫ﻣﻲﺑﺎﺷﺪ ﺑﻴﻤﺎريزاﻳﻲ اﻳﻦ ﻋﺎرﺿﻪ ﭼﻪ از ﻧﻈﺮ ﻫﺰﻳﻨﻪﻫﺎي درﻣﺎﻧﻲ و‬

‫اﻳﻦ ﺑﻴﻤﺎري در ﺧﺎﻧﻮادهﻫﺎﻳﻲ ﻛﻪ ﺳﺎﺑﻘﻪ اﺑﺘﻼ ﺑﻪ اﻳﻦ ﺑﻴﻤﺎري را‬ ‫ﭼﻪ از ﻧﻈﺮ از ﻛﺎر اﻓﺘﺎدﮔﻲ‪ ،‬ﺑﺴﻴﺎر ﺑﺎﻻ و ﻳﻜﻲ از ﻋﻤﺪهﺗﺮﻳﻦ ﻣﺴﺎﺋﻞ‬

‫دارﻧﺪ ﺑﻴﺸﺘﺮ از ﺧﺎﻧﻮادهﻫﺎﻳﻲ اﺳﺖ ﻛﻪ در آﻧﻬﺎ زﻣﻴﻨﻪ ارﺛﻲ وﺟﻮد‬ ‫ﺑﻬﺪاﺷﺘﻲ‪ ،‬درﻣﺎﻧﻲ اﻧﺴﺎنﻫﺎ اﺳﺖ )‪ .(1‬دﻳﺎﺑﺖ‪ ،‬ﺑﻴﻤﺎري ﻣﺰﻣﻦ و‬

‫ﻧﺪارد )‪ .(7‬ﻫﻤﭽﻨﻴﻦ دﻳﺪه ﺷﺪه اﺳﺖ ﻛﻪ ﺷﻴﻮع دﻳﺎﺑﺖ ﻗﻨﺪي در‬ ‫ﭘﻴﺸﺮوﻧﺪهاي اﺳﺖﻛﻪ ﺑﺎﻋﺚ ﻧﺎﺗﻮاﻧﻲ و ﻣﺮگ وﻣﻴﺮ زودرس ﻣﻲﺷﻮد‬

‫دو ﻗﻠﻮﻫﺎي ﺗﻚﺗﺨﻤﻲ ﺑﻴﺶ از ‪ 3‬ﺑﺮاﺑﺮ دوﻗﻠﻮﻫﺎي دوﺗﺨﻤﻲ اﺳﺖ‬ ‫و ﻋﺎﻣﻞ اﺻﻠﻲ ﻛﻮري‪ ،‬ﺑﻴﻤﺎري ﻛﻠﻴﻮي ﭘﻴﺸﺮﻓﺘﻪ و ﻗﻄﻊ ﻋﻀﻮ ﺑﻮﻳﮋه‬

‫)‪ .(8‬و ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ اﻳﻨﻜﻪ ﻋﺎﻣﻞ اﻳﺠﺎد اﻳﻦ ﺑﻴﻤﺎري ﺑﻪ ﺻﻮرت ژن‬ ‫در ﺳﻨﻴﻦ ﻛﺎري اﺳﺖ )‪ .(2‬اﻳﻦ ﺑﻴﻤﺎري ﺑﺎ ﻣﺘﺎﺑﻮﻟﻴﺴﻢ ﻏﻴﺮﻃﺒﻴﻌﻲ‬

‫ﻣﻐﻠﻮب ﻣﻲﺑﺎﺷﺪ ﺣﺪود ‪ %22‬اﻓﺮاد ﻧﺎﻗﻞ اﻳﻦ ژن ﻫﺴﺘﻨﺪ‪.‬‬ ‫ﻛﺮﺑﻮﻫﻴﺪراتﻫﺎ‪ ،‬ﭘﺮوﺗﺌﻴﻦﻫﺎ و ﭼﺮﺑﻲﻫﺎ ﻫﻤﺮاه اﺳﺖ )‪ .(3‬دﻳﺎﺑﺖ‬

‫ﻛﺮوﻣﻮزوم اﻧﺴﺎﻧﻲ ‪ q21-q23‬ﺑﺎ دﻳﺎﺑﺖ ﻧﻮع دو در ارﺗﺒﺎط اﺳﺖ‬ ‫ﺷﻴﺮﻳﻦ )‪ (DM‬ﺑﻪ دو ﻧﻮع دﻳﺎﺑﺖ واﺑﺴﺘﻪ ﺑﻪ اﻧﺴﻮﻟﻴﻦ )دﻳﺎﺑﺖ ﻧﻮع‬

‫)‪ .(9‬ژنﻫﺎي ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ در اﻃﺮاف ﺑﺎﻧﺪ ‪ 34‬ﻛﺮوﻣﻮزوم‬ ‫ﻳﻚ‪ (IDDM ،‬و دﻳﺎﺑﺖ ﻏﻴﺮ واﺑﺴﺘﻪ ﺑﻪ اﻧﺴﻮﻟﻴﻦ )دﻳﺎﺑﺖ ﻧﻮع‬

‫ﺷﻤﺎرهي ‪ 9‬ﻗﺮار دارد ﻛﻪ در اﻳﻦ ﻣﻨﻄﻘﻪ دﮔﺮﮔﻮﻧﻲﻫﺎي ژﻧﺘﻴﻜﻲ‬ ‫دو‪ (NIDDM ،‬ﺗﻘﺴﻴﻢ ﻣﻲﺷﻮد‪ .‬در دﻳﺎﺑﺖ ﻧﻮع ﻳﻚ ﻛﻪ‬
‫] ‪[ Downloaded from jdn.zbmu.ac.ir on 2023-03-01‬‬

‫راﻳﺞ اﺳﺖ )‪ .(10‬ﮔﺮوهﺧﻮﻧﻲ اﻓﺮاد ﺟﺎﻣﻌﻪ ﺑﺴﺘﮕﻲ ﺑﻪ ﺣﻀﻮر و ﻳﺎ‬ ‫‪ 10 -15 %‬ﻛﻞ ﻣﻮارد دﻳﺎﺑﺖ را ﺗﺸﻜﻴﻞ ﻣﻲدﻫﺪ ﺗﻮﻟﻴﺪ اﻧﺴﻮﻟﻴﻦ از‬

‫ﻋﺪم ﺣﻀﻮر ژنﻫﺎي ‪ A‬و‪ B‬دارد اﻟﺒﺘﻪ ﻫﻴﭻ ﺑﻴﻤﺎري ﻧﺎﺷﻲ از ﻋﺪم‬ ‫ﭘﺎﻧﻜﺮاس ﺑﻪ ﻋﻠﺖ از ﺑﻴﻦ رﻓﺘﻦ ﺳﻠﻮلﻫﺎي ﺳﺎزﻧﺪه اﻧﺴﻮﻟﻴﻦ‪،‬‬

‫ﺑﻴﺎن آﻧﺘﻲژنﻫﺎي ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ‪ ABO‬ﺷﻨﺎﺧﺘﻪ ﻧﺸﺪه اﺳﺖ اﻣﺎ‬ ‫ﻣﺘﻮﻗﻒ ﻣﻲﺷﻮد ﺑﻪ ﻫﻤﻴﻦ ﺧﺎﻃﺮ اﻓﺮاد ﻣﺒﺘﻼ ﺑﻪ اﻳﻦ ﻧﻮع دﻳﺎﺑﺖ‬

‫ﺳﻮدﻣﻨﺪي ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ ﺑﻪﻋﻨﻮان اﺑﺰاري ﺑﺮاي ﺑﺮرﺳﻲ ﻋﻮاﻣﻞ‬ ‫ﺑﺎﻳﺪ از ﺑﺪو ﺗﺸﺨﻴﺺ‪ ،‬اﻧﺴﻮﻟﻴﻦ ﻣﻮرد ﻧﻴﺎز ﺑﺪن را ﺑﻪ ﺻﻮرت‬

‫ژﻧﺘﻴﻜﻲ درﺑﻴﻤﺎريﻫﺎي ﻣﺨﺘﻠﻒ ﻣﺸﺨﺺ ﺷﺪه اﺳﺖ و اﺳﺘﻌﺪاد‬ ‫ﺗﺰرﻳﻘﺎت روزاﻧﻪ ﺗﺄﻣﻴﻦ ﻛﻨﻨﺪ‪ .‬دﻳﺎﺑﺖ ﻧﻮع ﻳﻚ اﻏﻠﺐ در ﺳﻨﻴﻦ زﻳﺮ‬

‫اﺑﺘﻼ ﺑﻪ ﺑﻌﻀﻲ ﺑﻴﻤﺎريﻫﺎ ﺑﺎ ﻓﻨﻮﺗﻴﭗ ‪ ABO‬در ارﺗﺒﺎط اﺳﺖ‪ .‬از‬ ‫‪ 30‬ﺳﺎل ﺑﻪ وﺟﻮد ﻣﻲآﻳﺪ )‪ .(4‬در دﻳﺎﺑﺖ ﻧﻮع دو ﻛﻪ ﺑﻴﺸﺘﺮ در‬

‫ﺟﻤﻠﻪ ﺳﺮﻃﺎن ﻣﻌﺪه ﻛﻪ در اﻓﺮاد ﺑﺎ ﮔﺮوهﺧﻮﻧﻲ ‪ A‬ﺷﺎﻳﻊﺗﺮ اﺳﺖ و‬ ‫ﺑﺎﻟﻐﻴﻦ ﺑﺎﻻي‪ 30‬ﺳﺎل و ﭼﺎق دﻳﺪه ﻣﻲﺷﻮد و ‪ 85 -90%‬ﻛﻞ‬

‫زﺧﻢ دوازده ﻛﻪ در اﻓﺮاد ﺑﺎ ﮔﺮوه ﺧﻮﻧﻲ ‪ O‬ﺷﺎﻳﻊﺗﺮ اﺳﺖ )‪.(11‬‬ ‫ﻣﻮارد دﻳﺎﺑﺖ را ﺷﺎﻣﻞ ﻣﻲﺷﻮد اﻧﺴﻮﻟﻴﻦ ﺗﻮﻟﻴﺪ ﺷﺪه از ﭘﺎﻧﻜﺮاس ﺑﻪ‬

‫اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺑﺮاي ﺑﺮرﺳﻲ ارﺗﺒﺎط ﺑﻴﻦ اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ و ﻧﻮع ﮔﺮوه‬ ‫ﺧﻮﺑﻲ ﻋﻤﻞ ﻧﻤﻲﻛﻨﺪ‪ .‬در واﻗﻊ ﻳﺎ ﭘﺎﻧﻜﺮاس ﺑﻪ اﻧﺪازه ﻛﺎﻓﻲ اﻧﺴﻮﻟﻴﻦ‬

‫ﺧﻮﻧﻲ اﻓﺮاد ﻃﺮاﺣﻲ ﺷﺪ ﻛﻪ ﻳﺎﻓﺘﻪﻫﺎي اﻳﻦ ﭘﮋوﻫﺶ ﺑﻪ ﺷﻨﺎﺳﺎﻳﻲ‬ ‫ﺗﺮﺷﺢ ﻧﻤﻲﻛﻨﺪ و ﻳﺎ اﻳﻨﻜﻪ اﻧﺴﻮﻟﻴﻦ ﺗﺮﺷﺢ ﺷﺪه‪ ،‬ﺑﻪ ﻋﻠﺖ وﺟﻮد‬
‫] ‪[ DOR: 20.1001.1.23455020.1393.2.1.4.7‬‬

‫اﻓﺮاد در ﻣﻌﺮض ﺧﻄﺮ اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ ﻛﻤﻚ ﺧﻮاﻫﺪ ﻛﺮد و ﻣﻲﺗﻮان‬ ‫ﻣﻘﺎوﻣﺖ ﺑﻪ اﻧﺴﻮﻟﻴﻦ ﻣﺨﺼﻮﺻﺎً در اﻓﺮاد ﭼﺎق‪ ،‬ﻓﺎﻗﺪ ﻛﺎراﻳﻲ ﻻزم‬

‫ﺑﻪ اﻓﺮاد ﻣﺴﺘﻌﺪ از ﻫﻤﺎن ﻛﻮدﻛﻲ ﺗﻮﺻﻴﻪﻫﺎي ﻻزم ﺟﻬﺖ داﺷﺘﻦ‬ ‫اﺳﺖ )‪ .(5‬ﻋﻮاﻣﻞ ﻣﺘﻌﺪدي در اﻳﺠﺎد اﻳﻦ ﺑﻴﻤﺎري ﻧﻘﺶ دارﻧﺪ ﻛﻪ‬

‫ﺳﺒﻚ زﻧﺪﮔﻲ ﻓﻌﺎل و رژﻳﻢ ﻏﺬاﻳﻲ ﻣﻨﺎﺳﺐ را ﻧﻤﻮد ﺗﺎ ﺑﺪﻳﻨﻮﺳﻴﻠﻪ‬ ‫ﻣﻲﺗﻮان ﺑﻪ ﺑﻴﻤﺎريﻫﺎي ژﻧﺘﻴﻜﻲ و ﻓﺎﻣﻴﻠﻲ و وﺿﻌﻴﺖ دﻣﻮﮔﺮاﻓﻴﻜﻲ‬

‫اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ را در آﻧﻬﺎ ﻛﻤﺘﺮ ﻧﻤﻮد‪.‬‬ ‫اﻓﺮاد اﺷﺎره ﻛﺮد‪ .‬اﻏﻠﺐ اﻳﻦ ﻋﻮاﻣﻞ ﺗﻐﻴﻴﺮﭘﺬﻳﺮﻧﺪ ﻣﺎﻧﻨﺪ ﻓﺮﻫﻨﮓ‬

‫ﻏﺬاﻳﻲ‪ ،‬ﭼﺎﻗﻲ‪ ،‬ﺑﻲﺗﺤﺮﻛﻲ و‪ ...‬اﻣﺎ ﻳﻜﻲ از ﻓﺎﻛﺘﻮرﻫﺎي ﻣﻬﻢ ﺗﻐﻴﻴﺮ‬

‫‪٢٩‬‬
 ‫اﻣﻴﻨﻲ و ﻫﻤﻜﺎران‬ ‫ارﺗﺒﺎط ﺑﻴﻦ ﮔﺮوه ﻫﺎي ﺧﻮﻧﻲ ‪ABO‬و و‪RH‬و اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ‬

‫ﻣﻮاد و روشﻫﺎ‬

‫اﺧﺘﻼف دو ﮔﺮوه ﻣﻮرد ﻣﻄﺎﻟﻌﻪ از ﻧﻈﺮ ﻧﻮع ‪ Rh‬ﻣﻌﻨﻲدار ﺑﻮد‬ ‫در اﻳﻦ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ ﻣﻘﻄﻌﻲ ﺟﻤﻌﻴﺖ ﻣﻮرد ﻣﻄﺎﻟﻌﻪ‬
‫)‪.(P<0.0001‬‬ ‫ﺷﺎﻣﻞ‪ 237‬ﻧﻔﺮ از ﺑﻴﻤﺎران دﻳﺎﺑﺘﻲ ﺑﻮدﻧﺪ ﻛﻪ در ﻛﻼسﻫﺎي‬

‫ﺟﺪول ﺷﻤﺎره‪ : 1‬ﺗﻮزﻳﻊ ﻓﺮاواﻧﻲ ﻣﻄﻠﻖ و ﻧﺴﺒﻲ اﻓﺮاد ﻣﻮرد ﻣﻄﺎﻟﻌﻪ‬

‫آﻣﻮزش ﺗﻐﺬﻳﻪ ﺑﺮاي ﻣﺒﺘﻼﻳﺎن ﺑﻪ دﻳﺎﺑﺖ ﻛﻪ ﺗﻮﺳﻂ داﻧﺸﮕﺎه ﻋﻠﻮم‬

‫)ﻣﻘﺎﻳﺴﻪ ﮔﺮوه ﻣﻮرد و ﺷﺎﻫﺪ ( ﺑﺮﺣﺴﺐ ﻧﻮع ﮔﺮوهﺧﻮﻧﻲ‬

‫ﭘﺰﺷﻜﻲ ﺷﻴﺮاز ﺑﺮﮔﺰار ﻣﻲﮔﺮدد ﺷﺮﻛﺖ داﺷﺘﻨﺪ‪ .‬ﮔﺮوه ﺷﺎﻫﺪ ﻧﻴﺰ‬

‫ﺷﺎﻣﻞ ‪ 251‬ﻧﻔﺮ از اﻓﺮاد ﺳﺎﻟﻢ ﻣﺮاﺟﻌﻪ ﻛﻨﻨﺪه ﺑﻪ اﻳﺴﺘﮕﺎهﻫﺎي‬

‫ﺳﺎزﻣﺎن اﻧﺘﻘﺎل ﺧﻮن ﺷﻴﺮاز ﺑﻮدﻧﺪ‪ .‬ﻋﻮاﻣﻞ ﺧﺮوج از ﻣﻄﺎﻟﻌﻪ ﺑﺮاي‬

‫اﻓﺮاد ﮔﺮوه ﺷﺎﻫﺪ ﻋﺒﺎرت ﺑﻮدﻧﺪ از ﺑﻴﻤﺎران ﺑﺎ ﻣﺸﻜﻼت رواﻧﻲ‪،‬‬

‫ﺑﻴﻤﺎري ﺣﺎد و ﺳﺎﺑﻘﻪ ﻛﺘﻮاﺳﻴﺪوز دﻳﺎﺑﺘﻲ ﺑﺮاي ﺗﻌﻴﻴﻦ ﮔﺮوهﻫﺎي‬

‫ﺧﻮﻧﻲ از روشﻫﺎي اﺳﺘﺎﻧﺪارد ﺳﺮوﻟﻮژﻳﻜﻲ ﭘﻴﺮوي و از آﻧﺘﻲﺳﺮم‪-‬‬

‫ﻫﺎي ‪ anti-D ،anti-B ،anti-A‬اﺳﺘﻔﺎده ﺷﺪ‪ .‬دادهﻫﺎي ﺟﻤﻊ‬

‫آوري ﺷﺪه ﺗﻮﺳﻂ ﻧﺮماﻓﺰار ‪ spss‬وﻳﺮاﻳﺶ ‪ 18‬ﺑﺎ ﺑﻬﺮهﮔﻴﺮي از‬

‫] ‪[ Downloaded from jdn.zbmu.ac.ir on 2023-03-01‬‬

‫آزﻣﻮنﻫﺎي ﺗﻮﺻﻴﻔﻲ و آزﻣﻮن ﻛﺎي اﺳﻜﻮﺋﺮ ﺗﺠﺰﻳﻪ و ﺗﺤﻠﻴﻞ‬

‫ﺑﺤﺚ و ﻧﺘﻴﺠﻪ ﮔﻴﺮي‬
‫ﮔﺮدﻳﺪﻧﺪ‪.‬‬
‫ارﺗﺒﺎط ﮔﺮوهﻫﺎيﺧﻮﻧﻲ و ﺑﻴﻤﺎريﻫﺎي ﻣﺸﺨﺼﻲ ﺑﻪ روﺷﻨﻲ اﺛﺒﺎت‬
‫ﻳﺎﻓﺘﻪ ﻫﺎ‬
‫ﺷﺪه اﺳﺖ و ﺷﻮاﻫﺪ ﻧﺸﺎن داده ﻛﻪ ﻧﻮع ﮔﺮوهﺧﻮﻧﻲ ﻣﻤﻜﻦ اﺳﺖ‬
‫اﻓﺮاد در ﻣﺤﺪوده ﺳﻨﻲ ‪ 20‬ﺗﺎ ‪ 80‬ﺳﺎل ﻗﺮار داﺷﺘﻨﺪ ﻛﻪ اﻓﺮاد‬
‫ﻧﻘﺶ ﻣﻬﻤﻲ را در اﺑﺘﻼ ﺑﻪ اﻳﻦ ﺑﻴﻤﺎريﻫﺎ از ﺟﻤﻠﻪ زﺧﻢﻫﺎي‬
‫ﺑﻴﻤﺎر ﺷﺎﻣﻞ ‪ 163‬ﻧﻔﺮ )‪ (%68.8‬زن و ‪ 74‬ﻧﻔﺮ)‪ (%31.1‬ﻣﺮد ﺑﻮدﻧﺪ‪.‬‬
‫ﮔﻮارﺷﻲ و ﺳﺮﻃﺎن ﻣﻌﺪه اﻳﻔﺎ ﻛﻨﺪ ﺑﺎ اﻳﻦ ﺣﺎل‪ ،‬ﺑﺮﺧﻲ ﻣﻄﺎﻟﻌﺎت‬
‫ﮔﺮوهﺧﻮﻧﻲ ‪ 237‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ ﺷﺎﻣﻞ‪ 59 :‬ﻧﻔﺮ‬
‫ﻋﺪم ارﺗﺒﺎط ﺑﻴﻦ ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ﺑﺎ ﺑﻴﻤﺎريﻫﺎ از ﺟﻤﻠﻪ دﻳﺎﺑﺖ را‬
‫)‪56 ،A(%24.9‬ﻧﻔﺮ )‪15 ،B(%23.7‬ﻧﻔﺮ )‪107 ،AB(%6.3‬ﻧﻔﺮ‬
‫ﮔﺰارش ﻛﺮدهاﻧﺪ )‪ .(12‬ﻳﺎﻓﺘﻪﻫﺎي ﭘﮋوﻫﺶ ﺣﺎﺿﺮ ﻧﺸﺎن داد ﻛﻪ در‬
‫)‪ O(%45.1‬ﺑﻮدﻧﺪ‪ .‬در ﺣﺎﻟﻲ ﻛﻪ در ‪ 251‬ﻓﺮد ﮔﺮوه ﻛﻨﺘﺮل ﺗﻮزﻳﻊ‬
‫ﻫﺮ دو ﮔﺮوه‪ ،‬ﮔﺮوهﺧﻮﻧﻲ‪ O‬ﺑﺎﻻﺗﺮﻳﻦ ﻓﺮاواﻧﻲ را دارا اﺳﺖ ﻛﻪ ﺑﺎ‬
‫ﮔﺮوهﺧﻮﻧﻲ ﺑﻪ ﺷﻜﻞ‪63‬ﻧﻔﺮ)‪ 69 ،A(%25.1‬ﻧﻔﺮ )‪،B(%27.5‬‬
‫ﺗﻮزﻳﻊ ﮔﺮوهﺧﻮﻧﻲ در ﺟﺎﻣﻌﻪ ﻣﺎ ﻫﻤﺨﻮاﻧﻲ دارد‪ .‬اﻣﺎ آزﻣﻮن ﻛﺎي‬
‫‪18‬ﻧﻔﺮ)‪ AB (%7.2‬و‪ 101‬ﻧﻔﺮ )‪ O(%40.2‬ﺑﻮدﻧﺪ‪ .‬در ﻫﺮ دو ﮔﺮوه‬
‫اﺳﻜﻮﺋﺮ اﺧﺘﻼف ﻣﻌﻨﻲداري را ﺑﻴﻦ دو ﮔﺮوه از ﻧﻈﺮ ﮔﺮوهﻫﺎي‬
‫] ‪[ DOR: 20.1001.1.23455020.1393.2.1.4.7‬‬

‫ﻣﻮرد ﻣﻄﺎﻟﻌﻪ ﺷﺎﻳﻊﺗﺮﻳﻦ ﮔﺮوهﺧﻮﻧﻲ ﻣﺮﺑﻮط ﺑﻪ ﮔﺮوهﺧﻮﻧﻲ ‪ O‬ﺑﻮد‪.‬‬

‫ﺧﻮﻧﻲ ﻧﺸﺎن ﻧﺪاد و ارﺗﺒﺎط ﻣﻌﻨﻲداري ﺑﻴﻦ ﮔﺮوهﻫﺎيﺧﻮﻧﻲ و‬
‫اﺧﺘﻼف ﺑﻴﻦ دو ﮔﺮوه از ﻧﻈﺮ ﺗﻮزﻳﻊ ﮔﺮوهﺧﻮﻧﻲ ﺑﻪ ﻟﺤﺎظ آﻣﺎري‬
‫ﮔﺮوه ﻣﻮرد و ﺷﺎﻫﺪ ﻣﺸﺎﻫﺪه ﻧﺸﺪ )‪ .(P>0.05‬در اﻳﻦ ﻣﻄﺎﻟﻌﻪ‬
‫ﻣﻌﻨﻲدار ﻧﺒﻮد‪ .‬در ﮔﺮوه ﻣﻮرد )‪ 232(%97.9‬ﻧﻔﺮ ‪ Rh‬ﻣﺜﺒﺖ ﺑﻮدﻧﺪ‬
‫ارﺗﺒﺎط ﻧﻮع ‪ Rh‬و ﺑﻴﻤﺎري دﻳﺎﺑﺖ ﻧﻴﺰ ﺳﻨﺠﻴﺪه ﺷﺪ ﻛﻪ آزﻣﻮن‬
‫و )‪5 (%1.2‬ﻧﻔﺮ ‪Rh‬ﻣﻨﻔﻲ ﺑﻮدﻧﺪ‪ .‬در ﮔﺮوه ﺷﺎﻫﺪ )‪226 (%90‬ﻧﻔﺮ‬
‫ﻛﺎي اﺳﻜﻮﺋﺮ اﺧﺘﻼف ﻣﻌﻨﻲداري را ﺑﻴﻦ دو ﮔﺮوه ﻣﻮرد و ﺷﺎﻫﺪ‬
‫‪ Rh‬ﻣﺜﺒﺖ ﺑﻮدﻧﺪ و )‪ 25(%10‬ﻧﻔﺮ ‪Rh‬ﻣﻨﻔﻲ ﺑﻮدﻧﺪ‪.‬‬
‫‪٣٠‬‬
 ‫دوره ‪ –2‬ﺷﻤﺎره‪ -1‬ﺑﻬﺎر‪93‬‬ ‫ﻓﺼﻠﻨﺎﻣﻪ ﭘﺮﺳﺘﺎري دﻳﺎﺑﺖ داﻧﺸﻜﺪه ﭘﺮﺳﺘﺎري و ﻣﺎﻣﺎﻳﻲ زاﺑﻞ‬

‫ﺑﻴﻤﺎريﻫﺎي دﻳﮕﺮ ﺑﺎ ﮔﺮوهﻫﺎي ﺧﺎص ﺧﻮﻧﻲ وﺟﻮد دارد )‪ .(19‬ﺑﻴﻤﺎري‬ ‫ﻧﺸﺎن داد )‪ .(P<0.0001‬در ﻣﻄﺎﻟﻌﻪاي ﻛﻪ ﺗﻮﺳﻂ رﺣﻤﺎن و‬

‫دﻳﺎﺑﺖ‪ ،‬ﻧﻴﺰ ﻳﻜﻲ از ﺑﻴﻤﺎريﻫﺎي ﺷﺎﻳﻊ ﺟﻮاﻣﻊ ﺑﺸﺮي اﺳﺖ ﻛﻪ ﻧﻘﺶ‬ ‫ﻫﻤﻜﺎراﻧﺶ در ﺑﻨﮕﻼدش ﺑﺮ روي ‪ 2312‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ و‬

‫ارث و ژﻧﺘﻴﻚ در آن ﻛﺎﻣﻼً ﻣﺸﺨﺺ ﻣﻲﺑﺎﺷﺪ‪ ،‬ﺑﻪ ﻧﻈﺮ ﻣﻲرﺳﺪ ﻛﻪ‬ ‫‪ 8936‬ﻧﻔﺮ ﮔﺮوه ﻛﻨﺘﺮل ﮔﺰارش ﺷﺪ ﻛﻪ ﺑﻴﻦ ﮔﺮوهﻫﺎيﺧﻮﻧﻲ و دﻳﺎﺑﺖ‬

‫ﻓﺮﺿﻴﻪ ارﺗﺒﺎط ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ﺧﺎص ﺑﺎ اﻳﻦ ﺑﻴﻤﺎري‪ ،‬ﻓﺮﺿﻴﻪاي ﺑﺎ ﻣﻌﻨﺎ‬ ‫ارﺗﺒﺎﻃﻲ وﺟﻮد ﻧﺪارد )‪ .(13‬ﻫﻤﭽﻨﻴﻦ در ﻣﻄﺎﻟﻌﻪاي دﻳﮕﺮ در ﻫﻨﺪ ﻛﻪ‬

‫و ﻗﺎﺑﻞ ﻣﻼﺣﻈﻪ ﺗﻠﻘﻲ ﺷﻮد‪ .‬زﻳﺮا ژن ﮔﺮوه ﺧﻮﻧﻲ در اﻃﺮاف ﺑﺎﻧﺪ ‪34‬‬ ‫روي ‪ 511‬ﺑﻴﻤﺎر ﻣﺒﺘﻼ ﺑﻪ دﻳﺎﺑﺖ و ‪ 457‬ﻓﺮد ﺳﺎﻟﻢ اﻧﺠﺎم ﺷﺪ ﻧﻴﺰ‬

‫ﻛﺮوﻣﻮزوم ﺷﻤﺎرهي ‪ 9‬ﻗﺮار دارد و ﻧﺤﻮه ﺗﺄﺛﻴﺮ ﮔﺮوهﺧﻮﻧﻲ ﺑﻪ ﭼﮕﻮﻧﮕﻲ‬ ‫ارﺗﺒﺎﻃﻲ ﺑﻴﻦ ﮔﺮوهﺧﻮﻧﻲ و دﻳﺎﺑﺖ ﻣﺸﺎﻫﺪه ﻧﺸﺪ )‪ Kamil .(9‬و‬

‫ﺗﺄﺛﻴﺮ ژنﻫﺎ ﺑﺮ ﻳﻜﺪﻳﮕﺮ و ژنﻫﺎﻳﻲ ﻛﻪ ﻫﺮ ﭼﻨﺪ ﻧﺎﻣﺮﺑﻮط اﻣﺎ در‬ ‫ﻫﻤﻜﺎران در ﻣﻄﺎﻟﻌﻪ ﺧﻮد روي ‪ 70‬ﺑﻴﻤﺎردﻳﺎﺑﺘﻲ و ‪ 140‬ﻓﺮد ﺳﺎﻟﻢ‬

‫ﻣﺠﺎورت ﻳﺎ ﻧﺰدﻳﻚ آﻧﻬﺎ ﻗﺮار دارﻧﺪ ﺑﺴﺘﮕﻲ دارد )‪(20‬؛ و ﺑﻪ اﻳﻦ ﻋﻠﺖ‬ ‫ارﺗﺒﺎط ﻣﻨﻔﻲ ﺑﻴﻦ ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ ‪ A‬و ‪ O‬را ﺑﺎ دﻳﺎﺑﺖ ﻧﻮع دو ﮔﺰارش‬

‫اﺳﺖ ﻛﻪ ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ ﻣﻲﺗﻮاﻧﻨﺪ روي ﺗﻌﺪاد زﻳﺎدي از ﺳﻴﺴﺘﻢﻫﺎي‬ ‫ﻛﺮدﻧﺪ )‪ Qureshi .(14‬و ‪ Bhatti‬در ﻣﻄﺎﻟﻌﻪ ﺧﻮد ﻣﺸﺎﻫﺪه ﻧﻤﻮدﻧﺪ‬

‫ﺑﺪن از ﺟﻤﻠﻪ آﻧﺰﻳﻢﻫﺎي ﮔﻮارﺷﻲ و اﻧﺘﻘﺎل دﻫﻨﺪهﻫﺎي ﺷﻴﻤﻴﺎﻳﻲ‬ ‫ﻛﻪ ﺷﻴﻮع دﻳﺎﺑﺖ ﻧﻮع دو در ﮔﺮوهﺧﻮﻧﻲ ‪ B‬ﺑﻴﺸﺘﺮ از ﺳﺎﻳﺮ ﮔﺮوهﻫﺎي‪-‬‬

‫ﻋﺼﺒﻲ اﺛﺮ ﺑﮕﺬارﻧﺪ‪ .‬از ﺟﻤﻠﻪ ﻣﺤﻘﻘﻴﻦ ارﺗﺒﺎط ژﻧﺘﻴﻜﻲ دﻗﻴﻘﻲ ﺑﻴﻦ‬ ‫ﺧﻮﻧﻲ اﺳﺖ اﻣﺎ ﻧﺘﻮاﻧﺴﺘﻨﺪ ﺑﻴﻦ آﻧﻬﺎ اﺧﺘﻼف ﻣﻌﻨﻲداري ﺑﻴﺎﺑﻨﺪ )‪.(15‬‬

‫ﮔﺮوهﺧﻮﻧﻲ و ﺳﺮﻃﺎن ﺳﻴﻨﻪ از ﻃﺮﻳﻖ ژﻧﻲ ﻛﻪ ﻋﺎﻣﻞ ﻣﺴﺘﻌﺪﻛﻨﻨﺪه‬ ‫در ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ ﮔﺮوهﺧﻮﻧﻲ ‪ O‬ﻓﺮاوانﺗﺮﻳﻦ ﮔﺮوهﺧﻮﻧﻲ در دو ﮔﺮوه‬
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‫ﺳﺮﻃﺎن ﺳﻴﻨﻪ اﺳﺖ و ﻧﺰدﻳﻚ ﺑﺎﻧﺪ ‪ 34‬ﻛﺮوﻣﺰم ‪ 9‬ﻗﺮار دارد را اراﺋﻪ‬ ‫ﻣﻮرد و ﺷﺎﻫﺪ ﺑﻮد و ﭘﺲ از آن ﺑﻪ ﺗﺮﺗﻴﺐ ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ‪ A‬و ‪B‬‬

‫دادﻧﺪ )‪ .(21‬ارﺗﺒﺎط ﻣﺮﻣﻮز دﻳﮕﺮي ﻧﻴﺰ وﺟﻮد دارد ﻛﻪ ﺑﻴﺎﻧﮕﺮ راﺑﻄﻪ‬ ‫و ‪ AB‬ﻓﺮاوانﺗﺮﻳﻦ ﺑﻮدﻧﺪ‪ .‬در ﻣﻄﺎﻟﻌﻪاي ﻛﻪ ﺗﻮﺳﻂ ﻟﻬﺴﺎﻳﻲ و‬

‫ﺑﻴﻦ ﮔﺮوهﺧﻮﻧﻲ و ﻣﻐﺰ اﺳﺖ ژن آﻧﺰﻳﻢ )دوﭘﺎﻣﻴﻦ ﺑﺘﺎﻫﻴﺪروﻛﺴﻴﺪاز( ﻛﻪ‬ ‫ﻫﻤﻜﺎراﻧﺶ در ﻣﺮﻛﺰ دﻳﺎﺑﺖ ﻛﺮﻣﺎن ﺑﺮ روي ‪ 500‬ﺑﻴﻤﺎر دﻳﺎﺑﺘﻲ در ﺳﺎل‬

‫ﻣﻮﺟﺐ ﺗﺒﺪﻳﻞ دوﭘﺎﻣﻴﻦ ﺑﻪ ﻧﻮرآدرﻧﺎﻟﻴﻦ ﻣﻲﺷﻮد درﺳﺖ در ﺑﺎﻧﺪ ‪24‬‬ ‫‪ 1375‬اﻧﺠﺎم ﺷﺪه ﺑﻮد ﻧﻴﺰ ارﺗﺒﺎط ﻣﻌﻨﻲداري ﻣﻴﺎن ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ و‬

‫ﻛﺮوﻣﻮزوم ‪ 9‬ﻗﺮار ﮔﺮﻓﺘﻪ اﺳﺖ ﺑﻪ ﻋﺒﺎرت دﻳﮕﺮ در ﺑﺎﻻي ژن ﻣﺮﺑﻮط ﺑﻪ‬ ‫اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ ﻣﺸﺎﻫﺪه ﻧﺸﺪ‪ .‬در ﻣﻄﺎﻟﻌﻪ دﻳﮕﺮي ﻛﻪ‬

‫ﮔﺮوهﺧﻮﻧﻲ ﻧﺸﺴﺘﻪ اﺳﺖ ﻛﻪ اﻳﻦ اﻣﺮ اﺛﺮات ﮔﺴﺘﺮده در راﺑﻄﻪ ﺑﻴﻦ‬ ‫ﺗﻮﺳﻂ ‪ MC connel‬و ﻫﻤﻜﺎراﻧﺶ ﺑﺮ روي ﺑﻴﻤﺎران دﻳﺎﺑﺘﻲ اﻧﺠﺎم ﺷﺪ‬

‫ﮔﺮوهﺧﻮﻧﻲ و اﺳﺘﺮس‪ ،‬ﺳﻼﻣﺖرواﻧﻲ و ﺣﺘﻲ وﻳﮋﮔﻲﻫﺎي ﺷﺨﺼﻴﺘﻲ‬ ‫ﻧﺸﺎن داد ﻛﻪ ارﺗﺒﺎط ﺑﻴﺸﺘﺮي ﻣﻴﺎن اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ و ﮔﺮوهﺧﻮﻧﻲ ‪A‬‬

‫دارد )‪ .(22‬ﻫﻤﻪ اﻳﻦ ﺷﻮاﻫﺪ و ﺷﻮاﻫﺪ ﺑﺴﻴﺎر دﻳﮕﺮ اﺣﺘﻤﺎل ارﺗﺒﺎط‬ ‫ﻧﺴﺒﺖ ﺑﻪ ‪ B‬وﺟﻮد دارد )‪ Anderson .(16‬و ﻫﻤﻜﺎراﻧﺶ در‬

‫ﮔﺮوهﻫﺎي ﺧﻮﻧﻲ ﺑﺎ دﻳﺎﺑﺖ را ﺗﻘﻮﻳﺖ ﻣﻲﻛﻨﺪ ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﮔﺴﺘﺮدﮔﻲ‬ ‫ﻣﻄﺎﻟﻌﻪي ﺧﻮد ﻧﺸﺎن دادﻧﺪ ﻛﻪ ﺑﻴﻤﺎري دﻳﺎﺑﺖ ﺑﺎ ﮔﺮوهﺧﻮﻧﻲ ‪ O‬ارﺗﺒﺎط‬

‫ﻧﺘﺎﻳﺞ‪ ،‬ﻣﻄﺎﻟﻌﺎت وﺳﻴﻊﺗﺮي در ﻧﻘﺎط ﻣﺨﺘﻠﻒ دﻧﻴﺎ ﺑﻪ ﻣﻨﻈﻮر اﺛﺒﺎت‬ ‫دارد )‪ .(17‬ﻣﻄﺎﻟﻌﻪ دﻳﮕﺮي ﻛﻪ ﺗﻮﺳﻂ ‪ Tedeschi‬و ﻫﻤﻜﺎراﻧﺶ‬
‫] ‪[ DOR: 20.1001.1.23455020.1393.2.1.4.7‬‬

‫ارﺗﺒﺎط ﺑﻴﻦ ﮔﺮوهﺧﻮﻧﻲ و دﻳﺎﺑﺖ ﻣﻠﻴﺘﻮس ﻣﻮرد ﻧﻈﺮ ﻣﻲﺑﺎﺷﺪ ﺗﺎ ﺑﺎ‬ ‫اﻧﺠﺎم ﺷﺪ ﻧﺸﺎنداد ﻛﻪ ﺑﻴﻤﺎري دﻳﺎﺑﺖ ﺑﺎ ﮔﺮوهﺧﻮﻧﻲ ‪ B‬ارﺗﺒﺎط دارد‬

‫ﺷﻨﺎﺳﺎﻳﻲ ﮔﺮوهﻫﺎي در ﻣﻌﺮض ﺧﻄﺮ اﻳﻦ اﻓﺮاد در ﻫﻤﺎن ﺳﺎلﻫﺎي‬ ‫)‪ .(18‬ﮔﺮوهﻫﺎيﺧﻮﻧﻲ ﺑﻪ ﻋﻨﻮان ﻋﻮاﻣﻞ ﻣﻬﻢ و ﻣﺆﺛﺮ ژﻧﺘﻴﻜﻲ در‬

‫اﺑﺘﺪاي زﻧﺪﮔﻲ ﺑﺎ رﻋﺎﻳﺖ ﺳﺒﻚ زﻧﺪﮔﻲ ﺳﺎﻟﻢ ﻋﻮاﻣﻠﻲ ﻛﻪ ﻣﻨﺠﺮ ﺑﻪ‬ ‫ﻧﺴﻞﻫﺎي ﻣﺨﺘﻠﻒ ﺛﺎﺑﺖ ﺑﺎﻗﻲ ﻣﻲﻣﺎﻧﻨﺪ و ارﺗﺒﺎط ﻣﺸﺨﺺ و ﺛﺎﺑﺖ‬

‫دﻳﺎﺑﺖ ﻣﻲﺷﻮد را در ﺧﻮد ﻛﺎﻫﺶ دﻫﻨﺪ‪.‬‬ ‫ﺷﺪهاي ﻣﻴﺎن ﺑﻴﻤﺎريﻫﺎﻳﻲ ﻣﺎﻧﻨﺪ زﺧﻢ ﻣﻌﺪه و ﺳﺮﻃﺎن ﻣﻌﺪه و ﺑﺮﺧﻲ‬

‫‪٣١‬‬
 ‫اﻣﻴﻨﻲ و ﻫﻤﻜﺎران‬ ‫و اﺣﺘﻤﺎل اﺑﺘﻼ ﺑﻪ دﻳﺎﺑﺖ‬RH‫و و‬ABO ‫ارﺗﺒﺎط ﺑﻴﻦ ﮔﺮوه ﻫﺎي ﺧﻮﻧﻲ‬

Relation between Blood Groups ABO & Rh in Patients Diabetic

Tavasolian F1, Abdolahi E1, Vakili M2, Amini A3*

1. MSc in Immunology, Shahid Sadughi medical university of Yazd, Faculty of medicine, department of Immunology,Sanandaj, Iran.

2. Ph.d in Social Medicine, Shahid Sadughi medical university of Yazd , Faculty of medicine, department of Social Medicine, Iran.

3. MSc in Hematology, Shahid Sadughi medical university of Yazd, Faculty of medicine, department of Hematolology, Iran

*Corresponding author: Ali Amini , E-mail: TAV.15600@gmail.com

Abstract

Introduction: Diabetes is a chronic disease that causes progressive disability and

precocious deaths. Factors such as genetic, immunological and environment are involved
in diabetes mellitus. The aim of this study was to investigate the association between
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diabetes and blood groups.

Methodology: This was a cross-sectional study that determined the blood group of 237
diabetic patients compared with 251 control subject.

Results: Blood group of 237 patients included, 24.9% (59) A, 23.7 % (56) B, 6.3% (15)
AB, 45.1% (107) O, and blood group of 251 subjects in the control group included, 63%
(25) A, 69% (25.6) B, 18 % 06.8) AB and 101% (42.6) O.

Conclusion: This study found no significant association between diabetes and blood
group. The difference between the two groups in terms of Rh type was significant (P
<0.0001).

Key words: Diabetes, Blood group, RH.

[ DOR: 20.1001.1.23455020.1393.2.1.4.7 ]

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