M2: CLIN PHARM MODULAR RATIONALE M2: CLIN PHARM MODULAR RATIONALE

Study online at https://quizlet.com/_ep79a5 Study online at https://quizlet.com/_ep79a5

1. a. Jonathan Roberts First Hospital pharmacist 6. a. Amphotericin B Treatment for question number 5
polyene antifungal (for systemic
a. Jonathan Roberts fungal infection) a. Amphotericin B
b. Christopher Marshall b. Co-trimoxazole
c. Carl Wilhelm Scheele c. Chloramphenicol
d. Friedrich Wilhelm Adam Serturner d. Amikacin

2. A. Reticulocytes Which is not a white blood cell 7. a. Nephrotoxicity Side effect of answer in number 5

A. Reticulocytes a. Nephrotoxicity
B. Eosinophils b. Hematopoietic disturbances
C. Basophils c. Grey Baby Syndrome
D. Neutrophils d. Ototoxic

3. A. Category D An error that reached the patient that re- 8. c. Targets cell membrane synthe- MOA of answer in number 5
sulted in the need for increased patient sis
monitoring, but no patient harm. a. Targets 50s
b. Targets 30s
A. Category D c. Targets cell membrane synthesis
B. Category A d. Targets cell wall
C. Category C
D. Category F 9. b. Chloramphenicol DOC for Typhoid fever

4. D. Category F An error that resulted in initial or pro- a. Amikacin

longed hospitalization and caused tem- b. Chloramphenicol
Category F - Frolonged hospital- porary patient harm. c. Amphotericin B
ization
Category E - Entervention: need- A. Category D 10. b. Grey baby syndrome Side effect effect of answer in number 9
ed treatment or intervention B. Category A
Category C - Chamba: reached C. Category C a. Ototoxic
the patient but did not cause pa- D. Category F b. Grey baby syndrome
tient harm c. Nephrotoxic
Category B - Buti na lang: did not
reach the patient 11. d. Lymphocytes It plays a dominant role in immunologic
activity and appear to produce antibodies
5. B. Cryptococcus neoformans Which fungal organism causes Meningitis
a. Neutrophils
*the only fungal organism in the A. Neisseria meningitidis b. Monocytes
choices B. Cryptococcus neoformans
1 / 11 2 / 11
 M2: CLIN PHARM MODULAR RATIONALE M2: CLIN PHARM MODULAR RATIONALE
Study online at https://quizlet.com/_ep79a5 Study online at https://quizlet.com/_ep79a5
c. Basophils c. Griseofulvin
d. Lymphocytes d. Pioglitazone

12. A. Hypothyroidism Cretinism is associated with 17. B. Osteoporosis Answer in number 16 is used for:

A. Hypothyroidism A. Diabetes
B. Hyperthyroidism B. Osteoporosis
C. Hypoparathyroidism C. Fungal infections
D. Hyperparathyroidism
18. b. Fosamax Brand Name for number 16
13. A. SJS In this serve form of erythema multiforme,
there is involvement of the oronasal a. Diamicron
anogenic mucosa. b. Fosamax
c. Piozone
A. SJS
B. Anaphylactic shock 19. A. Beta-2 agonists Which of the following is used in the emer-
C. Exfoliative dermatitis gency treatment of asthma?

14. A. Phase 1 Phase of Clinical Trial that involves testing A. Beta-2 agonists
on healthy individuals B. Methylxanthine
Phase 2 - Proof of Concept is in- C. Corticosteroids
dicated; Drug used in target pop- A. Phase 1 D. Muscarinic agonist
ulation B. Phase 2
Phase 3 - Multicenter trials and C. Phase 3 20. A. Salbutamol Example of drug under the pharmacolog-
Proof of drug licensing D. Phase 4 ic class in Number 20
Phase 4 - Post-marketing sur-
veillance A. Salbutamol
B. Aminophylline
15. B. MI Creatinine kinase is associated with C. Betamethasone
D. Ipratropium
A. Angina pectoris
B. MI 21. A. Colchicine Which of the following is used for acute
gout?
16. b. Alendronate Should be taken 30 minutes before the
first food, beverage, or medication of the A. Colchicine
day, taken with a full glass of water B. Allopurinol
C. Sulfinpyrazone
a. Gliclazide D. Probenecid
b. Alendronate
22.
3 / 11 4 / 11
 M2: CLIN PHARM MODULAR RATIONALE M2: CLIN PHARM MODULAR RATIONALE
Study online at https://quizlet.com/_ep79a5 Study online at https://quizlet.com/_ep79a5
B. Menadione - Rationale: Mena- Decreases the anticoagulant effect of presence or absence of the dis- A. Cross sectional
dione is Vit K3, which can antag- warfarin ease B. Case series
onize effect of Warfarin Cross sectional - studied at one C. Cohort
A. Cimetidine point in time D. Case Control
B. Menadione Case series - compilation of case
C. Phenylbutazone reports
D. None of the above
28. A. Phenytoin Most commonly used to treat digitalis-in-
23. A. Lumbar puncture Method of extracting CSF duced ventricular and supraventricular
tachycardia:
A. Lumbar puncture
B. Thoracentesis A. Phenytoin
C. Centesis B. Quinidine
C. Flecainide
24. a. Katzung book Primary source except: D. Propafenone

Journal yung tatlong choices a. Katzung book 29. A. Staphylococcus The most important use of Vancomycin is
b. Journal yung tatlong choices its action against what microorganism?
*Vancomycin: indicated for
25. C. Pyrazinamide - usually Myrin P is usually stopped after two MRSA (Methicillin-resistant A. Staphylococcus
stopped after 2 months due to months. What drug causes the toxicity? Staphylococcus aureus) B. Streptococcus
risk of hepatotoxicity and liver C. Pneumococcal
necrosis A. Rifampicin
B. Isoniazid 30. C. FH The patient's mother has diabetes while
C. Pyrazinamide his father has hypertension. What kind of
D. Ethambutol information is this?

26. C. Hepatotoxicity The associated toxicity of the answer in A. PMH

number 25 is: B. CC
Nephrotoxicity - Streptomycin: C. FH
an amiNOglycoside — Nephro- A. Nephrotoxicity D. SH
toxic, Ototoxic B. Peripheral neuropathy
Peripheral neuropathy - Isoni- C. Hepatotoxicity 31. b. Bone softening Osteomalacia means
azid D. Reticular damage
Ocular complications - EYE- a. Inflammation of the bone
thambutol b. Bone softening
c. Pus in the bone
27. C. Cohort Study design wherein samples are cho-
sen based on the presence of risk factors. 32. A. Basophils WBC increased in inflammation:
Case Control - based on the
5 / 11 6 / 11
 M2: CLIN PHARM MODULAR RATIONALE M2: CLIN PHARM MODULAR RATIONALE
Study online at https://quizlet.com/_ep79a5 Study online at https://quizlet.com/_ep79a5
Neutrophils - increased bacterial A. Basophils A. may be due to excessive pro- Gout:
and fungal infection B. Neutrophils duction of uric acid
Eosinophils - increased during C. Eosinophils A. may be due to excessive production of
parasitic infections D. Lymphocytes uric acid
Lymphocytes - increased in viral B. may be due to increased renal elimina-
infection tion of uric acid
results in the deposition of crystals of xan-
33. B. Secretory Type of diarrhea caused by bacterial in- thine in the joints
fection C. is characterized by excessive calcium
Osmotic - diarrhea caused by in- deposited in the joints
gestion of magnesium hydroxide A. Osmotic D. is the result of hypourecemia
B. Secretory
C. Exudative 38. A. PE It is the findings of the examination of the
D. Altered motility patient.

34. C. Hypertension Most common cardiovascular disorder is: A. PE

B. PMH
A. Angina pectoris C. FH
B. Arrhythmia
C. Hypertension 39. C. TSH This is carried out in thyroid function mon-
D. Myocardial infarction itoring.

35. A. Myopathy Muscle weakness and muscle wasting A. HbA1c

B. BUN
Tachypnea - rapid rate of breath- A. Myopathy C. TSH
ing B. Tachypnea
Dysphasia - an impairment of the C. Dysphasia 40. A. Hypokalemia- Potassium (K+) Predisposes to digoxin toxicity
language aspect of speech competes for digoxin binding
sites -> decreased K+ = in- A. Hypokalemia
36. B. Peptic ulcer disease An endoscopy may provide a helpful clue creased effect of digoxin B. Hyperkalaemia
for the diagnosis of which of the follow- C. Hypocalcemia
Rationale: An upper gastroin- ing?
testinal (GI) endoscopy is a pro- 41. C. Opthalmoscope used to investigate retinopathy
cedure to look at the inside of A. Endocarditis
your oesophagus (gullet), stom- B. Peptic ulcer disease Stethoscope - used to assess A. Stethoscope
ach and duodenum using a flexi- C. Aplastic enemaDiabetes breath sounds B. Reflex hammer
ble telescope. (Reference: Upper D. mellitusConstipation Reflex hammer - used to test C. Opthalmoscope
GI endoscopy and colonoscopy) deep tendon reflexes

37. 42. D. vitamins

7 / 11 8 / 11
 M2: CLIN PHARM MODULAR RATIONALE M2: CLIN PHARM MODULAR RATIONALE
Study online at https://quizlet.com/_ep79a5 Study online at https://quizlet.com/_ep79a5
Total parenteral nutrition should be pro- MAO enzyme inactivates
tected from light because it contains:
A. Serotonin
A. Fats B. Epinephrine
B. Carbohydrates C. Norepinephrine
C. electrolytes D. All of the above
D. vitamins
E. proteins 48. A. Enzyme MAO is identified as

43. D. 1962 PSHP was established in what year? A. Enzyme

B. Hormone
A. 1930
B. 1942 49. C. Phenylketonuria This is a metabolic disease caused by
C. 1950 insufficiency on the levels of the enzyme
D. 1962 phenylalanine hydroxylase:
E. 1970
A. Ketoacidosis
44. A. adrenal hyperplasia Cushing's syndrome is associated with: B. Idiosyncrasy
C. Phenylketonuria
A. adrenal hyperplasia
B. adrenal insufficiency 50. A. myocardial infarction Streptokinase is useful for patients with:
C. Hyperthyroidism
D. Hypothyroidism Streptokinase is a fibrinolytic A. myocardial infarction
agent. It destroys blood clots. B. hypertension
45. A. Barrett's esophagus Normal squamous epithelium lining of the C. congestive heart failure
esophagus is replaced by goblet cells D. Angina pectoris

A. Barrett's esophagus 51. C. Rehabilitation centers Outpatient health care settings include
B. Esopaghitis the following except:
C. GERD
A. Clinics
46. A. Achalasia Characterized by incomplete LES relax- B. Day surgery units
ation, increases LES tone, lack of peri- C. Rehabilitation centers
stalsis of the esophagus D. Emergency rooms

A. Achalasia 52. D. Insulin beta-blockers + in- The responses of which of the following
B. GERD sulin = increased risk of HYPO- drug should be monitored when it is used
C. Mallory-Weiss GLYCEMIA simultaneously with propranolol?

47. D. All of the above A. digoxin

9 / 11 10 / 11
M2: CLIN PHARM MODULAR RATIONALE
Study online at https://quizlet.com/_ep79a5
B. Quinidine
C. chlorothiazide
D. Insulin

11 / 11