Dr Igor Mićunović

CLINICAL APPLICATION OF XNKQ THERAPY IN P.R.

CHINA
TCM Podcast www.tcmpodcast.me
AAM www.uacg.me
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Email: igormicunovic77@gmail.com

Dr Igor Micunovic Ph.D

President od AAM – Acupuncturists Association of Montenegro
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针药结合治疗缺血性中风病
的系统研究
The system research of Acupuncture and herbs
to treat ischemic stroke

石学敏
SHI Xuemin

天津中医药⼤学第⼀附属医院
The First Teaching Hospital of Tianjin University of
Traditional Chinese Medicine
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中⻛病的治疗难点
The problem of treating apoplexy
如何减轻⾎管神经单元的损害、促进重构神经组
织、重建脑组织循环是神经功能恢复的根本。中⻛病
治疗的难点及突破点，聚焦在神经与⾎管的新⽣。
How to reduce the damage of neurovascular unit, promote
reconstruction nerve tissue and reconstruction brain circulation is
neurological recovery. The treatment of stroke, focus on problems and
breakthrough of new blood vessels and nerves.

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⽬前，治疗中⻛病最有效的⽅法是卒中单元，但是现代
医学意义上的卒中单元需要较⾼的软硬件配备，⽆法于现有
医疗资源基础上推⼴应⽤。所以，如何利⽤有效的中医⼿段
构建符合中国特⾊的“中⻛单元”是今后重要的研究⽅向。

Currently, the treatment of stroke are the most effective ways

to stroke, but modern medical unit on the significance of the software
and hardware unit needs higher stroke with existing medical
resources, not in based on application. Therefore, how to effectively
use the traditional method to set up Chinese characteristic "stroke
unit" is an important research direction in future.

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针刺和有效中药制剂是我国治疗中⻛病的重要⼿段，也
是构建“中⻛单元”的主要因素。由“醒脑开窍针刺法”、“丹芪
偏瘫胶囊”相结合为关键内核的“⽯⽒中⻛单元”，在临床上取
得了显著疗效，并被国家列为重⼤科技推⼴项⽬。

Acupuncture and herbs are effective treatment in China and an

important factor of "stroke unit". “Shi’s stroke unit “which be made of
“XNKQ”acupuncture therapy and Danqi hemiplegia capsule, get great
clinical effect, and has achieved remarkable listed by the state
science and technology major promotion projects

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在选穴上以阴经和督脉穴为主，并强调针刺手

法量学规范，有别于传统的取穴和针刺方法。

The points on Yin meridians and Du meridian are mainly

selected and standard quantitative manipulations are applied

emphatically, which are quite different from traditional point
selection and acupuncture manipulations in treatment of apoplexy.

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治疗方法
Treatment

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1.处 方
主穴：内关(手厥阴心包经)
人中(督脉)
三阴交(足太阴脾经)

1. Point Prescription
Mainpoints:
Neiguan (PC 6, the Pericardium Meridian of Hand-Juejin)
Renzhong (DU 26, the DU Meridian)
Sanyinjiao (SP 6, the Spleen Meridian of Foot-Taiyin)

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辅穴：极泉(手少阴心经)
委中(足太阳膀胱经)
尺泽(手太阴肺经)

Supplementary points：
Jiquan (HT 1,the Heart Meridian of Hand-shaoyin)
Weizhong (BL 40,the Bladder Meridian of Foot- Taiyang)
Chize (LU 5, the Lung Meridian of Hand-Taiyin)

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配穴：吞咽障碍加风池、翳风、完骨；手指握固加
合谷；语言不利加上廉泉，金津、玉液放血；足内
翻加丘墟透照海。

Point Modification：For difficulty of swallowing, Fengchi (GB

20),Yifeng (SJ 17) and Wangu (GB 12) are added. For failing to
extend fingers with stiffness, Hegu (LI 4) is added. For slurred
speech, Shanglianquan (EX-HN) is added, and Jinjin (EX-HN 12)
and Yuye (EX-HN13) are used with blood-letting method. For
strephenopodia, penetrating method from Qiuxu (GB 40) to
Zhaohai (KI 6) is used.

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2.操作方法 Manipulation

内 关
Neiguan
(PC 6)

直刺0.5~1寸，采用捻转提插结合泻法，施手法1分钟；
First puncture bilateral Neiguan (PC 6) perpendicularly for 0.5-1 cun,
using combinative reducing method of lifting-thrusting and twirling-
rotating the needle for 1 minute;

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人 中
Renzhong
(DU 26)

向鼻中隔方向斜刺0.3~0.5寸，用重雀啄法，至眼球湿润或流泪为度 ；
Secondly puncture Renzhong(DU 26) obliquely upwards to the
nasal septum for 0.3-0.5 cun with heavy bird-pecking method until
the patient’s eyeballs are moistened or tears flow down.

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极 泉
Jiquan
(HT 1)

原穴沿经下移1寸，避开腋毛，直刺1~1.5寸，用提插泻法，以患侧上肢抽动3次为度。

Select Jiquan(HT 1) point at 1 cun below the original location along the
heart meridian to keep away from the armpit hair, Puncture
perpendicularly for 1-1.5 cun with reducing method of lifting and thrusting
the needle to make the affected upper limb have tic for three times.

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尺 泽
Chize
(LU 5)

屈肘成120度角，直刺1寸，用提插泻法，使患者前臂、手指抽动3次为度。
Perpendicularly puncture Chize (LU 5) for 1 cun depth while the
forearm bends to form an angle of 120 degrees with reducing
manipulation of lifting and thrusting the needle until the affected
arm and fingers have tic for three times.

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⻛池、完⻣、翳⻛
Fengchi(GB 20)
Wangu(GB 12)
Yifeng(SJ 17)

针向结喉，进针2~2.5寸采用小幅度高频率捻转补法，每穴施手法1分钟；

Puncture Fengchi (GB 20), Wangu (GB 12) and Yifeng (SJ 17) in the
direction of the laryngeal protuberance for 2-2.5 cun, with reinforcing
manipulation of twirling and rotating the needle in high frequency and
small amplitude for 1 minute to each acupoint.

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合谷针向三间穴
Hegu(LI 4)
to
Sanjian(LI 3)

进针1~1.5寸，采用提插泻法，使患者第二手指抽动或五指自然伸展为度；
Puncture Hegu (LI 4) 1-1.5 cun in depth with the needle tip toward
Sanjian (LI 3), with reducing method of lifting and thrusting to make
the patient’s second finger or five fingers extended freely.

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上廉泉
Shanglianquan
(EX-HN)

针向舌根1.5~2寸，用提插泻法；

Puncture Shanglianquan (EX-HN) for 1.5-2 cun, with the needle tip
towards the root of the tongue and reducing method of lifting and
thrusting the needle.

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委 中
Weizhong
(BL 40)

仰卧直腿抬高取穴，直刺0.5~1寸，施提插泻
法，使患侧下肢抽动3次为度。

Select Weizhong (BL 40) point with the supine position and the
lower limb lifted, puncture perpendicularly for 0.5-1 cun, with
reducing method of lifting and thrusting to make the lower limb
have tic for 3 times.
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金津、玉液
Jinjin(EX-HN12)
Yuye(EX-HN13)

用三棱针点刺放血，出血1~2毫升；
Prick Jinjin (EX-HN12) and Yuye (EX-HN13) with the three-edged
needle to cause bleeding for 1-2ml.

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丘墟透向照海穴
Qiuxu(GB 40)
to
Zhaohai(KI 6)

约1.5~2寸，局部酸胀为度。
Puncture Qiuxu (GB 40) 1.5-2 cun in depth with the needle tip
toward Zhaohai(KI 6),until soreness and distension occurred
locally.

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中风病其他并发症的治疗
Treatment of Complications of
Apoplexy

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(1) 便秘：针外水道、外归来、丰隆。

Constipation: Puncture Waishuidao (EX-CA), Waiguilai (EX-CA)

and Fenglong(ST 40)

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(2) 呼衰：针刺双侧气舍

Respiratory Failure: Puncture bilateral Qishe(ST 11)

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(3) 尿失禁、尿潴留：针中极、曲骨、
关元、局部施灸、按摩或热敷

Incontinence of Urine, Retention of Urine: Puncture Zhongji (RN 3),Qugu (RN 4),
Sanyinjiao (SP 6), Yinlingquan (SP 9). Moxibustion is applied on the local area,
while massage and hot compress are applicable too.

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颈椎夹脊穴

Cervical Jiaji Points(EX-B2)

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(5) 复视：针天柱、晴明、球后

Double Vision: Puncture Fengchi (GB 20), Tianzhu (BL 10),

Jingming (BL 1) and Qiuhou (EX-HN7)

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(6) 癫痫： 针大陵、鸠尾

Epilepsy: Puncture Daling (PC 7), Jiuwei (RN 15)

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(7) 肩周炎：针肩髃、肩髎、肩内陵、
肩贞、肩中俞、肩外俞，痛点刺络拔罐

Periarthritis of Shoulder: Puncture Jianneiling (EX-UE), Jianliao (SJ 14),

Jianzhen(SI 9), Jianzhongshu(SI 15), Jianwaishu (SI 14).Apply blood
letting and cupping method to the local pain point.

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(8) 血管性痴呆：针百会、四神聪、
四白、太冲

Vascular Dementia: Puncture Baihui (DU 20), Sishencong (EX-

HN1), Sibai (ST 2) and Taichong (LR 3).

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太 冲
Taichong (LR 3)

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(9) 睡眠倒错：针上星、神门

Paradoxic Sleep: Puncture Shangxing (DU 23), Shenmen (HT 7).

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安全性评价：
Safety evaluation

Ø 不良反应：未出现严重不良反应

Ø Adverse reaction: did not appear serious adverse

reactions

极少数出现轻微不良反应，主要有皮下出血，血肿，疼痛。

A mild adverse reactions, subcutaneous bleeding,

hematoma, pain

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醒脑开窍针刺法对缺血区脑组织的改善 85

“XNKQ” can improve the brain ischemia area

形态学研究，证明针刺可促进侧枝循环建立
Morphology research that acupuncture can promote collateral circulation

阻断大脑中动脉后，大脑表面缺血区所见：
Block after middle cerebral artery surface area, the brain ischemia

梗塞半球 缺血后
脑表面缺血区 自身代偿情况 针刺干预情况
Cerebral infarction After
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ischemia Their ischemia intervention
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醒脑开窍针刺法对病变神经元结构的修复
Acupuncture to repair pathological neuron structure
针刺保护细胞形态、减轻神经元损伤、12h内促进微管微丝等细胞的“⻣架”
的再⽣与修复
Acupuncture protect cells form, reduce damage, promote neurons 12h microtubules
microfilament cells "skeleton" renewable and repair

针刺前： 针刺3h后： 针刺 6h后：

神经细胞溶解、破坏 线粒体轻度肿胀 线粒体肿胀减轻

针刺12h后： 针刺24h后：
线粒体完整， 神经细胞基本正常
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醒脑开窍针法对脑梗死患者脑葡萄糖代谢的影响 87
Acupuncture in patients with cerebral infarction of the brain glucose
metabolism
醒脑开窍针刺法可以：
•促进病灶周围功能重组 Promote surrounding function restructuring
•激活运动功能区域 Activation function area
•促使正常脑区的代偿 To decompensation the normal brain areas
•改善与记忆、认知、语言功能和情绪等相关区域的代谢。
Improve memory, cognition, emotion and language functions related
areas of metabolism

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l 治疗中风病恢复期的国家新药，纯中药制剂。
Treatment of national drug stroke recovery, traditional Chinese medicine
preparation
l 具有补气活血、豁痰熄风的功效
Fill with blood, and the efficacy of wind tax-exempt phlegm off
l 2001年获国家新药证书（国药准字z20010105）
2001 was approved by the state drug certificate (z20010105)
l 2002年获得国家GMP认证并投产上市
2002 obtains the national GMP authentication and production

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丹芪偏瘫胶囊的药物组成及功效
The capsule and partial drug efficacy

处⽅：⻩芪、丹参、川芎、⽔蛭、⼈⼯⽜⻩、全蝎、⽯菖蒲等。
Prescription: astragalus, danshen, artificial bezoar and leeches, chuanxiong rhizoma,
whole xie, etc.

功能：益⽓活⾎，豁痰熄⻛。
Function: qi, sputum extinguish wind. Tax-exempt

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 药物作用及特点
Dr Igor Mićunović

Drug and characteristics

1. 减少脑梗死⾯积：药理实验表明，该药可以有效降低脑梗塞
组织百分⽐，改善实验动物⾏为障碍。
1.Reduce cerebral infarction area: the pharmacological experiments show that
can effectively reduce cerebral infarction, the improvement of experimental
animals percentage organization behavior.

2. 保护及修复受损脑细胞：药理实验表明，该药增加脑供⾎，有
效恢复受损脑细胞功能。
2. protection and repair damaged brain cells: that the drug increases
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3. 有效恢复肢体功能：临床实验结果显示，该药对改善肢体

功能效果明显。
3 .effectively restore limb function: clinical experiment results show that the
drug to improve functional effect is obvious.

4. 降低⾎粘度：药理实验及临床实验表明，该药改善⾎液流
变学指标，降低⾎粘度。
4 reduced blood viscosity, pharmacological experimental and clinical
experiments showed that the drug improving hemorheology indices, reduce
blood viscosity.

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5. 重病重剂，起效迅速：脑卒中病情较重，不⽤重剂难以
起效，故每⽇每次⽤量较⼤，经过临床观察，该药对恢复早
期脑卒中患者，起效迅速。
5 Illness weight, agent quickly: stroke disease is heavier, not heavy agent to effect,
so every large dosage, daily clinical observation, the drug for early stroke patients,
quickly.

6. 全成分提取⽣产⼯艺先进：采⽤韩国技术制造的动态提
取设备，充分提取有效成份。

6 .All components extraction advanced production technology, USES the south

Korean technology of manufacturing equipment, fully dynamic extracting effective

components extraction.

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Dr Igor Mićunović 丹芪偏瘫胶囊，已获得国际认可
Hemiplegia capsule, has gained international
recognition

题⽬：Dianqi Piantang Jiaonang(DJ),a traditional Chinese Medicine in

post-stroke recovery
中药丹芪偏瘫胶囊在中⻛后的康复作⽤
杂志：Stroke 卒中（美国） 影响因⼦：6.499
作者：Christopher Chen, MD;(新加坡国⽴⼤学药理学博⼠)
结论：经过对605例患者进⾏随机对照研究证明，与对照中成药相⽐丹芪偏
瘫胶囊可显著改善患者神经功能缺损，提⾼⽣活质量，且具有较好的
安全性。
After patients required for 605 randomized study compared with
controls, proprietary hemiplegia capsules can significantly improve
patient neurologic deficits, and improve the quality of life, and has good
safety. www.igormicunovic.com
Dr Igor Mićunović 题⽬：Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a
Chinese medicine, in vitro and in vivo

中药丹芪偏瘫胶囊(MLC601, MLC901)在体内、体外的神经保护及再⽣作⽤

杂志：Neuropharmacology 神经药理学杂志（英国） 影响因⼦：3.383

作者：C. Heurteaux （法国⽡勒堡尼斯⼤学）

摘要：丹芪偏瘫胶囊可以防⽌神经元死亡，促进神经再⽣，促进细胞增殖、神经突起⽣⻓，
促进密集性的轴突、树突⽹络的发展。中⻛超早期应⽤本品可以降低死亡率，对于中⻛不
同时期的治疗有着重要的意义。

Hemiplegia capsules can prevent neurons, promote nerve regeneration

death, promote cell proliferation, nerve growth and promote protuberant
coarctation of axons, dendritic network development. Use this product super
early stroke reduces mortality, different period of treatment for stroke has
important significance.

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题⽬：Danqi Piantan Jiaonang Does Not Modify Hemostasis, Hematology,and

Biochemistry in Normal subjects and Stroke Patients

丹芪偏瘫胶囊对正常受试者和中⻛病⼈凝⾎、⽣化指标的影响

杂志：cerebrovascular diseases 脑⾎管病杂志 瑞⼠ 影响因⼦：3.041

作者： Robert Gan 新加坡国⽴脑神经医学院

结论：丹芪偏瘫胶囊不会明显改变正常受试者和中⻛病⼈的⾎液、⽌⾎和⽣化参数。

具有很好的安全性。

Hemiplegia capsules won't change significantly normal

subjects and stroke patients, bleeding and biochemical
parameters of blood. Good safety

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Dr Igor Mićunović

题⽬：A double-blind, placebo-controlled, randomized phase II pilot study to

investigate the potential efficacy of the traditional chinese medicine Neuroaid
(MLC 601) in enhancing recovery after stroke (TIERS).
丹芪偏瘫胶囊治疗中⻛后恢复期的⼆期临床研究：随机、对照、双盲试验
杂志：cerebrovascular diseases 脑⾎管病杂志 瑞⼠ 影响因⼦：3.041
作者：Keng He Kong,新加坡，宏茂桥医院
结论：丹芪偏瘫胶囊可以显著改善中⻛患者神经功能和⽣活能⼒，⽽且对后循环梗
死和严重的中⻛患者也有良好的治疗效应

Hemiplegia capsules can significantly improve neural function and

stroke patients, but also for life cycle and serious infarction after
stroke patients also has a good effect

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Dr Igor Mićunović 以“醒脑开窍”针法、丹芪偏瘫胶囊为组合的针药结合治疗缺血性中风
97
病取得了巨大的成果
“XNKQ”acupuncture therapy and Danqi hemiplegia capsule,treatment of ische
mic apoplexy made great achievements
• 国家科技部、中医药管理局科技成果推广项目
National science and technology department, administration of traditional
Chinese medicine science promotion project
• 已推广到全国和世界60多个国家和地区，形成了辐射全球的技术平台
Has extended to the world in more than 60 countries and regions of the world,
formed the radiation technology platform

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Dr Igor Mićunović

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Dr Igor Mićunović

患者：Deven
职业：健美教练
国籍：美国

一个关乎希望、勇气和整个家庭奔向中风康复的非凡旅程

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Dr Igor Mićunović

Thank You 谢 谢

TCM Podcast www.tcmpodcast.me

AAM www.uacg.me
Personal www.igormicunovic.com

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