Disease Causative Agent DOC Gold Standard Dx

Gonorrhea Neisseria gonorrhoeae Ceftriaxone + Doxycycline NAAT

Syphilis Treponema pallidum Benzathine penicillin G 2.4 MU Direct Microscopy: Darkfield
Chancroid Haemophilus ducreyi Ceftriaxone Direct Microscopy: Gram Stain
Bacterial vaginosis Gardnerella vaginalis Metronidazole Culture
Trichomoniasis Trichomonas vaginalis Metronidazole or tinizadole 2g single dose Direct microscopy
Vulvovaginal candidiasis Candida albicans Oral fluconazole or azole cream or suppository
Culture
Chlamydial lymphogranuloma Chlamydia Trachomatis serovars L1, L2 and L3 Doxycycline NAAT
Psittacosis C. Chlamydia Psittaci Azithromycin Serology
Acquired Immunodeficiency Syndrome (AIDS) Human immunodeficiency virus (HIV) HAART PCR
Genital Herpes Herpes simplex virus (HSV) Type 2 Acyclovir PCR/Tube culture isolation
Kaposi sarcoma HHV 8 Doxorubicin Serologic assays (No Gold standard)
Molluscum contagiosum virus (MSV) Cidofovir Hx and PE
Condyloma acuminata Human papillomaviruses (HPV) Podophyllin PCR
Ureaplasma urealyticum Azithromycin Culture
Mycoplasma genitalium Doxycycline + Azithromycin Culture
Hepatitis Hep B, C Interferon-a and lamivudine (New antivirals for
Serology
HepC Simeprevir, Sofosbuvir, Lepidasvir)
Pediculosis of the groin Pthirus pubis Permethrin Physical finding of live adult lice and viable eggs on the hair shafts usu in pubic area
UTI S. saprophyticus TMP-SMX, quinolones Culture
Donovanosis Calmeto bacterium granulomatis Azithromycin Dark-staining Donovan bodies on tissue crush preparation or biopsy