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Advances in Predictive, Preventive and Personalised Medicine
Series Editor: Olga Golubnitschaja

Lotfi Chaari Editor

Digital Health in
Focus of Predictive,
Preventive and
Personalised
Medicine
Digital Health in Focus of Predictive, Preventive
and Personalised Medicine
Advances in Predictive, Preventive and
Personalised Medicine

Volume 12

Series Editor:
Olga Golubnitschaja
Excellence Rheinische Friedrich-Wilhelms University of Bonn,
Bonn, Germany

Editorial Board
Babak Baban, Augusta University, Augusta, GA, USA
Rostylav Bubnov, Clinical Hospital ‘Pheophania’ of State Affairs Department,
Kyiv, Ukraine
Vincenzo Costigliola, European Medical Association, Brussels, Belgium
Godfrey Grech, University of Malta Medical School, Msida, Malta
Mahmood Mozaffari, Augusta University, Augusta, GA, USA
Paolo Parini, Karolinska Institutet, Stockholm, Sweden
Friedermann Paul, Charité University Medicine Berlin, Berlin, Germany
Byong Chul Yoo, National Cancer Center, Goyang-Si, Korea (Republic of)
Xianquan Zhan, Central South University, Changsha, China
Russell J. Andrews, Nanotechnology & Smart Systems Groups, NASA Ames
Research Center, Aerospace Medical Association, Moffett Field, CA, USA
Holger Fröhlich, Bonn-Aachen International Center for Information Technology
(B-IT), University of Bonn, AI & Data Science Group, Bioinformatics, Fraunhofer
SCAI, Bonn, Germany
Suzanne Hagan, Glasgow Caledonian University, Glasgow, UK
Yoshihiro Kokubo, National Cerebral and Cardiovascular Center, Suita, Japan
Kurt Krapfenbauer, Medical University of Vienna, Vienna, Austria
Halina Podbielska, Wrocłsaw University of Science and Technology, Wrocław,
Poland
R. Andrew Tasker, University of Prince Edward Island, Charlottetown, PE, Canada
Christine Nardini, University of Bologna and Verona, Cryolab and Diatheva, Italy
Laboratory Medicine, Karolinska Institute, Stockholm, Sweden
Pavol Zubor, National Institute of Oncology, Oslo, Norway
Lotfi Chaari, Higher Institute of Computer Science and Multimedia of Sfax, Sakiet
Ezzit, Tunisia
Jiri Polivka Jr., Department of Histology and Embryology, Biomedical Centre,
Faculty of Medicine in Plzeň, Plzeň, Czech Republic
Silvia Mandel, University of Haifa, Haifa, Israel
Carl Erb, Private Institute of Applied Ophthalmology, Berlin, Germany
Wei Wang, School of Medical and Health Sciences, Edith Cowan University, Perth,
WA, Australia
More information about this series at http://www.springer.com/series/10051
Lotfi Chaari
Editor

Digital Health in Focus


of Predictive, Preventive
and Personalised Medicine
Editor
Lotfi Chaari
IRIT-ENSEEIHT (UMR 5505)
University of Toulouse
TOULOUSE CEDEX 7, France

ISSN 2211-3495 ISSN 2211-3509 (electronic)


Advances in Predictive, Preventive and Personalised Medicine
ISBN 978-3-030-49814-6 ISBN 978-3-030-49815-3 (eBook)
https://doi.org/10.1007/978-3-030-49815-3

© Springer Nature Switzerland AG 2020


This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on microfilms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology
now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a specific statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book
are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or
the editors give a warranty, expressed or implied, with respect to the material contained herein or for any
errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional
claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG.
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
What This Book Series Is About

Current Healthcare: What Is Behind the Issue?

For many acute and chronic disorders, the current healthcare outcomes are con-
sidered as being inadequate: global figures cry for preventive measures and per-
sonalised treatments. In fact, severe chronic pathologies, such as cardiovascular
disorders, diabetes and cancer, are treated after onset of the disease, frequently
at near end stages. Pessimistic prognosis considers pandemic scenario for type 2
diabetes mellitus, neurodegenerative disorders and some types of cancer over the
next 10–20 years followed by the economic disaster of healthcare systems in a
global scale.

Advanced Healthcare Tailored to the Person: What Is Beyond


the Issue?

Advanced healthcare promotes the paradigm change from delayed interventional to


predictive medicine tailored to the person, from reactive to preventive medicine and
from disease to wellness. The innovative Predictive, Preventive and Personalised
Medicine (PPPM) is emerging as the focal point of efforts in healthcare aimed
at curbing the prevalence of both communicable and non-communicable diseases,
such as diabetes, cardiovascular diseases, chronic respiratory diseases, cancer and
dental pathologies. The cost-effective management of diseases and the critical role
of PPPM in modernisation of healthcare have been acknowledged as priorities by
global and regional organisations and health-related institutions, such as the United
Nations Organisation, the European Union and the National Institutes of Health.

vii
viii What This Book Series Is About

Why Integrative Medical Approach by PPPM as the Medicine


of the Future?

PPPM is the new integrative concept in healthcare sector that enables to predict
individual predisposition before onset of the disease, to provide targeted preventive
measures and to create personalised treatment algorithms tailored to the person. The
expected outcomes are conducive to more effective population screening, prevention
early in childhood, identification of persons at risk, stratification of patients for
the optimal therapy planning, prediction and reduction of adverse drug-drug or
drugdisease interactions relying on emerging technologies, such as pharmacogenet-
ics, pathology-specific molecular patters, subcellular imaging, disease modelling,
individual patient profiles, etc. Integrative approach by PPPM is considered as the
medicine of the future. Being at the forefront of the global efforts, the European
Association for Predictive, Preventive and Personalised Medicine (EPMA, http://
www.epmanet.eu/) promotes the integrative concept of PPPM among healthcare
stakeholders, governmental institutions, educators, funding bodies, patient organ-
isations and public domain.
Current book series, published by Springer in collaboration with EPMA,
overview multidisciplinary aspects of advanced biomedical approaches and
innovative technologies. The integration of individual professional groups into
the overall concept of PPPM is a particular advantage of this book series. Expert
recommendations focus on the cost-effective management tailored to the person
in health and disease. Innovative strategies are considered for standardisation of
healthcare services. New guidelines are proposed for medical ethics, treatment of
rare diseases, innovative approaches to early and predictive diagnostics, patient
stratification and targeted prevention in healthy individuals, persons at risk,
individual patient groups, subpopulations, institutions, healthcare economy and
marketing.
About the Book Series Editor

Prof. Dr. Olga Golubnitschaja

Dr. Olga Golubnitschaja Department of Radiology, Medical Faculty, Rheinische


Friedrich-Wilhelms-Universität, Bonn, Germany, has studied journalism, biotech-
nology and medicine and has been awarded research fellowships in Austria, Russia,
the UK, Germany, the Netherlands and Switzerland (early and predictive diagnostics
in paediatrics, neurosciences and cancer). She is the author of more than 400
well-cited international publications (research and review articles, position papers,
books and book contributions) in the innovative field of predictive, preventive
and personalised medicine (PPPM) with the main research focus on pre- and
perinatal diagnostics, diagnostics of cardiovascular disease and neurodegenerative
pathologies, predictive diagnostics in cancer and diabetes.
She has been awarded National and International Fellowship of the Alexander
von Humboldt Foundation and Highest Prize in Medicine and Eiselsberg Prize in
Austria.
Since 2009, Dr. Golubnitschaja is the Secretary General of the European
Association for Predictive, Preventive and Personalised Medicine (EPMA, Brussels)
networking over 50 countries worldwide (www.epmanet.eu), Series Editor of
Advances in Predictive, Preventive and Personalised Medicine (Springer Nature),

ix
x About the Book Series Editor

Editor of Predictive Diagnostics and Personalised Treatment: Dream or Reality


(Nova Science Publishers, New York 2009) and Co-editor of Personalisierte
Medizin (Health Academy, Dresden 2010).
She is the European Representative in the EDR Network at the National Institutes
of Health, USA (http://edrn.nci.nih.gov/).
She is a regular reviewer for over 30 clinical and scientific journals and serves
as a grant reviewer for national (ministries of health in several European countries)
and international funding bodies.
Since 2007 until now, she has been working as the European Commission
evaluation expert for FP7, Horizon 2020, IMI-1 (Innovative Medical Initiatives) and
IMI-2. From 2010 to 2013, she was involved in creating the PPPM-related contents
for the European Programme ‘Horizon 2020’.
Currently, Dr. Golubnitschaja is Vice-Chair of the Evaluation Panel for Marie
Curie Mobility Actions at the European Commission in Brussels.
Preface

Predictive, Preventive and Personalised Medicine (3PM) is a new paradigm for both
bio/medical sciences and management of medical services created and promoted by
the expert groups of EPMA in early twenty-first century.
On the other hand, Information Technology (IT) comprises essential tools for
many aspects of societal organisation at individual and population levels, being
therefore instrumental for the development and implementation of advanced 3PM
concepts benefiting healthy individuals, patients, healthcare system, and the society
as a whole.
Potential IT/3PM benefits could be well exemplified by the current Covid-19
Pandemic challenge, when optimal policy-making decisions could be made only
by application of predictive IT algorithms for cost-effective targeted preventive
measures saving lives and considering the entire spectrum of socio-economical
issues related to this complex situation.
Contextually, this book addresses the IT-generated solutions for practical
implementation of 3PM concepts. It presents innovative methods, algorithms and
approaches which synergistically demonstrate a potential to advance 3PM concepts
and implementation. A spectrum of relevant IT solutions is considered such as
predictive and prognostic tools, health monitoring for targeted prevention, Internet
of Things (IoT), Artificial Intelligence (AI), big data analysis and personalisation
of treatment algorithms.

Toulouse, France Lotfi Chaari

xi
Introduction

Keywords: Predictive Preventive Personalised Medicine (PPPM, 3PM); eHealth;


IoT for Health; Artificial Intelligence; Big Data Analysis; Deep Learning; Health
Monitoring; 3D Visualization; Covid-19 Pandemic Monitoring

Introducing Information Technology (IT) tools in today’s and future medicine is


being increasingly considered all over the world, especially in developed countries.
Indeed, these countries are suffering the most from population aging and chronic
diseases. This induces original challenges not only for healthcare but also for well-
being. In this sense, Predictive, Preventive and Personalised Medicine (3PM) has
been identified since more than a decade as a research avenue having huge potential
for developed societies.

From Traditional to 3PM

The history of medicine[1] is rich in important events and discoveries. For cen-
turies, medicine has regularly faced important challenges. Evolution has therefore
happened relatively to historical events, but also with respect to the practice method-
ology. Regarding events, there is no better example than the current Coronavirus
Pandemic, which is demonstrating that healthcare systems in both developed and
developing countries are not adapted to such situations.
In terms of practice methodology, medicine moved from Traditional (T) practice
to Complementary and Alternative Medicine (CAM) and then to Person-Centred
Medicine (PCM), Individualised Medicine (IM), Stratified Medicine (SM), Person-
alised Medicine (PM), and more recently Predictive, Preventive and Personalised
Medicine (3PM). 3PM is becoming today one of the main priorities of the European
Commission (EC) to solve current health challenges [2]. Although these challenges
are to a large extent due to population aging trends, chronic and severe diseases,
earlier considered as being linked to the elderly, nowadays occur more and more
frequently to younger generations, such as diabetes mellitus type 2, some types of
aggressive cancers and ‘young’ stroke, among others [3,4,5,6]. Contextually, inno-

xiii
xiv Introduction

vative population screening programmes based on advanced concepts of prediction,


targeted prevention and personalisation of medical services have to be investigated.

3PM Meeting IT

Today, the paradigm of handling chronic diseases is facing a shift from reactive
to Predictive, Preventive and Personalised. Recent studies clearly established this
evidence in general [7] and specific chronic diseases such as heart failure [8].
This paradigm shift has been conducted by handling more patient-related data.
As most of today’s applications, these data may be of very large volumes. It
is mostly collected from sensors either related to people’s physiological state or
environment.
To analyse the generated data volumes, it is not possible any more to rely on
manual or operator-based tools. Hopefully, research during the last two decades in
the field of IT has led to the development of many automatic and efficient tools to
collect, process and analyse data. The 3PM community has therefore managed to
formulate unsolved problems to be investigated using IT tools [9, 10].

IT Meeting 3PM

On the other hand, IT has completely changed our lives. Starting from homes,
vehicles or even work and restaurants, we use IT tools throughout the day. On the
other hand, IT today is contributing to the understanding and monitoring of the
current Covid-19 Pandemic [11]. This allowed countries to adapt their prediction
and prevention strategies either through non-pharmacological interventions (NPI)
or personalised imagery-based testing [12]. 3PM is therefore being adopted as a
paradigm to handle both the pandemic and post-pandemic phases.
In the context of healthcare, IT has a lot offer, such as patients management
at hospitals, exploration tools like imagery, telemedicine, and data-driven clini-
cal decision systems (CDS). More recently, Artificial Intelligence (AI) is being
investigated deeper despite the sensitivity of the medical field [13]. Specifically,
the AI community [8] has investigated solving 3PM problems. In parallel, similar
contributions in the field of 3PM have been made by other scientific communities
such as Internet of Things (IoT) [14].
This book addresses new contributions in the field of IT regarding 3PM.
It therefore contributes to document how IT is meeting 3PM to solve current
problems and give new perspectives for the future. The book’s content covers tools
serving personalised prediction, tools for diagnosis and prevention, monitoring,
visualisation, data analytics, AI and personalized medical systems.
Introduction xv

The reported original contributions have been presented to the second Inter-
national Conference on Digital Health Technologies (ICDHT 2019). This book
therefore provides one with a technical idea about future trends using IT tools for
3PM.

References

[1] Golubnitschaja, O., Baban, B., Boniolo, G., Wang, W., Bubnov, R., Kapalla, M., Krapfen-
bauer, K., Mozaffari, M.S., Costigliola, V: Medicine in the early twenty-first century:
paradigm and anticipation - EPMA position paper 2016. EPMA J. 7(23), (2016)
[2] Lemke, H.U., Golubnitschaja, O.: Towards personal health care with model-guided medicine:
long-term PPPM-related strategies and realisation opportunities within ‘Horizon 2020’.
EPMA J. 5(1), 8 (2014)
[3] Duarte, A.A., Mohsin, S., Golubnitschaja, O.: Diabetes care in figures: current pitfalls and
future scenario. EPMA J. 9(2), (2018)
[4] Kunin, A., Polivka, J. Jr., Moiseeva, N., Golubnitschaja, O.: “Dry Mouth” and “Flammer”
syndromes – neglected risks in adolescents and new concepts by predictive, preventive and
personalised approach. EPMA J. 9(3), 307–317 (2018)
[5] Golubnitschaja, O., Flammer, J.: Individualised patient profile: Clinical utility of Flam-
mer syndrome phenotype and general lessons for predictive, preventive and personalised
medicine. EPMA J. 9(1), 15–20 (2018)
[6] Polivka, J. Jr., Polivka, J., Pesta, M., Rohan, V., Celedova, L., Mahajani, S., Topolcan, O.,
Golubnitschaja, O.: Risks associated with the stroke predisposition at young age: facts and
hypotheses in light of individualized predictive and preventive approach. EPMA J. 10(1),
81–99 (2019)
[7] Seifirad, S., Haghpanah, V.: Inappropriate modeling of chronic and complex disorders: How
to reconsider the approach in the context of predictive, preventive and personalized medicine,
and translational medicine. EPMA J. 10(3), 195–209 (2019)
[8] Barrett, M., Boyne, J., Brandts, J., Brunner-La Rocca, H.P., De Maesschalck, L., De Wit, K.,
Dixon, L., Eurlings, C., Fitzsimons, D., Golubnitschaja, O., Hageman, A., Heemskerk, F.,
Hintzen, A., Helms, T.M., Hill, L., Hoedemakers, T., Marx, N., McDonald, K., Mertens, M.,
Müller-Wieland, D., Palant, A., Piesk, J., Pomazanskyi, A., Ramaekers, J., Ruff, P., Schütt,
K., Shekhawat, Y., Ski, C.F., Thompson, D.R., Tsirkin, A., van der Mierden, K., Watson,
C., Zippel-Schultz, B.: Artificial intelligence supported patient self-care in chronic heart
failure: a paradigm shift from reactive to predictive, preventive and personalised care. EPMA
J. 10(4), 445–464 (2019)
[9] Fröhlich, H., Patjoshi, S., Yeghiazaryan, K., Kehrer, C., Kuhn, W., Golubnitschaja, O.:
Premenopausal breast cancer: potential clinical utility of the multi-omic based machine
learning approach for patient stratification. EPMA J. 9(2), (2018)
[10] Gerner, C., Costigliola, V., Golubnitschaja, O.: Multiomic patterns in body fluids: Technolog-
ical Challenge with a Great Potential to Implement the Advanced Paradigm of 3P Medicine.
Mass Spectrometry Rev. 195–209 (2019)
[11] Chaari, L., Golubnitschaja, O.: Covid-19 pandemic by the “real-time” monitoring: the
Tunisian case and lessons for global epidemics in the context 3PM strategies. EPMA J.
(2020) https://doi.org/10.1007/s13167-020-00207-0
xvi Introduction

[12] Xiaowei, X., Xiangao, J., Chunlian, M., Peng, D., Xukun, L., Shuangzhi, L., Liang, Y.,
Yanfei, C., Junwei, S., Guanjing, L., Yongtao, L., Hong, Z., Kaijin, X., Lingxiang, R., Wei,
W.: Deep learning system to screen coronavirus disease 2019 pneumonia. In: arXive. 2020.
https://arxiv.org/ftp/arxiv/papers/2002/2002.09334.pdf. Accessed 21 Feb 2020
[13] Davenport, T., Ravi, K.: The potential for artificial intelligence in healthcare. Future
Healthcare J. 6(2), 94–98 (2019)
[14] Schreier, G.: The internet of things for personalized health. Stud. Health Technol. Inform.
200, 22–31 (2014)
Contents

A New Scalable and Comprehensive Real-Time Evaluation System


of Dependence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Marie-Claude Mendo, Julien Mistrzak, Vincent Peirolo,
and Laurent Billonnet
An Ontology Based Authentication Framework for Healthcare
Monitoring . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Amira Henaien and Hadda BelHadj
DeepLCP: Towards a DeepLearning Approach to Prevent Lung Cancer . 17
Mayssa Ben Kahla, Dalel Kanzari, and Ahmed Maalel
A Sleep Monitoring Method with EEG Signals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25
Yessrine Abichou, Siwar Chaabene, and Lotfi Chaari
Numerical Simulation of Venous System Blood Flow for Hepatic
Donor Patient and Portal Hypertension’s Proposed Measurement . . . . . . . . 33
Safa Ben Cheikh Souguir, Raouf Fathallah, Asma Ben Abdallah,
Badii Hmida, and Mohamed Hedi Bedoui
Medical Decision-Making: Incompressible Blood Flow Simulation
for the Coronary Artery and Bifurcation Stenosis with CFD Module . . . . 39
Houneida Sakly, Mourad Said, and Moncef Tagina
Accurate Left Ventricular Segmentation Based on Morphological
Watershed Transformation Towards 3D Visualization . . . . . . . . . . . . . . . . . . . . . . 51
Khouloud Boukhris, Ramzi Mahmoudi, Badii Hmida,
and Mohamed Hédi Bedoui
A Smart Search Functionality for a Memory Prosthesis: A Semantic
Similarity-Based Approach . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Fatma Ghorbel, Wafa Wali, Elisabeth Métais, Fayçal Hamdi,
and Bilel Gargouri

xvii
xviii Contents

An Efficient Image Retrieval Using Medical-Dependent Features . . . . . . . . . 67


Hajer Ayadi and Mouna Torjmen-Khemamkhem
Brain Image Processing Using Deep Learning: An Overview . . . . . . . . . . . . . . 77
Rahma Kadri, Mohamed Tmar, and Bassem Bouaziz
Discrete Optimization Model of Free-Fall-Flow-Rack Based
Automated Drug Dispensing System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
Dhiyaeddine Metahri and Khalid Hachemi
Intuitive and Intelligent Solutions for Elderly Care . . . . . . . . . . . . . . . . . . . . . . . . . . 101
Neja Samar Brenčič, Marius Dragoi, Irina Mocanu, and Tomasz Winiarski
Interactive Data Visualization for eHealth Retrieval System . . . . . . . . . . . . . . . 109
Nesrine Ksentini, Mohamed Tmar, and Faïez Gargouri
Accuracy Assessment of a Deep-Learning Based Segmentation Tool
Over Right Ventricle Short-Axis Slices . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121
Asma Ammari, Ramzi Mahmoudi, Badii Hmida, Rachida Saouli,
and Mohamed Hédi Bedoui
Big Data Analytics in Healthcare . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
Wayne Matengo, Ezekiel Otsieno, and Kelvin Wanjiru
Towards an Oversampling Method to Improve Hepatocellular
Carcinoma Early Prediction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
Mahbouba Hattab, Ahmed Maalel, and Henda Hajjami Ben Ghezala
Towards a Chatbot Based Smart Pervasive Healthcare Medical
Emergency Cases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Nourchène Ouerhani, Ahmed Maalel, and Henda Ben Ghézela
A Tool for Multi-scale Modeling of Software Architectures:
Application to the Smart Home for Telemonitoring Elderly People
at Home . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155
Ilhem Khlif, Mohamed Hadj Kacem, Khalil Drira, and Ahmed Hadj
Kacem

Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
12 A. Henaien and H. BelHadj

Knowledge Management System

Medecine User
Identification Sensor
Ontology Profile
Ontology Ontology
Ontology

Dataset

Reasoner
Engine
Pellet
DataSet Server API

Jena API
Knowledge Component Data Component

Controler

Models

Views

Application Component

Networking Component

Sensing Component

Fig. 1 General architecture of ontology based authentication framework


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MP24900.
F. A. C. T. S.
MP25340.
Fairbanks, Douglas, Jr.
LP43608.
Fairchild Industries, Inc.
LP43226.
Falcon, prince of birds.
MP25202.
Falcon’s adventure.
R570317.
Fallen.
LP43487.
Fallen image.
LP43303.
Fall of the House of Usher.
LP43353.
Fall of Troy.
LP43361.
Fame is the spur.
LF154.
Fannie Mae guide to buying, financing and selling your home.
MP25415.
Fantasy of Siam.
R572006.
Farmer in a changing America.
MP24840.
Farmer’s daughter.
R578233.
Far world.
R572331.
Fatal decision.
LP43321.
Fatal memory.
LP43478.
Feather in his hare.
R569649.
Fedderson, Don.
LP43202.
Federal National Mortgage Association.
MP25415.
Feeding.
MP25115.
Feed Service Corporation.
MP25479.
Feelings.
MP25076.
Feiner (Richard) and Company, Inc.
R576618.
Felipa: north of the border.
LP43080.
Ferrell (J. W.) Company, Inc.
MP25171.
Ferris, Bill.
MP25277.
Fiesta.
R578944.
Fiesta Films.
MP25063.
50 happy years.
MP25387.
Fifty years of thorns and roses.
LP43122.
Fighting frontiersman.
R567582.
Film Archives Company.
LP43259.
LP43353.
R577971.
R577972.
FilmFair Communications.
MP24934.
MP24935.
MP24936.
FilmFair, Inc.
MP24934.
MP24935.
MP24936.
Film making techniques.
MP25420.
Film Production Unit, Iowa State University, Ames. SEE Iowa State
University of Science and Technology, Ames. Film Production
Unit.
Films, Inc.
MP24863 - MP24867.
MP24912.
MP25473 - MP25474.
MP25476.
Films of Scotland.
LP43189.
MP24876.
Filmways Television Productions, Inc.
LP43607.
Final semester.
LP43144.
Fine arts and humanities.
LP42945.
Fire in the laboratory.
MP25234.
Fire Service Extension and Film Production Unit, Iowa State
University. SEE Iowa State University of Science and Technology,
Ames. Fire Service Extension and Film Production Unit.
First aid action.
MP24847.
First day of your life.
LP43152.
First encounter.
MU8943.
First hurrah.
LP43215.
Fitch, John T.
MP25228 - MP25234.
Fitch, Robert M.
MP25228 - MP25234.
Fitzgerald, F. Scott.
LP43372.
Five days in the death of Sergeant Brown.
LP43106.
Five Hand Company.
LP43138.
Five on the black hand side.
LP43138.
Five will get you six.
LP43151.
Fixation and dehydration in haemanthus.
MP25306.
Flammability and flame retardants in plastic.
MP25276.
Flint Laboratories, division of Travenol Laboratories, Inc. SEE
Travenol Laboratories, Inc. Flint Laboratories.
Flood tide.
LF132.
Flossie and religion.
LP43607.
Flowering and fruiting of papaya.
MP24969.
Flying sportsman in Jamaica.
R578349.
FNMA. SEE Federal National Mortgage Association.
Foibles.
LP43071.
Food chains in a lake environment.
MP24762.
Food labeling: Understanding what you eat.
MP24988.
Food: the story of a peanut butter sandwich.
LP43078.
Fool and his money.
LP43417.
Fool’s gold.
R573667.
Fools rush in.
LF134.
Football fanfare.
R568015.
Ford Foundation.
MP24902.
Ford Motor Company.
LP43469.
Forest animals and their young.
MP24795.
For richer, for poorer.
LP43219.
For the love of pizza.
LP43105.
For the love of Rusty.
R578897.
For the rest of your life.
MP25227.
Fortune hunters.
R567077.
Foul hunting.
R578550.
Fowl brawl.
R570075.
Fowler, Bruce.
MP25303.
MP25304.
Fox, J. Lawrence.
MP25312 - MP25315.
Fragile possession.
LP43455.
Framed.
R572335.
Franciscan Communications Center.
MP24901.
MP24916.
Franck, Edward A.
MP24886.
Frangakis, Nicholas.
MP25066.
Franklin, Robert J.
MP25421.
Freedom trap.
LP42953.
Freeman, Everett.
LP43575.
Freeman, Leonard.
LP42947.
LP42948.
LP42949.
Freeman (Leonard) Productions, Inc.
LP43048.
LP43049.
Free men triumph.
R570071.
Freleng.
LP43130 - LP43133.
LP43137.
LP43630 - LP43631.
LP43634 - LP43636.
French Revolution: the Bastille.
LP43085.
French Revolution: the terror.
LP43096.
Friend of the family.
LP43216.
Fright and flight.
LP43284.
Fright night.
R577569.
From Homo Erectus to Neanderthal.
MP24742.
From the source.
MP25226.
Frozen war, America intervenes in Russia, 1918–1920.
MP25181.
Frugal Films, Ltd. Kotch Company.
LP43606.
Fruit fly: a look at behavior biology.
MP25430.
Fruiting of cacao (Theobroma cacao)
MP24971.
Fruiting of coffee (Coffea arabica)
MP24974.
Fugitive.
LP42987 - LP43046.
Fulkerson, Ann Tavi.
MU8902.
Fuller, Samuel.
LP43118.
Fun and fancy free.
R577489.
Functions.
MP24732.
Fundamental theorem.
MP25051.
Fun on a weekend.
R577972.
Fun with speech sounds.
MP25015.
Fury / Impala / Galaxie 500 comparison.
MP25034.
Fussy baby.
MP25123.
Future action computerized training system.
MP25340.
Fuzz brothers.
LP42968.
Fuzz lady.
LP43165.
G
Gainsborough Pictures, Ltd.
LF137.
LF138.
LF142.
LF149.
LF150.
LF152.
R578286.
R578604.
Gait and musculoskeletal disorders.
MP25261.
Galapagos: Darwin’s clues.
MP24892.
Gallant, Denise P.
MU8997.
Game for one player.
LP43493.
Game of showdown.
LP43430.
Games.
MP25078.
Gandy Goose in Fortune hunters.
R567077.
Gandy Goose in It’s all in the stars.
R570610.
Gandy Goose in Mexican baseball.
R579969.
Gandy Goose in Peace time football.
R572099.
Gandy Goose in The Golden hen.
R572101.
Gardner, B. T.
MP25170.
Gardner (James) Child Development Centers.
MP25358.
Gardner, R. A.
MP25170.
Garner Ted Armstrong.
MP24724 - MP24731.
MP24797 - MP24798.
MP24809 - MP24827.
MP24887.
MP24992 - MP25012.
MP25147 - MP25153.
MP25206 - MP25213.
MP25248 - MP25253.
MP25283.
MP25285 - MP25289.
MP25495 - MP25500.
Gashouse kids.
R569740.
Gassner, Mordi.
MU8910.
Gathering information for weather forecasting.
MP24774.
Gaucho.
LP43352.
Gaumont British Distributors, Ltd.
LF128.
Gay anties.
R567284.
Gearing.
MP24923.
Gears and machines.
MP24749.
Gellerman effective supervision series.
MP25013.
MP25135.
MP23136.
Gemini descending.
LP43420.
General Film Distributors, Ltd.
LF128.
LF137 - LF140.
LF151.
R574818.
R578285.
R578287.
R578288.
General Foods Corporation. Beverage and Breakfast Foods Division.
MP24828.
General Motors.
MU8973.
General Motors Corporation. Chevrolet Motor Division.
MU8944 - MU8949.
MU8987.
MU8989 - MU8990.
MU9006 - MU9007.
General Motors Corporation. Oldsmobile Division.
MP25477.
General Motors Institute, Flint, MI.
MP25275 - MP25276.
MP25423.
Generation 70, Inc.
LP43623.
Gentleman Joe Palooka.
R577414.
Geothermal power.
MP25039.
Gettysburg - 1863.
MP25065.
Ghetto clinic.
LP43592.
Ghost of the dancing doll.
LP43425.
Giddy up woe.
LP43132.
Giffith, James F.
MP24829.
Gifts and long letters.
LP43442.
Gilbert Film Associates.
MP25429.
Gillette Company.
MP25049.
MP25050.
Gillette Company. Safety Razor Division.
MU8971.
Ginn and Company.
MP25137.
MP25138.
MP25139.
Ginn instructional film series on political roles.
MP25137.
MP25138.
MP25139.
Girl named Tham.
LP43142.
Girls and gags.
R568021.
Girl who ran out of night.
LP43614.
Gladiator.
LP43491.
Glen/Kaye Films.
MP25487.
Gloriously clean/campus.
MP24843.
Go Cub Scouting.
MP24982.
Godwin Bevers Company, Inc.
MU8986.
Go faster.
LP43098.
Golan, Menahem.
LP42940.
Goldberg Werrenrath Productions.
MP25269.
MP25270.
Golden Door Productions.
MP24908.
Golden hen.
R572101.
Golden Salamander.
LF133.
Goldsmith, Isadore.
LF124.
R575036.
Gold struck.
LP43133.
Goldwhite, Harold.
MP25299 - MP25300.
MP25316 - MP25320.
MP25398 - MP25399.
Goldwyn (Samuel) Productions, Inc.
R574865.
R574866.
Good bad egg.
R577565.
Goodbye my love.
LP42987.
Good guys and the bad guys.
LP43013.
Goodman, Dolores M.
MU9011.
Good sense about your stomach.
LP43307.
Good thing.
MP24910.
Goofy golf.
R578420.
Goofy gophers.
R567287.
Gordon’s war.
LP43208.
Grappling groaners.
R578908.
Grass story.
LP43611.
Gravity.
MP25221.
Great expectations.
R578288.
Great Gatsby.
LP43372.
Great land.
MU8937.
Great moments from “Birth of a nation.”
LP43201.
Great Outdoor Productions.
MU8950.
Great piggy bank robbery.
R567283.
Greeks: in search of meaning.
LP43095.
Green corner.
MP25273.
Greene Valley grandparents.
MP25277.
Greenfield, Amy.
MP24736.
Greenwich Film Productions.
LP42971.
Greenwood Press, Inc.
MP24896.
Gregory, John R.
MP24844.
Grid approach to conflict solving.
MP25292.
Griffin, Patrick.
MP25181.
Griffith (Andy) Enterprises.
LP43320.
Grotto of greed.
R578424.
Group 7A elements: Chemical properties.
MP25229.
Group 7A elements: Physical properties.
MP25228.
MP25231.
Group 7B elements: Manganese.
MP25230.
Groverton Productions, Ltd.
LP43140 - LP43158.
LP43409 - LP43412.
Growth and development, toilet training.
MP25116.
Growth and fruiting of African oil.
MP24972.
Growth and fruiting of banana.
MP24970.
Growth and fruiting of pineapple.
MP24973.
Guess who owes Lucy $23.50.
LP43560.
Guided by the nene.
MP24913.
Guilt of Janet Ames.
R572336.
Gutman (Leo A.) Inc.
R570569.
Gyroscope.
MP25224.
H
Haley, Gail E.
LP42979.
Half wits holiday.
R570073.
Hall, Richard.
MU8904.
Hall, Richard S.
MU8903.
Hammer, Jerry.
LP43350.
Handi Wipes, Betsy Cullen, golf ’74 ABC.
MP25443.
Handi Wipes, Betsy Cullen, golf ’74 CBS / NBC.
MP25493.
Handling reagents.
MP25295.
Handling walk ins.
MP25144.
Hangman’s wages.
LP43389.
Hang up.
LP43186.
Hanick, Jack M.
MP25134.
Happy go lucky.
R579970.
Harbor Productions, Inc.
LF157.

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