10/2/23, 11:40 AM Drug Metabolism - Clinical Pharmacology - MSD Manual Professional Edition

Common Substances That Interact With Cytochrome P-

450 Enzymes

Enzyme Substrates Inhibitors Inducers

Acetaminophen
Caffeine
Clarithromycin
Estradiol
Haloperidol Charcoal-broiled
Amiodarone
Lidocaine beef
Cimetidine
Methadone Cigarette smoke
Ciprofloxacin
CYP1A2 Olanzapine Omeprazole
Erythromycin
Propranolol Phenobarbital
Fluvoxamine
Ritonavir Phenytoin
Ticlopidine
Tacrine Rifampin
Theophylline
Tricyclic antidepressants
Verapamil
(R)-Warfarin

Celecoxib
Diclofenac
Fluoxetine Amiodarone
Glipizide Cimetidine
Glyburide Fluconazole
Indomethacin Lovastatin Dexamethasone
Nifedipine Ritonavir Phenobarbital
CYP2C9 Phenytoin Sertraline Other barbiturates
Piroxicam Sulfamethoxazole Phenytoin
Progesterone Topiramate Rifampin
Testosterone Trimethoprim
Tricyclic antidepressants Voriconazole
Valproate Zafirlukast
Voriconazole
(S)-Warfarin

Cimetidine
Diazepam
Fluoxetine
(S)-Mephenytoin
Fluvoxamine Carbamazepine
Omeprazole
Ketoconazole Phenobarbital
CYP2C19 Pentamidine
Lansoprazole Prednisone
Propranolol
Omeprazole Rifampin
Voriconazole
Paroxetine
(R)-Warfarin
Ticlopidine

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Enzyme Substrates Inhibitors Inducers

CYP2D6 Beta blockers Amiodarone Carbamazepine

Codeine Bupropion Dexamethasone
Dextromethorphan Celecoxib Phenobarbital
Flecainide Cimetidine Phenytoin
Haloperidol Fluoxetine Rifampin
Lidocaine Fluvoxamine
Mexiletine Metoclopramide
Morphine Methadone
Omeprazole Paroxetine
Phenothiazines Quinidine
Quinidine Ritonavir
Risperidone Sertraline
Selective serotonin
reuptake inhibitors
Tamoxifen
Testosterone
Tramadol
Trazodone
Tricyclic antidepressants
Venlafaxine

Alcohol
Acetaminophen
CYP2E1 Disulfiram Isoniazid
Alcohol
Tobacco use

CYP3A4 Amiodarone Amiodarone Carbamazepine

Aprepitant Amprenavir Dexamethasone
Azole antifungals Atazanavir Isoniazid
Benzodiazepines Azole antifungals Phenobarbital
Calcium channel blockers Cimetidine Phenytoin
Caffeine Ciprofloxacin Prednisone
Carbamazepine Clarithromycin Rifampin
Clarithromycin Delavirdine
Cyclosporine Diltiazem
Delavirdine Erythromycin
Enalapril Fluoxetine
Estradiol Fluvoxamine
Estrogen Grapefruit juice
Erythromycin Indinavir
Fentanyl Metronidazole
Finasteride Nefazodone
Indinavir Nelfinavir
Lidocaine Nifedipine
Lopinavir Omeprazole
Loratidine Paroxetine

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Enzyme Substrates Inhibitors Inducers

Methadone Posaconazole
Nelfinavir Propoxyphene
Omeprazole Ritonavir
Opioid analgesics Saquinavir
Prednisone Sertraline
Progesterone Verapamil
Ritonavir Voriconazole
Saquinavir
Sildenafil
Sirolimus
Statins
Tacrolimus
Tamoxifen
Tricyclic antidepressants
(R)-Warfarin

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MSD MANUAL
Professional Version

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