PMID- 26740292

OWN - NLM
STAT- MEDLINE
DCOM- 20171215
LR - 20181113
IS - 1600-0765 (Electronic)
IS - 0022-3484 (Print)
IS - 0022-3484 (Linking)
VI - 51
IP - 5
DP - 2016 Oct
TI - The effect of an inhibitor of gut serotonin (LP533401) during the induction
of
periodontal disease.
PG - 661-8
LID - 10.1111/jre.12346 [doi]
AB - BACKGROUND AND OBJECTIVE: LP533401 is an inhibitor of tryptophan hydroxylase
1,
which regulates serotonin production in the gut. Previous work indicates that
LP533401 has an anabolic effect in bone. Thus, we hypothesized that
inhibition of
gut serotonin production may modulate the host response in periodontal
disease.
In this study, we aimed to analyze the effects of LP533401 in a rat
periodontitis
model to evaluate the role of gut serotonin in periodontitis pathophysiology.
MATERIAL AND METHODS: Twenty-four rats were divided into three groups:
treated
group (T: ligature-induced periodontal disease and LP533401, 25 mg/kg/d) by
gavage; ligature group (L: ligature-induced periodontal disease only); and
control group (C: without ligature-induced periodontal disease). After 28 d,
radiographic alveolar bone support was measured on digital radiographs, and
alveolar bone volume fraction, tissue mineral density and trabeculae
characteristics were quantified by microcomputed tomography in the right
hemi-mandible. Left hemi-mandibles were decalcified and alveolar bone loss,
attachment loss and area of collagen in the gingiva were histologically
analyzed.
RESULTS: Significant difference between the L and C groups was found,
confirming
that periodontal disease was induced. We observed no difference between the T
and
L groups regarding alveolar bone destruction and area of collagen.
CONCLUSION:
LP533401 (25 mg/kg/d) for 28 d does not prevent bone loss and does not
modulate
host response in a rat model of induced periodontal disease.
CI - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Lima, G M G
AU - Lima GM
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
FAU - Corazza, B J M
AU - Corazza BJ
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
FAU - Moraes, R M
AU - Moraes RM
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
FAU - de Oliveira, F E
AU - de Oliveira FE
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
FAU - de Oliveira, L D
AU - de Oliveira LD
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
FAU - Franco, G C N
AU - Franco GC
AD - Department of General Biology, State University of Ponta Grossa - UEPG, Ponta
Grossa, Paraná, Brazil.
FAU - Perrien, D S
AU - Perrien DS
AD - Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center,
Nashville, TN, USA.
AD - Department of Orthopedic Surgery & Rehabilitation and Vanderbilt University
Institute of Imaging Sciences, Vanderbilt University Medical Center,
Nashville,
TN, USA.
AD - Department of Veterans Affairs, Tennessee Valley Healthcare System,
Nashville,
TN, USA.
FAU - Elefteriou, F
AU - Elefteriou F
AD - Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center,
Nashville, TN, USA.
AD - Departments of Medicine, Pharmacology and Cancer Biology, Vanderbilt
University
Medical Center, Nashville, TN, USA.
FAU - Anbinder, A L
AU - Anbinder AL
AD - Department of Bioscience and Oral Diagnosis, Institute of Science and
Technology
of São José dos Campos, Univ Estadual Paulista - UNESP, São José dos Campos,
SP,
Brazil.
LA - eng
GR - IK2 BX001634/BX/BLRD VA/United States
GR - S10 RR027631/RR/NCRR NIH HHS/United States
PT - Journal Article
DEP - 20160106
PL - United States
TA - J Periodontal Res
JT - Journal of periodontal research
JID - 0055107
RN - 0 (LP533401)
RN - 0 (Pyrimidines)
RN - 333DO1RDJY (Serotonin)
RN - 9007-34-5 (Collagen)
SB - IM
MH - Alveolar Bone Loss/diagnostic imaging/drug therapy/pathology/prevention &
control
MH - Animals
MH - Collagen
MH - Disease Models, Animal
MH - Gingiva/pathology
MH - Ligation/adverse effects
MH - Male
MH - Mandible/pathology
MH - Periodontal Attachment Loss/diagnostic imaging/prevention & control
MH - Periodontal Diseases/*drug therapy/*pathology
MH - Periodontitis/drug therapy/pathology
MH - Pyrimidines/*antagonists & inhibitors
MH - Rats
MH - Rats, Wistar
MH - Serotonin/*metabolism/physiology
MH - X-Ray Microtomography/methods
PMC - PMC5630139
MID - NIHMS908942
OTO - NOTNLM
OT - bone
OT - enterochromaffin cells
OT - periodontitis
OT - serotonin
COIS- The authors declare no conflict of interest.
EDAT- 2016/01/08 06:00
MHDA- 2017/12/16 06:00
PMCR- 2017/10/06
CRDT- 2016/01/08 06:00
PHST- 2015/11/01 00:00 [accepted]
PHST- 2016/01/08 06:00 [entrez]
PHST- 2016/01/08 06:00 [pubmed]
PHST- 2017/12/16 06:00 [medline]
PHST- 2017/10/06 00:00 [pmc-release]
AID - 10.1111/jre.12346 [doi]
PST - ppublish
SO - J Periodontal Res. 2016 Oct;51(5):661-8. doi: 10.1111/jre.12346. Epub 2016
Jan 6.