Trial exam 1

Part 1 (Dr./Safaa) Choose the correct answer :

1) For particle size analysis using sedimentation technique , ……………. is best used for
preparation of dispersion
a. Disodium hydrogen phosphate
b. Sodium citrate
c. Sodium dihydrogen phosphate
d. 1% Tween 80

2)

3)

4)
 Augmentin

5
EXAM
)

6)

Because antihypertensives
are potent drugs
(NOT formulated as powders)
9 EXAM

10 EXAM

11

12) Different polymorphs are ………………..

a. Different in outer shape of crystals
b. Physically different
c. Equal in thermodynamic stability
d. Chemically different
13)

14) Compaction of powder leads to …………………….. EXAM

a) decrease in porosity

b) Increase in bulkiness

c) Decrease in density

d) All of the above

15

16 EXAM
 17

18

EXAM

19
20
EXAM

21

22
23

24 EXAM

25

26

EXAM
 27

EXAM

EXAM
28

29

30) Histogram is a plot of ……………………

a) % Frequency against range of particle size

b) % Frequency against log particle size
c) % Frequency against mean particle size
d) % Frequency against average particle size
31

32 EXAM

33) Crystal growth ………………………

a) Occurs during storage of suspensions prepared using the stable form of a drug
b) Has no effect on particle size distribution
c) Is prevented by using the unstable polymorph of a drug
d) Occurs during storage of suspensions prepared using metastable form of a drug
 34
EXAM

35

36

EXAM

37
 2021 Exam

1) The B.P. classification for particle size of powders using sieving technique can be used for all of
the following EXCEPT ……………… powders
a) Moderately fine
b) Moderately coarse
c) Super fine
d) Fine

EXAM
2) Concerning ICH guidelines , which of the following is NOT TRUE ?
a) Particle size specification is established only for soluble drugs due to concern of bioavailability
b) Guidelines is needed if the particle size of the drug is critical to bioavailability
c) Guidelines is needed if the particle size of the drug affects the flowability
d) Particle size specification is established only for poorly soluble drugs due to concern of content
uniformity

3) B.P. recommends uniformity of content test for the following powder , EXCEPT ………
a) Oral powders with active ingredient less than 2 mg/dose
b) Oral powders with active ingredient less than 2% of total mass
c) Topical powders with active ingredient less than 2 mg/dose
d) Oral dry herbal powders

4) The following is used to calculate projected diameter (dp) …………………..

a) Sieving c) Sedimentation technique
b) Optical microscopy d) Coulter counter

5) Shelf-life of Augmentin powder is ………………………….. EXAM

a) 2 – 3 years in dry form
b) One week at room temperature after reconstitution with water
c) Two weeks in refrigerator after reconstitution in water
d) Both (a) and (c)

6) Frequency distribution curve for powders , all of the following is true except …………….
a) If it is positively skewed curve , the mode has small value
b) If it is positively skewed curve , the mode has large value
c) If it is negatively skewed curve , the mode has large value
d) In normal frequency distribution , the mode has intermediate value

7) The following is NOT a derived property of a powder

a) Surface area c) Packing arrangement
b) Flow properties d) Bulkiness
 EXAM
8) Helium tensiometer is used for determination of ………………..
a. True density c. Granular density of non-porous powders
b. Granular density d. Both (a) and (c)

9) The following specific surface area is true

a) Sv = c) Sw =

b) Sv = d) Sw =

10) Which of the following is NOT true about bulkiness ?

a) Decreased with increased surface area
b) Increased in fine powder
c) =

d) Is the specific bulk volume

11) The coefficient of friction is ……………….. EXAM

a) The angle of repose
b) Decreased with irregular particles
c) The tangent of angle of repose
d) Increased by addition of glidants

12) The flow property of powders is

a) Good for particles of high density
b) Good for irregular particles
c) Good for highly porous powders
d) Good for moist , flat , elongated particles

13) Compression
a) Decrease surface area and tablet hardness EXAM
b) Decrease the particles' densities
c) Decrease the granule volume of porous powders
d) Decrease the disintegration time

14) In tablet manufacture & capsule filling , the following is NOT true
a) Compressibility of powders is more than 40
b) Compressibility of powders is 18 - 21
c) Elimination of fines by granulation
d) Enhance the flow properties by granulation
15) Particle size analysis by sedimentation technique can be used for the following EXCEPT
a) Dilute suspensions (1 – 2%) c) Colloidal dispersions
b) Deflocculated suspensions d) When Reynold's no. is more than 0.2

EXAM
16) FDA guide to inspection of oral dosage forms is important …………….. (EXAM)
a) For pre/post approval issues for development and validation
b) For demonstration of bioequivalence between batches
c) When the processes of manufacture are modified or changed
d) All of the above

17) The dose of the following drug is reduced 20 folds by micronization

a) Digoxin c) Spironolactone
b) Griseofulvin d) Insulin.

18) The following diameters are obtained from Edmundson's equation ………… EXAM
a) Harmonic mean diameter , when P is positive
b) Geometric mean diameter , when P is negative
c) Length arithmetic mean diameter , when P is positive , its value is 1
d) Length arithmetic mean diameter , when P is zero

19) The flow property is ………….. (Mark the false statement)

a) Poor for particles in the subsieve range
b) Good for size range 400 – 800 micron
c) Excellent for particles with C.C.I less than 15%
d) Good for cohesive powders

20) Controlling the particle size , accurate metering of the dose is the main requirement for …..
a) Oral preparation containing potent drug
b) Powder for cutaneous application
c) Insufflation
d) Powders for injection

21) Powders with particle size 50 – 100 micron EXAM

a) Can be used for preparation of ophthalmic products
b) Can be used for manufacture of tablets and filling of capsules
c) Can be used in preparation of dentifrices
d) Do NOT cause grittiness in ointments and creams

23. The sterility tests is carried out for the following EXAM

a) Douche powder c) Powders for cutaneous application

b) Effervescent powder d) Dusting powder
23) Which of the following is true
a) Best angle of repose is 35o
b) Lubricants are added to improve the flow properties of powers
c) Free flowing is the opposite of dustibility
d) Increased angle of repose above 40 chance the flow properties

24) The following method used for particle size analysis is affected by particle shape EXAM
a) Optical microscopy
b) Sedimentation
c) Sieving
d) Laser light scattering

25) The structure units of crystalline solids are:

a) Arranged in fixed lattices produce crystals of low melting points
b) Randomly arranged produce crystals of high melting points
c) Randomly arranged produce crystals of low solubility
d) Arranged in fixed geometric patterns produce crystals of definite shape

26) Which of the following is TRUE

a) Anhydrous ampicillin has higher solubility
b) Anhydrous ampicillin has lower bioavailability
c) Bonds between atoms and molecules in amorphous form are strong
d) Crystal habit result in higher solubility of crystals

27) Adducts :
a) Are pseudopolymorphic forms
EXAM
b) Affect flow properties and compressibility of powders
c) Are Occlusion solvates
d) Are amorphous
EXAM
29-Which of the following is TRUE:
a- Adducts result from association of Solvent molecules with drug during crystallization
b- Pseudopolymorphs are formed due to presence of solvent in the unit structure of crystal
c- Occlusion solvates show no association of solvent molecules during crystallization
d- pseudopolymorphism result from association of solvent molecules with drug during crystallization

30-Which of the following is TRUE:

a- Unstable form may result from super cooling of the melted
b- Infra-red analysis of amorphous form shows definite peaks
c- Metastable forms have low solubility
d- Isotropic crystals show 2 or 3 different light velocities or refractive indices
31-Which of the following is TRUE: EXAM

a- Thermal gravimetry is used to detect pseudopolymorphic forms

b- Crystallization produces endothermic effect
c- Infra-red spectroscopy is used to detect the packing pattern of atoms
d- X-ray patterns for amorphous powders show peaks

32- Hot-stage microscopy detect the following: EXAM

a- Transition temperature
b- Rate of transition
C- Stability of metastable form
d- All of the above

33- Which of the following is NOT TRUE for polymorphic transition:

a- Granulation may result in formation of hydrous form
b- Enantiotroic system are irreversible ,while monotropic are reversible
c- Crystal growth result during storage of suspensions prepared with the metastable form
d- Surfactants, colloids ,polymers prevent polymorphic transition

34- Which of the following is TRUE:

a- The most soluble form of prednisolone is used for the preparation of subcutaneous implants
b- The anhydrous form of theophylline has high dissolution rate
c- The more soluble form of riboflavin is used for parenteral formulations
d- All of the above

‫صفاء‬/‫زيادات مهمة خاصة بجزء د‬

In Edmundson equation (‫ )دول حفظ زي ما هما مش علينا شرحهم‬:

 If P is positive  The mean is arithmetic (‫)حسابي‬

 If P is Zero  The mean is arithmetic (‫)هندسي‬
 If P is negative  The mean is harmonic

Important notes :

 Average particle size of emulsion & suspensions  0.5 – 10 micron

 Potassium Clavulanate (Augmentin®)  Stored in refrigerator after reconstitution (2 weeks)
 Adducts :
o They are occlusive solvates
o They result from entrapment of solvent molecules inside unit cell during crystallization