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Genetics Why We Are Who We Are 1St Edition Tom Jackson Online Ebook Texxtbook Full Chapter PDF
Genetics Why We Are Who We Are 1St Edition Tom Jackson Online Ebook Texxtbook Full Chapter PDF
Genetics Why We Are Who We Are 1St Edition Tom Jackson Online Ebook Texxtbook Full Chapter PDF
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This edition published in 2018 by Cavendish Square Publishing, LLC
243 5th Avenue, Suite 136, New York, NY 10016
First Edition
Website: cavendishsq.com
This publication represents the opinions and views of the author based on his or her
personal experience, knowledge, and research. The information in this book serves as a
general guide only. The author and publisher have used their best efforts in preparing
this book and disclaim liability rising directly or indirectly from the use and application
of this book.
All websites were available and accurate when this book was sent to press.
The images used in this book come from either the public domain or from the public
commons unless otherwise stated.
The Questions
Introduction
Q1 What is a gene?
Glossary
Index
THEQUESTIONS
INTRODUCTION
So our throwaway use of the word “gene” is a new term for an old
idea, the process of inheritance. Genetics is the science of
inheritance, and its practitioners seek to uncover its mechanisms.
What they have discovered not only tells us about where we came
from and what makes us who we are, it also points the way to the
future of engineering, agriculture, and medicine. The big question is,
do you want to know some more?
Q1
WHAT IS A
GENE?
The idea of genetics goes at least as far back as the 4th century BCE
with the likes of Hippocrates and Aristotle. Both Greeks, the former
was a founding figure of medical science, while the latter was the first
empiricist, who sought to explain nature through its actions—the
things he saw it do—rather than by a prefigured intellectual
framework. Both had the same kind of idea about heredity, about the
topic we now call genetics. And their concept was the one preferred
by Charles Darwin as he set out his theory of evolution by natural
selection in 1859.
Hippocrates
Aristotle
Charles Darwin
Darwin did not need to explain the mechanism of heredity for his
theory to work. He nevertheless opted for a rather general hypothesis
of heredity known as pangenesis, which was largely unchanged from
the days of Classical Greece. As the name suggests, pangenesis relies
on every part of the body transmitting information about itself to the
offspring. The ancient Greeks believed that some of these
instructions were carried in the father’s semen, which they saw as a
kind of refined blood, and others came from the menstrual blood of
the mother.
Sperm and eggs were believed to hold homunculi, or little people, who contained the human spirit.
Charles Darwin adapted the concept to include cell theory, the fact,
unknown to the Greeks, that all living bodies are made up of tiny
units called cells. His proposal was that inherited information was
carried in hypothetical particles called gemmules. Darwin was quick
to point out that his was pure speculation, but the basic idea was
that every part of the body pumped out gemmules into the blood
stream, and they collected in a critical mass inside the cells of the
genitals. From there, the gemmules passed to the next generation,
where they were used to guide the development of all the requisite
body parts. In this way he imagined an army of immortal particles
that flowed from generation to generation. So he had intuitively
defined some basic characteristics required of an inheritance
mechanism but had created some problems, too. For example, how
long would it take for the body to become crammed with gemmules
accrued from each passing generation?
Ironically, someone else had already found the answer, albeit one that
would need to be fleshed out over many decades more.
The word “genetics” is derived from the genesis, a Greek term for
“origin.” Darwin had spliced “genesis” to “pan,” forming
“pangenesis,” to name his inheritance theory, and he and others had
bandied around the adjective “genetic”— meaning “of the origin”—
in their discussions on the matter. However, the noun “genetics”—
the study of inheritance— did not appear until 1905, thanks to the
Cambridge professor William Bateson. Bateson is not, however, the
founding figure of the field, nor is the Dane Wilhelm Johannsen who
coined the word “gene” in 1909. Instead the study of genetics began
in a cloistered garden in a Czech abbey in the 1850s.
Gregor Mendel
Among the fruits and vegetables tended by the monks were stands of
pea plants. These belonged to Gregor Mendel, an ethnic German
monk living during the days of the Austro-Hungarian Empire. At
university Mendel had become interested in heredity under the
teaching of Johann Nestler, a professor who combined the disciplines
of natural history and agriculture. Since the dawn of civilization,
people had been steering the inheritance process to produce better
livestock and crops, and Mendel wanted to know more about how that
worked.
“The word “genetics” is derived from
“genesis,” a Greek term for “origin.””
The pea has been cultivated since Neolithic times and had
become a staple vegetable in Europe by the 10th century CE. As
market gardeners had known for centuries, the seeds from one
plant could produce offspring with a wide variety of
characteristics frequently different from those of the parents.
The traits that Mendel studied included plant height, flower
color, and seed shape, among several others.
With this system in place, Mendel was able to investigate how single
traits were passed through the generations. To this end he bred
hybrids, plants that had parents with two different traits. For
example, he took the pollen from a tall plant and transferred it by
hand to the flower of a short plant. The plants selected for this
experiment were purebreds. In other words, when they (or actually
their ancestors) self-pollinated they always produced offspring with
the same trait in question— in our example, they were either tall or
short.
Finally the third law is the Law of Dominance. This is the bit that
many people will have heard something about. A gene can exist in
several forms, and this is the root of the great variety of plants among
and between each generation. A version of a gene is an allele. This
rather unwieldy word was coined in the 1930s and arrived to us via
German. It means something like “of one another.” So the gene for
flower color has several alleles, the gene for seed shape also, and the
gene for height has a tallness allele and a shortness allele.
Mendel realized that one version, one allele, would be dominant over
the others. He described those weaker genes as recessive. Whenever
a dominant allele was present, that would be the one expressed by
the plant—or any organism. Remember, Mendel knew factors (our
alleles) exist in pairs, with one inherited from each parent, so there
are three possible combinations: Two dominant alleles, two recessive
alleles, or one of each.
These laws are the first foundations of genetics, and Mendel had
worked backwards to them from the results of his hybridization
experiments. Let’s take a look at his thinking using the example
of tall and short plants. The experiment showed that tallness is
dominant over shortness. The parent plants are purebred. That
means that the tall plant has two copies of the tallness allele
(TT), and the short one has two for shortness (tt).
The hybrids of the first generation are all tall because they have
received a dominant tallness allele from the tall parent. They
also have a shortness allele from the other, but because this is
recessive, it does not show itself. In our shorthand, their alleles
are Tt.
This is how the second generation always has a ratio of 3:1 tall
to short. It’s not always the case with every self-cross. Even
Mendel could not manipulate every single allele, and so there is
a small amount of random variation. However, Mendel did the
experiment so many times that the pattern became clear.
Genetics began with the Mendelian laws, but they were just the
beginning and far from the be all and end all of the science. Not all
genes follow the Law of Dominance. Some alleles are co-dominant, so
when they are purebred, they each show different characteristics, but
when they are found together in a hybrid, they produce a third,
entirely different trait. The genes that govern colors of some animal
fur follow the co-dominance rules.
Georges Cuvier
The giraffe, with its long legs and neck, was a key example of
Lamarck’s theory. According to Lamarckism, the reason why giraffes
have long necks is because their short-necked ancestors were always
straining upwards to reach the freshest leaves at the tops of trees and
out of the reach of rivals. With each passing generation, the
stretching bore fruit, and their necks and legs grew longer and longer.
Once giraffes had evolved to be as tall as trees they no longer needed
to stretch, and so the evolutionary process stopped.
Hooke’s microscope
In the late 1830s, cell biologists, chief among them the Germans
Theodor Schwann and Matthias Schleiden, proposed a set of rules
that became known as cell theory. Rule one was that all living
organisms are composed of one or more cells. Number two stated
that the cell is the most basic unit of life. Finally, rule three was the
big reveal: All cells arise from pre-existing, living cells.
Binary fission
APPENDIX TO CHAPTER IV