5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat

igh-fat diet-induced obesity mouse based …

 Log in | Register
 Cart

Home All Journals International Journal of Food Sciences and Nutrition List of Issues
Volume 74, Issue 5 Normal diet ameliorates obesity more saf ....


International Journal of Food Sciences and Nutrition 
Volume 74, 2023 - Issue 5

345 0 1
Views CrossRef citations to date Altmetric
In vitro and animal studies

Normal diet ameliorates obesity more safely

and effectively than ketogenic diet does in
high-fat diet-induced obesity mouse based
on gut microbiota and lipid metabolism
Yunlong Dong, Hongjie Song, Andrew J. Holmes, Jiabao Yan, Cuiru Ren, Ying Zhang,
... show all
Pages 589-605 | Received 15 Feb 2023, Accepted 06 Jul 2023, Published online: 20 Jul 2023

 Cite this article  https://doi.org/10.1080/09637486.2023.2235899

 Full Article  Figures & data  References  Citations  Metrics

 Reprints & Permissions Read this article

Abstract

Growing evidence supports the efficacy of ketogenic diets for inducing weight loss, but
there are also potential health risks due to their unbalanced nutrient composition. We
aim at assessing relative effectiveness of a balanced diet and ketogenic diet for reversing
metabolic syndrome in a diet-induced C57BL/6J mouse model. Mice were fed high-fat

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 1/6
5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based …

diet to induce obesity. Obese individuals were then fed either ketogenic or balanced
diets as an obesity intervention. Serum, liver, fat and faecal samples were analysed. We
observed that both diet interventions led to significant decrease in body weight. The
ketogenic intervention was less effective in reducing adipocyte cell size and led to
dyslipidaemia. The composition of the gut microbiome in the balanced diet intervention
was more similar to the non-obese control group and had improved functional
attributes. Our results indicate intervention with balanced diets ameliorates obesity
more safely and effectively than ketogenic diets in diet-induced obesity mouse model.
 Keywords: Obesity ketogenic diet gut microbiota lipid metabolism normal diet

Acknowledgments

We thank Prof. Dr. Zhenlong Wang, Dr. Hong Sun and Dr. Guangning Kou for helpful
discussion regarding this manuscript.

Authors’ contributions

HJ Song and ZW Cui designed the research; HJ Song, JB Yan, Y Zhang, W Zhao, and JH
Yuan performed the experiment; HJ Song, YL Dong, ZW Cui, JB Yan, Y Zhang, CR Ren and
YY Cheng analysed the data; HJ Song, YL Dong, ZW Cui, Andrew Holmes and David
Raubenheimer wrote the article; ZW Cui supervised the project. All authors have read
and agreed to the published version of the manuscript.

Disclosure statement

The authors declare no conflict of interest.

Institutional review board statement

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 2/6
5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based …

This study was carried out by the guidelines of the NIH for care and use of lab animals.
Additionally, the animal experimental procedures were approved by the Life Sciences
Institutional Review Board of Zhengzhou University (Approval number: ZZUIRB 2020-39).

Additional information
Funding

This research was funded by China Postdoctoral Science Foundation (2019M662520) and
Top-notch Talents of Zhengzhou University (32211502, 32212341, 32340114).

Log in via your institution

 Access through your institution

Log in to Taylor & Francis Online

 Log in

Restore content access

 Restore content access for purchases made as guest

Purchase options * Save for later

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 3/6
5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based …

PDF download + Online access

48 hours access to article PDF & online version
Article PDF can be downloaded
Article PDF can be printed
USD 61.00  Add to cart

Issue Purchase
30 days online access to complete issue
Article PDFs can be downloaded
Article PDFs can be printed
USD 910.00  Add to cart

* Local tax will be added as applicable

Related Research 
People also read Recommended articles Cited by

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 

Daniel J. Klionsky et al.

Autophagy
Published online: 8 Feb 2021


Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female
mice 

Zeang Wu et al.
International Journal of Food Sciences and Nutrition
Published online: 19 Jul 2023

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 4/6
5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based …

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 

Daniel J Klionsky et al.

Autophagy
Published online: 21 Jan 2016


View more

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 5/6
5/21/24, 3:09 PM Normal diet ameliorates obesity more safely and effectively than ketogenic diet does in high-fat diet-induced obesity mouse based …

Information for Open access

Authors Overview

R&D professionals Open journals

Editors Open Select

Librarians Dove Medical Press

Societies F1000Research

Opportunities Help and information

Reprints and e-prints Help and contact

Advertising solutions Newsroom

Accelerated publication All journals

Corporate access solutions Books

Keep up to date

Register to receive personalised research and resources

by email

 Sign me up
 


Copyright © 2024 Informa UK Limited Privacy policy Cookies Terms &

conditions Accessibility

Registered in England & Wales No. 3099067

5 Howick Place | London | SW1P 1WG

https://www.tandfonline.com/doi/full/10.1080/09637486.2023.2235899?src=most-read-last-year 6/6