5/21/24, 3:11 PM Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation

isation study: Internation…

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Volume 75, Issue 1 Assessing the causal association between ....

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International Journal of Food Sciences and Nutrition 
Volume 75, 2024 - Issue 1

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Studies in humans

Assessing the causal association between

dietary vitamin intake and lymphoma risk: a
Mendelian randomisation study
Mingming Zhou, Junfen Xia, Xiaolin Chen, Tiantian Wu, Kedi Xu, Yuanlin Zou, ... show all
Pages 92-101 | Received 10 Jul 2023, Accepted 28 Oct 2023, Published online: 07 Nov 2023

 Cite this article  https://doi.org/10.1080/09637486.2023.2278420

 Full Article  Figures & data  References  Supplemental  Citations

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Abstract

Observational studies of diet-related vitamins and lymphoma risk results were

inconsistent. Our study aimed to estimate the causality between dietary vitamin intake
and lymphoma through a Mendelian randomisation (MR) study. We enrolled dietary-
related retinol, vitamin C, vitamin E, vitamin B6 and vitamin B12 as exposures of interest,
with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) as the outcome. The
causal effects were estimated using inverse variance weighting (IVW), MR-Egger

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5/21/24, 3:11 PM Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation study: Internation…

regression analysis and weighted median, supplemented by sensitivity analyses. The

results revealed that genetically predicted dietary vitamin B12 intake was associated
with a reduced HL risk (OR = 0.22, 95% CI 0.05–0.91, p = 0.036). The Q test did not reveal
heterogeneity, the MR-Egger test showed no significant intercepts, and the leave-one-
out (LOO) analysis did not discover any SNP that affect the results. No causal
relationship about dietary vitamin intake on the NHL risk was observed.
 Keywords: Mendelian randomisation dietary vitamin Hodgkin lymphoma Non-Hodgkin lymphoma

causal effect

Acknowledgments

We want to acknowledge the participants and investigators of the FinnGen study, the UK
Biobank, the TAG, the Neale Lab, and the GIANT consortium.

Authors’ contributions

MZ and CS designed the research. JX, XC, TW, KX, YZ, SZ, PG, HC, and SF conducted the
research. MZ analysed the data and wrote the manuscript. CS supervised the study
conduct and reviewed the manuscript critically. All the authors read and approved the
final version of the manuscript.

Disclosure statement

No potential competing interest was reported by the author(s).

Data availability statement

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5/21/24, 3:11 PM Assessing the causal association between dietary vitamin intake and lymphoma risk: a Mendelian randomisation study: Internation…

All data are publicly available. Summary GWAS statistics related to dietary vitamins are
publicly available at https://gwas.mrcieu.ac.uk. FinnGen Consortium GWAS summary
statistics for lymphoma are available at https://www.finngen.fi/en.

Additional information
Funding

This work was supported by Henan University Science and Technology Innovation
Talents Support Program [19HASTIT005].

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