5/21/24, 3:31 PM Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female

female mice: International Jo…

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Volume 74, Issue 5 Alterations of gut microbiome and metabo ....

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International Journal of Food Sciences and Nutrition 
Volume 74, 2023 - Issue 5

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In vitro and animal studies

Alterations of gut microbiome and

metabolism induced by inulin associated
with weight loss in obese female mice
Zeang Wu , Mei Zhang, Yuhong Deng, Guangyuan Zhou, Meng Yang  &
Haixia Wang 
Pages 606-620 | Received 10 Mar 2023, Accepted 06 Jul 2023, Published online: 19 Jul 2023

 Cite this article  https://doi.org/10.1080/09637486.2023.2235901

 Full Article  Figures & data  References  Supplemental  Citations

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Abstract

Our previous work revealed the microbiota-dependent beneficial effects of inulin in

obese male mice, but the effects in obese female mice were not determined. High-fat
diet (HFD)-induced obese female mice were switched to normal diets and gavaged with
normal saline or inulin for 10 weeks. Inulin supplementation significantly accelerated
weight loss and reversed HFD-induced gut microbiota dysbiosis in obese female mice,
and also reduced the ratio of Firmicutes/Bacteroidetes and enriched the abundance of

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5/21/24, 3:31 PM Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female mice: International Jo…

norank_f_Muribaculaceae and Alistipes. In addition, 52 key serum metabolites were

distinctly altered after inulin supplementation. Among them, andrographolide and
monoacylglycerols (18:4) increased more than 9-fold and 14-fold, respectively, while
phosphatidylcholine (PC) (18:1e/2:0), PC (20:1/20:2) and PC (19:1/19:1) decreased. In
conclusion, gut microbiota and metabolites were closely associated with the beneficial
effects of inulin in accelerating weight loss in obese female mice.
 Keywords: Obesity inulin gut microbiota Muribaculaceae monoacylglycerol

Author contributions

All authors contributed to the work presented in this paper. Experimental design by
Zeang Wu and Haixia Wang; Project administration by Mei Zhang, Yuhong Deng, and
Guangyuan Zhou; data processing by Haixia Wang and Mei Zhang; Graphical
visualisation by Haixia Wang and Zeang Wu; Writing – original draft by Zeang Wu; Writing
– review & editing by Meng Yang and Haixia Wang. Zeang Wu and Mei Zhang contributed
equally to this work.

Ethics statement

This study did not conduct any experimental work with humans. Animal studies were
approved by the ethics committee of Shihezi University (NO.A2020-001-01).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

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5/21/24, 3:31 PM Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female mice: International Jo…

Reasonable requests for data and code may be directed to the corresponding author.

Additional information
Funding

This work was supported by the program of Shihezi University (ZZZC202024A and
ZZZC201946A) and the Medjaden Academy & Research Foundation for Young Scientists
(Grant No. MJA202306029).

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