RODAKS
Surrounding fat cells in apoptotic
1. Ribosomes are synthesized by the:
a. Endoplasmic reticulum
b. Mitochondrion
c. Nucleolus
d. Golgi apparatus
2. The transition from the G1 to S stage
of the cell cycle is regulated by:
a. Cyclin B/CDK1 complex
b. Cyclin A/CDK2 complex
c. Cyclin D1
d. Cyclin E/CDK2 complex
3. Regulation of the hematopoietic
microenvironment is provided by the:
a. Stromal cells and growth factors
b. Hematopoietic stem cells
c. Liver and spleen
d. Cyclins and caspases
4. During the second trimester of fetal
development, the primary site of blood
cell production is the:
a. Bone marrow b. Spleen
c. Lymph nodes d. Liver
5. Which one of the following cytokines
is required very early in the
differentiation ofa hematopoietic stem
cell?
a. IL-2 b. IL-8
c. EPO d. FLT3 ligand
A.
6. What erythroid precursor can be
described as follows: The cell is of
medium size compared with other
normoblasts, with an N:C ratio of
nearly 1:1. The nuclear chromatin is
condensed and chunky throughout the
nucleus. No nucleoli are seen. The
cytoplasm is gray-blue.
a. Reticulocyte
b. Pronormoblast
c. Orthochromic normoblast
d. Polychromatic normoblast
7. At which normoblastic stage does
globin production begin?
a. Orthochromic normoblast
b. Pronormoblast
c. Polychromatic normoblast
d. Basophilic normoblast
8. In the bone marrow, erythroid
precursors are located:
a. Surrounding macrophages in
erythroid islands
b. Adjacent to megakaryocytes along
the adventitial cell lining
c.
islands
d. In the center of the hematopoietic
cords
9. Which of the following determines the
timing of egress of RBCs from the bone
marrow?
a.Stromal cells decrease production of
adhesive molecules over time as RBCs
mature.
b.Endothelial cells of the venous sinus
form pores at specified intervals of
time, allowing egress of free cells.
c.Periodic apoptosis of pronormoblasts
in the marrow cords occurs.
d.Maturing normoblasts slowly lose
receptors for adhesive molecules that
bind them to stromal cells.
10. Which RBC process does not require
energy?
a. Cytoskeletal protein deformability
b. Maintaining cytoplasm cationic
electrochemical gradients
c. Oxygen transport
d. Preventing the peroxidation of
proteins and lipids
11. Which is true concerning 2,3-BPG?
a. Enhances O2 release from hemoglobin
b. Source of RBC ATP
c. Source of RBC glucose
d. The least abundant of RBC
organophosphates
12. Which of the following helps maintain
RBC shape?
a. Cytoskeletal proteins
b. Glycocalyx
c. GPI anchor
d. Membrane phospholipids
13. The glycolipids of the RBC membrane:
a. Attach the cytoskeleton to the lipid
layer
b. Carry RBC antigens
c. Constitute ion channels
d. Provide flexibility
14. RBC membrane cholesterol is
replenished from the:
a. Cytoplasm
b. EMB pathway
c. Mitochondria
d. Plasma
15. Which of the following is an example
of a transmembrane or integral
membrane protein?
a. Actin
b. b. Ankyrin
 c. Glycophorin A
d. d. Spectrin

1. C
2. D
3. Sad
4. C
5. D
6. D
7. B
8. A
9. D
10. C
11. A
12. A
13. B
14. D
15. C