Hypertonic Saline (3% and 5% Sodium Chloride Injection) Drug Information - Description, User Reviews, Drug Side Effects, Interactions - Prescribing Information at RxList
P.01 FOUNDATIONS OF NEONATAL RESUSCITATION Alveoli is filled with lung fluid instead of air, and therefore no (Part 1&2) gas exchange happens between the fetal lung and Dr. Balud | 01/17/2021 pulmonary circulation. Instead, oxygen is transferred from the maternal circulation to the fetal circulation via the OUTLINE placenta I. Neonatal Resuscitation Fetus are adapted to low po2 (20 mmHg) II. Why do newborns require different approach to In utero, fetus dependent on placenta for gas exchange resuscitation? Pulmonary arterioles are constricted: III. Fetal Physiology o Since the alveoli are filled with fluid, the IV. After Baby’s Birth surrounding pulmonary capillaries, arterioles and V. Normal Transition venules are constricted VI. What can go wrong during transition? Pulmonary blood flow is diminished: VII. Signs of A Compromised Newborn o Because of this, there is marked decrease in blood VIII. In Utero or Prenatal Compromise flow into the lungs IX. Resuscitation Flow Diagram Blood flow is diverted across the patent ductus arteriosus: X. Pre-resuscitation Preparation o Because of this hypertensive state, blood that is XI. Neonatal Resuscitation supposed to flow to the lungs is then diverted into the aorta via the patent ductus arteriosus, diluting OBJECTIVES: further the oxygen concentration of the blood in Importance of resuscitation skills the aorta Physiologic changes during and after birth Neonatal Resuscitation Flow diagram format FROM THE ATTACHED VIDEO CLIP: Communication and teamwork skills used by effective Because of the constricted blood vessels in the lungs, most resuscitation teams of the blood bypasses the lungs, and instead passes into the aorta via the ductus arteriosus I. NEONATAL RESUSCITATION NEONATAL DEATHS 45% of under-five deaths in 2015 35%of under-five deaths in 2015
WHY LEARN NEONATAL RESUSCITATION?
Birth asphyxia 23% of approximately 4M neonatal deaths/year worldwide For many NB appropriate resuscitation not readily available o Improved by more widespread use of resuscitation techniques
WHICH BABIES REQUIRE RESUSCITATION?
ALL newborns (NB)require assessment Figure 1: Fetal Circulation Anatomy ~10%of NB requires some assistance to begin breathing at birth <1%need extensive resuscitative measures to survive IV. AFTER BABY’S BIRTH A. LUNGS AND CIRCULATION AFTER DELIVERY II. WHY DO NEWBORNS REQUIRE DIFFERENT APPROACH TO Fetal lung fluid leaves alveoli: RESUSCITATION? o At birth, as the newborn takes the first few A. ADULT CARDIAC ARREST breaths, several changes occur, whereby the lungs Most often a complication of trauma or existing heart take over the lifelong function of respiration. disease o Following birth, the lungs expand as they filled o A sudden arrhythmia → ineffective heart with air. The fetal lung fluid gradually leaves the contraction → decreased cardiac output and most alveoli. importantly, brain circulation → loss of o Hematogenous consciousness → stops breathing o Lymphatics o During the arrest, O 2 and CO2in the blood are o Aspiration usually normal o Vaginal squeeze o Chest compressions are needed to be started o Expelled immediately in order to maintain circulation until electrical defibrillations or medications restore Lung expands with air: cardiac functions o It is important that the bay takes the initial respiration immediately for a more efficient B. NEWBORNS NEEDING RESUSCITATION clearing of the alveolar fluid from the baby’s lungs. Most newborns requiring resuscitation have a healthy heart o Otherwise, fluid will be retained and may cause Newborns requiring resuscitation have a problem in unwanted complications such as transient respiration, in contrast to adults whose main problem is tachypnea or worse, persistent pulmonary cardiac→ inadequate gas exchange hypertension of the newborn. o Respiratory failure may occur before or during birth FROM THE ATTACHED VIDEO CLIP: o Placenta responsible for in utero respiration Fluid in the alveoli is absorbed into the lung tissue, and replaced by air. The oxygen in the air diffuses into blood vessels that surround the alveoli. III. FETAL PHYSIOLOGY A. IN THE FETUS
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PEDIATRICS II Saint Louis University School of Medicine MMXXII Blood oxygen levels rise: o And since the lungs now take over the function of the placenta for gas exchange, the pulmonary blood now will be increasingly oxygenated. Ductus arteriosus now constricts: o This increase in the oxygen concentration on the blood will now cause a constriction of the ductus arteriosus, which will usually be completed by the 10th day of life Blood flow through the lungs to pick up oxygen: o There will now be increased blood flow through the lungs to pick up oxygen for peripheral circulation. Figure 2: Constricted Blood Vessels and Fluid-filled Alveoli FROM THE ATTACHED VIDEO CLIP: As blood levels of oxygen increase and pulmonary blood vessels relax, the ductus arteriosus begins to constrict. Blood previously diverted through the ductus arteriosus, now flows through the lungs where it picks up more oxygen to transport to tissues throughout the body.
Figure 3: Infant’s First Breath with Fetal Lung Fluid
Figure 7: Fetal Lung and Circulation Before Birth
Figure 4: Infant’s Second Breath with Air
Figure 8: Fetal Lung and Circulation After Birth
Pulmonary arterioles dilate
Pulmonary blood flow increases o As a consequence of the clearance of the alveolar fluid leaving the alveoli, the pulmonary vessels now relax, and thus allows increase in pulmonary blood flow.
Figure 5: Infant’s Subsequent Breaths with Air
Figure 6: Dilated Blood Vessels After Birth with Oxygen in
Alveoli Figure 9: Alveoli Before and After Birth
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PEDIATRICS II Saint Louis University School of Medicine MMXXII When babies are deprived of oxygen (in utero or after delivery), they undergo a well-defined sequence of events V. NORMAL TRANSITION that starts with cessation of respiration. The following 3 major changes take place within seconds During primary apnea, the newborn responds to stimulation. after birth: Instruction Tip: Initiate resuscitation immediately. o Alveolar fluid is absorbed into lung tissue and Resuscitation may be inappropriately delayed if the health replaced by air care provider does not recognize the need for neonatal o Umbilical arteries and vein constrict thus resuscitation. Any delay in transferring a compromised increasing blood pressure: Umbilical arteries and newborn to the resuscitation team is unacceptable practice. veins are clamped, removing the low resistance placental circuit and increasing systemic blood B. SECONDARY APNEA pressure. Continued O2 deprivation → secondary apnea + continued o Blood vessels in the lungs relax, increasing fall in heart rate and blood pressure pulmonary blood flow. Secondary apneaCANNOT be reversed by tactile stimulation; assisted ventilation must be provided VI. WHAT CAN GO WRONG DURING TRANSITION If oxygen deprivation continues, deep gasping respirations Lack of ventilation of the newborn’s lungs → sustained develop, the heart rate continues to decrease, and the blood constriction of the pulmonary arterioles → prevents systemic pressure decreases arterial blood from being oxygenated An important point is that, during secondary apnea, Prolonged lack of adequate perfusion and oxygenation → stimulation will not restart the baby’s breathing. Assisted damage to brain, damage to other organs, or death ventilation must be provided to reverse the process A baby may encounter difficulty before labor, during labor, triggered by oxygen deprivation. If a baby doesn’t begin to or after birth. Some of the problems that may disrupt normal breathe immediately after being stimulated, he or she is transition are: likely in secondary apnea and will require positive-pressure o The baby may not breathe sufficiently to force ventilation. fluid from the alveoli, or foreign material such as Instructor Tip: Quickly achieve and maintain oxygenation in meconium that may prevent air from entering the full-term and post-term newborns after perinatal hypoxia- alveoli. ischemia because they are especially prone to persistent o Excessive blood loss may occur, or there may be pulmonary hypertension. inadequate cardiac contractility, or bradycardia Initiation of effective POSITIVE PRESSURE from hypoxia and ischemia. VENTILATION during secondary apnea usually results in: RAPID IMPROVEMENT IN HEART RATE VII. SIGNS OF A COMPROMISED NEWBORN Most babies in secondary apnea will respond to effective The compromised baby may exhibit one or more of the ventilation with a rapid improvement in heart rate. following clinical findings: The longer a baby has been in secondary apnea, the longer o Poor muscle tone it will take for spontaneous breathing to resume. o Depressed respiratory drive due to insufficient If heart rate does not improve rapidly with effective oxygen reaching the brain ventilation, myocardial function may be compromised and o Bradycardia chest compressions and/or medications may be required. o Low blood pressure o Tachypnea (rapid respirations) IX. RESUSCITATION FLOW DIAGRAM o Cyanosis (blue color) Initial Assessment: Words of caution: Other conditions, such as infection, o Determine if the baby can remain with the mother hypoglycemia, or depressant drugs given to the mother or should be moved to a radiant warmer for before birth, may also cause these symptoms. further evaluation Airway: o Perform the initial steps to establish an open airway and support spontaneous respiration Breathing: o Positive pressure ventilation is provided to assist breathing for babies with apnea or bradycardia o Other interventions (CPAP: Continuous Positive Airway Pressure or oxygen) maybe appropriate if baby is breathing spontaneously but has labored breathing (CPAP) or low oxygen saturation (oxygen) Circulation: o If severe bradycardia persists despite assisted ventilation, circulation is supported by performing chest compressions, coordinated with PPV (Positive Pressure Ventilation) Drugs: o If severe bradycardia persists despite assisted Figure 10: Good Tone with Cyanosis VS Bad Tone with ventilation and coordinated chest compressions, Cyanosis the drug EPINEPHRINE is administered as PPV and chest compressions continue VIII. IN UTERO OR PRENATAL COMPROMISE A. PRIMARY APNEA When a fetus/newborn first becomes deprived of oxygen, an initial period of attempted rapid breathing occurs, followed by primary apnea with dropping of heart rate. This improves with TACTILE STIMULATION.
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PEDIATRICS II Saint Louis University School of Medicine MMXXII X. PRE-RESUCITATION PREPARATION resuscitated will not make it, and other sensitive FOCUS ON TEAMWORK information. Poor teamwork and communication were the most common root causes for potentially preventable infant EFFECTIVE COMMUNICATION deaths in the delivery room Every team member shares responsibility for ongoing Therefore, one of the emphasis also of the neonatal assessment resuscitation program, whether it be the AAP or NRPh+ Share information: communicate with each other version is the planning on how the team will be contacted, Direct request to a specific individual who will be responding. And that before entering any Call team member by name resuscitation calls or codes, each team members need to Make eye contact understand his role and tasks he or she will be assigned. Speak clearly Ask receiver to report back as soon as the task is completed. PERSONNEL AND EQUIPMENT ALL deliveries should be attended by at least 1 person whose only In order to have effective communication, again, every team responsibility is the baby and who is capable of initiating member shares responsibility for ongoing assessment. If you were resuscitation. Either that person or someone else, who is available the one who took the history it is your responsibility to share what immediately, should have the skills required to perform a pertinent information should be shared with each team member. complete resuscitation For example, the mother is Hepatitis B positive, then this should be Prepare necessary equipment: shared to each member of the team especially those that will handle o Turn on radiant warmer anything with blood, so that they will have to take necessary o Set delivery room temperature to 26°C precautions like wearing of gloves and goggles. Or if the mother is o Check the equipment COVID suspect, of has positive COVID swab, then every member of the team should be alerted to be able to wear the proper protective PRE-RESUCITATION BRIEFING equipment. Planning how the team will be contacted and who will It would be better if we put our name on our chest area so that respond we can call each other by name, and direct our request to a specific Each team member needs to understand his role and the individual. Make an eye contact when talking to your members, tasks he or she will be assigned. You try to identify the role speak clearly, and ask the receiver to report back as soon as the of each member of the resuscitation team. Who will be there task is completed. For example, the leader orders: Gilbert, please during the catch, and where will the help be contacted and administer epinephrine 1:10,000 dilution, 0.5 mL via the umbilical how. catheter bolus now. Then after Gilbert does his task, he echoes by Assess perinatal risk factors so that you will know what to saying epinephrine, 1:10,000 0.5mL given via umbilical catheter. anticipate. Identify a team leader ACCURATE DOCUMENTATION Delegate tasks: who is responsible to do the initial steps of Complete records are important for clinical decision making resuscitation and positive pressure ventilation, who will be and source for quality improvement data for the future doing the chest compressions, where will these people be Events during resuscitation documented as they occur; positioned with respect to the baby, who will document all supplemented with retrospective narrative summary the things going on during the resuscitation, who will be the Use single time reference to avoid confusion, especially timer, who will be the nurse who is responsible for the when data is to be used for court cases supplies and equipment, are all the equipment already Recorder should not be responsible for other roles (assigned within reach? If not, then identify which are not available to experienced team member) as she needs to focus and not and make sure to replenish them even before the delivery is be distracted as she documents the resuscitation called, on when and how to and the proper way of Use well designed forms that follow NRP / NRPH+ flow substituting the chest compressor. It would also be best if diagram for more rapid data entry you already perform a mock code to orient you on how to go about during the actual resuscitation. POST-RESUSCITATION DEBRIEFING Identify who will document events as they occur Reinforces good teamwork habits and helps team identify Determine what supplies and equipment will be needed areas of improvement for future resuscitations Identify how to call for additional help Quick debriefing immediately after the event and a more comprehensive debriefing may be scheduled afterward TEAM LEADER Debriefings do not have to find major problems to be Mastery of the Neonatal Resuscitation Program (NRP) Flow effective Diagram o May identify series of small changes that result in Effective leadership skills – good communication skill significant improvements in your team’s performance o Clear directions: clear, direct and audible enough o Share information with other members of the team, for example, he should mention to the members of the team that they should be wearing gloves because the mother is a diagnosed case of HIV for their protection; he should not be withholding such information from the members of the team or else he will lose their trust. o Delegate responsibilities ensuring coordinated care o Maintaining professional environment Remain aware of entire clinical situation, not only about how long the duration of the resuscitation is going on. Maintain view of big picture (not distracted by single activity) The leader should also be aware of other circumstances like knowing that the baby is a precious child, wherein the mother is already in her mid 40s and may not be able to conceive a child anymore should this baby being
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PEDIATRICS II Saint Louis University School of Medicine MMXXII Category II or III fetal heart Shoulder dystocia pattern Maternal general anesthesia Meconium-stained amniotic fluid Maternal magnesium therapy Prolapsed umbilical cord Placental abruption
WHAT QUESTIONS TO ASK BEFORE EVERY BIRTH
What is the expected gestational age? o Preterm: then you will need equipment particularly for thermoregulation, assisting the breathing of the baby, surfactant, umbilical venous catheter insertion and the like. o Postmature: then you will expect the baby to be possibly meconium-stained if not aspirated meconium already and that the baby might be born limp and will require assistance in the initiation of breathing. Is the amniotic fluid clear? o A clear amniotic fluid would make the resuscitating team at ease. But a meconium-stained fluid will keep them on their toes as they will now need to assess if the baby, upon birth, is active or limp. How many babies are expected? o Knowing the answer to this will make the team prepare or additional team if we are expecting multiple pregnancy, as compared to when this is a singleton pregnancy. Are there any additional risk factors? o Does the mother have SLE? Was the baby antenatally diagnosed to have congenital anomalies that will hinder the normal transition process, does the baby need an immediate surgical intervention upon birth, so that we need the surgery team on stand by at the time the baby is delivered? Figure 11: Debriefing form. Where questions are asked about what was the best part of the RESUSCITATION TEAM resuscitation event, what was the most challenging part, what areas Every birth should be attended by at least 1 qualified still need to be worked upon for improvement. (There are different individual, skilled in the initial steps of newborn care and available templates of debriefing form online, and your institution may PPV, whose only responsibility is the management of the have its own debriefing form being used) newborn baby. o This individual should be skilled in performing the initial steps of newborn care and positive pressure ventilation. XI. NEONATAL RESUSCITATION If risk factors are present, at least 2 qualified people PERINATAL FACTORS INCREASING THE LIKELIHOOD OF should be at the delivery room, plus another members of the NEONATAL RESUSCITATION team on standby nearby. Again, these two qualified people should be only managing the newly born baby. It is ideal to know if there are any risk factors surrounding the Qualified team should have at least one with full birth of the baby so that the pediatric team would be ready, be able to resuscitation skills, including endotracheal intubation, organize a resuscitation team way before the birth of the baby, chest compressions, emergency vascular access and delegate task to each members of the team, check for the supplies and medication administration, should be identified and equipment and their functionality. But often times, in the real world, immediately available for every resuscitation and should not there are instances when the mother arrives at the emergency room be on an on-call basis. about to give birth, giving the pediatric team insufficient time to fully organize a resuscitation team, much less delegate a task or have a briefing. PRE-RESUSCITATION TEAM BRIEFING Review the risk factors and management plans developed ANTENATAL RISK FACTORS during antenatal counselling (during the briefing before Gestational age <36 0/7 weeks Oligohydramnios entering the delivery room) Gestational age >41 0/7 weeks Fetal hydrops o For example, you have a baby who had an Preeclampsia or eclampsia Fetal macrosomia antenatal diagnosis of gastroschisis, and who is Maternal hypertension Intrauterine growth restriction about to be delivered via NSD, aside from Multiple gestation Significant fetal malformation or organizing the pediatric resuscitation team, you anomalies ought also to have consulted a pediatric surgeon Fetal anemia prior to the delivery. The parents should have Polyhydramnios No prenatal care consulted this surgeon, who in turn will explain to INTRAPARTUM RISK FACTORS the parents what will be anticipated, whether they Emergency cesarean delivery Intrapartum bleeding will do direct closure of the defect immediately at Forceps or vacuum-assisted Chorioamnionitis birth, or will they do a staged reduction of the delivery intestines and perform the primary closure later. Breech or other abnormal Narcotics administered to Identify team leader (based on the characteristics discussed presentation mother within 4 hours of before), discuss the possible scenarios that your team may delivery encounter, assign roles and responsibilities
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PEDIATRICS II Saint Louis University School of Medicine MMXXII o Who will perform initial assessment beyond positive pressure ventilation, the nurse in charge o Who will stimulate the baby should already lay out the equipment for better access o Who will start PPV if needed during cannulation of the umbilical vessels. o Who will document events: it would be best to For extremely preterm infants, aside from preferably have a prepared documentation form or template using a blade double 0, be ready as well with a food-grade for easier input of the data during the actual plastic bag, (or the resealable bag) which will be used to resuscitation event. wrap the preterm upon birth for thermoregulation. Remember that extremely preterm infants have weaker muscle tone which causes now extension of all extremities, RESUSCITATION SUPPLIES AND EQUIPMENT increasing the body surface area, hence bigger area loss. We Supplies and equipment should be prepared and checked counter that disadvantage by trying to prevent all heat loss. if functional. And when in the delivery room, it is already An alternative will be to wrap the baby with plastic wrap. laid out in such a way that when it is needed, it is already If thermal mattress is also available, then it would be useful within reach and without the necessity to look for it first to use it while resuscitating a small preterm for heat when asked by the team leader. In areas where transport incubator may not be Most important thing to check will be the bag-mask available in transporting the baby to the nursery for more apparatus, be sure that it really works, and you are using intensive care, a close relative, preferably the father may the appropriate volume. The 200-mL bag is for the be asked to carry the baby, kangaroo-mother-care or newborn, whereas the 700 mL is for older infants and skin-to-skin-contact style in order to minimize pediatric patients. Please don’t interchange. evaporative heat loss during transport. For the laryngoscope, make sure that the bulb has a strong light, batteries should be changed regularly. The blade appropriate to use for newborns would be UMBILIVAL VESSEL MISCELLANEOUS straight compared to older children and adults where the CATHETERIZATION curved blade is preferred. This is due to the peculiarity of Sterile gloves Gloves and appropriate personal the anatomy of their larynx, especially of the epiglottis. An protection extremely premature infant , or those who are less than Anti-septic prep solution Radiant warmer or other heat 28 weeks gestational age, would require a blade double sources 0. Bigger preterm infants will require blade 0, whereas Umbilical tape Temperature sensor with sensor term infants would require blade 1. cover for radiant warmer (for use during prolonged SUCTION EQUIPMENT POSITIVE PRESSURE resuscitation) VENTILATION EQUIPMENT Small clamp (hemostat) Firm, padded resuscitation Bulb syringe Device for delivering PPV surface Mechanical suction and tubing Face masks, newborn & preterm Forceps (optional) Timer or clock with second hand sizes warmed linens Suction, catheters, 5F or 6F, Oxygen source Scalpel Beanie 10F, 12F or 14F Umbilical catheters 3.5F, 5F Stethoscope 8F feeding tube or large syringe Compressed air source Three-way stop cock Tape ¾ or ½ inch Meconium aspirator Oxygen blender to mix O2 & CA Syringes 3-ml, 5ml ECG monitor and ECG leads with flowmeter & tubing Needle or puncture device for Intraosseous needle (optional) Pulse oximeter with sensor & needleless system cover NSS for flushes Target O2 saturation table Clear adhesive dressing to INTUMATION EQUIPMENT MEDICATIONS temporarily secure umbilical Laryngoscope with straight Epinephrine 1:10,000 (Since the venous catheter to abdomen blades, No 0 & No 1 commercially available (optional) epinephrine is 1:1000 FOR VERY PREMATURE INFANTS concentration, it would be best Size 00-laryngoscope blades (optional) to have a pre-mixed 1:10,000) Food grade plastic blade (1-gallon size) or plastic wrap Extra bulbs & batteries for NSS for volume expansion Thermal mattress laryngoscope Transport incubator to maintain baby’s temperature during move to Stylet (optional) D10W (optional) the nursery Measuring tape NSS for flushes Endotracheal tube insertion Syringes 1-ml, 3-ml, 5-ml to 60- depth table ml FOCUS ON TEAMWORK Scissors Waterproof tape or tube- BEHAVIOR EXAMPLE securing device • Anticipate and plan • Identify the risk factors so Scissors that this will preempt you Waterproof tape or tube- how to plan the resuscitation securing device • Know which providers will be Alcohol pads called to attend the birth CO2 detector or capnograph based on the perinatal risk Laryngeal mask and 5-ml factors syringe • Perform a standardized 5F or 6F OGT if insertion port equipment check before present on LM every birth • Assign roles and Be on the ready as well with the equipment for umbilical responsibilities (You can post vessel catheterization. As the resuscitation progresses at the inner side of the
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PEDIATRICS II Saint Louis University School of Medicine MMXXII nursery door the composition • Clearly identify the leader • If risk factors are present, of the resuscitation team and identify a leader before the their designated roles and birth and perform a pre- responsibilities) resuscitation team briefing (& mock resuscitation during your free time so as to master the correct sequence of things) to ensure that • Use all available information • A good history investigation everyone is prepared, and • Use available resources prior to birth will be very responsibilities are defined. useful in anticipating every move inside the delivery NRP KEY BEHAVIORAL SKILLS room Know your environment • Ask the obstetric provider the Use available information 4 pre-birth questions to Anticipate and plan identify risk factors and align Clearly identify a team leader your preparation based on Communicate effectively the risk factors provided. Delegate workload optimally • Prepare additional supplies Allocate attention wisely and equipment as necessary, Use available resources based on these risk factors Call for additional help when needed • If the baby has gastroschisis, Maintain professional behavior then you might need already the presence of pediatric surgeon at the delivery room as well • Know your environment • Orienting yourself with the nursery and its set-up prior to starting to work in it • Know how the resuscitation team is called and how additional personnel and resources can be summoned. • Know how to access additional equipment and supplies for a complex resuscitation
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PEDIATRICS II Saint Louis University School of Medicine MMXXII APPENDIX
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PEDIATRICS II Saint Louis University School of Medicine MMXXII
This is the local version of the resuscitation flow diagram
that was created for the Philippines. This simplifies the complicated flow diagram of the AAP and AHA. Both algorithms emphasizes that the baby should already have established breathing during the first 60 seconds of life. If not yet, then we go down the resuscitation pathway as outlined.
Hypertonic Saline (3% and 5% Sodium Chloride Injection) Drug Information - Description, User Reviews, Drug Side Effects, Interactions - Prescribing Information at RxList