20 Differences between Humoral Immunity

and Cell mediated Immunity

June 19, 2018
Biology Educational Videos
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Here are some differences:
S.N.
Characteristics
Humoral Immunity
Cell-mediated Immunity
References
Humoral and Cell mediated Immunity

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Here are some differences:

S.N. Characteristics Humoral Immunity Cell-mediated Immunity
 The immunity mediated by
The immunity that identifies
macromolecules found in the
and destroys infected cells in
1. Definition extracellular body fluids is called
the body is called cell-
humoral immunity. (“humor” a
mediated immunity.
medieval term for body fluid)
The main cell involved in
The main cell involved in
2. Mediator cell-mediated immunity are
humoral immunity are B-cells.
T-cells.
Helper T cells, cytotoxic T-
B cells, T cells, and
3. Components cells, natural killer cells, and
macrophages.
macrophages.
The humoral immunity protects The cell-mediated immunity
4. Pathogen against extracellular pathogens protects against intracellular
and also their toxin. pathogens.
It responds to any cell that
Recognize antigens or pathogens displays aberrant MHC
Pathogen
5. that are circulating in the lymph markers, including cells
recognition
or blood. invaded by pathogens, tumor
cells, or transplanted cells.
Phagocytes and antibodies Receptors and MHC
6. Antigen detectors themselves are used to detect molecules on the cell surfaces
antigens. are used to detect antigens.
T-cell receptors on cells bind
B-cells produce antibodies and
7. Antigen Binding to T-cells which in turn bind
the antibodies bind to antigens.
to antigens.
Antigens must be processed
Do not require the processing of and presented for T-
8. Antigen Processing
antigens. lymphocyte mediated
response.
It involves B-cell receptors It involves T-cell receptors
9. Receptor Involved
(BCRs). (TCRs).
CD3 molecular complex
Accessory surface
Igα, Igβ, Fc receptors, CD40,
10. receptors/molecule
CD21 Dimer of ∑ chain, CD4, CD8,
s
CD2, CD28, integrins
Type of T-cell Only the T helper cell (CD4+) is Both CD4+ and CD8+ T cells
11.
involved involved. are involved.
Antibodies are not formed in
Antibodies Antibodies are formed in a
12. a cell-mediated immune
formation humoral response.
response.
13. Onset The onset is rapid. The onset is delayed.
The end result of the activation is The end result of the
14. Result the differentiation of plasma B- activation is the secretion of
cells, secreting antibodies. cytokines.
 It protects against fungus,
Extracellular bacterial or viral
15. Protection against viruses, and intracellular
pathogens.
bacterial pathogens.
Immunological It does not provide It provides immunological
16.
surveillance immunological surveillance. surveillance.
Hypersensitivity type I, II, and Hypersensitivity type IV is
Hypersensitivity
17. III is mediated by humoral mediated by cell-mediated
reactions
immunity. immunity.
Role in Organ It may be involved in early graft
It participates in rejections of
18. transplantation and rejection due to preformed
organ transplants.
Grafting antibodies.
As it destroys the tumor and
Immunity against It does not provide immunity
19. cancerous cells, it provides
cancer against cancer.
protection against cancer.
Skin test for the development
20. Assessment method From plasma level of antibodies of delayed-type of
hypersensitivity