11020210093 Adinda Zahra Usman

DEFINITION CLINICAL MANIFESTASION

ETIOLOGY Secondary syphilis (stage II):
A sexually transmitted • Appears 6-8 weeks after stage I

infection caused by Treponema pallidum, a • Constitutional symptoms (+)

• Copper penny rash: red-brown polymorphic skin
Treponema pallidum and is spiral-shaped Gram- lesion
• Generalized lymphadenopathy
chronic negative bacterium
Secondary syphilis lesions usually appear first on the
palms of the hands/feet.

SUPPORTING EXAMINATION
ISLAMIC PERSPECTIVE
Q.S. AL ISRA : 32
SECONDARY • Microbiology
• Dark field microscope: finds Treponema Pallidum

SYPHILIS
directly
• Serological examination
• Non-Treponemal Antibodies: VDRL, RPR (used for
assess screening, and assess IgM and IgG antibodies)
• Treponemal antibodies: TPHA, FTA-Abs, TPPA, EIA (
used for confirmation tests)

COMPLICATIONS TREATMENT
PROGNOSIS Benzyl benzathine penicillin G 2.4 million units
Untreated syphilis infection can lead to single dose, IM
irreversible neurological and cardiovascular
complications. Depending on the stage, The prognosis of syphilis Alternative :
neurosyphilis can manifest as meningitis,
stroke, cranial nerve palsies during early
depends on the stage and Non-Pregnant : Doxycycline
neurosyphilis or tabes dorsalis, dementia, and extent of organ involvement. 2x100 mg, PO 30 days
Pregnant : Eritromisin
general paresis during late neurosyphilis. 4x500 mg, PO 30 hari

Tudor ME, Al Aboud AM, Leslie SW, et al. Syphilis. [Updated 2023 May 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www-ncbi-nlm-nih-gov.translate.goog/books/NBK534780/?
_x_tr_sl=en&_x_tr_tl=id&_x_tr_hl=id&_x_tr_pto=tc
11020210093 Adinda Zahra Usman