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Chapter 10 - The Cardiovascular System
Kacmarek et al.: Egan’s Fundamentals of Respiratory Care, 11th Edition
MULTIPLE CHOICE
1. The apex of the heart (tip of the left ventricle) lies just above the diaphragm at a level
corresponding to which intercostal space?
a. Fourth
b. Fifth
c. Sixth
d. Seventh
ANS: B
The apex of the heart is formed by the tip of the left ventricle and lies just above the
diaphragm at the level of the fifth intercostal space.
3. Tissue layers making up the heart wall include which of the following?
1. Endocardium
2. Epicardium
3. Myocardium
a. 1, 2, and 3
b. 2 and 3 only
c. 2 only
d. 1 and 3 only
ANS: A
The heart wall consists of three layers: (1) the outer epicardium, (2) the middle myocardium,
and (3) the inner endocardium.
6. Narrowing of the mitral valve (mitral stenosis) results in which of the following?
a. Increased afterload on left ventricle
b. Increased preload on right ventricle
c. Increased pulmonary congestion
d. Systemic hypertension
ANS: C
Stenosis is a pathologic narrowing or constriction of a valve outlet, which causes increased
pressure in the affected chamber and vessels. Both conditions affect cardiac performance. For
example, in mitral stenosis, high pressures in the left atrium back up into the pulmonary
circulation. This can cause pulmonary edema.
8. What are the first arteries to branch off the ascending aorta?
a. Brachiocephalic
b. Carotid
c. Coronary
d. Subclavian
ANS: C
Two main coronary arteries, a left and a right, arise from the root of the aorta.
10. The branches of the left coronary artery DO NOT supply which area of the heart?
a. Majority of the interventricular septum
b. Majority of the left ventricle
c. Majority of the left atrium
d. Sinus node
ANS: D
In combination, the branches of the left coronary artery normally supply most of the left
ventricle, the left atrium, and the anterior two-thirds of the interventricular septum.
11. Before draining into the right atrium, where do the large veins of the coronary circulation
gather together?
a. Coronary sinus
b. Left posterior coronary vein
c. Right coronary sulcus
d. Thebesian veins
ANS: A
These veins gather together into a large vessel called the coronary sinus, which passes left to
right across the posterior surface of the heart. The coronary sinus empties into the right
atrium.
12. Mixing of venous blood with arterial blood (a right-to-left shunt) occurs normally because of
which of the following?
1. Congenital cardiac defects
2. Bronchial venous drainage
3. Thebesian venous drainage in the heart
a. 1, 2, and 3
b. 2 and 3 only
c. 1 only
d. 2 only
ANS: B
Because the thebesian veins bypass, or shunt, around the pulmonary circulation, this
phenomenon is called an anatomical shunt. When combined with a similar bypass in the
bronchial circulation (see Chapter 7), these normal anatomical shunts account for
approximately 2% to 3% of the total cardiac output.
15. Intercalated discs in the myocardium perform a very important function. Which of the
following describes that function?
a. Absolute refractory period
b. Automaticity
c. Contractility
d. Electrical conduction
ANS: D
Cardiac fibers are separated by irregular transverse thickenings of the sarcolemma called
intercalated discs. These discs provide structural support and aid in electrical conduction
between fibers.
17. Which vessels in the body act like faucets, controlling the flow of blood into the capillary
beds?
a. Arteries
b. Arterioles
c. Veins
d. Venules
ANS: B
Just as faucets control the flow of water into a sink, the smaller arterioles control blood flow
into the capillaries. Arterioles provide this control by varying their flow resistance. For this
reason, arterioles are often referred to as resistance vessels.
18. Why are the vessels of the venous system, particularly the small venules and veins, termed
capacitance vessels?
a. They transmit and maintain the head of perfusion pressure.
b. They can alter their capacity to maintain adequate perfusion.
c. They determine the afterload on the left ventricle.
d. They maintain a constant environment for the body’s cells.
ANS: B
By quickly changing its holding capacity, the venous system can match the volume of
circulating blood to that needed to maintain adequate perfusion. Accordingly, the components
of the venous system, especially the small, expandable venules and veins, are termed
capacitance vessels.
19. Which of the following mechanisms facilitate venous return to the heart?
1. Sodium/potassium pump
2. Sympathetic venomotor tone
3. Cardiac suction
4. Skeletal muscle contraction
a. 1 and 2 only
b. 2, 3, and 4 only
c. 1, 2, 3, and 4
d. 3 and 4 only
ANS: B
The following four mechanisms combine to aid venous return to the heart: (1) sympathetic
venous tone, (2) skeletal muscle pumping, or “milking” (combined with venous one-way
valves), (3) cardiac suction, and (4) thoracic pressure differences caused by respiratory efforts.
21. Which of the following equations would you use to compute systemic vascular resistance?
a. (Mean aortic pressure right atrial pressure) ÷ CO
b. (Mean aortic pressure/right atrial pressure) CO
c. (Mean aortic pressure − right atrial pressure) ÷ CO
d. (Right atrial pressure − mean aortic pressure) ÷ CO
ANS: C
SVR = (mean aortic pressure – right atrial pressure)/CO.
23. Which of the following equations best depicts the factors determining mean arterial blood
pressure?
a. Mean arterial pressure = cardiac output ÷ vascular resistance
b. Mean arterial pressure = cardiac output vascular resistance
c. Mean arterial pressure = right atrial pressure − aortic pressure
d. Mean arterial pressure = vascular resistance ÷ cardiac output
ANS: B
Average blood pressure in the circulation is directly related to both cardiac output and flow
resistance.
Mean arterial pressure = cardiac output vascular resistance.
24. Mean arterial blood pressure can be regulated by changing which of the following?
1. Capacity of the circulatory system
2. Effective volume of circulating blood
3. Tone of the capacitance vessels (veins)
a. 1 and 2 only
b. 2 only
c. 1, 2, and 3
d. 3 only
ANS: C
All else being constant, mean arterial pressure is directly related to the volume of blood in the
vascular system and inversely related to its capacity. A change in the tone of the capacitance
vessels alters their capacity.
Mean arterial pressure = volume/capacity.
25. During exercise, cardiac output increases dramatically, but mean arterial blood pressure rises
very little. Why is this so?
a. Venules constrict, increasing vascular resistance.
b. Arterioles dilate, decreasing vascular capacity.
c. Arterioles constrict, increasing vascular resistance.
d. Muscle vessels dilate, increasing vascular capacity.
ANS: D
For example, when exercising, the circulating blood volume undergoes a relative increase, but
blood pressure remains near normal. This is because the skeletal muscle vascular beds dilate,
causing a large increase in system capacity.
26. During blood loss due to hemorrhage, perfusing pressures can be kept near normal until the
volume loss overwhelms the system. Why is this so?
a. Arteries constrict, increasing vascular resistance.
b. Arterioles dilate, decreasing vascular capacity.
c. Muscle vessels dilate, increasing vascular capacity.
d. Venules constrict, decreasing vascular capacity.
ANS: D
When blood loss occurs, as with hemorrhage, system capacity is decreased by constricting the
venous vessels. Thus, perfusing pressures can be kept near normal until the volume loss
overwhelms the system.
28. The cardiovascular system regulates perfusion mainly by altering which of the following?
a. Capacity and resistance of blood vessels
b. Rate of cardiac contractions
c. Strength of cardiac contractions
d. Volume of cardiac contractions
ANS: A
The cardiovascular system regulates blood flow mainly by altering the capacity of the
vasculature and the volume of blood it holds.
29. What is the primary function of local or intrinsic cardiovascular control mechanisms?
a. Alter local blood flow according to tissue needs.
b. Alter the rate of cardiac contractions.
c. Maintain a basal level of systemic vascular tone.
d. Control the capacity of the venous reservoir.
ANS: A
Local, or intrinsic, controls operate independently, without central nervous control. Intrinsic
control alters perfusion under normal conditions to meet metabolic needs.
30. Central, or extrinsic, control of the cardiovascular system occurs through the action of which
of the following?
1. Autonomic nervous system
2. Circulating humoral agents
3. Local metabolites
a. 1, 2, and 3
b. 2 and 3 only
c. 3 only
d. 1 and 2 only
ANS: D
Central, or extrinsic, control involves both the central nervous system and circulating humoral
agents.
32. Which of the following variations control blood flow to the brain?
a. Central neural innervation
b. Circulation of humoral agents
c. Local metabolic control mechanisms
d. Local myogenic control mechanisms
ANS: C
Metabolic control involves the relationship between vascular smooth muscle tone and the
level of local cellular metabolites. The vascular tone in the brain is the most sensitive to
changes in the local metabolite levels, particularly those of CO2 and pH.
33. Which of the following variation(s) control(s) blood flow to the heart?
1. Local metabolic control mechanisms
2. Local myogenic control mechanisms
3. Central neural innervation
a. 1, 2, and 3
b. 2 and 3 only
c. 1 only
d. 1 and 3 only
ANS: B
The vasculature of the heart shows a strong response to both myogenic and metabolic factors.
34. Which portion of the nervous system is mainly responsible for the central control of the blood
flow?
a. Higher brain centers
b. Parasympathetic nervous system
c. Somatic (voluntary) nervous system
d. Sympathetic nervous system
ANS: D
Central control of blood flow is achieved primarily by the sympathetic division of the
autonomic nervous system.
DIF: Application REF: p. 217 OBJ: 4
35. Central mechanisms cause contraction and increased resistance to blood flow mainly through
which of the following?
a. Adrenergic stimulation and the release of norepinephrine
b. Cholinergic stimulation and the release of acetylcholine
c. Cholinergic stimulation and the release of norepinephrine
d. Stimulation of specialized alpha-adrenergic receptors
ANS: A
Smooth muscle contraction and increased flow resistance are mostly caused by adrenergic
stimulation and the release of norepinephrine.
36. Smooth muscle relaxation and vessel dilation are caused mainly by which of the following?
1. Action of local metabolites
2. Cholinergic stimulation
3. Stimulation of beta-adrenergic receptors
a. 1 and 3 only
b. 2 and 3 only
c. 1 and 2 only
d. 1, 2, and 3
ANS: B
Smooth muscle relaxation and vessel dilation occur as a result of stimulation of cholinergic or
specialized beta-adrenergic receptors.
37. Which of the following formulas is used to calculate the total amount of blood pumped by the
heart per minute, or cardiac output?
a. Blood pressure SV
b. Rate SV
c. SV ÷ rate
d. SV vascular resistance
ANS: B
Cardiac output = heart rate stroke volume.
38. What is an approximate normal resting cardiac output for a healthy adult?
a. 75 ml/min
b. 500 ml/min
c. 2000 ml/min
d. 5000 ml/min
ANS: D
A normal resting cardiac output of approximately 5 L/min can be calculated by substituting a
normal heart rate (70 contractions/min) and stroke volume (75 ml, or 0.075 L, per
contraction).
Cardiac output = 70 beats/min 0.075 L/beat = 5.25 L/min.
41. Given a stroke volume of 40 ml and an end-diastolic volume (EDV) of 70 ml, what is the
patient’s ejection fraction (EF)?
a. 0.57
b. 1.75
c. 67
d. 2800
ANS: A
Given a stroke volume of approximately 40 ml, and an EDV of 70 ml, the ejection fraction
can be calculated as follows:
EF = SV/EDV= 40 ml/70 ml = 0.57, or 57%.
43. The heart’s ability to vary stroke volume based solely on changes in end-diastolic volume is
based on what mechanism?
a. Automaticity
b. Autoregulation
c. Bohr equation
d. Frank-Starling’s law
ANS: D
The heart’s ability to change stroke volume solely according to the EDV is an intrinsic
regulatory mechanism based on the Frank-Starling’s law.
44. Which of the following are true of the force against which the left ventricle must pump?
1. Referred to as left ventricular afterload.
2. Equivalent to systemic vascular resistance.
3. Helps to determine left ventricular stroke volume.
a. 1 and 3 only
b. 1 and 2 only
c. 1, 2, and 3
d. 2 and 3 only
ANS: C
A major factor affecting stroke volume is the force against which the heart must pump. This is
called afterload. In clinical practice, left ventricular afterload equals the SVR. In other words,
the greater the resistance to blood flow, the greater is the afterload.
45. Which of the following would have a negative impact on cardiac contractility?
1. Acidosis
2. Digitalis
3. Hypoxia
4. Norepinephrine
a. 1, 2, and 3
b. 2 and 4 only
c. 4 only
d. 1 and 3 only
ANS: D
Profound hypoxia and acidosis impair myocardial metabolism and decrease cardiac
contractility.
47. Where are the central centers responsible for regulating the cardiovascular system located?
a. Aortic bodies
b. Brainstem
c. Carotid arteries
d. Cerebral hemispheres
ANS: B
Central control of cardiovascular function occurs via interaction between the brainstem and
selected peripheral receptors.
48. What is the affect on the cardiovascular medullary centers when the cerebral carbon dioxide is
low?
a. Excitatory
b. Inhibitory
c. No affect
d. Increased vascular tone
ANS: B
The cardiovascular centers are also affected by local chemical changes in the surrounding
blood and cerebrospinal fluid. For example, decreased levels of carbon dioxide tend to inhibit
the medullary centers.
49. In order to function effectively, the central cardiovascular control center must receive signals
regarding changes in blood volume or pressure. From where do these signals come?
a. Central chemoreceptors
b. Hypothalamus
c. Peripheral baroreceptors
d. Skeletal muscles
ANS: C
The greater the blood pressure, the greater is the stretch and the higher is the rate of neural
discharge from the peripheral baroreceptors to the cardiovascular centers in the medulla.
51. Vascular low-pressure baroreceptors have their greatest impact on which system?
a. Central chemoreceptors
b. Endocrine
c. Exocrine
d. Renin-angiotensin
ANS: D
The low-pressure atrial and venous baroreceptors regulate plasma volume mainly through
their effects on the following:
• Renal sympathetic nerve activity
• Release of antidiuretic hormone (ADH), also called vasopressin
• Release of atrial natriuretic factor (ANF)
• Renin-angiotensin-aldosterone system
54. Significant loss of blood volume causes an increase in which of the following?
1. Vascular tone
2. Secretion of antidiuretic hormone (ADH)
3. Heart rate
a. 1, 2, and 3
b. 2 and 3 only
c. 1 and 3 only
d. 1 and 2 only
ANS: A
As the blood loss becomes more severe (20%), atrial receptor activity decreases further. This
increases the intensity of sympathetic discharge from the cardiovascular centers. Plasma ADH
and heart rate continue to climb, as does peripheral vasculature tone.
55. During the normal events of the cardiac cycle, which of the following statements is true?
a. Electrical depolarization follows mechanical contraction.
b. Electrical depolarization precedes mechanical contraction.
c. Heart sounds precede electrical depolarization.
d. Heart sounds precede cardiac valve opening or closing.
ANS: B
The P wave signals atrial depolarization. Within 0.1 sec, the atria contract, causing a slight
rise in both atrial and ventricular pressures (the A waves).
56. Immediately following the P wave of the electrocardiogram, an A wave appears on both the
left and right heart pressure graphs. This A wave corresponds to which of the following?
a. Atrial contraction
b. Atrioventricular valve closure
c. Semilunar valve closure
d. Ventricular contraction
ANS: A
The P wave signals atrial depolarization. Within 0.1 sec, the atria contract, causing a slight
rise in both atrial and ventricular pressures (the A waves).
57. The first heart sound is associated with what mechanical event of the cardiac cycle?
a. Atrioventricular valve closure
b. Atrioventricular valve opening
c. Semilunar valve closure
d. Semilunar valve opening
ANS: A
As soon as ventricular pressures exceed those in the atria, the atrioventricular valves close.
Closure of the mitral valve occurs first, followed immediately by closure of the tricuspid
valve. This marks the end of ventricular diastole, producing the first heart sound on the
phonocardiogram.
58. Opening of the semilunar valves occurs when which of the following occurs?
a. The pressures in the arteries exceed those in the ventricles.
b. The pressures in the atria exceed those in the ventricles.
c. The pressures in the ventricles exceed those in the aorta and pulmonary artery.
d. The pressures in the ventricles exceed those in the atria.
ANS: C
Within 0.05 sec, ventricular pressures rise to exceed those in the aorta and pulmonary artery.
This opens the semilunar valves.
59. Toward the end of systole, as repolarization starts (indicated by the T wave), the ventricles
begin to relax. Which of the following will occur next?
a. Rapid rise in ventricular pressures.
b. Arterial pressures exceed ventricular pressures.
c. Closure of the atrioventricular valves.
d. Opening of semilunar valves.
ANS: B
Toward the end of systole, as repolarization starts (indicated by the T wave), the ventricles
begin to relax. Consequently, ventricular pressures drop rapidly. When arterial pressures
exceed those in the relaxing ventricles, the semilunar valves shut.
60. The semilunar valves close when which of the following occurs?
a. The pressures in the arteries exceed those in the ventricles.
b. The pressures in the ventricles and arteries become equal.
c. The pressures in the atria exceed those in the ventricles.
d. The pressures in the ventricles exceed those in the atria.
ANS: A
Toward the end of systole, as repolarization starts (indicated by the T wave), the ventricles
begin to relax. Consequently, ventricular pressures drop rapidly. When arterial pressures
exceed those in the relaxing ventricles, the semilunar valves shut.
61. The second heart sound is associated with what mechanical event of the cardiac cycle?
a. Atrioventricular valve closure
b. Atrioventricular valve opening
c. Semilunar valve closure
d. Semilunar valve opening
ANS: C
Closure of the semilunar valves generates the second heart sound.
62. The dicrotic notch recorded in the aorta immediately follows what mechanical event of the
cardiac cycle?
a. Closure of the aortic valve
b. Closure of the atrioventricular valves
c. Isovolume contraction
d. Opening of the aortic valve
ANS: A
Rather than immediately dropping off, aortic and pulmonary pressures rise again after the
semilunar valves close. Note the feature termed the dicrotic notch, which is caused by the
elastic recoil of the arteries. This recoil provides the extra “push” that helps maintain the head
of pressure created by the ventricles.
63. During the later stages of ventricular relaxation, the pressures in their chambers drop below
those in the atria. This results in which of the following?
1. Rapid drop in atrial pressures
2. Opening of the atrioventricular valves
3. Rapid ventricular filling
4. V pressure wave
a. 2 and 3 only
b. 1 and 2 only
c. 1, 2, 3, and 4
d. 2, 3, and 4 only
ANS: C
As the ventricles continue to relax, their pressures drop below the pressures in the atria. This
drop reopens the atrioventricular valves. As soon as the atrioventricular valves open, the blood
collected in the atria rushes to fill the ventricles, causing a rapid drop in atrial pressures (the V
wave).
66. An abnormal amount of fluid can accumulate between the layers of the pericardium resulting
in which of the following?
a. Pericardial effusion
b. Pulmonary embolism
c. Atrial fibrillation
d. Premature ventricular contractions
ANS: A
Abnormal amount of fluid can accumulate between the layers resulting in a pericardial
effusion.
68. What is the role of the dense connective tissue termed annulus fibrosi cordis in the function of
the heart?
a. Provides an anchoring structure for the heart valves, and also electrically isolates
the atria from the ventricle.
b. Allows the blood to enter the left atrium from the right atrium before birth.
c. Pulls in the right ventricular wall, aiding its contraction.
d. Separate the right and left ventricles.
ANS: A
It provides an anchoring structure for the heart valves; it also electrically isolates the atria
from the ventricle.