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Pennockaheyworthbe FACTSsettling Jses21
Pennockaheyworthbe FACTSsettling Jses21
www.elsevier.com/locate/ymse
a
Rady Children’s Hospital, San Diego, CA, USA
b
Department of Orthopaedic Surgery, Boston Children’s Hospital, Boston, MA, USA
c
Children’s Healthcare of Atlanta, Atlanta, GA, USA
d
Texas Scottish Rite Hospital for Children, Dallas, TX, USA
e
Division of Sports Medicine, Boston Children’s Hospital, Boston, MA, USA
f
C.S. Mott Children’s Hospital, Ann Arbor, MI, USA
g
UCSF Benioff Children’s Hospital–Oakland, Oakland, CA, USA
h
Campbell Clinic Orthopaedics, Memphis, TN, USA
i
Washington University Orthopedics, St. Louis, MO, USA
Background: Progressive displacement of diaphyseal clavicle fractures has been observed in adult patients, at times necessitating a
change from nonoperative to operative treatment. Whether this occurs in adolescent patients has not been well investigated. The purpose
of this study was to assess the rate and extent of progressive clavicle fracture displacement in adolescent patients following injury and
during the early stages of healing.
Methods: This was a multicenter study evaluating prospective data that had previously been collected as part of a larger study evalu-
ating the functional outcomes of adolescent clavicle fractures. A consecutive series of completely displaced diaphyseal clavicle fractures
Institutional review board approval was received through the University of After Adolescent Clavicle Trauma and Surgery) Study Group with Boston
California, San Diego Human Research Protections Program (project no. Children’s Hospital, Boston, MA.
121458), as well as the Boston Children’s Hospital Institutional Review *Reprint requests: Andrew T. Pennock, MD, Rady Children’s Hospital,
Board (protocol no. P00004816). 3020 Children’s Way, MC 5062, San Diego, CA 92123, USA.
1
This study was conducted at Rady Children’s Hospital, San Diego, CA, E-mail address: apennock@rchsd.org (A.T. Pennock).
and collaboratively among all sites affiliated with the FACTS (Function
1058-2746/$ - see front matter Ó 2021 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.
https://doi.org/10.1016/j.jse.2021.05.006
2 A.T. Pennock et al.
in patients aged 10-18 years treated at 1 of 3 tertiary-care pediatric trauma centers was included; all fractures underwent standardized
imaging within 2 weeks of the date of injury and during the course of healing (5-20 weeks after injury). Measurements of clavicle short-
ening, superior displacement, and angulation were performed using validated techniques. Progressive displacement and/or interval
improvement in fracture alignment, as well as the subsequent need for surgical intervention, was noted. Patient demographic and radio-
graphic parameters were assessed as possible risk factors for interval displacement.
Results: One hundred patients met the inclusion criteria. Mean end-to-end shortening, cortex-to-cortex shortening, superior displace-
ment, and angulation at the time of injury were 24 mm, 15 mm, 15 mm, and 7 , respectively. At a mean of 10 weeks after injury, the
fracture alignment improved across all 4 measurements for the overall cohort, with mean improvements of 3.5 mm in end-to-end short-
ening, 3.3 mm in cortex-to-cortex shortening, 2.1 mm in superior displacement, and 2 in angulation. By use of a clinical threshold of a
change in shortening or displacement of 10 mm or change in angulation of 10 , 26% of fractures improved, 4% worsened, and 70%
remain unchanged. Patients with more severe fractures were more likely to have improved alignment than were patients with less dis-
placed fractures (P < .001). No patient underwent surgical intervention for progressive displacement.
Conclusion: Significant early improvements in fracture alignment were observed in a substantial percentage of adolescent patients with
completely displaced clavicle fractures. Among the most severely displaced fractures, shortening improved approximately 6 mm and
angulation improved approximately 9 . In 4% of cases, increased displacement was observed, but this tended to be mild, and in no
cases did it prompt surgical intervention. This finding indicates that the true final deformity after an adolescent clavicle fracture is
commonly less than that present at the time of injury.
Level of evidence: Level IV; Case Series; Treatment Study
Ó 2021 Journal of Shoulder and Elbow Surgery Board of Trustees. All rights reserved.
Keywords: Adolescent; clavicle fracture; progressive displacement; shortening; remodeling; settling
Clavicle fractures account for 10%-15% of all skeletal and can better tolerate and adapt to the altered mechanics
injuries in children, and the incidence in adolescents is associated with a malunited clavicle. Second, residual
twice that in any other age group, likely owing to more growth in the clavicle, whose growth plates have been
involvement in sports and other high-risk activities.10,18 shown to remain open up to age 25 years, may allow bony
Roughly 90% of clavicle fractures in adolescents are remodeling.7,9,14 Third, ‘‘settling’’ of the fracture may
diaphyseal, and a recent descriptive epidemiology study occur during the early phases of healing, which may make
revealed that over half of these (54%) will be completely an initial injury pattern that looks quite severe less dra-
displaced with mean fracture shortening of 12-22 mm.5,17 matic as the fracture heals. Recent literature in adult pa-
Prior to the turn of the century, operative treatment of tients, however, may suggest that this third possibility is
this injury was uncommon in both children and adults; unlikely, given a relatively high rate of progressive
Kubiak and Slongo10 reported an operative rate of 0.8% for displacement and surgical conversion in this older
pediatric diaphyseal clavicle fractures over a span of 21 population.13,16
years. More recently, a number of randomized studies in the The purpose of this study was to use prospectively
adult population have suggested that operative treatment of collected radiographic data from a multicenter study group
displaced, shortened fractures can decrease the rate of to evaluate the rate and extent of change of adolescent
nonunion and symptomatic malunion.3,19,21 Subsequently, clavicle fracture alignment during the early phases of
the rate of operative treatment of adolescent clavicle frac- healing. Furthermore, we sought to quantify the specific
tures has increased substantially, largely owing to extrap- changes in radiographic alignment and to identify potential
olation from the adult data as well as parent and/or child risk factors for fracture displacement.
demand, despite a paucity of evidence-based support spe-
cific to the adolescent population.4,22
Despite this trend, current literature suggests that the Materials and methods
majority of adolescent clavicle fractures can be treated
nonoperatively with good functional outcomes, a high rate This was a multicenter study using prospectively collected data,
of return to sport, and a low incidence of complications which were acquired as part of a larger study group evaluating the
such as nonunion and symptomatic malunion. Unlike adult functional outcomes of adolescent clavicle fractures. The current
fractures, which have a symptomatic malunion rate be- study focused on a consecutive series of patients from 3 different
geographically distinct pediatric trauma centers. The inclusion
tween 10% and 15% with nonoperative treatment, signifi-
criteria included adolescent patients (aged 10-18 years) with
cant functional deficits have not been noted in adolescent completely displaced diaphyseal clavicle fractures who had an
patient populations.2,6,20 There are several potential reasons anteroposterior (AP) radiograph of the affected clavicle taken
these younger patients may recover and perform better than within 14 days of their injury, as well as a second AP radiograph
their adult counterparts after displaced fractures. First, the taken during the intermediate phase of healing, when sufficient
adolescent population might be more resilient to this injury advanced callus was seen traversing the fracture site, so as to
Displaced adolescent clavicle fracture alignment changes 3
Table II Fracture shortening, angulation, and superior displacement data for 100 adolescent clavicle fractures
Injury radiograph Healing radiograph Interval D P value
End-to-end shortening, mm 24.2 8.2 20.7 6.7 3.5 4.4 <.001
Cortex-to-cortex shortening, mm 14.6 7.3 11.4 5.5 3.3 4.7 <.001
Superior displacement, mm 14.6 5.2 12.4 4.5 2.1 3.8 <.001
Angulation, 7 10 6 7 2 8 .055
Data are presented as mean standard deviation.
Figure 2 Distribution of the change in fracture end-to-end shortening (A) and cortex-to-cortex shortening (B) from the time of injury to
the time of fracture healing for the entire cohort of 100 patients. Positive values represent an improvement in fracture shortening, whereas
negative values represent a worsening.
Displaced adolescent clavicle fracture alignment changes 5
Superior displacement
At the time of the healing radiograph, end-to-end fracture Overall, 75% of the cohort did not experience a significant
shortening improved by a mean of 3.5 4.4 mm (range, 5.3 change (>10 or >10 mm) in the radiographic variables
mm of worsening to 15.6 mm of improvement), representing (shortening, vertical displacement, and/or angulation).
an overall reduction in fracture shortening by 15% (P < .001). Among the 25% of the cohort that did have a significant
6 A.T. Pennock et al.
Figure 4 Distribution of the change in superior fracture displacement from the time of injury to the time of fracture healing for the entire
cohort of 100 patients. Positive values represent an improvement in superior displacement, whereas negative values represent a worsening.
Discussion
Figure 6 Distribution of the change in fracture angulation from the time of injury to the time of fracture healing for the entire cohort of
100 patients. Positive values represent an improvement in fracture angulation, whereas negative values represent a worsening.
5. Ellis HB, Li Y, Bae DS, Kalish LA, Wilson PL, Pennock AT, et al.
and Ossur; and receives publishing royalties and financial Descriptive epidemiology of adolescent clavicle fractures: results from
or material support from Saunders/Mosby-Elsevier and the FACTS (Function after Adolescent Clavicle Trauma and Surgery)
Wolters Kluwer Health–Lippincott Williams & Wilkins. prospective, multicenter cohort study. Orthop J Sports Med 2020;8:
Ying Li is a paid consultant for Medtronic and is a 2325967120921344. https://doi.org/10.1177/2325967120921344
6. Herzog MM, Whitesell RC, Mac LM, Jackson ML, Culotta BA,
board or committee member of POSNA and Scoliosis Axelrod JR, et al. Functional outcomes following non-operative versus
Research Society (SRS). operative treatment of clavicle fractures in adolescents. J Child Orthop
Nirav K. Pandya is a paid consultant for Orthopedi- 2017;11:310-7. https://doi.org/10.1302/1863-2548.11.160267
atrics and is a board or committee member of POSNA 7. Hughes JL, Newton PO, Bastrom T, Fabricant PD, Pennock AT. The
and PRISM. clavicle continues to grow during adolescence and early adulthood.
HSS J 2020;16:372-7. https://doi.org/10.1007/s11420-020-09754-8
Coleen S. Sabatini is a board or committee member 8. Jacobsen FS. Periosteum: its relation to pediatric fractures. J Pediatr
of AAOS, J. Robert Gladden Society, MiracleFeet Orthop B 1997;6:84-90.
Medical Advisory Board, and POSNA. 9. Jit I, Kulkarni M. Times of appearance and fusion of epiphysis at the
David D. Spence receives publishing royalties and medial end of the clavicle. Indian J Med Res 1976;64:773.
financial or material support from Elsevier; receives 10. Kubiak R, Slongo T. Operative treatment of clavicle fractures in
children: a review of 21 years. J Pediatr Orthop 2002;22:736-9.
research support from Orthopediatrics; and is a board or 11. Li Y, Donohue KS, Robbins CB, Pennock AT, Ellis HB Jr, Nepple JJ,
committee member of POSNA. et al. Reliability of radiographic assessments of adolescent midshaft
Samuel C. Willimon is a paid consultant for Smith & clavicle fractures by the FACTS Multicenter Study Group. J Orthop
Nephew Endoscopy. Trauma 2017;31:479-84. https://doi.org/10.1097/BOT.
Philip L. Wilson receives research support from Allo- 0000000000000877
12. Malik A, Jazini E, Song X, Johal H, O’Hara N, Slobogean G, et al.
Source and Ossur; receives publishing royalties and financial Positional change in displacement of midshaft clavicle fractures: an
or material support from Elsevier; is on the editorial or aid to initial evaluation. J Orthop Trauma 2017;31:e9-12. https://doi.
governing board of the Journal of Pediatric Orthopedics; org/10.1097/BOT.0000000000000727
and is a board or committee member of POSNA. 13. Marsh JL, Slongo TF, Agel J, Broderick JS, Creevey W, DeCoster TA,
The FACTS group has received funding from: Boston et al. Fracture and dislocation classification compendiumd2007:
Orthopaedic Trauma Association classification, database and out-
Children’s Hospital Center for Program for Patient Safety comes committee. J Orthop Trauma 2007;21:S1-6. https://doi.org/10.
and Quality Research Grant (2013), Boston Children’s 1097/00005131-200711101-00001
Hospital Family Trust Private Donation (2015), and 14. McGraw MA, Mehlman CT, Lindsell CJ, Kirby CL. Postnatal growth
POSNA Directed Research Grant (2015-2018). of the clavicle: birth to 18 years of age. J Pediatr Orthop 2009;29:937-
Jeffrey J. Nepple is on the editorial or governing 43. https://doi.org/10.1097/BPO.0b013e3181c11992
15. Onizuka N, Anderson JP, Gilbertson JA, MacCormick LM, Cole PA.
board of Arthroscopy; is a board or committee member Displacement of diaphyseal clavicle fractures related to patient posi-
of PRISM Society; is a paid consultant for Responsive tion and progressive displacement in the peri-injury period. J
Arthroscopy and Smith & Nephew; receives research Shoulder Elbow Surg 2018;27:667-73. https://doi.org/10.1016/j.jse.
support from Smith & Nephew and Zimmer; and is a 2018.01.004
paid presenter or speaker for Smith & Nephew. 16. Plocher EK, Anavian J, Vang S, Cole PA. Progressive displacement of
clavicular fractures in the early postinjury period. J Trauma 2011;70:
The other authors, their immediate families, and any 1263-7. https://doi.org/10.1097/TA.0b013e3182166a6f
research foundations with which they are affiliated have 17. Postacchini F, Gumina S, De Santis P, Albo F. Epidemiology of
not received any financial payments or other benefits from clavicle fractures. J Shoulder Elbow Surg 2002;11:452-6. https://doi.
any commercial entity related to the subject of this article. org/10.1067/mse.2002.126613
18. Robinson CM. Fractures of the clavicle in the adult. Epidemiology and
classification. J Bone Joint Surg Br 1998;80:476-84.
19. Robinson CM, Goudie EB, Murray IR, Jenkins PJ, Ahktar MA,
Read EO, et al. Open reduction and plate fixation versus nonoperative
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