Unlocking Potential

Blood
Centers

INCREASING THE VALUE OF

BLOOD DONATIONS
 POTENTIAL CaridianBCT and Terumo Transfusion
are becoming Terumo BCT, the
world leader in blood component
technology. Together, we believe
in the potential of blood to do
even more for the world than it does
today. This belief unites our organi-
zation, inspires our innovation and
strengthens our collaboration with
customers to ultimately benefit the
patients we all serve.

As we strive to make even safer,

higher-quality transfusions
available to more people, we can
unlock the potential of blood. We
can help our customers bring even
more treatment options to patients
with advanced blood therapies.
And we support researchers in
developing cell therapies that may
fundamentally improve health
care. Terumo BCT is guided by our
customers’ needs, aspirations and
ongoing drive to improve efficiency
and patient outcomes.

04 Adding value at each step Terumo BCT

06 Donor management
08 Apheresis collections Unlocking the potential of blood
10 Whole blood collections
12 Processing
14 Pathogen reduction
16 Diversification
18 Working together
20 Research collaboration
26 Global presence
 ADDING VALUE AT EACH STEP

Whatever your challenges—whether you are contending with the economic environment, adapting to
changing demographics or expanding to meet new demand—Terumo BCT will work to deliver the advanced
technologies, trustworthy advice and follow-through that only a truly committed partner can provide.

We help blood centers increase the value per donor at each step:

DONOR MANAGEMENT
Matching each donor to better
collection options

COLLECTIONS
Enhancing efficiency and flexibility
COMPONENT PATIENT for in-center and mobile blood drives
DEMAND NEEDS

PROCESSING
Improving lab efficiency, blood component
quality and process control through automation

PATHOGEN REDUCTION
Working toward safer blood for patients,
safe and simple procedures for operators

04 05
 RESPONDING TO FUNDAMENTAL CHANGES WE HELP YOU WITH:

IN THE DEMAND FOR BLOOD DonorMAX Program

A donor-friendly kiosk, software system and recruitment
consultation program to convert donors to give blood via
apheresis, helping blood centers collect the components
Changing demographics needed that day.
Many societies around the world are experiencing aging populations. As people age, they become less likely and able
to donate blood. In addition, older people are more likely to need blood transfusions, putting further strain on blood centers. T-POD
A software system that helps blood centers better determine
Shifting ethnicities donor procedure eligibility in the interview room, enabling
In certain geographies, ethnic shifts have caused an increase in the demand for blood types currently in short supply. operators to collect better component combinations from
This trend will likely continue in the coming years. Unfortunately, traditional outreach efforts struggle to recruit people each donor.
who can donate the types of blood that were once considered rare.
Productivity Tools
Now more than ever, it’s critical for blood centers to match each donor to better collection options. We help optimize Educational resources to help support donor recruitment
collections by developing new approaches, training staff and implementing new technologies that engage and educate and increase collections within blood centers.
donors. Through these efforts, we help blood centers collect the components that reflect changing demand.
Product and service availability varies by country.

DONOR
MANAGEMENT

COLLECTIONS

COMPONENT PATIENT
DEMAND NEEDS
PROCESSING

PATHOGEN
REDUCTION

RIGHT DONOR
+
RIGHT PRODUCT
+
RIGHT TIME
=
MORE VALUE

06 07
 INTEGRATING IN-CENTER AND WE HELP YOU WITH:
MOBILE BLOOD DRIVES Trima Accel® Automated Blood Collection System
The world’s leading automated apheresis collection system
enables blood centers to collect any blood component in
any combination.
At Terumo BCT, we believe in an integrated approach to apheresis collections. Donor education and qualification,
collection technology and performance management systems work together as an efficient, automated solution.
INFORMATION TECHNOLOGY SYSTEMS
This integrated approach has led to the wide adoption of our technology throughout the world. Most importantly,
we deliver the only apheresis system that can collect any blood component in any combination, uniquely positioning Cadence Data Collection System
us to help you target specific component needs and quickly respond to any fluctuation in demand. A network device that enables our team of experienced
professionals to perform dynamic data analysis to help
Our technology is already the global leader for in-center use and is gaining popularity for mobile drives. Mobile donors blood centers improve operational efficiency.
appreciate knowing they can give up to six times more platelets per donation compared to whole blood donations.
Plus, they may be able to donate platelets nearly every other week, as compared to every other month with whole Outcome Review
blood donations. For blood centers, using a single technology in-center and for mobile drives creates greater efficiencies A customizable analysis tool that helps blood centers identify
and enhances the value of each donation. additional collection opportunities, performance benchmarks
and areas for potential increased efficiencies.
Vista® Information System
A software system that helps blood centers proactively adapt
to changing blood component demand by guiding collection
efforts to make sure the right products are collected at the right
time, from the right donor. Via electronic recordkeeping of
each collection, the system also helps blood centers improve
regulatory compliance and reporting.
Trima Accel System Reporter
A data transfer system that automatically records procedure
data and easily uploads the information to a computer in a
convenient, easy-to-understand format.
APHERESIS SOLUTIONS
A range of solutions compatible with apheresis collections,
including anticoagulant, platelet additive solution (PAS) and
red cell storage solution.

Product and service availability varies by country.

DONOR
MANAGEMENT

COLLECTIONS
(APHERESIS)
COMPONENT PATIENT
DEMAND NEEDS
PROCESSING

PATHOGEN
REDUCTION

MORE COMPONENTS PER DONOR

+
MORE FREQUENT DONATIONS
=
MORE VALUE

08 09
 RESPECTING THE VALUE OF WE HELP YOU WITH: TERUFLEX® blood bags
Gives blood centers flexibility with a range of whole blood
WHOLE BLOOD DONATIONS T-RAC-II collection bags without leukocyte-reduction filters and
A system that helps standardize blood collections and can multiple bag configurations, collection volume options and
transfer supporting data via wireless or wired connections. anticoagulant/preservative combinations.

Each unit of whole blood can help multiple patients, so it is essential that the process and products used to collect IMUFLEX® blood bag systems with in-line filters
blood respect the inherent value of every donation. We have understood and supported these all-important blood Flexible system of blood bags equipped with specialized
collections for more than 40 years, with a diverse range of reliable, innovative products. leukocyte-reduction filters to meet your specific collection
requirements:
Not only do our collection products and accessories meet high standards for quality and safety today, our innovation
pipeline will remain focused on enhancing donor comfort and increasing efficiencies within component laboratories. • WB-SP—Produce three blood components:
For example, we are introducing the use of whole blood collection bags that are compatible with automated processing red blood cells, plasma and platelets
to help lower costs and risks. • WB-RP—Produce two blood components:
red blood cells and plasma
• Red Cell Filter—Produce plasma, platelet
concentrate and red cell concentrate
• Collection Line—Equipped with a needle
protector and sampling system for added safety
Atreus® Whole Blood Processing System disposables
Disposable collection sets aid automated whole blood
processing, complete with an organizer to facilitate moving,
loading and unloading.
INFORMATION TECHNOLOGY SYSTEMS
TOMEs
A multi-directional data management software that supports
whole blood collection activities with the T-RAC-II.
Accessories
Terumo BCT also offers a range of blood collection accessories
and processing solutions.

Product and service availability varies by country.

DONOR
MANAGEMENT

COLLECTIONS
(WHOLE BLOOD)
G
COMPONENT PATIENT
DEMAND NEEDS
PROCESSING
N
N

PATHOGEN
REDUCTION

DONOR COMFORT
+
IMPROVED LABORATORY EFFICIENCIES
=
MORE VALUE

10 11
 PROVIDING A CLEAR PATH TO AUTOMATED WE HELP YOU WITH: TSCD® II, TSCD® and SCD®-II B Sterile Tube Welders
While maintaining a functionally closed system, these devices
BLOOD PROCESSING Atreus system create strong and consistent sterile welds for your docking
The first system to automate the steps of whole requirements.
blood processing.

Making the transition from manual to automated whole blood processing can greatly improve efficiency, TACSI® Terumo Automated Centrifuge
blood product quality and process control. and Separator Integration
An automated Buffy Coat processor that improves efficiency
As a trusted partner, Terumo BCT is here to help you make that transition. Our systems automate most by processing six pooled units at a time.
manual processing steps and we have the knowledge and experience to improve your entire whole blood process.
OrbiSac System
A clear path to automated processing The first system to merge the manual steps involved
Making the change from manual to automated processing might seem out of reach. Terumo BCT works closely in Buffy Coat platelet and pooling processing into one
with customers around the world to establish and share best practices. Through this collaboration, we help automated procedure.
blood centers achieve the benefits of automated whole blood processing.
T-ACE II+
This flexible automated blood component expressor brings a
high degree of flexibility to automated component separation
T-SEAL-II and Teruseal® Tube Sealers
Versatile table top technologies that produce reliable,
quality seals that are easy to separate.
INFORMATION TECHNOLOGY SYSTEMS
Atreus System Manager
Works with the Atreus system to improve process control,
regulatory compliance and management reports.
Cadence Data Collection System
A network device that enables our team of experienced
professionals to perform dynamic data analysis to help blood
centers improve operational efficiency.
TOMEs
A multi-directional data management solution to support
whole blood collection activities with the T-RAC-II.
Product and service availability varies by country.

DONOR
MANAGEMENT

COLLECTIONS

COMPONENT PATIENT
DEMAND NEEDS
PROCESSING

PATHOGEN
REDUCTION

AUTOMATED COMPONENT PROCESSING

+
AUTOMATED COMPLIANCE SUPPORT
+
AUTOMATED DATA MANAGEMENT
=
MORE VALUE

12 13
 REALIZING THE POTENTIAL WE HELP YOU WITH:

OF PATHOGEN REDUCTION Mirasol® Pathogen Reduction Technology System

Innovative technology using riboflavin and ultraviolet light to
inactivate residual white blood cells and reduce the level of
known and unknown pathogens before blood products are
Few technologies have the potential to improve blood safety the way our Mirasol® Pathogen Reduction transfused.
Technology system does. The technology inactivates residual white blood cells and reduces the level
of known and unknown pathogens. It is designed to be safe and simple for operators. Mirasol® Manager
Integrates with the system to capture and store data to help
The Mirasol system uses riboflavin (vitamin B2), a naturally occurring, non-toxic compound and ultraviolet light ensure accurate reporting and simplified data management.
to work toward safer blood for patients. The system is also a model of efficiency, with a single platform for treating
platelets and plasma today, and, potentially, whole blood in the future. Product and service availability varies by country.

DONOR
MANAGEMENT

COLLECTIONS

COMPONENT PATIENT
DEMAND NEEDS
PROCESSING

PATHOGEN
REDUCTION

SAFETY FOR OPERATORS

+
EFFECTIVE PATHOGEN TREATMENT
+
SIMPLICITY OF ONE PLATFORM
=
MORE VALUE

14 15
 DIVERSIFICATION Growing in new directions
At Terumo BCT, not only are we committed to adding value
to your current operations, we can also help you expand into
new areas.

Therapeutic apheresis
In many locations around the world, plasmapheresis,
cytapheresis and red blood cell exchange are expanding the
number of treatment options for patients. These treatments
are being applied in freestanding clinics, dedicated therapeutic
apheresis centers or in conjunction with local hospitals.

Cell therapy
Cell therapies have the potential to fundamentally change the
way many diseases are treated. Blood cells collected from as
little as 25 mL of bone marrow can be expanded into hundreds
of millions of cells.

Terumo BCT provides the right tools to help you effectively

implement a cell therapy program that complements existing
services while you achieve new levels of patient care. Regardless
of the development path you pursue, we can support your
center with a scalable solution to help advance your efforts
to move from the laboratory, to clinical trial and ultimately
commercial availability.

HELPING BLOOD WE HELP YOU WITH:

CENTERS DIVERSIFY
Spectra Optia® Apheresis System
A flexible system that helps produce reliable therapeutic
apheresis results across a wide range of operator skills and
patient conditions.

Elutra® Cell Separation System

The world’s first functionally closed system for monocyte
enrichment.

COBE® 2991 Cell Processor

A versatile, reliable system for multiple cell processing
procedures, with automation to help ensure repeatable results.

Quantum® Cell Expansion System

A functionally closed, hollow-fiber bioreactor system that
streamlines cell expansion through a reproducible, scalable
automated process.

Product and service availability varies by country.

16 17
 WORKING TOGETHER Each and every exchange we have with our customers is
important. By fostering open and ongoing relationships,
we bring more value to you, our industry and ultimately the
patients we’re all focused on serving.

By actively listening, we can develop technologies to better

meet your specific needs. Even after a technology is in place,
we continue to serve you with comprehensive technical and
operator training, responsive support, and flexible service
options to help prevent and resolve issues.

Education and training

Our programs provide your operators and technicians with the
knowledge and confidence they need in the most convenient
way possible. Basic or advanced, in-person or online, your
facility or ours, instructor-led or self-paced—our wide range
of learning options strive to meet your specific requirements.

Clinical and technical support

Day after day and year after year, our experienced team is
responsive to your needs. We provide implementation support,
investigative problem-solving and specialized software support.
By helping integrate information technology system, we can
improve the flow of data. We can even remotely monitor various
technologies to help improve their performance. We also offer
multiple service plans to meet your specific needs.

Sharing insights
We believe in sharing information and experiences, and we
encourage our customers to do the same. By applying customer
experiences from around the world, we can help simplify how
you adopt our technology, measure performance for improved
accuracy, improve existing operations and expand into new
areas. We also leverage the invaluable insight and feedback
from our customers to help shape existing technologies and
upcoming innovations.

Knowledge center
This dynamic online resource enables you to access technical
and clinical information helpful in operating and maintaining
INNOVATIONS THAT UNLOCK our systems. With a few clicks, you can easily find education and
POTENTIAL CAN ONLY BE REALIZED training materials, operator manuals, quick reference guides,
THROUGH COLLABORATION scientific literature, clinical white papers and much more.

18 19
 BY ACCELERATING RESEARCH, WE CAN
SPEED UP INNOVATION, MAKE IT
MORE RELEVANT AND UNLOCK THE
POTENTIAL OF BLOOD

20 21
 RESEARCH RESEARCH IDENTIFIES NEEDS AND
PROVES OR DISPROVES THE VALUE
OF NEW APPROACHES

INSIGHT SHARED INSIGHT CREATES WIDER

DEMAND FOR IMPROVEMENTS

INNOVATION INNOVATION TRANSLATES

INSIGHTS INTO SOLUTIONS THE ROLE OF RESEARCH
THAT WORK IN PRACTICE
Health care advancements depend on research to identify
issues and objectively evaluate potential solutions. With these
findings in mind, new innovations can be developed and
ultimately brought to health care practitioners to move
health care forward.

22 23
RESEARCH COLLABORATION
AUSTRALIA, EUROPE AND NORTH AMERICA
PLASMA EXCHANGE IN ANCA-ASSOCIATED VASCULITIS
A 500-patient study conducted in collaboration with 100 institutions around
the world including the European Vasculitis Study Group and the Vasculitis
Clinical Research Consortium. Supported in conjunction with the U.S. National
Institutes of Health, U.S. Food and Drug Administration, Canadian Institutes
of Health Research, United Kingdom National Institute for Health Research,
Australian Department of Health and Fresenius Medical Care.
OBJECTIVE
Evaluate the efficacy of therapeutic plasma exchange and the safe reduction
of Glucocorticoid dosing to treat severe vasculitis where antineutrophil
cytoplasmic antibodies (ANCAs) are detected.
FRANCE AND GERMANY
STEM CELL EXPANSION
Collaboration with the CASCADE Consortium.
OBJECTIVE
Develop standardized GMP methods for culturing/expanding adult
mesenchymal stem cells for research and clinical applications.
DENMARK
PRESS TRIAL
Supporting a 40-patient study conducted in collaboration with
Rigshospitalet–Copenhagen University Hospital.
OBJECTIVE
Evaluate the viability of Mirasol-treated platelets stored in platelet
additive solution for seven days.
ITALY
IPTAS CLINICAL TRIAL
Supporting an 800-patient study conducted in collaboration with the
Italian National Institute of Transfusion Medicine.
OBJECTIVE
Evaluate the clinical effectiveness of Mirasol-treated platelets in plasma
and test the possibility of preventing alloimmunization reactions in
patients who receive multiple transfusions.
At Terumo BCT, we recognize the need for both basic and applied research and aspire to expand our efforts.
To help accelerate research, we invest in applied research projects around the world and make our technologies
and expertise readily available. The insights generated by these research efforts can create a wider demand for
product improvements and enable us to innovate new technologies, bringing them to market sooner.
Not all products currently available in all countries.
FRANCE FRANCE
HEPATITIS C REDUCTION TRIAL PLASMASEP TRIAL
Supporting in vitro studies with University Hospital of Amiens. Supporting a prospective 80-patient, double-blind placebo-controlled
study in collaboration with University Hospital, Bordeaux, France.
OBJECTIVE
Evaluate the effectiveness of the Mirasol Pathogen Reduction OBJECTIVE
Technology System on the hepatitis C virus. Evaluate the efficacy of therapeutic plasma exchange on Multiple
Sclerosis patients who experience relapses without improvement
after steroid treatment.
UNITED STATES UNITED STATES
DONOR CONVERSION TRIAL PATHOGEN REDUCTION STUDY
Supporting a five-month trial in collaboration with United Blood Services Developing methods for reducing the infectious pathogen load in blood
of Louisiana. products with the support of the U.S. Department of Defense (DoD).
This includes in vitro work evaluating pathogen kill levels, cell and protein
OBJECTIVE quality, blood product functionality and in vivo studies in human subjects.
Evaluate the effectiveness of the DonorMAX program to convert people In 2010, an in vivo feasibility study under a Food and Drug Administration
from donating whole blood to apheresis collections. Investigational Device Exemption was completed as part of this
program with funding from the DoD.
OBJECTIVE
Evaluate the efficacy of the Mirasol system in providing safer and more
effective blood for patients who experience life-threatening blood loss.
 OUR GLOBAL PRESENCE MAKES With more than 2,500 associates in 30 countries, Terumo BCT is closely connected to our customers around the world.
We achieve a lot by working closely with customers, and our team of highly-skilled specialists continually builds these
PARTNERSHIP POSSIBLE relationships. We support thousands of systems in over 90 countries and the average relationship with our customers
spans more than 20 years. Terumo BCT also has long-lasting relationships with influential industry organizations such as
the AABB, the Advanced Medical Technology Association, ASFA, Eucomed, the International Society of Blood Transfusion,
the National Blood Foundation and many others throughout the world.

TO LEARN MORE, VISIT WWW.TERUMOBCT.COM

22
CaridianBCT and Terumo Transfusion are becoming Terumo BCT, the world leader in
blood component technology. Our products and services are designed to set new levels of
performance today, and our innovation pipeline strives to substantially improve blood collection
and processing, blood therapies and the development of cell therapies in the years ahead.

TERUMO BCT
UNLOCKING THE POTENTIAL OF BLOOD

CaridianBCT, Inc. CaridianBCT (Asia Pacific) Ltd.

10811 West Collins Avenue
Lakewood, Colorado 80215-4440
USA
USA Phone: 1.877.339.4228
Phone: +1.303.231.4357
Fax: +1.303.542.5215
Room 3903-3903A, 39/F
New York Life Tower, Windsor House
311 Gloucester Road
Causeway Bay, Hong Kong
Phone: +852.2283.0700
Fax: +852.2576.1311
©2011 CaridianBCT, Inc. / PN 306620-160

CaridianBCT Europe N.V. CaridianBCT Latin America

Europe, Middle East and Africa Juncal 1311 4th Floor
Ikaroslaan 41 C1062ABO
1930 Zaventem Buenos Aires
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Phone: +32.2.715.05.90 Phone: +54.11.5530.5200

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TERUMOBCT.COM