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MedicinesVILDAREST M 50/500mg Tablet 15's

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Generic Name
INTRODUCTION Metformin 500 mg+Vildagli
VILDAREST M 50/500MG TABLET is a combination of Metformin and Vildagliptin, which belongs to a ptin 50 mg
group of medicines called Antidiabetic agents. VILDAREST M 50/500MG TABLET is used to manage
type 2 diabetes (also known as non-insulin-dependent diabetes mellitus) in adult patients whose
diabetes cannot be controlled by diet and exercise alone and/or with other medicines used to manage
diabetes (insulin or sulphonylureas such as glimepiride and glipizide).

Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the
insulin that is produced does not work well. Symptoms include excessive urination, excessive thirst,
hunger, fatigue, and blurred vision.

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Before taking VILDAREST M 50/500MG TABLET, inform your doctor if you have liver, kidney, or heart
problems. It should be used during pregnancy only if advised by your doctor, and it is not
recommended for pregnant women. VILDAREST M 50/500MG TABLET is not suitable for use in
children and adolescents under 18 years of age, and it should be used with caution in elderly patients
(65 years of age and above).

Avoid consumption of alcohol during treatment with VILDAREST M 50/500MG TABLET, as it may
increase the risk of lactic acidosis. The most common side effects of taking VILDAREST M 50/500MG
TABLET are nausea, vomiting, stomach pain, headache, low blood sugar, and diarrhea. Contact your
doctor if any of the symptoms worsen.

USES OF VILDAREST M 50/500MG TABLET

To manage type II diabetes mellitus (whose diabetes cannot be controlled by diet and exercise
alone and/or with other medicines used to manage diabetes)

HOW VILDAREST M 50/500MG TABLET WORKS

VILDAREST M 50/500MG TABLET helps to control the blood sugar level, where metformin makes the
body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells
utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver
and reduce its absorption in the body.

Vildagliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl
peptidase (DPP)-4 that indirectly increases insulin secretion in the body. Collectively, VILDAREST M
50/500MG TABLET controls blood sugar levels in patients with type II diabetes.

DIRECTIONS FOR USE

Always take VILDAREST M 50/500MG TABLET as directed by your physician. Take this medicine with
or just after the food, swallow the medicine as a whole and do not crush or chew the medicine. Your
doctor will decide the correct dose and duration for you, depending on your age and health condition.
Do not stop taking VILDAREST M 50/500MG TABLET without informing your doctor.

SIDE EFFECTS OF VILDAREST M 50/500MG TABLET

COMMON

Nausea
Vomiting
Diarrhoea
Stomach pain
Loss of appetite
Dizziness
Headache
Metallic taste
Low blood glucose
Uncontrolled trembling

UNCOMMON

Joint pain, tiredness

Constipation
Swollen hands, ankles, or feet (oedema)

RARE

Stop taking VILDAREST M 50/500MG TABLET and contact your doctor immediately if you experience
any of the following side effects:

Symptoms of lactic acidosis (such as vomiting, stomach pain, decreased heartbeat, difficulty
breathing, muscle cramps, general weakness with severe tiredness, or reduced body
temperature)
Signs of an inflamed pancreas (severe and persistent pain in the abdomen with or without
nausea or vomiting)

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Signs of liver disease like hepatitis (such as yellowing of the skin and eyes, nausea, loss of
appetite, or dark-colored urine)
Severe allergic reactions called angioedema (such as swelling of the face, lips, mouth, tongue, or
throat that may lead to difficulty breathing or swallowing)
Conditions that may be associated with dehydration, such as severe vomiting, diarrhea, fever,
exposure to heat, or drinking less fluid than normal

HOW TO MANAGE SIDE EFFECTS

Constipation

Consume fiber-rich foods such as fresh fruits and vegetables, whole-grain cereals, and plenty of fluids.
Exercise more regularly and stay active. Consult your doctor if the symptom does not improve.

Diarrhea

Drink lots of fluids, such as water or fruit juices, to keep yourself hydrated. Avoid taking any medicine
on your own to treat diarrhoea. Consult your doctor if the symptom does not improve.

Headache

Rest and relax. Drink a sufficient amount of fluids, such as water. Apply a pain-relieving balm to the
head if required. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Stick to simple meals. Avoid eating oily, fried, or spicy food. Do not perform any strenuous activities
immediately after eating. Consult your doctor if the symptom does not improve.

Stomach Pain

Rest and relax. Eat and drink slowly, or try to have smaller and more frequent meals. Keep a heating
pad on your stomach. Do not self-treat on your own; consult your doctor if the symptom does not
improve on its own.

WARNING & PRECAUTIONS

PREGNANCY CONTRAINDICATED

VILDAREST M 50/500MG TABLET is generally not recommended for pregnant women unless it is
considered necessary. Consult your doctor before taking VILDAREST M 50/500MG TABLET.

BREASTFEEDING CONTRAINDICATED

VILDAREST M 50/500MG TABLET is not recommended for use by breastfeeding women. Consult
your doctor before taking VILDAREST M 50/500MG TABLET.

DRIVING AND USING MACHINES USE WITH CAUTION

Do not drive or operate any machines if you experience dizziness after taking VILDAREST M
50/500MG TABLET.

ALCOHOL CONTRAINDICATED

Consumption of alcohol is not recommended during treatment with VILDAREST M 50/500MG

TABLET since it may increase the risk of lactic acidosis.

KIDNEY CONTRAINDICATED

VILDAREST M 50/500MG TABLET is not recommended in patients with severely reduced kidney
function. Consult your doctor before taking VILDAREST M 50/500MG TABLET.

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LIVER CONTRAINDICATED

VILDAREST M 50/500MG TABLET is not recommended in patients with liver disease. Consult your
doctor before taking VILDAREST M 50/500MG TABLET.

ALLERGY CONTRAINDICATED

Do not take VILDAREST M 50/500MG TABLET if you are allergic (hypersensitive) to metformin or
vildagliptin.

HEART DISEASE CONTRAINDICATED

VILDAREST M 50/500MG TABLET is not recommended in patients who recently had a heart attack or
heart failure or any signs of heart problems such as serious blood circulation problems or difficulty
breathing. Consult your doctor before taking VILDAREST M 50/500MG TABLET.

USE IN PEDIATRICS CONTRAINDICATED

VILDAREST M 50/500MG TABLET is not recommended for use in children and adolescents less than
18 years of age due to a lack of safety and effectiveness. Consult with your doctor for advice.

USE IN GERIATRICS MONITORING REQUIRED

VILDAREST M 50/500MG TABLET should be used with caution in elderly patients above 65 years of
age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending
on kidney function, and your kidney function will be monitored regularly. Consult with your doctor
before taking VILDAREST M 50/500MG TABLET.

OTHERS

VILDAREST M 50/500MG TABLET is not recommended for you if you have:

Type 1 diabetes mellitus

Uncontrolled diabetes (with severe low blood sugar levels, nausea, vomiting, diarrhea, rapid
weight loss, ketoacidosis, or lactic acidosis)
Severe infection or seriously dehydrated
Are going to have a contrast x-ray (a specific type of x-ray involving an injectable dye)

Before taking VILDAREST M 50/500MG TABLET, inform your doctor if you have or had:

Disease of the pancreas

Going to undergo any surgery
Vitamin B12 deficiency
Malnutrition with adrenal or pituitary insufficiency

INTERACTIONS

A. Drug-Drug interactions:

Before taking VILDAREST M 50/500MG TABLET, inform your doctor if you are taking any of these
medicines:

Glucocorticoids such as dexamethasone and prednisolone (used to manage inflammation)

Beta-2 agonists such as albuterol and terbutaline (used to manage respiratory disorders)
Diuretics such as chlorthalidone and hydrochlorothiazide (used to increase urine production)
Ibuprofen and celecoxib (to manage pain and inflammation)
Angiotensin-converting enzyme (ACE) inhibitors (Ex. enalapril, lisinopril) and angiotensin II
receptor antagonists (Ex. losartan, telmisartan) (to manage high blood pressure)
Medicines affecting the nervous system and thyroid
Other medicines used to manage diabetes (Ex. glimepiride, glipizide)
Ranolazine (used to manage chest pain)
Dolutegravir (used to manage HIV infection)
Vandetanib (used to manage medullary thyroid cancer)
Cimetidine (used to manage heartburn and peptic ulcers)

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Overdosage:

If you or anyone else accidentally takes too much of VILDAREST M 50/500MG TABLET, consult your
doctor immediately. Overdosage symptoms of VILDAREST M 50/500MG TABLET might include low
blood sugar levels, lactic acidosis, muscle pain, mild and transient burning or tickling sensations in the
body, fever, and oedema.

SYNOPSIS

Drug : Metformin and Vildagliptin

Pharmacological Category : Antidiabetic agent (Biguanides & Dipeptidyl Peptidase 4 inhibitor)
Therapeutic Indication : Type 2 Diabetes Mellitus
Dosage Forms : Tablet

MORE INFORMATION

Keep VILDAREST M 50/500MG TABLET out of reach of children

Do not store above 30°C

FAQs ABOUT VILDAREST M 50/500MG TABLET

Q: What is VILDAREST M 50/500MG TABLET used for?

A: VILDAREST M 50/500MG TABLET is used to manage type 2 diabetes (also known as non-insulin-
dependent diabetes mellitus) in adults whose diabetes cannot be controlled by diet and exercise alone
and/or in combination with other diabetes medications (insulin or sulphonylureas such as glimepiride
or glipizide).

Q: Is it safe to use VILDAREST M 50/500MG TABLET on elderly patients?

A: VILDAREST M 50/500MG TABLET should be used with caution in elderly patients over 65 years of
age, especially in patients with impaired kidney function. Your doctor will adjust the dose depending
on kidney function, and your kidney function will be monitored regularly. Consult with your doctor
before taking VILDAREST M 50/500MG TABLET.

Q: Is it safe to use VILDAREST M 50/500MG TABLET in patients with heart problems?

A: VILDAREST M 50/500MG TABLET is not recommended in patients who have recently had a heart
attack, heart failure, or any signs of heart problems such as serious problems with blood circulation or
difficulty breathing. Consult your doctor before taking VILDAREST M 50/500MG TABLET.

Q: What are the most common side effects of taking VILDAREST M 50/500MG TABLET?

A: The most common side effects of taking VILDAREST M 50/500MG TABLET are nausea, vomiting,
stomach pain, headache, dizziness, loss of appetite, metallic taste, uncontrolled trembling, low blood
sugar, and diarrhea. Contact your doctor if any of the symptoms worsen.

Q: Can I consume alcohol while taking VILDAREST M 50/500MG TABLET?

A: Consumption of alcohol is not recommended during treatment with VILDAREST M 50/500MG

TABLET since it may increase the risk of lactic acidosis. Consult your doctor before taking VILDAREST
M 50/500MG TABLET if you are an alcoholic or have a history of alcoholism.

REFERENCES

1. KD Tripathi MD. Hormones and related drugs. Essentials of Medical Pharmacology. Seventh edition.
New Delhi, May 2013. Page – 274.

2. Paresh Ved and Samrat Shah. Evaluation of vildagliptin and fixed dose combination of vildagliptin
and metformin on glycemic control and insulin dose over 3 months in patients with type 2 diabetes
mellitus. March 2012. [Accessed on 30th June 2021]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354946/

3. Serge Halimi, Anja Schweizer, Biljana Minic, James Foley and Sylvie Dejage. Combination treatment
in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. March
2008. [Accessed on 30th June 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515409/

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4. Novartis Pharma GmbH. Electronic Medicines Compendium (EMC) [Revised in August 2021]
[Accessed on 30th June 2021] https://www.medicines.org.uk/emc/files/pil.6226.pdf

5. Cipla Ltd. VYSOV-M Tablets (Vildagliptin + Metformin hydrochloride). [Revised in July 2020]
[Accessed on June 30, 2021] https://ciplamed.com/print-product-pdf/37162

USEFUL DIAGNOSTIC TESTS

HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Blood Glucose Fasting (FBS)
Random Blood Sugar (RBS)
Post Prandial Blood Sugar (PPBS)
Insulin – Fasting
Insulin Postprandial (PP)
Vital Diabetes Care
Extended Diabetes Care
Advance Diabetes Care
Comprehensive Diabetes Care

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop, Pharm.D

Last updated on 17 Jan 2024 | 10:08 AM(IST)

Net Qty
1N

Shelf Life
720 Days

Item Weight
25 g

Ingredient
Metformin 500 mg+Vildagliptin 50 mg

Hsn Code
30049099

Show more

DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the
advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay
in seeking it because of something you have read on this website.

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