A B C D E

1
Breast Dx Case BreastDX-01-0001 BreastDX-01-0002 BreastDX-01-0003

Background
2

Pathology Dx benign fibrosis infiltrat lobular Invasive ductal CA

3

4 Which breast L R L
5 ER pos pos
6 PR neg (stain moderate) pos (weak)
7 HER2 neg neg
8 E-Cadherin neg
9 Ki67 high prolif intermed prolif
10 Oncotype score
11 Oncotype risk
12 Age decade 40 50
Path report Notes re-bx single 1cm residual CA focus re-bx 6/21/10 was
scar tissue from RT
rx

13
 F G H I J
1
BreastDX-01-0004 BreastDX-01-0005 BreastDX-01-0006 BreastDX-01-0007 BreastDX-01-0008

benign fibrosis infiltrating ductal CA benign fibroadenoma benign fibrosis

3

4 L R L
5 pos (strongly)
6 pos (weak)
7 moderate by FISH
8
9 high prolif
10
11
12 40
RIGHT BREAST MASS:
INFILTRATING DUCTAL
CARCINOMA, MODIFIED SCARFF-
BLOOM-RICHARDSON
GRADE-II/III. A 5% INTRADUCTAL
13 CARCINOMA COMPONENT,
COMEDO TYPE, NUCLEAR GRADE
III/III, IS ALSO PRESENT.re-bx
2/3/11 was no residual tumor
 K L M N O P
1
BreastDX-01-0009 BreastDX-01-0010 BreastDX-01-0011 BreastDX-01-0012 BreastDX-01-0013 BreastDX-01-0014

history of left breast cancer

2 (invasive ductal cancer),
status post left partial
mastectomy
invasive intraductal ductal CA in situ benign invasive ductal CA
3

4 L L R R
5 pos pos
6 pos pos
7 neg neg
8 pos
9 high prolif
10
11
12 40
re-bx 2/3/09 at mastectomy
calcific shows no 1/2/09 show
residual tumor invasive ductal
with axillary mets
13
 Q R S T U
1
BreastDX-01-0015 BreastDX-01-0016 BreastDX-01-0017 BreastDX-01-0018 BreastDX-01-0019

stromal hyperplasia invasive ductal CA

3

4 R L
5 neg
6 neg
7 neg
8
9 high prolif
10
11
12
mastectomy

13
 V W X Y
1
BreastDX-01-0020 BreastDX-01-0021 BreastDX-01-0022 BreastDX-01-0023

benign fibroadenoma ductal CA in situ invasive lobular

3

4 R R R
5 pos pos
6 pos pos
7 pos neg
8 pos
9 low prolif
10
11
12
RIGHT BREAST CALCIFICATION post surg path Invasive Lobular
WITH NEEDLE LOCATION: 12/30/10 showed Carcinoma, S/P
FIBROADENOMA (1.9CM). only scar Neoadjuvant Therapy
REMAINING BREAST TISSUE WITH Size of invasive
ADENOSIS, FOCAL component:
13 FIBROADENOMATOUS CHANGES, 2.5X2X2cm (largest
APOCRINE METAPLASIA, focus) Tumor focality:
FIBROCYSTIC CHANGES, SMALL Multiple foci of
INTRADUCTAL PAPILLOMAS, AND invasion Number of
USUAL TYPE DUCTAL lymph nodes with
HYPERPLASIA. macrometastases
MICROCALCIFICATIONS (>0.2 cm): 2 Size of
 Z AA AB
1
BreastDX-01-0024 BreastDX-01-0025 BreastDX-01-0026

known left breast CA with indeterminate early 40s with left breast cancer. LMP unknown
2 microcalcification clusters in right breast

invasive ductal ducta CA in situ INVASIVE DUCTAL CARCINOMA, MODIFIED SCARFF-

BLOOM-RICHARDSON GRADE-I/III. A LESS THAN 5%
3
INTRADUCTAL CARCINOMA COMPONENT, NUCLEAR
GRADE-II/III, IS ALSO PRESENT.
4 L L L
5 weak neg pos (strong)
6 weak neg pos (strong)
7 neg pos pos
8
9 high prolif intermed prolif
10 8
11
12 60
Left breast: INVASIVE DUCTAL CARCINOMA, mastectomy; INVASIVE DUCTAL CARCINOMA, MODIFIED
MODIFIED SCARFF-BLOOM-RICHARDSON SCARFF-BLOOM-RICHARDSON GRADE-I/III. A LESS THAN
GRADE-III/III. 5% INTRADUCTAL CARCINOMA COMPONENT, NUCLEAR
GRADE-II/III, IS ALSO PRESENT.
13
 AC AD AE AF AG
1
BreastDX-01-0028 BreastDX-01-0029 BreastDX-01-0030 BreastDX-01-0031 BreastDX-01-0032

benign fibrocyst Ductal carcinoma in-situ , solid type,

3
nuclear grade III/III.

4 L
5 pos
6 neg
7 pos
8
9 low prolif
10
11
12 50
Ductal carcinoma in-situ , solid type,
nuclear grade III/III.

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 AH AI AJ AK
1
BreastDX-01-0033 BreastDX-01-0034 BreastDX-01-0035 BreastDX-01-0036

history of left breast cancer treated with lumpectomy

2 and radiation therapy

intraductal CA benign benign

3

4 L R
5 neg
6 neg
7 pos
8
9 high prolif
10
11
12 40

13