25/05/2024, 10:43 Blood/Brain Barrier (BBB) Studies - Creative Biolabs

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Blood/Brain Barrier (BBB) Studies (blood-brain-barrier-bbb-studies.htm)

Blood/Brain Barrier (BBB) Studies

The blood/brain barrier (BBB) is formed by the brain endothelial cells and is identified as a structural and chemical
barrier between the brain and systemic circulation. BBB studies are prerequisite for explaining preclinical efficacy
and toxicology results. On the other hand, overcoming the obstacles of delivering therapeutic drugs to specific
sites of the brain has become a main challenge of treating most brain diseases. With years of operational
experience, Creative Biolabs now provides BBB study services using qualitative measurements of drug exposure,
to evaluate your new therapeutic agents.

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Blood/Brain Barrier (BBB)

The blood/brain barrier (BBB) is highly selective semipermeable membrane barrier, which is defined as a physical

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and metabolic barrier that separates the circulating blood from the brain and extracellular fluid in the central
nervous system (CNS). The blood/brain barrier is formed of brain capillary endothelium. It permits water, some
gases, and lipid-soluble molecules to pass by passive diffusion, and also allows the selective transport of
molecules such as glucose and amino acids that are essential to neural function. Moreover, it prevents the
entrance of lipophilic potential neurotoxins by means of the P-glycoprotein-mediated active transport mechanism.
Astrocytes have been supposed to be necessary to set up the blood-brain barrier. However, a few regions in the
brains do not have a blood/brain barrier, such as the circumventricular organs.

Fig.1. The illustration of the blood-brain barrier (BBB). (Liu, et al., 2012)

Blood/Brain Barrier (BBB) Permeability

Drug delivery across the BBB is challenging, predominantly due to the physical restriction of paracellular diffusion
between the endothelial cells which constitute the microvessels of the BBB, as well as the activity of efflux
transporters which speedily expel back into the capillary lumen turning into a wide range of xenobiotics. The BBB
creates an obstacle to drug delivery that prevents essentially 100% of large-molecule drugs (e.g., monoclonal
antibodies, antisense drugs) and more than 98% of small molecule drugs from entering the brain under normal
circumstance. Consequently, it is of significant importance to characterize the BBB permeability of candidate drugs
as early as possible in drug discovery.

Our Advantages

A team of scientists who are proficient in BBB studies;

Extensive experience with various administration routes, including IV, IP, PO, IM, IN, SC, and ICV, as well as short-
or long-term continuous infusions;
Combination of BBB studies and bioanalytical method.

What We Offer

Creative Biolabs is recognized as a world leader in the industry of drug discovery, providing standard and
customized in vivo pharmacokinetic assays with the largest and most diverse portfolio. Our scientists specialized in
BBB studies will work with you to characterize the properties of your drug candidate to develop a dosing and
sample collection strategy that will offer the most meaningful data for your research. BBB studies in Creative
Biolabs can be conducted with both standard or custom bioanalytical methods, to provide a complete
pharmacokinetic profile for your drug candidate.

Additionally, Creative Biolabs now offers a set of in vivo pharmacokinetic assay services in addition to cassette
dosing studies, including:

PK Biomarker Assessment (/drug-discovery/therapeutics/pk-biomarker-assessment.htm)

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Parallel/Crossover Study (/drug-discovery/therapeutics/parallel-crossover-study.htm)
Cassette Dosing Studies (/drug-discovery/therapeutics/cassette-dosing-studies.htm)
Investigative or Screening Studies (/drug discovery/therapeutics/investigative or screening studies htm)
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25/05/2024, 10:43 Blood/Brain Barrier (BBB) Studies - Creative Biolabs
Investigative or Screening Studies (/drug-discovery/therapeutics/investigative-or-screening-studies.htm)
Bioavailability and Bioequivalence (/drug-discovery/therapeutics/bioavailability-and-bioequivalence.htm)

Besides, you might be also interested in other in vivo PK studies (/drug-discovery/therapeutics/in-vivo-pk-

studies.htm) listed below:

Method Development and Validation (/drug-discovery/therapeutics/method-development-and-validation.htm)

In vivo ADME (/drug-discovery/therapeutics/in-vivo-adme.htm)
Dose Response Assessment (/drug-discovery/therapeutics/dose-response-assessment.htm)
Interspecies Scaling (/drug-discovery/therapeutics/interspecies-scaling.htm)

PK/Bioanalysis for the Samples (/drug-discovery/therapeutics/pk-bioanalysis-for-the-samples.htm)

Pharmacokinetics Disease Models (/drug-discovery/therapeutics/pharmacokinetics-disease-models.htm)
Pharmacokinetics Models (/drug-discovery/therapeutics/pharmacokinetics-models.htm)
Toxicokinetic Study (/drug-discovery/therapeutics/toxicokinetics-study.htm)

If you have any special needs in in vivo pharmacokinetic assays or be interested in learning more about Creative
Biolabs’ pharmacokinetic assay services, please contact us (contact-us.htm) for more information.

Reference
1. Liu, T. B.; et al. Molecular mechanisms of cryptococcal meningitis. Virulence. 2012, 3(2): 173.

For Research Use Only.

Related Services:
Bioavailability and Bioequivalence (bioavailability-and-bioequivalence.htm)

PK Biomarker Assessment (pk-biomarker-assessment.htm)

Parallel/Crossover Study (parallel-crossover-study.htm)
Cassette Dosing Studies (cassette-dosing-studies.htm)

Investigative or Screening Studies (investigative-or-screening-studies.htm)

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