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Park ES, Yim HW, Lee KS. Progressive muscle relaxation therapy to relieve dental
anxiety: a randomized controlled trial.
Eur J Oral Sci 2018; 00: 1–7. © 2018 Eur J Oral Sci
Dental anxiety causes patients to refuse or delay treatment, which may exacerbate
oral diseases. The aim of the current randomized controlled trial was to determine
whether progressive muscle relaxation therapy could relieve dental anxiety. The trial
included 68 periodontal patients with dental anxiety scores of ≥13 who were ran-
domly assigned to either an intervention group or a control group (n = 34 per
group). The intervention group was administered progressive muscle relaxation ther-
apy for 20 min and oral health education for 15 min before periodontal treatment Kang Sook Lee, Department of Preventive
Medicine, College of Medicine, The Catholic
once per week for 4 wk. The control group was provided with oral health education
University of Korea, 222 Banpo-daero,
only, for the same duration. Changes in dental anxiety, depression symptoms, blood Seocho-gu, Seoul 137-701, Korea
pressure, heart rate, and salivary cortisol were evaluated 4 wk and 3 months after
the intervention. The intervention group exhibited statistically significantly greater Email: leekangs@catholic.ac.kr
reductions in dental anxiety scores than did the control group at the 4-wk ( 3.82 vs.
0.89) and 3-month ( 4.22 vs. 0.28) assessments. They also exhibited significantly Key words: dental health education;
greater reductions in depression symptoms, systolic and diastolic blood pressure, depression; oral health education;
pulse rate, and salivary cortisol levels at both time-points. Progressive muscle relax- periodontal patients
ation therapy relieves tension and anxiety in dental patients. Accepted for publication October 2018
Dental anxiety is a complex phenomenon with physical, associated with symptoms of depression. In one previ-
mental, and social aspects (1). High levels of dental ous study (7), five patients exhibited clinically signifi-
anxiety can cause patients to experience stress and cant symptoms of depression during dental visits, and
refuse or delay treatment. This damages oral health antidepressant medication caused reduced saliva pro-
and leads to worsening of oral diseases. Dental anxiety duction, poor oral hygiene, and periodontal disease-
also interferes with successful treatment by causing related bacterial infection. Such physiological changes
increased perceptions of pain after treatment, thereby can lead to periodontal disease as a result of abnor-
delaying optimal recovery (2). The prevalence of dental mal immune responses (8). Thus, clinicians must be
anxiety in adult patients is approximately 20% (3), with aware of psychological parameters in patients with
5%–7% of patients experiencing extremely high levels dental anxiety.
of dental anxiety (4). Muscle relaxation therapy reduces the activity of the
SANTUCHI et al. (5) reported relatively high levels of sympathetic nervous system when stimulated by psy-
dental anxiety in periodontal patients, which were asso- chological and physiological responses, resulting in low
ciated with poor gingival status. Dental anxiety can be heart rate, low respiratory rate, and low blood pres-
reduced with the use of injected or inhaled sedatives. sure. In addition, it can effectively regulate the periph-
However, such drugs entail a risk of side effects, includ- eral and central nervous systems, thereby lowering
ing respiratory depression, gastrointestinal disorders, stress, anxiety, and depression levels, and thus is effec-
nausea, vomiting, and allergic reactions. Additionally, tive in treating several health problems (9). In previous
sedatives increase the cost of dental treatment, and the studies, Dental Anxiety Scale (DAS) scores were
body takes a long time to absorb injected sedatives, so reported to be significantly lower in a group receiving
they are of limited use in clinical settings. Therefore, progressive muscle relaxation therapy than in the corre-
drug-free methods are increasingly being used to ame- sponding control group (10), and patients receiving
liorate tension and moderate dental anxiety during muscle relaxation therapy reported that the dental anxi-
treatment (6). ety relief persisted during the subsequent dental visit
High dental anxiety is associated with oral health (11). ARMFIELD et al. (12) also suggested that progres-
issues and avoidance of dental care, and it can lead sive muscle relaxation therapy enables successful man-
to mental anxiety. In turn, poor oral health is agement of dental anxiety.
2 Park et al.
The purpose of this study was to establish the basis up to 10%, 35 patients were enrolled in each group to
of dental anxiety mitigation by progressive muscle ensure an adequate final sample size.
relaxation therapy in patients with dental anxiety.
The present randomized controlled trial (Clinical
Participants
Research Information Service trial registration number
KCT0001648) investigated whether progressive muscle The present study was approved by the Institutional
relaxation therapy could relieve dental anxiety, and if Review Board of The Catholic University of Korea. The
so, whether the anxiety-relieving effects of the therapy participants were 70 patients who visited a dental clinic in
lasted for 3 months in periodontal patients. The pri- Incheon, Republic of Korea, between 4 September 2015
mary outcome was relief from dental anxiety 3 months and 30 January 2016 for periodontal treatment. The inclu-
after commencement of the intervention, and the sec- sion criteria were as follows: chronic periodontal disease;
age 30–59 yr; consent to participate after being briefed on
ondary outcomes were reductions in dental anxiety, the purpose of the study; a DAS of ≥13 on the Corah den-
symptoms of depression, blood pressure, heart rate, tal anxiety scale (16); dental treatment planned for 5 wk
and salivary cortisol concentration, which are consid- or longer; one or more periodontal pockets ≥4 mm in
ered indicators of stress (13, 14), at 4 wk and 3 months depth; the absence of systemic diseases that could affect
after intervention commencement. periodontal disease; sightedness; literacy; and the ability to
understand the study and answer questions. Two patients
who did not meet the inclusion criteria were excluded: one
had a DAS of <13; and the other was unavailable for the
Material and methods collection of saliva samples between noon and 4 PM. Thus,
Sample size calculation 68 patients were ultimately included in this trial.
The patients were randomly assigned to either an inter-
Dental anxiety was set as the primary evaluation outcome vention group or a control group (n = 34 per group). Two
for calculating sample size. Based on existing research patients in the intervention group and three in the control
(15), a two-sided a-value of 0.05, a power of 0.80, and an group dropped out after intervention commencement
effect size of 0.72, a sample size of 31 was originally calcu- because they could not visit the clinic at the required time
lated as appropriate for intergroup comparison of mean for personal reasons. Thus, a total of 63 patients com-
anxiety scores. Based on an anticipated drop-out rate of pleted the trial (Fig. 1).
Fig. 1. Flow diagram of subject selection and allocation in accordance with Consolidated Standards of Reporting Trials
(CONSORT) guidelines. DAS, dental anxiety scale.
PMR therapy to treat dental anxiety 3
Table 2
Comparison of dental anxiety levels at 4 weeks and 3 months post-intervention
Study group
Variable Intervention (n = 34) Control (n = 34) P-value
Fig. 2. Comparisons of depression levels (A), systolic (B) and diastolic (C) blood pressure, pulse rate (D), and salivary cortisol
levels (E) in the intervention and control groups at 4 wk and 3 months after the intervention. f/u, follow up.
The decrease in diastolic blood pressure 4 wk after significantly greater in the intervention group than in
intervention commencement was significantly greater in the control group ( 7.4 vs. +0.5; P < 0.001).
the intervention group than in the control group ( 6.5 The decrease in pulse rate 4 wk after intervention
vs. +1.7; P < 0.001), and 3 months after commence- commencement was significantly greater in the interven-
ment of the intervention, the decrease was still tion group than in the control group ( 6.7 vs. +2.2;
6 Park et al.
P < 0.001), and 3 months after commencement of the studies have shown (27) that pharmacological interven-
intervention, the decrease was still significantly greater tion results in risk factors and adverse effects; notably,
in the intervention group than in the control group persistent dental anxiety relief has been found only
( 7.3 vs. +0.1; P = 0.002). from psychological interventions. Therefore, it is neces-
The decrease in salivary cortisol levels 4 wk after sary to use psychological intervention to alleviate den-
intervention commencement was significantly greater tal anxiety.
in the intervention group than in the control group The intervention group also exhibited reductions in
( 1.0 vs. 0.1; P = 0.007), and 3 months after com- symptoms of depression 4 wk and 3 months after start-
mencement of the intervention, the decrease was still ing the intervention, which is consistent with the results
significantly greater in the intervention group than in of a previous study in which patients with atopic der-
the control group ( 1.0 vs. +0.3; P = 0.002). matitis exhibited a significant decrease in depression
These results indicate that in both groups, dental symptoms 1 month after receiving muscle relaxation
anxiety, depression symptoms, systolic blood pressure, therapy twice daily for 4 wk (28). These results suggest
diastolic blood pressure, pulse rate, and salivary corti- that progressive muscle relaxation therapy effectively
sol levels had become reduced 4 wk after intervention alleviates depression stemming from dental anxiety.
commencement and that the effects of muscle relax- The authors of another study argued that depression
ation therapy lasted for at least 3 months. symptoms are strongly associated with dental anxiety
and that they have a stronger effect on particular types
of anxiety (7).
In patients who are extremely afraid of dental treat-
Discussion
ment, symptoms of depression are caused by a combi-
The present study examined the effects of progressive nation of subjective stress from past experiences and a
muscle relaxation therapy on periodontal patients’ den- negative emotional state. Participants treated using pro-
tal anxiety relief maintenance at 4 wk and 3 months gressive muscle relaxation therapy appear to experience
after intervention, and clearly demonstrated an associa- a positive emotional state repeatedly, which reduces
tion between progressive muscle relaxation therapy and dental anxiety, stabilizes patient behavior, and conse-
the relief of dental anxiety. This result is consistent quently ameliorates depression symptoms. Therefore, to
with that of a previous study which reported a signifi- reduce patients’ dental anxiety, dentists should be
cant decrease in anxiety in fracture patients who mindful of various psychological factors, particularly
received progressive muscle relaxation therapy every symptoms of depression.
morning and afternoon during hospitalization (13). The The intervention group in the present study exhibited
findings are also concordant with those of another a clinically significant decrease in salivary cortisol
study in which there was a significant reduction in anxi- levels. This is concordant with a previous study in
ety in patients with cancer who received therapy for which patients with breast cancer exhibited lower corti-
10 wk (26). sol levels after being administered therapy once per
Patients in the control group who did not receive week for 10 wk, whereas a control group that did not
progressive muscle relaxation therapy also experienced receive relaxation therapy exhibited an increase in corti-
a temporary decrease in dental anxiety at 4 wk post- sol levels (29). In the present study, because the two
intervention. However, at 3 months post-intervention, groups had similar gingival states and demographic
dental anxiety levels in the control group had increased characteristics, neither of these factors could have
again; by contrast, patients in the intervention group affected the variables evaluated. Therefore, progressive
continued to experience dental anxiety relief, which muscle relaxation therapy can effectively reduce stress
indicated the effectiveness of progressive muscle relax- and it appears to alleviate dental anxiety and help
ation therapy. The effects of therapy were observed to patients feel relaxed and calm, leading to decreased cor-
have lasted until 3 months post-intervention. On the tisol levels.
basis of these findings, it may be concluded that pro- There was a low drop-out rate in the present study
gressive muscle relaxation therapy administered on a (2.9%), and the LOCF method was used in cases of
long-term basis under constant monitoring to ensure missing data, for ITT analysis. Nevertheless, outcomes
moderation produces long-lasting positive effects. We did not differ between the ITT analyses with and with-
have found that the progressive muscle relaxation out the missing variables, perhaps because the study
response can facilitate stress relief in patients with den- used randomized allocation to prevent undue influence
tal anxiety. The DAS is an objective, reliable, and vali- by a third confounding factor and to minimize preju-
dated measure that is widely used in adult dental dice or bias, ensuring an objective and scientific
anxiety research worldwide. It evaluates dental anxiety approach toward evaluating the effect of progressive
using specific questions about the respondent’s dental muscle relaxation therapy on dental anxiety.
situation. The original study conducted by CORAH (16) The present study had several limitations. Because
demonstrated that the internal consistency of the dental the participants were enrolled from a single dental
anxiety questions was high (standardized Cronbach’s clinic, the generalizability of the intervention group,
a = 0.86), and therefore the scale can be considered as and consequently the external validity of the findings,
accurate. Psychological and pharmacological interven- may be limited. Psychological parameters, including
tions are effective in reducing dental anxiety. However, dental anxiety, were evaluated using self-reported
PMR therapy to treat dental anxiety 7
questionnaires and may therefore have been subjective. 11. LAMB DH, STRAND KH. The effect of a brief relaxation treat-
However, physiological indicators of anxiety, such as ment for dental anxiety on measures of state and trait anxi-
ety. J Clin Psychol 1980; 36: 270–274.
blood pressure, heart rate, and salivary cortisol levels, 12. ARMFIELD JM, HEATON LJ. Management of fear and anxiety
were objective. Studies involving longer follow-up peri- in the dental clinic: a review. Aust Dent J 2013; 58: 390–407.
ods are required to determine the duration of the 13. TAKAI N, YAMAGUCHI M, ARAGAKI T, ETO K, UCHIHASHI K,
effects of progressive muscle relaxation therapy. NISHIKAWA Y. Effect of psychological stress on the salivary
In the present study, the administration of progres- cortisol and amylase levels in healthy young adults. Arch Oral
Biol 2004; 49: 963–968.
sive muscle relaxation therapy over four sessions by a 14. PATIL SJ, SHAH PP, PATIL JA, SHIGLI A, PATIL AT, TAMAGOND
dental hygienist effectively alleviated dental anxiety in SB. Assessment of the changes in the stress-related salivary
periodontal patients for at least 3 months after the cortisol levels to the various dental procedures in children. J
intervention. Progressive muscle relaxation therapy can Indian Soc Pedod Prev Dent 2015; 33: 94–99.
15. LI Y, WANG R, TANG J, CHEN C, TAN L, WU Z, YU F, WANG
be used to relieve dental anxiety and stress in periodon- X. Progressive muscle relaxation improves anxiety and
tal patients. depression of pulmonary arterial hypertension patients. Evid
Based Complement Alternat Med 2015; 2015: 792895.
Acknowledgements – We are grateful to the survey respondents 16. CORAH NL. Development of a dental anxiety scale. J Dent
and wish to acknowledge the study assistants for their help with Res 1969; 48: 596.
patient interviews. 17. BECK AT, WARD CH, MENDELSON M, MOCK J, ERBAUGH J.
An inventory for measuring depression. Arch Gen Psychiatry
Conflict of interests – The authors have no conflict of interests to 1961; 4: 561–571.
declare. 18. FUKUI M, HINODE D, YOKOYAMA M, YOSHIOKA M, KATAOKA
K, ITO HO. Levels of salivary stress markers in patients with
anxiety about halitosis. Arch Oral Biol 2010; 55: 842–847.
19. GEORGIEV A, PROBST M, DE HERT M, GENOVA V, TONKOVA A,
VANCAMPFORT D. Acute effects of progressive muscle relaxation
References on state anxiety and subjective well-being in chronic Bulgarian
1. CARLSSON SG, WIDE BOMAN U, LUNDGREN J, HAKEBERG M. patients with schizophrenia. Psychiatr Danub 2012; 24: 367–372.
Dental anxiety - a joint interest for dentists and psychologists. 20. KIM BI, KWON HG, KIM SH, KIM YS, KIM HS, RO HJ. Text-
Eur J Oral Sci 2013; 121(3 Pt 2): 221–224. book of oral care products, 2nd edn. Seoul: Charm Yun Pub-
2. THOMA MV, ZEMP M, KREIENBUHL € L, HOFER D, SCHMIDLIN lishing, 2016; 1–195.
PR, ATTIN T, EHLERT U, NATER UM. Effects of music lis- 21. LAHMANN C, SCHOEN R, HENNINGSEN P, RONEL J, MUEHLBA-
CHER M, LOEW T, TRITT K, NICKEL M, DOERING S. Brief
tening on pre-treatment anxiety and stress levels in a dental
hygiene recall population. Int J Behav Med 2015; 22: 498– relaxation versus music distraction in the treatment of dental
505. anxiety. A randomized controlled clinical trial. J Am Dent
3. HUMPHRIS G, KING K. The prevalence of dental anxiety Assoc 2008; 139: 317–324.
across previous distressing experiences. J Anxiety Disord 22. HUGHES JW, FRESCO DM, MYERSCOUGH R, VAN DULMEN
2011; 25: 232–236. MH, CARLSON LE, JOSEPHSON R. Randomized controlled trial
4. SPINDLER H, STAUGAARD SR, NICOLAISEN C, POULSEN R. A of mindfulness-based stress reduction for prehypertension.
randomized controlled trial of the effect of a brief cognitive- Psychosom Med 2013; 75: 721–728.
behavioral intervention on dental fear. J Public Health Dent 23. LOE H, SILNESS J. Periodontal disease in pregnancy. I. Preva-
2015; 75: 64–73. lence and severity. Acta Odontol Scand 1963; 21: 533–551.
5. SANTUCHI CC, CORTELLI SC, CORTELLI JR, COTA LO, ALEN- 24. WILKINS EM. Clinical dental hygiene, 9th edn. Seoul: Daehan
CAR CO, COSTA FO. Pre- and post-treatment experiences of
Narae Publishing, 2007; 116–127.
fear, anxiety, and pain among chronic periodontitis patients 25. GREENSTEIN G. The role of bleeding upon probing in the
treated by scaling and root planing per quadrant versus diagnosis of periodontal disease. A literature review. J Peri-
one-stage full-mouth disinfection: a 6-month randomized odontol 1984; 55: 684–688.
controlled clinical trial. J Clin Periodontol 2015; 42: 1024– 26. BUTOW PN, BELL ML, SMITH AB, FARDELL JE, THEWES B,
1031. TURNER J, GILCHRIST J, BEITH J, GIRGIS A, SHARPE L, SHIH S,
6. JEONG H, JEONG JY, LEE DW. Dental sedation methods that MIHALOPOULOS C, MEMBERS OF THE CONQUER FEAR AUTHOR-
SHIP GROUP. Conquer fear: protocol of a randomised con-
dentists should know before opening an office. Seoul: Myeong-
mun Publishing, 2011; 325–327. trolled trial of a psychological intervention to reduce fear of
7. ANTTILA S, KNUUTTILA M, YLOSTALO€ P, JOUKAMAA M. Symp- cancer recurrence. BMC Cancer 2013; 13: 201.
toms of depression and anxiety in relation to dental health 27. DEVA PA. Strategies to manage patients with dental anxiety
behavior and self-perceived dental treatment need. Eur J Oral and dental phobia: literature review. Clin Cosmet Investig
Sci 2006; 114: 109–114. Dent 2016; 8: 35–50.
8. BERGSTROM€ J. Tobacco smoking and chronic destructive peri- 28. BAE BG, OH SH, PARK CO, NOH S, NOH JY, KIM KR, LEE
odontal disease. Odontology 2004; 92: 1–8. KH. Progressive muscle relaxation therapy for atopic der-
9. GOLEMAN D, GURIN J. Mind body medicine how to use your matitis: objective assessment of efficacy. Acta Derm Venereol
mind for better health. New York: Consumers Reports Book, 2012; 92: 57–61.
1993; 125–149. 29. PHILLIPS KM, ANTONI MH, LECHNER SC, BLOMBERG BB, LLA-
BRE MM, AVISAR E, GLUCK € S, DERHAGOPIAN R, CARVER CS.
10. MILLER MP, MURPHY PJ, MILLER TP. Comparison of elec-
tromyographic feedback and progressive relaxation training Stress management intervention reduces serum cortisol and
in treating circumscribed anxiety stress reactions. J Consult increases relaxation during treatment for nonmetastatic breast
Clin Psychol 1978; 46: 1291–1298. cancer. Psychosom Med 2008; 70: 1044–1049.