JAHANGIRNAGAR UNIVERSITY

Faculty of Biological Sciences

Department of Public Health and Informatics

Course Name: Biostatistics and Bioinformatics; Course Code: PHI 2205; Credit: 3.0; Year: 2nd Year 2nd Sem

Instructor Name: Lakshmi Rani Kundu; Email: lakshmi@juniv.edu

COURSE INFORMATION
Day & Time Monday: 12.00-12.50, Thursday: 11.00-11.50
Statistical analysis provides the methods to identify the patterns in the data and interpret
the findings in a public health context. The goal of biostatistics is to disentangle the data
Rationale received and make valid inferences that can be used to solve problems in public health.
In this course, students will learn the statistical methods that can be used in analyzing
health data and help in making inference.
.This course will help the students-
• To compute probabilities for various discrete and continuous probability
distributions;
• To demonstrate the sampling distribution of different statistics;
• To estimate population parameters (means and proportions) with high reliability
Course Objectives based on the information contained in the sample;
• To reach decisions about large body of data by examining only a small part of
the data;
• To develop knowledge about Bioinformatics concept;
• To realize Protein sequencing and genome mapping; and
• To know Protein structure and gene finding.
Successful completion of this course, students will be able to-
• Explain the similarities and differences between discrete and continuous
distributions and when the use of each is appropriate.
• Understand how to use a sampling distribution to calculate basic probabilities.
Learning Outcomes • Interpret a confidence interval from both a practical and a probabilistic
viewpoint.
• Correctly interpret results and draw valid conclusions based on hypothesis
testing;
• Calculate and interpret z, t, F, and chi-square test statistics for making statistical
inferences.
• Enrich knowledge about Bioinformatics concept.
• Understand Protein sequencing and structure

TEXT BOOKS
1. Daniel, W. W. & Cross C.L. (2013). Biostatistics: A Foundation for Analysis in the Health Sciences, 10th
ed., John Wiley & Sons, Inc.

REFERENCES
1. Chap T. Le & Eberly, L. E. (2016). Introductory Biostatistics, 2nd ed., John wiley and sons, Inc.,
Hoboken, New Jersey.
2. Bernard Rosner (2016). Fundamentals of Biostatistics, 8th ed., Cengage learning.
3. Prem S. Mann (2012). Introductory Statistics, 8th ed., Wiley.

CLASS ROOM RULES OF CONDUCT: CELLULAR PHONES SHOULD BE “TURNED OFF’/“SILENT MODE” DURING THE CLASS.

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COURSE CONTENTS & SCHEDULE
Lecture Topic Ref. Reading

1 Discrete probability distribution: Binomial distribution D- Chapter: 4 (Sec: 4.3, Page: 99)

2 Discrete probability distribution: Poisson distribution D- Chapter: 4 (Sec: 4.4, Page: 108)
3 Continuous probability distribution: Normal distribution D- Chapter: 4 (Sec: 4.6, Page: 116)
Continuous probability distribution: Standard normal
4 D- Chapter: 4 (Sec: 4.6, Page: 116)
distribution
5 Sampling distribution: Distribution of the sample mean D- Chapter: 5 (Sec: 5.2, 5.3; Page: 135)
Sampling distribution: Distribution of the sample
6 D- Chapter: 5 (Sec: 5.5, Page: 150)
proportion
7 Estimation: Confidence interval for population mean D- Chapter: 6 (Sec: 6.2, Page: 165)
Confidence interval for the difference between two
8 D- Chapter: 6 (Sec: 6.4, Page: 177)
population means
Confidence interval for a proportion and difference
9 D- Chapter: 6 (Sec: 6.5, 6.6 Page: 185)
between two proportion
1st Tutorial (20 Marks)

Hypothesis testing: Null and alternative hypothesis, level

D- Chapter: 7 (Sec: 7.1, 7.2, Page: 215,
10 of significance, p-value, Type I and Type II error, A
222)
single population mean (t-test and z-test)
Hypothesis testing: The difference between two
11 D- Chapter: 7 (Sec: 7.3, Page: 236)
population means
Hypothesis testing: A single population proportion and
12 difference between two population proportion D- Chapter: 7 (Sec: 7.5, 7.6; Page: 257)

13 Measures of association: Chi-square test Handout

14 Paired t-test D- Chapter: 7 (Sec: 7.4, Page: 249)

15 McNemar’s chi-square test Handout
nd
2 Tutorial (20 Marks)

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