Professional Documents
Culture Documents
11 Thalamic Atrophy and Cognition in Multiple Sclerosis
11 Thalamic Atrophy and Cognition in Multiple Sclerosis
uk/abstract/MED/17875909
Clear Search
Advanced Search
Houtchens MK, Benedict RH, Killiany R, Sharma J, Jaisani Z, Singh B, Weinstock-Guttman B, Guttmann CR, Bakshi R
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA.
Neurology [2007, 69(12):1213-23]
Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural
DOI: 10.1212/01.wnl.0000276992.17011.b5
OBJECTIVES: Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple
sclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strong
correlation with cognitive impairment, suggesting clinical relevance of damage to surrounding structures, such as the thalamus.
Previous imaging and pathology studies have demonstrated thalamic involvement in MS. In this study, we tested the hypothesis
that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function.
METHODS: We studied 79 patients with MS and 16 normal subjects. A subgroup of 31 MS subjects underwent cognitive testing.
The thalamus was segmented in whole from three-dimensional MRI scans. We also determined whole brain atrophy (brain
parenchymal fraction), third ventricular width, and whole brain T2-weighted (fluid-attenuated inversion recovery) hyperintense,
T1 hypointense, and gadolinium-enhanced lesion volumes.
RESULTS: Normalized thalamic volume was 16.8% lower in the MS group (p < 0.0001) vs controls. Cognitive performance in all
domains was moderately to strongly related to thalamic volume in the MS group (r = 0.506 to 0.724, p < 0.005), and thalamic
volume entered and remained in all regression models predicting cognitive performance. Thalamic volume showed a weak
relationship to physical disability score (r = -0.316, p = 0.005).
CONCLUSION: These findings suggest that thalamic atrophy is a clinically relevant biomarker of the neurodegenerative disease
process in multiple sclerosis.
Read Article at intl.neurology.org (Subscription required)
Brain atrophy as a marker of cognitive impairment in mildly disabling relapsing-remitting multiple sclerosis.
(PMID:18727673)
Short-latency afferent inhibition predicts verbal memory performance in patients with multiple sclerosis.
(PMID:18854915)
Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study.
(PMID:19022861)
Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures.
(PMID:19022862)
Deep gray matter T2 hypointensity correlates with disability in a murine model of MS.
(PMID:19162280)
3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis.
(PMID:19281850)
1 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data.
(PMID:19696139)
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis.
(PMID:19888926)
Thalamocortical sensorimotor circuit in multiple sclerosis: an integrated structural and electrophysiological assessment.
(PMID:20162580)
Cognition in multiple sclerosis: relevance of lesions, brain atrophy and proton MR spectroscopy.
(PMID:20635111)
Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis.
(PMID:15228758)
Benedict RH, Carone DA, Bakshi R
Journal of neuroimaging : official journal of the American Society of Neuroimaging [2004 Jul;14(3 Suppl):36S-45S]
2 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Multiple sclerosis.
(PMID:17226744)
Benedict RH, Bobholz JH
Seminars in neurology [2007 Feb;27(1):78-85]
The relationship between MRI and PET changes and cognitive disturbances in MS.
(PMID:16650436)
Sørensen PS, Jønsson A, Mathiesen HK, Blinkenberg M, Andresen J, Hanson LG, Ravnborg M
Journal of the neurological sciences [2006 Jun 15;245(1-2):99-102]
[Cognitive impairment].
(PMID:19361675)
Reuter F, Audoin B, Rico A, Malikova I, Ranjeva JP, Pelletier J
Revue neurologique [2009 Mar;165 Suppl 4:S113-22]
Role of MRI in multiple sclerosis II: brain and spinal cord atrophy.
(PMID:14766398)
Zivadinov R, Bakshi R
Frontiers in bioscience : a journal and virtual library [2004 Jan 1;9:647-64]
T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis.
(PMID:17425729)
Neema M, Stankiewicz J, Arora A, Dandamudi VS, Batt CE, Guss ZD, Al-Sabbagh A, Bakshi R
3 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Journal of neuroimaging : official journal of the American Society of Neuroimaging [2007 Apr;17 Suppl 1:16S-21S]
Cognitive loss in multiple sclerosis. Case reports and review of the literature.
(PMID:2644924)
Franklin GM, Nelson LM, Filley CM, Heaton RK
Archives of neurology [1989 Feb;46(2):162-7]
MRI relapses have significant pathologic and clinical implications in multiple sclerosis.
(PMID:17346748)
Traboulsee A
Journal of the neurological sciences [2007 May 15;256 Suppl 1:S19-22]
Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis.
(PMID:16385017)
Bakshi R, Dandamudi VS, Neema M, De C, Bermel RA
Journal of neuroimaging : official journal of the American Society of Neuroimaging [2005;15(4 Suppl):30S-45S]
[Disseminated sclerosis: organic basis for mental disorders and cognitive dysfunction].
(PMID:2006091)
4 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
[Memory in multiple sclerosis: review of performance and relationship with clinical variables and neuroimaging].
(PMID:9951032)
Porcel J, Barrios M, Borràs C, Guàrdia J
Revista de neurologia [1998 Dec;27(160):1034-42]
Brain and spinal cord atrophy in multiple sclerosis: role as a surrogate measure of disease progression.
(PMID:11524021)
Simon JH
CNS drugs [2001;15(6):427-36]
Brain reorganization during attention and memory tasks in multiple sclerosis: insights from functional MRI studies.
(PMID:16626753)
Mainero C, Pantano P, Caramia F, Pozzilli C
Journal of the neurological sciences [2006 Jun 15;245(1-2):93-8]
Relation between functional brain imaging, cognitive impairment and cognitive rehabilitation in patients with multiple sclerosis.
(PMID:17503130)
Penner IK, Opwis K, Kappos L
Journal of neurology [2007 May;254 Suppl 2:II53-7]
5 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
(PMID:17531854)
Zivadinov R, Cox JL
International review of neurobiology [2007;79:449-74]
Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis.
(PMID:16533137)
Tekok-Kilic A, Benedict RH, Zivadinov R
Expert review of neurotherapeutics [2006 Mar;6(3):323-31]
[Cognitive and emotional disorders in multiple sclerosis. Can a management strategy be envisioned?].
(PMID:10815288)
Pelletier J, Benoit N, Montreuil M, Habib M
Pathologie-biologie [2000 Mar;48(2):121-31]
6 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis.
(PMID:15949493)
Inglese M, Benedetti B, Filippi M
Journal of the neurological sciences [2005 Jun 15;233(1-2):15-9]
Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy.
(PMID:15228759)
Meier DS, Weiner HL, Khoury SJ, Guttmann CR
Journal of neuroimaging : official journal of the American Society of Neuroimaging [2004 Jul;14(3 Suppl):46S-53S]
Biomarkers and surrogate outcomes in neurodegenerative disease: lessons from multiple sclerosis.
(PMID:15717029)
Miller DH
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics [2004 Apr;1(2):284-94]
[The application of magnetic resonance imaging transfer to the study of multiple sclerosis patients: review and analysis of literature].
(PMID:12690734)
Grimaud J, Zhou LQ, Zhu YM
Revue neurologique [2002 Dec;158(12 Pt 1):1157-73]
Cognition and fatigue in multiple sclerosis: Potential effects of medications with central nervous system activity.
(PMID:16847774)
Oken BS, Flegal K, Zajdel D, Kishiyama SS, Lovera J, Bagert B, Bourdette DN
Journal of rehabilitation research and development [2006 Jan-Feb;43(1):83-90]
7 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Pain in Parkinson's disease and multiple sclerosis: its relation to the medial and lateral pain systems.
(PMID:16143170)
Scherder E, Wolters E, Polman C, Sergeant J, Swaab D
Neuroscience and biobehavioral reviews [2005;29(7):1047-56]
Brain atrophy in multiple sclerosis: what we know and would like to know.
(PMID:17262994)
Simon JH
Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Dec;12(6):679-87]
Measures of cognitive and emotional changes in multiple sclerosis and underlying models of brain dysfunction.
(PMID:16626747)
Gainotti G
Journal of the neurological sciences [2006 Jun 15;245(1-2):15-20]
8 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Measures of physical and cognitive function and work status among individuals with multiple sclerosis: a review of the literature.
(PMID:15794498)
Pompeii LA, Moon SD, McCrory DC
Journal of occupational rehabilitation [2005 Mar;15(1):69-84]
Neuropsychological evaluation and treatment of multiple sclerosis: the importance of a neuro-rehabilitation focus.
(PMID:15893679)
Pepping M, Ehde DM
Physical medicine and rehabilitation clinics of North America [2005 May;16(2):411-36, viii]
Cognitive function and cerebral assessment in patients who have Cushing's syndrome.
(PMID:15850847)
Bourdeau I, Bard C, Forget H, Boulanger Y, Cohen H, Lacroix A
Endocrinology and metabolism clinics of North America [2005 Jun;34(2):357-69, ix]
Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy
and lesion burden.
(PMID:14967771)
Benedict RH, Weinstock-Guttman B, Fishman I, Sharma J, Tjoa CW, Bakshi R
Archives of neurology [2004 Feb;61(2):226-30]
Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis.
9 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
(PMID:11843699)
Bermel RA, Bakshi R, Tjoa C, Puli SR, Jacobs L
Archives of neurology [2002 Feb;59(2):275-80]
Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis.
(PMID:16966509)
Benedict RH, Bruce JM, Dwyer MG, Abdelrahman N, Hussein S, Weinstock-Guttman B, Garg N, Munschauer F, Zivadinov R
Archives of neurology [2006 Sep;63(9):1301-6]
Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis.
(PMID:16900757)
Brass SD, Benedict RH, Weinstock-Guttman B, Munschauer F, Bakshi R
Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Aug;12(4):437-44]
Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results
from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) study.
(PMID:19542262)
Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Goretti B, Caniatti L, Di Monte E, Ferrazza P, Brescia Morra V, Lo Fermo S, Picconi O,
Luccichenti G, COGIMUS Study Group
Multiple sclerosis (Houndmills, Basingstoke, England) [2009 Jul;15(7):779-88]
T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study.
(PMID:11790232)
Bakshi R, Benedict RH, Bermel RA, Caruthers SD, Puli SR, Tjoa CW, Fabiano AJ, Jacobs L
Archives of neurology [2002 Jan;59(1):62-8]
Brain atrophy and lesion load as explaining parameters for cognitive impairment in multiple sclerosis.
(PMID:16193889)
Lazeron RH, Boringa JB, Schouten M, Uitdehaag BM, Bergers E, Lindeboom J, Eikelenboom MI, Scheltens PH, Barkhof F, Polman CH
Multiple sclerosis (Houndmills, Basingstoke, England) [2005 Oct;11(5):524-31]
Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis.
(PMID:19752305)
Calabrese M, Agosta F, Rinaldi F, Mattisi I, Grossi P, Favaretto A, Atzori M, Bernardi V, Barachino L, Rinaldi L, Perini P, Gallo P, Filippi M
Archives of neurology [2009 Sep;66(9):1144-50]
Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis.
(PMID:18725589)
Amato MP, Portaccio E, Stromillo ML, Goretti B, Zipoli V, Siracusa G, Battaglini M, Giorgio A, Bartolozzi ML, Guidi L, Sorbi S, Federico A, De Stefano
N
Neurology [2008 Aug 26;71(9):632-8]
Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy.
(PMID:14732374)
Taylor I, Butzkueven H, Litewka L, MacGregor LR, Szoeke C, Cook M, Mitchell P, Kilpatrick TJ, Tubridy N
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [2004 Feb;11(2):153-8]
The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with
multiple sclerosis.
(PMID:10987895)
Berg D, Mäurer M, Warmuth-Metz M, Rieckmann P, Becker G
Archives of neurology [2000 Sep;57(9):1289-92]
MRI techniques and cognitive impairment in the early phase of relapsing-remitting multiple sclerosis.
10 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
(PMID:11338408)
Zivadinov R, De Masi R, Nasuelli D, Bragadin LM, Ukmar M, Pozzi-Mucelli RS, Grop A, Cazzato G, Zorzon M
Neuroradiology [2001 Apr;43(4):272-8]
Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study.
(PMID:11176944)
Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL
Archives of neurology [2001 Jan;58(1):115-21]
Brain atrophy in relapsing-remitting multiple sclerosis: relationship with 'black holes', disease duration and clinical disability.
(PMID:10727693)
Paolillo A, Pozzilli C, Gasperini C, Giugni E, Mainero C, Giuliani S, Tomassini V, Millefiorini E, Bastianello S
Journal of the neurological sciences [2000 Mar 15;174(2):85-91]
The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study.
(PMID:14616292)
Lin X, Blumhardt LD, Constantinescu CS
Acta neurologica Scandinavica [2003 Dec;108(6):401-6]
Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shortening.
(PMID:17690319)
Janardhan V, Suri S, Bakshi R
Radiology [2007 Sep;244(3):823-31]
The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with
misclassification correction.
(PMID:15961046)
Sanfilipo MP, Benedict RH, Sharma J, Weinstock-Guttman B, Bakshi R
NeuroImage [2005 Jul 15;26(4):1068-77]
Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis.
(PMID:11030802)
Janardhan V, Bakshi R
Archives of neurology [2000 Oct;57(10):1485-91]
Association of neocortical volume changes with cognitive deterioration in relapsing-remitting multiple sclerosis.
(PMID:17698706)
Amato MP, Portaccio E, Goretti B, Zipoli V, Battaglini M, Bartolozzi ML, Stromillo ML, Guidi L, Siracusa G, Sorbi S, Federico A, De Stefano N
Archives of neurology [2007 Aug;64(8):1157-61]
Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis.
(PMID:16534104)
Sanfilipo MP, Benedict RH, Weinstock-Guttman B, Bakshi R
Neurology [2006 Mar 14;66(5):685-92]
11 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Cognitive decline in multiple sclerosis: impact of topographic lesion distribution on differential cognitive deficit patterns.
(PMID:19667010)
Tiemann L, Penner IK, Haupts M, Schlegel U, Calabrese P
Multiple sclerosis (Houndmills, Basingstoke, England) [2009 Oct;15(10):1164-74]
White matter and lesion T1 relaxation times increase in parallel and correlate with disability in multiple sclerosis.
(PMID:12242554)
Parry A, Clare S, Jenkinson M, Smith S, Palace J, Matthews PM
Journal of neurology [2002 Sep;249(9):1279-86]
Determination of ventricular diameters in multiple sclerosis patients with transcranial sonography (TCS)--a two year follow-up study.
(PMID:14999486)
Kallmann BA, Sauer J, Schliesser M, Warmuth-Metz M, Flachenecker P, Becker Dagger G, Rieckmann P, Mäurer M
Journal of neurology [2004 Jan;251(1):30-4]
Cognitive reserve moderates the negative effect of brain atrophy on cognitive efficiency in multiple sclerosis.
(PMID:19573279)
Sumowski JF, Chiaravalloti N, Wylie G, Deluca J
Journal of the International Neuropsychological Society : JINS [2009 Jul;15(4):606-12]
Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis.
(PMID:19687451)
Zivadinov R, Weinstock-Guttman B, Hashmi K, Abdelrahman N, Stosic M, Dwyer M, Hussein S, Durfee J, Ramanathan M
Neurology [2009 Aug 18;73(7):504-10]
Cognitive impairment in patients with relapsing-remitting multiple sclerosis. The correlation with MRI lesion volume.
(PMID:19105110)
Karlińska I, Siger M, Lewańska M, Selmaj K
Neurologia i neurochirurgia polska [2008 Sep-Oct;42(5):416-23]
Brain atrophy as a marker of cognitive impairment in mildly disabling relapsing-remitting multiple sclerosis.
(PMID:18727673)
Sánchez MP, Nieto A, Barroso J, Martín V, Hernández MA
European journal of neurology : the official journal of the European Federation of Neurological Societies [2008 Oct;15(10):1091-9]
Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship to
clinical findings.
(PMID:11296581)
Bakshi R, Benedict RH, Bermel RA, Jacobs L
Journal of neuroimaging : official journal of the American Society of Neuroimaging [2001 Apr;11(2):129-36]
[Magnetic resonance imaging correlates of cognitive dysfunction in patients with multiple sclerosis].
(PMID:10935260)
12 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Filippi M
Revista de neurologia [2000 Jun 16-30;30(12):1253-6]
Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings.
(PMID:12810771)
Piras MR, Magnano I, Canu ED, Paulus KS, Satta WM, Soddu A, Conti M, Achene A, Solinas G, Aiello I
Journal of neurology, neurosurgery, and psychiatry [2003 Jul;74(7):878-85]
Volumes of brain atrophy and plaques correlated with neurological disability in secondary progressive multiple sclerosis.
(PMID:10426145)
Dastidar P, Heinonen T, Lehtimäki T, Ukkonen M, Peltola J, Erilä T, Laasonen E, Elovaara I
Journal of the neurological sciences [1999 May 1;165(1):36-42]
T1 lesion load and cerebral atrophy as a marker for clinical progression in patients with multiple sclerosis. A prospective 18 months follow-up
study.
(PMID:11509079)
Sailer M, Losseff NA, Wang L, Gawne-Cain ML, Thompson AJ, Miller DH
European journal of neurology : the official journal of the European Federation of Neurological Societies [2001 Jan;8(1):37-42]
Thalamic atrophy in Huntington's disease co-varies with cognitive performance: a morphometric MRI analysis.
(PMID:15459079)
Kassubek J, Juengling FD, Ecker D, Landwehrmeyer GB
Cerebral cortex (New York, N.Y. : 1991) [2005 Jun;15(6):846-53]
Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis.
(PMID:17938370)
Gordon-Lipkin E, Chodkowski B, Reich DS, Smith SA, Pulicken M, Balcer LJ, Frohman EM, Cutter G, Calabresi PA
Neurology [2007 Oct 16;69(16):1603-9]
Neuropsychological and MRI measures predict short-term evolution in benign multiple sclerosis.
(PMID:19641173)
Portaccio E, Stromillo ML, Goretti B, Zipoli V, Siracusa G, Battaglini M, Giorgio A, Bartolozzi ML, Guidi L, Sorbi S, Federico A, Amato MP, De Stefano
N
Neurology [2009 Aug 18;73(7):498-503]
Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation.
(PMID:15205136)
Sharma J, Sanfilipo MP, Benedict RH, Weinstock-Guttman B, Munschauer FE 3rd, Bakshi R
AJNR. American journal of neuroradiology [2004 Jun-Jul;25(6):985-96]
Gray matter atrophy in patients with ischemic stroke with cognitive impairment.
(PMID:18258824)
Stebbins GT, Nyenhuis DL, Wang C, Cox JL, Freels S, Bangen K, deToledo-Morrell L, Sripathirathan K, Moseley M, Turner DA, Gabrieli JD, Gorelick
PB
Stroke; a journal of cerebral circulation [2008 Mar;39(3):785-93]
13 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
An fMRI study of planning-related brain activity in patients with moderately advanced multiple sclerosis.
(PMID:15471372)
Lazeron RH, Rombouts SA, Scheltens P, Polman CH, Barkhof F
Multiple sclerosis (Houndmills, Basingstoke, England) [2004 Oct;10(5):549-55]
Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients.
(PMID:11266686)
Bakshi R, Dmochowski J, Shaikh ZA, Jacobs L
Journal of the neurological sciences [2001 Mar 15;185(1):19-26]
Brain atrophy in multiple sclerosis: impact of lesions and of damage of whole brain tissue.
(PMID:12356208)
Kalkers NF, Vrenken H, Uitdehaag BM, Polman CH, Barkhof F
Multiple sclerosis (Houndmills, Basingstoke, England) [2002 Oct;8(5):410-4]
Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS.
(PMID:10680783)
Blinkenberg M, Rune K, Jensen CV, Ravnborg M, Kyllingsbaek S, Holm S, Paulson OB, Sørensen PS
Neurology [2000 Feb 8;54(3):558-64]
Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy.
(PMID:18829629)
Benedict RH, Ramasamy D, Munschauer F, Weinstock-Guttman B, Zivadinov R
Journal of neurology, neurosurgery, and psychiatry [2009 Feb;80(2):201-6]
The relationship between inflammation and atrophy in clinically isolated syndromes suggestive of multiple sclerosis: a monthly MRI study after
triple-dose gadolinium-DTPA.
(PMID:15083288)
Paolillo A, Piattella MC, Pantano P, Di Legge S, Caramia F, Russo P, Lenzi GL, Pozzilli C
Journal of neurology [2004 Apr;251(4):432-9]
Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis.
(PMID:17673493)
Lin X, Tench CR, Morgan PS, Constantinescu CS
Journal of neurology, neurosurgery, and psychiatry [2008 Apr;79(4):437-41]
Cognitive impairment in relapsing-remitting multiple sclerosis can be predicted by imaging performed several years earlier.
(PMID:17986503)
Summers M, Fisniku L, Anderson V, Miller D, Cipolotti L, Ron M
Multiple sclerosis (Houndmills, Basingstoke, England) [2008 Mar;14(2):197-204]
14 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Neocortical volume decrease in relapsing-remitting multiple sclerosis with mild cognitive impairment.
(PMID:16631794)
Portaccio E, Amato MP, Bartolozzi ML, Zipoli V, Mortilla M, Guidi L, Siracusa G, Sorbi S, Federico A, De Stefano N
Journal of the neurological sciences [2006 Jun 15;245(1-2):195-9]
Thalamic involvement and its impact on clinical disability in patients with multiple sclerosis: a diffusion tensor imaging study at 3T.
(PMID:19369608)
Tovar-Moll F, Evangelou IE, Chiu AW, Richert ND, Ostuni JL, Ohayon JM, Auh S, Ehrmantraut M, Talagala SL, McFarland HF, Bagnato F
AJNR. American journal of neuroradiology [2009 Aug;30(7):1380-6]
Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis.
(PMID:10644780)
Filippi M, Tortorella C, Rovaris M, Bozzali M, Possa F, Sormani MP, Iannucci G, Comi G
Journal of neurology, neurosurgery, and psychiatry [2000 Feb;68(2):157-61]
Brain atrophy and lesion load in a large population of patients with multiple sclerosis.
(PMID:16043800)
Tedeschi G, Lavorgna L, Russo P, Prinster A, Dinacci D, Savettieri G, Quattrone A, Livrea P, Messina C, Reggio A, Bresciamorra V, Orefice G,
Paciello M, Brunetti A, Coniglio G, Bonavita S, Di Costanzo A, Bellacosa A, Valentino P, Quarantelli M, Patti F, Salemi G, Cammarata E, Simone IL,
Salvatore M, Bonavita V, Alfano B
Neurology [2005 Jul 26;65(2):280-5]
Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction.
(PMID:17263004)
Lazeron RH, de Sonneville LM, Scheltens P, Polman CH, Barkhof F
Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Dec;12(6):760-8]
Brain MRI lesions and atrophy are related to depression in multiple sclerosis.
(PMID:10817583)
Bakshi R, Czarnecki D, Shaikh ZA, Priore RL, Janardhan V, Kaliszky Z, Kinkel PR
Neuroreport [2000 Apr 27;11(6):1153-8]
Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple
sclerosis.
(PMID:17524670)
Tekok-Kilic A, Benedict RH, Weinstock-Guttman B, Dwyer MG, Carone D, Srinivasaraghavan B, Yella V, Abdelrahman N, Munschauer F, Bakshi R,
Zivadinov R
NeuroImage [2007 Jul 15;36(4):1294-300]
Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis.
(PMID:9267977)
Hohol MJ, Guttmann CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL
Archives of neurology [1997 Aug;54(8):1018-25]
Magnetic resonance imaging measures of brain and spinal cord atrophy correlate with clinical impairment in secondary progressive multiple
sclerosis.
(PMID:18632782)
Furby J, Hayton T, Anderson V, Altmann D, Brenner R, Chataway J, Hughes R, Smith K, Miller D, Kapoor R
15 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis.
(PMID:17623735)
Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL
Multiple sclerosis (Houndmills, Basingstoke, England) [2007 Sep;13(8):1004-10]
Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects.
(PMID:11437165)
Zorzon M, de Masi R, Nasuelli D, Ukmar M, Mucelli RP, Cazzato G, Bratina A, Zivadinov R
Journal of neurology [2001 May;248(5):416-21]
Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis.
(PMID:18556361)
Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR
AJNR. American journal of neuroradiology [2008 Sep;29(8):1465-70]
Infratentorial hypointense lesion volume on T1-weighted magnetic resonance imaging correlates with disability in patients with chronic cerebellar
ataxia due to multiple sclerosis.
(PMID:11440742)
Hickman SJ, Brierley CM, Silver NC, Moseley IF, Scolding NJ, Compston DA, Miller DH
Journal of the neurological sciences [2001 Jun 15;187(1-2):35-9]
T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis.
(PMID:19482861)
Ceccarelli A, Filippi M, Neema M, Arora A, Valsasina P, Rocca MA, Healy BC, Bakshi R
Multiple sclerosis (Houndmills, Basingstoke, England) [2009 Jun;15(6):678-86]
Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis.
(PMID:10696031)
Rovaris M, Filippi M, Minicucci L, Iannucci G, Santuccio G, Possa F, Comi G
AJNR. American journal of neuroradiology [2000 Feb;21(2):402-8]
Whole-brain atrophy in multiple sclerosis measured by two segmentation processes from various MRI sequences.
(PMID:14607319)
Horsfield MA, Rovaris M, Rocca MA, Rossi P, Benedict RH, Filippi M, Bakshi R
Journal of the neurological sciences [2003 Dec 15;216(1):169-77]
Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis.
(PMID:9702685)
Filippi M, Mastronardo G, Rocca MA, Pereira C, Comi G
Journal of the neurological sciences [1998 Jun 30;158(2):148-53]
16 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL.
(PMID:17620550)
Viswanathan A, Gschwendtner A, Guichard JP, Buffon F, Cumurciuc R, O'Sullivan M, Holtmannspötter M, Pachai C, Bousser MG, Dichgans M,
Chabriat H
Neurology [2007 Jul 10;69(2):172-9]
[Reduced signal intensity of T2 weighted MR imaging of thalamus and putamen in multiple sclerosis in Japan].
(PMID:11186904)
Nishii T, Hirata A, Masaki T, Kaida K, Nakamura R, Motoyoshi K, Kamakura K
Rinsho shinkeigaku = Clinical neurology [2000 Jul;40(7):677-82]
Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS.
(PMID:16360321)
Morgen K, Sammer G, Courtney SM, Wolters T, Melchior H, Blecker CR, Oschmann P, Kaps M, Vaitl D
NeuroImage [2006 Apr 15;30(3):891-8]
Memory performance in multiple sclerosis patients correlates with central brain atrophy.
(PMID:16900756)
Hildebrandt H, Hahn HK, Kraus JA, Schulte-Herbrüggen A, Schwarze B, Schwendemann G
Multiple sclerosis (Houndmills, Basingstoke, England) [2006 Aug;12(4):428-36]
Back to results
Formats
Abstract
Full Text
PDF
Search by Subject
Adult
Age Factors
Atrophy
Cognition Disorders
Disability Evaluation
Female
Humans
Immunologic Factors
Male
Middle Aged
Multiple Sclerosis
Neuropsychological Tests
17 of 18 5/19/2011 8:56 PM
Thalamic atrophy and cognition in multiple sclerosis. - Abstract - UK Pu... http://ukpmc.ac.uk/abstract/MED/17875909
Regression Analysis
Sex Factors
Thalamus
Third Ventricle
UK PubMed Central is a service of the UKPMC Funders Group working in partnership with the British Library, University of Manchester and the European Bioinformatics Institute in
cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine (NCBI/NLM). It includes content provided to the PubMed Central
International archive by participating publishers.
18 of 18 5/19/2011 8:56 PM