N GENE PROTEIN SEQUENCE

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1. MMP2 72kDa type IV Collagenase AF-P08253-F1 Initiates a primary innate immune
response by inducing mitochondrial-
nuclear stress signaling with
activation of the pro-inflammatory
NF-kappaB,NFAT and IRF
transcriptional pathways.
2. MMP9 Matrix Metalloproteinase AF-P14780-F1 Plays role in bone osteoclastic
resorption.
3. MAPK10 Mitogen Activated Protein AF-P53779-F1 Signals pathways for extracellular
Kinase 10 stimuli such as proinflammatory
cytokines
4. MAP2K4 Dual specificity mitogen AF-P45985-F1
activated protein kinase
kinase 4
5. MAP2K7 Dual specificity mitogen AF-O14733-F1
activated protein kinase
kinase 7
6. NMI N-myc-interactor AF-Q13287-F1 NMI activates NF-kappa-B
signaling adjacent macrophages
through toll-like receptors 4/TLR4
7. CCL20 C-C Motif chemokine 20 AF-P78556-F1
8. CCL22 C-C Motif chemokine 22 AF-O00626-F1
9. CCL3 C-C Motif chemokine 3 AF-P10147-F1 It’s a monokine with inflammatory
and chemokinetic properties
10. CXCL8 Interleukine-8 IL-8 AF-P10145-F1 Responsible for the binding of the
proinflammatory cytokine IL-18
11. IL-18R1 Interleukin 18 receptor 1 AF-Q13478-F1
12. NLRP3 NACHT, LRR and PYD AF-Q96P20-
Domains containing protein 3 F1
13. CARD Caspase recruitment domain AF-Q5XLA6- Regulates procaspase-1/CASP1
17 containing protein 17 F1 activation implication in the
regulation of the proteolytic
maturation of pro-IL-1β and its
release during inflammation.
14. MZBI Marginal Zone B- and B1- AF-Q8WU39- Acts as a hormone regulated
Cell-Specific Protein F1 adipokine/proinflammatory
cytokines that is implicated in
causing chronic inflammation.
15. NLRC4 NLR Family CARD Domain AF-Q9NPP4- It’s a component of inflammasomes
Containig Protein 4 F1 that indirectly senses specific
proteins from pathogenic bacteria
and fungi and responds by
assembling an inflammasome
complex that promotes caspase-1
activation, cytokines production and
macrophage pyroptosis.