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PAPER ID-420368 Subject Code: BP605T

Roll No:

BPHARMA
(SEM VI) THEORY EXAMINATION 202-22
PHARMACEUTICAL BIOTECHNOLOGY- THEORY
Time: 3 Hours
Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then
choose suitably.

SECTION: A
1. Attempt all questions in brief. 10 x 2 = 20
Name any two methods of Enzyme Immobilization.
b What is the role of transducers in Biosensor?
DNALigase and Restriction Endonuclease enzymes are
used for which purpose?
d. Give two applications of Genetic Engineering in medicine.
e. Define the term Immunitý.
f Name the immunoglobulin which is responsible .for Rh immune
response
g. Give full form of ELISA, Give its application also.
h Differentiate between Mutants &Mutagens. 92
i Who discovered Penicillin? Why it is more effective against Gram Positive
Bacteria?
Define Fermentation. Give two examples of Fermenter.

sCTION: B
2. Attempt any two parts of the following: 2x 10 = 20
Explain in detail biotechnological production of hormone Insulin by usinig rDNA technology.
b Discuss Hybridoma Technology in detail. Add a note on the applicions of hybridoma
technology.
Write a descriptive note on i) ELISA ii) Western Bletting Technique

SECTION:C
3. Attempt any five partsof the following: 7x5=35
a. Describe the principle of Biosensor. Explain different types of biosensors.
b. Explain the production of enzyme Amylase, or Protease. Discuss their applications also.
C. Differentiate between Eukaryotic ahd Prokaryotic genome with the help of diagram.

d. Classify Immunity.Compare and oontrast Cellular &Humoral Immunity.

What do you understand by Interferon? Write a descriptive note on Polymerase Chain Reaction
r (PCR)
f What are the different types of fermentation methods? Discuss.
Givebasic principles of genetic engineering.

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PAPÉR ID-420877
Subject Code: BP601T
Roll No:a 2 ooo sooo|3
BPHARMA
(SEM I) THEORY EXAMINATION 2021-22
MEDICINAL CHEMISTRY III-THEORY
Time: 3 Hours
Total Marks: 75
Note: Attempt all Sections. If require any missing data; then choose suitably.

SECTION A
1. Attempt allquestions in brief. 10x 2 = 20
a. What is B-lactam antibiotics? Give some examples.
b. Draw the chemical structures of
minocycline and doxycycline.
C. Write the mechanism of action of Chloramphenicol.
d. Define prodrugs with examples.
Enlist urinary tract anti-infective agents.
f Write the mode of action and uses of zidovudine.
Write mode of action and synthesis of isoriazid.
h. Define anthelmintic agents. Write the synthesis of Mebendazole.
1. Define OSAR.
j. Describe applications of combinarorial Chemistry.

SECTION B
2,. Attempt any two parts of the following: 2 x 10 = 20
Discuss in detail about cephalosporins with suitable examples.
b. Explain SAR of tetracycline. Discuss its mechanism of action and hses.
C. Describe structure activity relationship of 4-amino quinolon. Explain mechanism of action and
synthesis of Chloroquine.

SECTION¢}
3. Attempt any five parts of the foliowing 7x5=35
a. Explain substituent hydophobicity constant in relation to drug design.
b Explain in detail about aminoglycosides with examples.
C. Discuss chemistry, classification and SAR of Sulfonamides with suitable examples.
d. Classify synthetic antifungal agents. Describe mechanism of action, synthesis and uses of
Miconazole.

Define combinatorial chemistry and explain in detail about solid phase synthesis.
f Define and classify anti tubercular agents. Explain in detail with suitable example.
Describe the synthesis and uses of Acyclovir, Ciprofloxacin and Dapsone.
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Subject Code: BP603T
PAPER ID-420838
Roll No:

BPHARMA
(SEM VI) THEORY EXAMINATION 2021-22
HERBAL DRUG TECHNOLOGYTHEORY
Time: 3 Hours
Total Marks: 75
Note: 1. Atempt all Sections. If require any missing data; then choose suitably.
SECTION: A
1. Attempt all questions. 10 x 2 = 20
a. Define herb and herbal medicine
b What do you mean by Bio-insecticides?
C. Define neutraceuticals.
d. Write botanical source and uses of Feenugreek.
e. What are viscosity builders? Give çxample.
f. What is the significane of natural colorants? Give example of one natural colorant.
g. Define Patent.
h. Differentiate between bioprospecting and biopiray,
i. What are bleaching agent?
Gives twoexamples of natural sweeteners,)

SECTION: B
2. Attempt any twoparts of the following: "2x 10 =20
a. Write an exhaustive note on WHO guidelines on Quality Control of herbs.
b. What do you mean by GMP? Write its components and objectives /n detail.
9 0 6 :

C. What is herb-drug interaction? Discuss with examples.

SECTION: C
3. Attempt any five parts of the following: 7x5=35

as Write about principles of Ayurveda and Homeopáthy systems of medicines.

b: Write a note on nutraceuticals.
c.'| Write an exhaustive note on excipients, their individual significance along with
exarmples.
d. What are IPR? Give its types, Explain in detail about the case of biopiracy of Neem.
e. Write composition of ASU-DTABand ASU-DCC and their responsibilities.
f. What are Novel Dosage forms? How they differ from conventional dosage forms?
Explain phytosomes in detail.
g.1 Write a note on Arishtha or Bhasams.
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Subject Code: BP602T
PAPER ID-420124
Roll No:

BPHARMA
(SEM VI) THEORY EXAMINATION 2021-22
PHARMACOLOGY III THEORY
Time: 3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.
SECTION A
1. Attempt all questions in brief. 110 x2= 20
a.Mention four antidiarrhoeal drugs.
b. Define genotoxicity.
C. What is biosimilars?
Enlist nonsystemic antacids.
e. What is biological clock?
f. How does cotrimoxazole acts in our body?
g. Suggest antidote for heavymetal poisoning.
h. Mention few examples of uses of corticosteroids.
i. Name the drugs used in the treatment of leprosy.
Definechronotherapy and rhythm.
SECTION B(
2. Attempt any two parts of the following: 2x 10 =20
a. Classify antiemetics. Explain mechanismof action, uses and side effects of
domperidone.
b. Narrate the various reasons for drug resistänce and suggest some measures to
them.
C. Explain the various categories of antitubercular drugs with examples-and their
mechanism of.action. What is DOTS therapy?
SECTION C
3. Attempt any five parts of the following: 7x5=35
a. What is bronchial asthma? Classify the drugs used for its treatment suggesting their
mechanism of action.
b. Briefly narrate the various categories of antibiotics Suggesting their mechanism of
action with examples.
C.Write an exhaustive note on Sexually transmitted-diseases.
d. Illustrate with suitable examples the various typesi¡fimmunostimulants.
e. Explain the clinical symptoms and management of barbituratesand arsenic poisoning.
f Write short notes on:
i. Acute and chronic toxicity
ii. Protein drugs
g. Explain the mechanism of action, side effects and therapeutic uses of alkylating agents.
 Printed rage: Iof i
Subject Code: BP604T
PAPER ID-420235
Roll No:

BPHARMA
(SEM VI) THEORY EXAMINATION 2021-22
BIOPHARMACEUTICS AND PHARMACOKINETICS -THEORY
Timè3 Hours Total Marks: 75
Note: 1. Attempt all Sections. If require any missing data; then choose suitably.

SECTION A
1. Attempt all questions in brief. 10 x 2 = 20
a Classify different types of pharmacokihetic models.
b. Compare absolute bioavailability yth relative bioavailability.
C. Define clearance. What are its units?
d. Define volume of distribution.
What are the advantages of IV infusion injection?
f Enumerate the factors affecting drug absorption.
g. Mention the non-renal routes of drug excretion of drugs.
h. How willyou define steady state drug levels?
i. Define Nonlinear Pharmacokinetics.
i Enlist the various methods to enhancethe dissolution rates of poorly soluble drugs.
1 0 3 . 1 :

SECTIONB
2 x 10= 20
2. Attempt any twc parts of the following:
a Discuss the various mechanismsof drug absorption through GIT.
b. Howv willyou calculate loading dose? Discuss its role in maintenance of dose.
C. Describe Michaelis-menton method of estimating pharmacokineticparameters.

SECTION¢
7x5=35
3. Atempt any five parts of the following:
a. Describe the various factors causing non-linearity.
absorption rate
b. Write a detailed note on WagnerNelson method for the calculation of
constant for extravascular administrátion.
model.
c. Explain in detail the plasma level time curve for a two compartment open
renal excretion of drugs.
d. What do you mean by drug metabolism? Explain factors affecting
assessment.
e. Enumerate the objectives of bioavailability. Discuss the direct methods for tis
Give the kinetics of protein binding along with its clinical significance.
g. What is AUC? Describe the trapezoidal method for its
calculation.
 PAPER ID-420492
Subject Code: BP606T
Roll No: T3
BPHARMA
(SEM VI) THEORY
Time: 3 Hours
EXAMINATION
QUALITY ASSURANCE- THEORY2021-22
Note: 1. Attempt all Sections. If Total Marks: 75
require any missing data; then' choose suitably.
1. SECTION A
a.
Attempt all questions in brief.
Define the term 10 x 2 = 20
b. Calibration.
Compare the qualification and validation of
C. What is the definition of instruments.
d. Quality by desigri (QbD).
Define the Quality Control.
e.
Outline the role of quality
f. Define the applications
documentation in pharmaceutical industries.
of Q-series guidelines in quality control and
g. List the requirements for good assurance.
h.
laboratory practices.
Summarize the role of environmentalcontrol for
quality control.
1. Define Batch formula record.
P 2 2 E 1

Define the term GMP.

SECTION B
3
2.
Attempt any two parts of the following: 2x 10= 20
Write the principles and procedures of NABL Accreditation.
b. Write a note on Total Quality
management.
C. Discuss the types of validation processes with their
importane and the scope.
SECTION C
3. Attempt any five partsof the following: 7x5=35
a. Explain the ISO 9000 guidelines.
b. Discuss the procedure for maintenance of sterile areas and control of
pharmaceutical industries. contamination in
C. Write a note on Master formula record and SOP.
d. Define complaints. Discuss the procedure for evaluation of complaints.
e. Discuss the General Provisions of Good Laboratory Practices.
f. Construct a short note on good warehousing practices.
g. Outline the concept of total quality management with its elements and philosophies.