suppositories -

Formulation
Considerations
Drug vs . Base Approximate Drug
Conceptual Illustration
Characteristics Release Rate

Oil-soluble drug with Oily

base
slaw release; poor escaping

tendency
⑳
Water-soluble drug with
Sily base
Rapid release

⑳
Oil-soluble
water
drug with
miscible base
Moderate release rate
⑳ ⑧ 8o
Water-miscible drug with
water miscible base
Moderate release; based
diffusion ; all water soluble
on

⑳ 30 mins

Suppositories Types -

of Bases

Base Type Description Release Examples

Fatty
/ -
Melting point slightly -
Melts in 3 - 7 -
CocoaButter (melts too
Oleaginous lower than body temp .
Mins between rapidly polymorphic)
,

Storage : Refrigerated 310C and 37 C Synthetic Triglycerides

°
e
,
g
- - .

·
below 25 C Rapid Fattibase, Witepsol Wecobee
°
or -

Hydrophilic drugs
formulated in these

Water - Dissolve in available -

Do notmelt-Glycerinated Gelatin (laxative
,
Soluble Volume of rectal flvid -
Dissolves in vaginal inserts)
-

Storage : Room 30-50 minutes -

PEG Polymers (of varying

D
temperature -
Slow molecular weights which
-

Lipophilic drugs determine melting temp ) .

formulated in these