PATIENT-CENTERED DRUG STUDY/ ANALYSIS

PATIENT’S INFORMATION
Name of Patient: Patient R.C.E Age: 70 Sex: Female Chief Complaint: Abdominal Pain
Diagnosis: T/C Paralytic Ileus; Colonic Diverticulitis; Erosive Gastritis;T/C CAP MR; Hypertension St.II
uncontrolled

DRUG INFORMATION
Drug Classification: Prokinetic Agents Generic Name: Prucalopride
Dosage: 1mg TAB OD Brand Name: Motegrity, Resolor, Resotran
Route of Administration: PO

MODE/ MECHANISM OF ACTION

Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG
channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs.

INDICATION
Prucalopride is indicated for the treatment of chronic
idiopathic constipation (CIC) in adults. CIC is one of
the most common chronic functional gastrointestinal
disorders worldwide. The diagnosis of this agent is
very hard and it can be confirmed if the patient
experience at least two of the following:
CONTRAINDICATION
Intestinal perforation or obstruction due to the
structural or functional disorder of gut wall,
obstructive ileus, severe inflammatory conditions of
the intestinal tract (e.g., Crohn disease, ulcerative
colitis, toxic megacolon/megarectum)

• Straining during more than 25% of the bowel

movements.
• Lumpy or hard stools in 25% of the bowel
movements.
• Sensation of incomplete evacuation in more
than 25% of all bowel movements.
• Sensation of anorectal blockage or
obstruction in more than 25% of the bowel
movements.
SIDE EFFECT AND ADVERSE REACTION
SIDE EFFECTS:

• headache
• abdominal pain or bloating
• nausea
• diarrhea
• dizziness
• vomiting
• gas
• fatigue

ADVERSE REACTIONS:

• unusual changes in mood or behavior,

• thoughts of hurting yourself,
• trying to hurt yourself, or
• suicide.

DRUG INTERACTIONS (Drug-Drug, Drug-Food, Drug-Laboratories)

DRUG: None

FOOD: None

LAB: None

NURSING CONSIDERATIONS/ HEALTH TEACHINGS

NURSING CONSIDERATIONS:
• Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in
energy, or start to act reckless.
• Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless,
violent, or scared.

HEALTH TEACHING
• Instruct patient to take prucalopride as directed. Advise patient to read Patient Information before
starting therapy and with each Rx refill in case of changes.
• Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal
products being taken and consult health care professional before taking any new medications.