Confidential C

NightView Product Introduction

19 April 2021

Gyorgyi Buocz

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OMRON
HEALTHCARE
Vision

Zero compromise on healthier lives.

© Copyright OMRON HEALTHCARE EUROPE

 Our Vision is to minimize the number of the Cardiovascular events, which is
the leading cause of death in the world

Afib is one of the key risks for stroke.

45% of the heart attacks are happening Due to the aging population, the number of Afib
during the night -> importance of being cases are growing dramatically: There are going
aware of the nocturnal hypertension is key to be 14-17 Million Afib patients in Europe with
120k-215k new cases per year in 2030

Source: https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1
© Copyright OMRON HEALTHCARE EUROPE
https://www.health.harvard.edu/heart-health/the-danger-of-silent-heart-attacks
Cardiovascular Strategy outline in order to achieve our Vision about
decreasing the number of the CV death

CARDIOVASCULAR
Vision: Decrease the number of the CV death

Expand HBPM
Providing solutions penetration and
Increase HCP
to detect and better enable patient for
recommendation
treat the most regular home blood
across all CV categories
important CV risks pressure
measurement Creation and
- Provide solutions for new
integration to the RPM
Expand our expertise and consumer groups (i.e: obese, care
- Building a medical systems
leadership in new givers) community from top KOLs
categories to provide full - Consumer education about
through the specialists and
monitoring of hypertension hypertension to decrease GPs
and Afib to manage leading undiagnosed and untreated
- Expand in medical sales
risks of CV events hypertension
channel
- Providing superior user
experience with our devices
(IWC) and solutions (OMRON
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connect)
Next to the regular hypertension management, we expand our expertise and leadership in
new categories to provide full monitoring of hypertension and Afib to manage leading risks
of CV events

Reducing number of silent

Reducing number strokes due to the
cardiovascular events due to the early
early detection of Afib
detection of nocturnal hypertension

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NightView

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 Office and home BPM is not enough to capture risks of events as they are
focusing only on the daytime BP measurement -> doctors often overdose
the medication to avoid silent events

Time of heart attacks

45%
55%

Night Day

Nighttime and 24 hours BP have higher correlation with risk of 45% of the heart attacks are happening
cardiovascular events and organ damage -> non dippers and during the sleep (they are called silent
negative dippers have significantly increased mortality vs dippers events)

* Ben-Dov et al., Hypertension. 2007;49:1235-1241

**https://www.health.harvard.edu/heart-health/the-danger-of-silent-heart-attacks
https://heart.bmj.com/content/105/2/98
© Copyright OMRON HEALTHCARE EUROPE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843819/
 The risk for cardiovascular events increase for the non-dippers or reverse
dippers -> Sleep apnea and resistant hypertensive patient are in the major
risk
Increased mortality for non-dippers and
risers

- Non-dippers and reverse dippers are in a high risk to
develop cardiovascular events vs the dippers
- Sleep apnea patients are often non dippers or reverse dippers
- Doctors would like to understand better the nocturnal values of
several types of patients:
- Resistant hypertensive people
- High CV risk patients who have comorbidities (obese, diabetes, other CV diseases)

- Doctors eventually find it useful for all hypertensive patients

https://heart.bmj.com/content/105/2/98
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843819/
© Copyright OMRON HEALTHCARE EUROPE
Ipsos Consumer research with Healthcare professionals, March 2018 Germany, Italy
NightView proposition

NightView gives a complete understanding of your patient blood pressure during the day
and during the sleep with one single device.
It provides consistent and relevant BP data without disturbing the sleep which finally
helps you to have the full comprehensive view on your patients’ cardiovascular condition.

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 NightView is clinically validated Wrist type of Blood Pressure
Monitor, validated on different positions/rotations of the
wrist*

HEM-9601T-E3
Automatic nocturnal
2am, 4am, 4h after setting
measurement
Data management OMRON connect
Piezzo pump -> completely silent
Limited impact on the sleep operation
quality Measurement during the cuff
inflation -> Gentle measurement
Accurate nocturnal measurement
Sigma cuff
even with rotation of the wrist
Price RRP 199 EUR, CP 112 EUR

* Reference: 1. Kuwabara M, Harada K, Hishiki Y, Ohkubo T, Kario K, Imai Y. Validation of a wrist-type home nocturnal blood
pressure monitor in the sitting and supine position according to the ANSI/AAMI/
© Copyright OMRON HEALTHCARE EUROPE
ISO81060-2:2013 guidelines: Omron
 3x more patients experienced good sleep quality with at-home wrist
monitor vs ABPM arm-cuff device*

- Completely silent pumping action and less compression with the

gentle inflation improves significantly the sleep quality vs ABPM
- Better sleep quality leads to more consistent nocturnal reading

* Reference: Imai Y, Asayama K, Fujiwara S, et al. Development and evaluation of a home nocturnal blood pressure monitoring
system using a wrist-cuff device. Blood Press Monit. 2018;23(6):318-326. © Copyright OMRON HEALTHCARE EUROPE
 93% of HCPs and patients would recommend NightView for regular home
use to track night time blood pressure

With this we can foresee the problem and we

can act before it get serious. (Sleep specialist -
Italy)

It’s the missing link (Cardiologist - Italy)

Usage test results in University Brussels w prof de Asmundis
31 patient trials (Cardiologist and GP patients -> Sleeping centers were
excluded due to COVID)
100% claimed superior comfort level v s ABPM during the night and 90%
during the day I would not use it only for patients with sleep
100% claimed easy to use the device, 82% easy to use OMRON connect apnea, I would extend its use to all hypertensive
patients. (Cardiologist - Italy)
93% would recommend NightView to patients to use at home

* Usage study w prof de Asmundis – University of Brussels, executed in Nov 2020 -Jan 2021
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**Ipsos Consumer research with Healthcare professionals, March 2018 Germany, Italy
NIGHTVIEW: Addresses a big need of HCPs to understand what happens
with the BP during the sleep.
As a new category, HCPs do not have any product awareness, and patients are not aware even of the
nocturnal hypertension issue.

Barriers

Objective is to reach with the

① Awareness product information and
HCPs - No awareness of the device
building related scientific work the
biggest coverage of HCPs

- Not aware of the nocturnal Patient journey starts in the

hypertension and its risks ② HCP office of the HCP -> HCP
Patients with recommendation and
and impacts recommendation
hypertension explanation will increase the
- Need a credible source to model credibility and the perception
understand the issue of easy to use

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 The primary objective of NightView for the first 3 years is to establish
home nocturnal BP measurement as a new category

FY20 FY21 FY22 FY23

Global consensus
Medical evidence generation lead by OHQ paper

① Engage with the KOLs and Cardiology Educational

HCPs is the foundation societies content generation
of establishing the
Local KOLs, Education through
category Universities, specialists congresses,
webinars and OA Including NightView
GP practitioners to the Hypertension
guidelines

② Using HCPs’ 53.6 More we reach

M
165 M
recommendation we the GPs, the
Expand usage in the
build the consumer Sleep apnea
more we can 443 M medical channels
broaden the All (positioning against
business Resistant target group
High CV risk
hypertensive
3.9
M hypertensive patients with ABPM)
comorbidities
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In order to be successful with these special products, we need to lead the
HCPs through their journey to make sure that they start to recommend
the product with confidence
HCP journey
GP and Cardiologist

Newsletters Webinars HCP portal Round tables

Potential
PR/Socials OMRON Academy Usability study Patient journey
Product info Prescription starts

Congresses
Medical detailing © Copyright OMRON HEALTHCARE EUROPE
Thank you!

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