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Efficacy and Safety 2
Efficacy and Safety 2
E \*
Arayat, Pampanga
In Partial Fulfillment
By:
Pescadera, Jovelyn T.
Guese, Michaela P.
Balatbat, Carlo S.
Diaz, Jonabea M.
Lalu, Jelaica M.
Turla, Alwyn P.
EXACT COLLEGES OF ASIA PAG
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APPROVAL SHEET
This research is entitled, “Efficacy and Safety: An Analysis on the Side Effects of
Y., Ocampo, Andrea Jane P., Pescadera, Jovelyn T., Daquiz, Carl Kevin M., Balatbat,
Carlo S., Guese, Michaela P., Diaz, Jonabea M., Lalu, Jelaica M., Turla, Alwyn P. . In
partial fulfillment of the requirements for the Science, Technology, Engineering and
JONEL M. FUERTEZ
Adviser
_______________________
Date Signed
_____________________________________________________________________
PANEL OF EXAMINEES
JEANNE FAHRINA M. SUMANG
Chairman
________________________
Date Signed
Approved and accepted as partial fulfillment of the requirements for the Science,
Technology, Engineering and Mathematics Strand.
Passed the final defense with a grade of ____ on January ____, 2023.
Abstract
Nowadays, having a healthy body is a must, it is well recognize that having a
healthy body can prevent different kind of diseases. But a lot of people nowadays are
struggling to get the nutrients that their body needs. That's the main reason why the
preparations intended to supplement the diet and provide nutrients, these supplements
will ensure to fill the nutrition gap of a body and improve the overall health and
wellness.The purpose of this study was to determine the safety and effectiveness of
dietary supplement and to identify the possible side effects of the said supplements
that will benefit the different sectors including the consumers, health professionals
and the future researchers. The data for this study will be gathered through interviews
Researchers politely asked them for permission to answer all the questions and assure
the participants that all the responses coming from them will be kept strictly
confidential and protected under the Republic Act 10173 or the data privacy act of
2012, the duration of each interview was approximately 2 to 3 minutes. The data was
analyzed using Content Analysis, emergent themes were Possible Side Effects,
Effectuality and Safeness, and Proper Taking of Supplement. Suggestions are made
include the need for deeper study about the side effects of dietary supplements and
further research should focus on one type of dietary supplement in order for the
CHAPTER I
paradigm, statement of the problem, hypothesis, significance of the study, scope and
Introduction
Having a healthy body is a must. It is well recognize that having this can
prevent one's body from having different kind of diseases, such as heart disease,
diabetes, and cancer. One of the major factors to have a healthy body is completing
your meals with go, grow, and glow foods in order to acquire the needed nutrients of
your body. Nutrients are the substances that we obtain from consuming food that our
bodies need to nourish and nurture. Furthermore, nutrients are the fuel that allows the
body to break down food and use it to repair and grow cells and tissue, which is what
Each and everyone of us has different problems in getting the enough nutrients
that our bodies need. A lot of people nowadays are maintaining a fit and sexy body,
thus they are regulating the food they intake. Some people, particularly the children,
are picky about what they eat. There are also several people who are cautious about
their health. These are the underlying factors why an individual decided to take a
supplements are preparations intended to supplement the diet and provide nutrients.
They include vitamins, minerals, fiber, fatty acids, or amino acids, that may be
EXACT COLLEGES OF ASIA PAG
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missing or may not be consumed in sufficient quantities in a person's diet (Aina &
Ojedokun, 2014). In addition to that, these supplements will ensure to fill the nutrition
years. As a matter of fact, based to the foreign survey conducted at Washington in the
year 2019 by Ipsos of CRN reveals that 77 percent of the Americans reporting are
consuming dietary supplements. This survey also found out that vitamins and
the recent local survey conducted by Rakuten Insight in 2020, 61 percent of the
respondents aged 55 years or older stated taking dietary supplements. The findings
also revealed that 61 percent of respondents age 16 to 24 are not taking this
supplements.
In view of the fact that the consumer of these supplements continue to rise, an
organization called American Cancer Society conducted a study about the safeness of
dietary supplements in the year 2021. According to their findings most people can
use dietary supplements safely as long as they do not take too much. But dietary
supplements are not totally safe, and taking them can have risks, especially for people
who are getting cancer treatment. Many supplements contain active ingredients that
can have strong effects in the body. Consumers must be aware to the possibility of a
bad reaction, especially when taking a new product. (National Institutes of Health,
2020)
As the usage of this supplement increases locally, the researchers are highly
advocate to conduct a study where dietary supplements and the users are examined.
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The study will take place in Exact Colleges of Asia where all of the researchers
studied.
While most of the users utilize these supplements on a daily basis, therefore
they should understand everything about this supplements. Thus, this study was
intended to test the efficiency and safeness of these supplements and to determine all
Since the utilization of these supplements have expanded both globally and
locally, thus each and everyone of us are highly encourage to be aware and open to
study will fill the knowledge gap and will serve as brochure in order to use the dietary
supplements properly.
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This study aims to identify all the possible side effects of taking dietary
supplements of the students of Exact Colleges Of Asia in the year 2022-2023. It also
serve as a basis for intervention program for the proper use of dietary supplements.
Specifically, this study was intended to seek for the answer to the following
questions ;
Conceptual Paradigm
of the study, it will describe how the study will be perform. The diagram follows an
IPO format namely input, process and output. The first box which is the input
includes the side effects of dietary supplement use and the efficacy and safety of these
supplements. The second box shows the process of data gathering through the method
of interview and research. As for the third box, the output analyzes all the possible
side effects of taking dietary supplements same as its effectiveness and safeness.
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Conceptual Framework
FEEDBACK
The specific intent of this study was only to focus on identifying the side
effects of dietary supplements use and to determine the effectiveness and safeness of
the said supplements. The study will take place at Exact Colleges Of Asia in the year
2022-2023. The participants of the study were the students of the said institution. The
major task of this study was to determine the effectiveness and safeness of the dietary
This study will be beneficial and important in the field of Health. It will show the
side effects of dietary supplements use and the safeness and effectiveness of taking
these supplements. The findings of the study could be significant to the following :
Consumers
This study shall serve as a guide and knowledge regarding the possible results
side effects.
Health Professionals
Statistical records and other reliable data of this study may serve as a shred of
evidence that shall guide these professionals through their journey. Pieces of
information stated in this research may serve as reading material and a basis for a
deeper understanding of the effect of dietary supplements, hence, may give an idea to
Future Researchers
This research may be used as a reference in future studies, which will be greatly
appreciated.
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Definition of Terms
Dietary Supplements - a product taken orally that contains one or more ingredients
(such as vitamins or amino acids) that are intended to supplement one's diet and are
Glow Foods - contain the Vegetables and the Fruits Group foods that supply the body
with vitamins and minerals to keep the body healthy and functioning properly.
Go Foods - the type of food that provide fuel and help us 'go' and be active.
Nourish - to furnish or sustain with nutriment : FEED / to promote the growth of.
Wellness - the state of being in good health, especially as an actively pursued goal.
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CHAPTER II
and methodologies conducted and published by foreign and local research in order to
Related Literature
Local Literature
According to Cruz, Tanchoco and Orense in their study in 2011 proves that
concerns about nutritional adequacy among the general public, combined with the
recent wellness movement, have fueled the rapid growth of health supplement use.
People are looking for new ways to improve their health, and natural cures are
becoming more popular than prescription drugs. The usage of dietary supplements is
becoming more popular among the general population of the United States. These
supplements account for a significant fraction of total vitamin and mineral intake in
Since dietary supplements are being used for improving the health, consumer
must determine whether they are utilizing dietary supplement either Drug-based or
dietary supplement. Based on FDA Philippines Officer Order No. 22 s. 1991, your
deficiency or disease; Has a concentration per dosage form of greater than 150
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percent of the Philippine Dietary Reference Index (PDRI) for water-soluble vitamins
and/or greater than 105 percent of the PDRI for fat-soluble vitamins; Takes the form
ingredients present. On the other hand, the product will be categorized as a food
supplement (more specifically a “processed food”) if: Its indication is that of “Dietary
or Health Supplement; Its concentration per dosage form is less than 105% of the
PDRI for fat- soluble vitamins and/or less than 150 percent for water-soluble
supplements became weapon to resist covid-19. The saying "health is wealth" has
never been more true than now, as the possibility of a COVID-19 pandemic looms.
People are beginning to place a greater emphasis on their loved ones' physical well-
being. With specialists estimating that a vaccine will take at least a year, if not longer,
them meet their daily energy and nutrient requirements. This makes people less
Foreign Literature
According to Binns, Lee, and Lee (2018), dietary supplements may be found
in many forms such as tablets, capsules, soft gels, gel caps, liquids, or powders. The
tablet, pill, softgel, chew or gum, or other product containing one or more
supplements. They can also be manufactured into other forms, such as a snack bar or
While on the other hand based on Rovira and others (2013), supplements can
classified comparably to their texture or form in which they are available as follows:
Vitamin and mineral supplements, whether they are combined in the form of
tablet in combination or not with carbohydrates, fats, vitamins and minerals, Amino
acids of every form and composition, Supplements for gaining weight, Meal
or without electrolytes and vitamins, Supplements which have natural anabolic effect,
and which are not included in the “banned substances list”, “Activator” supplements
of growth hormone and other hormones, Supplements of basic fatty acids, Foodstuffs
or food ingredients such as yeast, garlic, kelp, royal jelly and herbs. Thousands of
supplements are available on the market. Many are excellent, while others are
average, and a few are ineffective. Their manufacturing method and the source of
their basic components are the primary causes of their low efficiency.
but they should not be used to substitute comprehensive and balanced daily meals of
food substances, according to scientists and health specialists. The market for dietary
products, however, are not necessarily safe for everyone. Supplements having active
substances, users and physicians should study current literature. (Hassan et al. 2020)
generally offer includes high content of nutrients in small volumes; special nutrient
these formulations should be treated as a supplement of basic healthy diet and not as a
a result, doses become less and less effective. Thus, the human organism is forced to
work harder to eliminate the extra amounts of supplements taken in. All these factors
lead to the appearance of side effects due to toxicity of dietary supplements, which
depends on the factors including. The dosage, because exceeding the recommended
dosage may cause side effects; The duration of intake which is related to the fact that
contains, till the substance is eliminated; The special chemical properties of some
substances and their interactions with other foods and substances; The person’s
weight who takes those supplements; Age, because 33 lots of supplements are not
recommended for underaged persons or the elderly; and The individual capacity,
because each person reacts differently in the face of various substances (Oikonomou
2009).
Overdosing on protein can harm the kidneys and liver. A high carbohydrate
consumption in the form of powder might lead to weight gain. A high fatty acid intake
may impair the body's ability to manufacture certain muscle proteins. Finally,
Related Study
Local Study
In the Philippines, dietary risk is the top risk factor for diseases and is estimated
suffers from chronic energy deficiency and a high proportion (70–80%) of adults is
not meeting dietary requirements for many key micro-nutrients. The prevalence of
anemia among older adults is 24%. The Philippines is also experiencing double
burden of malnutrition. Three out of 10 adults are overweight or obese, and the
number of mortality and disability caused by ischemic heart disease, stroke, diabetes
and chronic kidney disease has increased by more than 25% in the past decade
(Angeles-Agdeppa et al. 2019). This is one of the major factors why Filipinos
On the other hand, Sacdalan and Angles conducted a local survey in 2018
where 380 patients with cancer on follow-up at the Philippine General Hospital
Medical Oncology outpatient clinic were surveyed regarding their status and patterns
of herbal product and dietary supplements (HDS) intake. 88.95 percent of the 380
respondents said they had ever used HDS, with 178 (46.84 percent) saying they had
used it in the previous month. The demographic features of HDS users and non-users
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were not significantly different. The majority of 338 ever users (63.02 percent) began
HDS only after a cancer diagnosis, with 62.72 percent reporting virtually daily use.
Users were mostly unmonitored (76.29 percent), and 42.31 percent said they used
HDS while taking systemic medication. Eighty-five patients (25.15%) said they had
patients had HDS discussions in the clinic, and only 24 (20.69 percent) of those
conversations were initiated by the doctor. As a result, HDS use is common among
Filipinos with cancer, which might cause delays and interfere with systemic
Since the use of herbal and dietary supplement (HDS) in cancer patients has
been increasing over the past years while the risk of its adverse effects and
undesirable reactions with conventional cancer treatment has also been accumulating.
Here enters the study conducted by Enriquez and Esplana in 2021 where an initial
survey was conducted among adult cancer patients undergoing treatment at the
Zamboanga City Medical Center Cancer Institute. More than half of the participants
(65.4%) had utilized HDS, and the majority (54.5%) were breast cancer patients with
stage II-III illness. The main motivations for using HDS were to treat cancer, cope
with chemotherapy, and relieve cancer symptoms. Most patients believe that HDS and
the majority of patients (36.36 percent), and the majority (50 percent) did not reveal
information to their primary health care providers. Eight respondents with incomes
below the minimum wage spent more than 25% of their earnings on HDS, with
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several spending more than 50%. This could put a strain on finances and lead to
treatment failure.
disinformation, health education must be prioritized. Screening and limiting HDS use
hospital policies and regulations. Larger future research on the impact of HDS use
during cancer treatment, as well as studies on the impacts of HDS on financial burden,
should be investigated.
Foreign Study
health concerns about their efficacy and long-term safety. Because many supplements
contain many substances, alter composition over time, or are used infrequently at
systems of voluntary adverse event reporting may take a long time to uncover public
health issues linked with supplement misuse. (Binns, Lee, Lee 2018).
Since the usage of dietary supplements rapidly increases Deran and Burku
considered as drugs. It is known that such supplements affect the health of the
Nutritional problems are now caused by insufficient and unbalanced diet. Efforts to
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achieve optimal nutrition boost people's willingness to try new foods (vitamins,
minerals, etc.). The functional qualities of foods (antioxidant, dietary fiber, amino
acid, and so on) are now leading to the development of novel dietary supplement
items that can help people who require them. Dietary supplements can have a variety
of negative effects in addition to their beneficial and supporting benefits. These side
effects can be quite dangerous. It's important to remember that dietary supplements
taken to help with metabolism can interact with medicines taken at the same time,
Furthermore, according to Binns, Lee, and Lee in the study they conducted in
the year 2018 the risks of using dietary supplements include organ damage from
CHAPTER III
RESEARCH METHODOLOGY
This chapter deals with the methodological procedures by which the data
relative to the research problem is collected. It presents the research design, locale and
respondents of the study, sample and sampling procedure, research instrument and the
Research Design
The design used in this study was descriptive research design. Wherein this
being studied. Furthermore, it focuses on answering who, what, when, where and how
questions that are related to a specific research problem. Therefore, describing the
possible side effects of taking dietary supplements is most relevant for a descriptive
research design.
The study was conducted at Exact Colleges Of Asia where all of the
researchers studied. Where in researches are highly advocate to conduct a study where
respondents of the study, definitely those who take Dietary Supplements. The
selecting the respondents. Under this, purposive sampling technique will be used. A
chosen respondents who judge as people with great enthusiasm about the study. This
type of sampling was chosen by the researchers to ensure that the selected
respondents will offer the most insight and information to the study. The researchers
chose 15 participants who take dietary supplements that are students of Exact
Colleges Of Asia.
Research Instrument
study, which will aid the researchers in determining the impacts of taking dietary
questions to be answered by selected participants. The researcher will use both open
Data Collection
The interview method will be used in this study, the researcher used a
purposive sample strategy to pick participants for an interview. The researchers use
the free time they have to ask the students in every classroom of Exact Colleges of
Asia (Senior High Department) if they are eligible for the study. The researchers
scheduled the morning shift interviewee to have the interview in the afternoon at
exactly 12:30pm to 1:00pm, while for the afternoon shift around 11:00am to 11:30am,
in order to prevent the interviewees from interrupting their classes. The researchers
used voice recording and interview transcript method for gathering the opinion and
questions are well-structured, prepared, and ordered in accordance with the study’s
goal. The participants will be encouraged to give as accurate and honest feedback as
CHAPTER IV
This chapter presents the relevant findings gathered from the selected 15
students of Exact Colleges of Asia Inc. Who served as respondents of this research.
The researchers gathered data through an in-depth interview. Content analysis is the
method used for analyzing the following qualitative data, due to its purpose that is to
determine the presence of certain words, themes, or concepts within some given
qualitative data. Using the said type of analysis, researchers can quantify and analyze
the presence, meanings, and relationships of such certain words, themes, or concepts (
Feeling of
tiredness Weight gain
Possible Side
Effects
Prone to
sleepiness Loss of appetite
In line with qualitative research done on the topic, possible side effects
shared experiences that happened to be the side effects of the dietary supplements.
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These students experienced different side effects such as weight gain, loss of appetite,
Participant 2 : "Yes I do, I always feel like I am sleepy, and it feels like I am always
tired."
Participant 5 : "I feel tired though I am not and I always want to sleep."
expect taking vitamin supplements will boost your energy and improve your overall
wellbeing. But this isn't always the case. When taken in high doses, some vitamins
concentrated source of calories and nutrients. However, they should be used only to
supplement your diet — not as a replacement for whole, nutrient-rich foods. Also
EXACT COLLEGES OF ASIA PAG
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keep in mind that while some supplements may more directly help you gain weight by
providing a boost of calories, others may have a more indirect effect by supporting
Participant 12 : " You lose your appetite every time you eat."
effects when taking dietary supplements. The side effects vary according to the type
Recommended
by Desired
Professionals effect
achieve
Effectuality and
Safeness
Experiences Improvement of
based health and
welness
This theme highlights the concern with how effective and how safe it is to use
Participant 2 : " It is fine, I think my immune system got stronger and I am not having
menstrual cramps too much and the amount of blood coming out in my private part
when I am in my period is lessened."
Participant 3 : “Yes, because lately I have noticed that I don't get cold as often as
before.”
Some dietary supplements can help you get adequate amounts of essential
nutrients if you don’t eat a nutritious variety of foods. However, supplements can’t
take the place of the variety of foods that are important to a healthy eating routine.
Majority of the dietary supplements can improve overall health and help manage
Participant 8 : "Make sure to consult your doctor first, whether the vitamins are okay
for you, and also if you have an allergy to the ingredients."
Participant 10 : "Ask professionals like doctors first because sometimes there are
supplements that are not allowed in our body."
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Participant 11 : " No, because my aunts and sisters said that it is really good for iron
deficiency when you have a menstrual period.”
Many supplements contain active ingredients that can have strong effects in
the body. Always be alert to the possibility of a bad reaction, especially when taking a
new product. Consumers who take dietary supplements at high doses are most likely
to have side effects or instead of prescribed medicines, or if you take many different
the supplement is beneficial to their health. According also to their responses they
Limiting the
supplement
intake
Avoid
unhealthy
habits
EXACT COLLEGES OF ASIA PAG
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The final theme refers to the proper ways on how to consume dietary
supplements in order to prevent the alarming side effects that may have a negative
Participant 1 : " Make sure you are not taking your supplement too much."
Participant 2 : " You should have a limit because it is bad when it is too much."
for your health. But one thing experts can agree on is that taking too much of certain
nutrients can be risky. Taking high doses of vitamins without your doctor's
recommendation puts you at risk of side effects that can be not only uncomfortable
Nutritients have a vital role in our body. Vitamins and minerals are essential to
helping your body develop and function as it should. While most people get all of
what's recommended by eating healthy, others need a little extra nutrient boost. That's
Participant 5 : "Have healthy habits, and if you want to achieve the purpose of the
supplement maintain it."
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Participant 6 : "Avoid unhealthy habits because you will not really achieve the effect
of your supplement if you have unhealthy habits."
Having an unhealthy habit can really affect ones health just like poor eating
habits. According to Langford and Kelly (2022), children with poor eating habits do
not consume the adequate amount of nutrients needed for growth and development.
These children may consume too few or too many nutrients, which may result in the
CHAPTER V
The main objectives of this research study were to determine how safe and how
effective the dietary supplements are and to identify what are the side effects of the
said supplement. This chapter presents the summary of the study undertaken, the
Theme 1 : Shows the possible side effects of taking dietary supplements in which the
The researchers discovered that taking dietary supplements can cause side
effects such as weight gain, loss of appetite, feeling of tiredness and prone to
participants' confidence that the supplements they take are safe and effective.
After analyzing their responses, it is clear that they are confident that the
based on the experiences of others. It is also clear that the supplement they consume is
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effective because their overall health and wellness was improved and the desired
Theme 3 : Outlines the proper way of dietary supplement use in order to prevent the
side effects. The theme also highlights the do's and don'ts in order to achieve the
order to prevent side effects the consumer must limit the supplement he/she intake.
The researchers also found that in order to achieve the full potential of the
supplement, the consumer must avoid unhealthy habits and maintain the consumption
of the supplement.
Conclusion
The study attempts to determine the efficacy and safety of dietary supplements
Specifically, this study was intended to seek for the answer to the following
questions ;
The aim of this study is to determine the side effects of dietary supplements and
to identify the safety and efficacy of the said supplement. After a thorough analysis of
1. The participants experienced different types of side effects such as weight gain,
loss of appetite, feeling of tiredness and being prone to sleepiness depending on the
2. The participants believe that dietary supplements are safe to use especially when it
supplement. The participants achieve the purpose of their supplement, meaning the
3. Proper taking of dietary supplement is found to be the best way to avoid the side
effects. Limiting the consumption intake of the supplement, avoidance of side effects
is found to be possible. While maintaining the intake of the supplement and avoiding
Recommendations
The following suggestions are offered for future research undertakings and for
possible actions :
1. The consumers must limit the consumption intake to prevent experiencing side
effects, and maintain the supplement consumption and avoid unhealthy habits to
2. For the assurance of the safety of the consumers, health professionals must detailed
and carefully instruct the consumers on how to take the dietary supplement properly
3. The future researchers should publish further research in order to identify the other
CURRICULUM VITAE
Age: 18
Sex: Female
Email : gatchalianluisamae@gmail.com
Height: 5'1
Weight: 40 kg
Parents:
Occupation: Welder
Occupation: Caregiver
CURRICULUM VITAE
Age: 18
Sex: Female
Email : ao6747243@gmail.com
Height: 5'1
Weight: 43 kg
Parents:
Occupation: Farmer
Occupation: Housewife
Award/s: None
Junior High School Graduated(2021) from: Sta. Rita National High School
CURRICULUM VITAE
Age: 17
Sex: Female
Email : pescaderajovelyn@gmail.com
Height: 5'2
Weight: 43 kg
Parents:
Occupation: Sewer
Award/s: Top 5
CURRICULUM VITAE
Age: 17
Sex: Male
Email : daquizkevin@gmail.com
Height: 5'8
Weight: 55 kg
Parents:
Occupation: Housewife
CURRICULUM VITAE
Age: 18
Sex: Male
Email : carlobalatbat028@gmail.com
Height: 5'10
Weight: 74 kg
Parents:
Award/s: None
Junior High School Graduated(2021) from: Telesforo and Natividad Alfonso High
School
CURRICULUM VITAE
Age: 17
Sex: Female
Email : michaelaguese07@gmail.com
Height: 5'0
Weight: 45 kg
Parents:
Occupation: Farmer
Occupation: Housewife
CURRICULUM VITAE
Age: 18
Sex: Female
Email : jonabeadiaz.05@gmail.com
Height: 5'6
Weight: 58 kg
Parents:
School Inc.
CURRICULUM VITAE
Age: 17
Sex: Female
Email : jelaicalalu3@gmail.com
Height: 5'6
Weight: 54 kg
Parents:
Occupation: Housewife
Award/s: None
CURRICULUM VITAE
Age: 20
Sex: Male
Email : turlaalwyn@gmail.com
Height: 5'8
Weight: 54 kg
Parents:
Occupation: \Farmer
Occupation: Housewife
Award/s: None