AMIDE Lidocaine Bupivacaine Mepivacaine Articaine Prilocaine

PRESENTATION Injectables, Gel, Ointment,

Spray
MARKETED 2% W/ o W/o 0.5% (w/) 3% w/o 4% w/ 3% w/
Adrenaline Adrenaline (1:200,000) 2% w/ Adrenaline Felypressin (1:1,850,000)
(1:50,000 – 1:100,000) Adrenaline (1:100,000) (1:100,00-1:200,000)

MAX DOSE(mg/kg) 4.4 1.3 4.4 7 6

MAX TOTAL DOSE 300-500mg 150 w/o 500 600 w/
(mg) 175 w/
ONSET OF ACTION 2-3 2 2 2-4
(min)
DURATION Pulp: Pulp: 3 h w/o: 60-150 min Pulp: Pulp: 2-3 h
(W/o & W/ VSC) w/: 2-6 h
w/o : 5-10 min Soft Tissues: 6 h 1:100.000: 75 min Soft Tissues: 2-4 h
w/ : 60 min 1:200.000: 45 min

Soft Tissues: Soft Tissues:

w/o : 1-2 h 1:100.000: 4 h

w/ : 3-4 h 1:200.000: 3 h

Only amide type used topically Higher potency than lido Indicated when VC Potency higher than Potency = lidocaine (1)
= high liposolubility contraindicated. lidocaine (1.5) Lower toxicity than
Lower toxicity than lidocaine (0.4)
Disadvantages: lidocaine (0.6) Disadvantage: lower VSC
Not in children/ disabled Better diffusion capacity potency
Cardiac toxicity through bone tissues
Long anesthesia Indication:
Coronary artery D
Patient w/ drug intention

Contraindications:
Hypersensitivity amide A
Methemoglobinemia