An aqueous (water-based) solution has a concentration of 0.3% (that means 0.

3g of
active substance in 100mL of solution). How many drops of solution are needed to get
150μg of the active substance?
We have an active substance, regularly in the form of powder, solved into a liquid (excipient = vehicle), more exactly in
water.

A. First, we should calculate the amount of liquid containing 150μg = 0.00015g of active substance.
We apply the rule of three (proportions):
0.3% concentration: 0.3g of active substance …………………………….…….100mL water
0.00015g of the active substance…………….…….X

100 mLX 0.00015 g

X= =0.05mL
0.3 g

B. Then, we should find how many drops corresponds to 0.05 mL of water solution.
1mL ……… 20 drops (it is water, so the gram, as a measurement unit for weight, corresponds to a volume of 1mL).
0.05mL………..Y drops
0.05 mLX 20 drops
Y= =1drop, which should be final the answer.
1 mL

Note: if you told 1g ---- 20drops, than 0.00015 = ?? (how many) drops, it is not correct, as the correspondence applies to
the solution (water solution, liquid), meaning to the liquid, whereas 0.00015 is the active substance, not the liquid.

Assuming a constant rate of elimination for ethanol of 1.5dg/L per hour, how long does
it take for the alcohol blood concentration of a person to decrease from an initial value of
1.4g/L to 0.8g/L?

1.5dg/L per hour =0.15g/L/h

1.4g/L – 0.8g/L=0.6g/L (this is how much alcohol concentration decreases with)

0.6g/L : 0.15g/L/h = 4 hours

Considering the density of alcohol ρ=0.8g/mL, how many drops of alcoholic solution
are found in one teaspoon?

First, we should know that the volume of a teaspoon is 5 mL. The volume is the same, no matter if into the teaspoon
there is water, syrup, oil, alcohol, Hg=mercury or other liquid. We know it from the fact that for water the teaspoon contains
5g of water, whereas 1mL corresponds to 1g.
Then, we should tell which the weight of the alcohol in one teasppon is.
 ρ=0,8g/mL →→→ 1mL …………………………….…….0.8g
5mL…………….…….X

5 mLX 0.8 g
X= =4g
1 mL
Afterwards, we tell:
1g alcohol …………………………….…….50 drops (this is the correspondece to be considered, according to the materials sent by
me, as you noticed, I have specifically mentioned it!!!). If you considered 64 drops per gram, you will get part of the score!)
4g alcohol …………….…….Y
4 gX 50 drops
Y= =200drops (final answer)
1g

Assuming a disposal (elimination) law corresponding to the 1st order kinetics, how long is it necessary a drug
(substance) to have its blood concentration reduced from 96 mg/mL to 6mg/mL? (half-time: T1/2 = 90 minutes)

1. To reduce the concentration from 96 mg/mL to 48 mg/mL it takes 90 minutes;

2. To reduce the concentration from 48 mg/mL to 24 mg/mL it takes 90 more minutes;
3. To reduce the concentration from 24 mg/mL to 12 mg/mL it takes 90 more minutes;
4. To reduce the concentration from 12 mg/mL to 6 mg/mL it takes 90 more minutes.

So totally, there is a 4 X 90 minutes = 360minutes = 6hours time (final answer).

ANY CORRECT way to solve, logically expressed and correct from the mathematical point of view, leading to
correct answer, is considered.

Considering the density of alcohol ρ=0.8g/mL, how many mL is one drop of alcohol?

1mL ------ 0.8g

X mL------1g
X=(1gx1mL)/0.8g=1.25mL

1g -----50 drops means:

1.25mL ----- 50 drops
Y ------1 drop

Y=(1.25mL*1drop)/50drops=0.025mL/drop