CASE REPORTS

BOOK 1.0
CONTRIBUTORS
Ofir Artzi
Dr. Ofir Artzi is an internationally renowned expert in the field of lasers and aesthetic dermatology.
He heads the centre for Aesthetic Dermatology at the department of Dermatology, Tel Aviv Medical
centre. The Centre is at the forefront of treatment, teaching and research in aesthetic dermatology. Dr.
Artzi has published many scientific medical articles and participates in many cosmetic clinical trials. He
is a member of many national and international dermatological and cosmetic professional associations
and has been honoured as a guest speaker at numerous national and international aesthetic and
dermatologic conferences.

Sergey Blokh
Sergey Blokh was born in Kazakhstan in 1974. In 1997 he has finished medical degree in an
Academy on Emergency medicine and General surgery. In 1999 he moved to Israel and keep on
working as a doctor in few hospitals in North area of Israel. In 2015 he finished his studies of aesthetic
medicine and non-surgical facial and body aesthetics treatments and started working at ANIA –
International Beauty Center – as a specialist in aesthetic medicine. During his work, dr. Blokh did some
researches and few clinical tests that leaded to new developments at the whole idea of antiaging
treatments. During his work as lecture and expert in aesthetic medicine, he provides masterclasses for
physicians interested to learn and “hands-on” practice for doctors. He never stops learning from the
best specialists of the world.

Sharon Davidson
Dr Sharon Davidson started her professional career as a successful dentist for 24 years. She had
been actively involved in the aesthetic field in Israel. for over 13 years. Over this time span she had
established a very extensive career in the aesthetics field. Her innovative and unique treatments and
approach to aesthetics gained her a leading position in the Israeli market. Dr Davidson owns a thriving
practice in the heart of Tel Aviv, where she offers a full spectrum of advanced non-surgical facial
aesthetic treatments utilizing the most efficient fillers and products. Throughout her career, she has
developed strong technical skills that help her to provide natural and perfect treatment results that are
based on tailor-made procedures that compliment perfectly each of her patients. A leading lecturer
and trainer in aesthetic facial treatments, for the past decade, Dr. Davidson has been sharing her
knowledges and techniques with hundreds of doctors. This took place through courses and practical
training in her own teaching institute as well as lectures given at the prestigious Tel Aviv University.

Jana Földesová
Dr. Jana Földesová is a Czech dermatologist, currently head physician at the Department of
Dermatology of the Kladno Regional Hospital. She practices privately at the Laser and aesthetic
clinic in Prague and Kladno. Dr. Jana Földesová graduated at the First Faculty of Medicine of Charles
University in Prague, then specialized in dermatology and attended postgraduate courses in corrective
and aesthetic dermatology.
She has wide scientific medical aptitudes, several years of experience in dermatological field in Czech
Republic, as well as from many internships and expert stays abroad. She regularly participates in
domestic and foreign seminars and congresses focused on laser and aesthetic medicine.

Lada Novotná
Dr. Lada Novotna is a Czech dermatologist trained in corrective dermatology, dermatosurgery, anti-
aging medicine and injection filler techniques. She works in private practice and helps as supervisor
in other well-known clinics around the whole country. She is a lecturer and a trainer in aesthetic
medicine. Dr Novotna graduated at the 3rd Medical Faculty of Charles University in Prague in 2005,
then specialized in the geriatric field, in dermatology and corrective. In 2009 she obtained a certificate
of completion of the basic internal stem.
CONTRIBUTORS
Nadezhda Pavlova
Russian doctor in aesthetic medicine trained also in therapy and physiotherapy, Nadezhda Pavlova
graduated at the Medical Universities of Nizhnii Novgorod and St. Petersburg. She is the leading
clinical specialist of the Beauty center “Adriatica” (in Nizhnii Novgorod city) and runs a full spectrum
of advanced non-surgical facial aesthetics treatments, including thread lifting. Thanks to her creative
vision and extensive professional knowledge, she provides excellent natural and refined aesthetic
results for her patients even in cases of complications resulting from the work of other professionals. In
Russia Dr. Pavlova has a reputation as a lector, trainer and expert in aesthetic medicine. It’s interesting
not only to observe her work with patients, but also to read her publications in various magazines.

Carlo Peramezza
Dr. Carlo Peramezza graduated in Medicine and Surgery and then specialized in Plastic and
Reconstructive Surgery at the University of Ancona. He successfully attended several classes and
obtained degrees in Omotoxicology, Omeopathy, Kinesiology, Neural Therapy and Hypnosis. Dr.
Peramezza strongly believes in a holistic approach, since taking care of the body allows to enhance
self-care skills. Aesthetics can provide natural results and be a medium to achieve harmony with
oneself.

Elena Rossi
Italian dermatologist and dermatological surgeon, Elena Rossi works in 4 hospitals in Modena (Italy)
and at the private clinic SkinCenter. Dr. Rossi has a wide surgical experience in over 4500 procedures,
mostly dealing with removal and reconstruction in patients with melanoma and non-melanoma skin
cancer. In her private practice, she deals with many non-surgical aesthetic treatments, with the
aim to obtain a natural beauty keeping always in mind the scientific approach of such procedures.
Internationally, since 2012, she trains and tutors students for the European Academy of Dermatology
and Venereology (EADV) in resident and specialist courses, on basic and advanced surgery and
cosmetic dermatology. Dr. Elena Rossi is a clinical lecturer and trainer, having carried out training in
over 20 countries. She cooperates with the University of Modena and Reggio Emilia, which is very
active in the cosmetic research, and is an author of several publications in cosmetic dermatology and
dermatologic surgery.

Naomi Sharon
Head of Haclinika - Life style & Beauty Clinic in Israel, Dr. Sharon works as Medical Physician and
Aesthetic Practitioner, a specialist in family medicine, and runs a full spectrum of advanced facial and
body aesthetic non-surgical procedures including obesity treatments - medically and aesthetically –
using medication, injection and EBD technology. Dr Sharon combines her creative talents with her
scientific medical attitudes to provide excellent natural and refined aesthetics results for her patients,
to keep the natural look and practice preservative and preventive aesthetic medicine. Dr Sharon is
a lecturer and trainer in applied anatomy for aesthetic medicine and instructor in facial hands-on on
various workshops in aesthetic procedures. She conducts research to develop and test non-surgical
techniques that can improve face and body rejuvenation procedures and outcomes. Dr Sharon has
published articles in international scientific journals.

Gabriel Siquier-Dameto
Dr. Gabriel Siquier is an experienced aesthetic physician and the founder of Dameto Clinics
International, established in the Netherlands and in Spain. He became Key Opinion Leader for major
pharmaceutical companies like IBSA, providing consultancy and presentations worldwide. Further,
he is a certified member of the Dutch society of aesthetic medicine (NVCG) and part of the research
group NEOMA at the University of Girona (Spain), where he is gaining his PhD.
SUMMARY
1 Facial remodeling PROFHILO® BAP Technique
Jana Földesová
6

2 Hypotrophic scar treated with PROFHILO®

Nadezhda Pavlova
8

3 Aliaxin® for upper lip asymmetry

Lada Novotná
12

4 Facial wrinkles treated with PROFHILO®

Naomi Sharon
14

5 VISCODERM® Hydrobooster for the treatment of male

scalp wrinkles
Gabriel Siquier-Dameto
16

6 Periorbital wrinkles: benefits of PROFHILO®

Sergey Blokh
18

7 Neck skin laxity: efficacy of PROFHILO® injections

Elena Rossi
20

8 Correction of atrophic acne scars with PROFHILO®

Ofir Artzi, Or Friedman
22

9 Combo treatment (Aliaxin® and PROFHILO®) to correct

long-term volumetric changes in the face
Carlo Peramezza
24

10 Barcode wrinkles treated with Aliaxin® and PROFHILO®

Sharon Davidson
26

THE COMPANY 28

DERMOAESTHETIC 29
CASE
REPORT 1 Jana Földesová
Dermatologist, Czech Republic
foldesovajana1972@gmail.com

Facial remodeling
PROFHILO® BAP Technique
Patient’s history and needs
67 yrs old, Czech Caucasian woman.
Dry skin type, reduced elasticity, laxity
• Hypertension (amlodipine + moxonidine + telmisartan/
hydrochlorothiazide)
• Bee sting allergy
The patient did not like the way she looked: she felt older.
BEFORE
She wanted to look younger and regain her
AFTER 60 DAYS
self-confidence.

The doctor’s opinion

Due to the patient’s skin type, the product

of choice for skin laxity was PROFHILO®:
• application of PROFHILO® brought the
expected results
• patient was very satisfied with results,
also improved psychologically.

Product and technique

PROFHILO® using the 5 point BAP technique:
5 bolus injections of 0.2 ml per side.

Epidermis

1
Dermis
3
2
Subcutaneous
tissue

Muscle
Periosteum
Bone 4 5
 Treatment protocol
1
3 2
2 3
4 5
1st treatment (T0)
PROFHILO® BAP technique 10
bolus injections 0.2 ml, 29G TW
12 mm needle.
Total product: 1 syringe 2 ml.
2nd treatment (1 month after T0)
PROFHILO® BAP technique 10
bolus injections 0.2 ml, 29G TW
12 mm needle.
Total product: 1 syringe 2 ml.
Control (2 months after T0)
Application of
PROFHILO® brought the
expected results.
Next treatment will be after
2-8 months, depending on
skin condition during the
control visit.
1
5
4
THE BAP TECHNIQUE
The BAP (Bio Aesthetic Points) technique is based on 5 injection
sites chosen in anatomically related areas to minimize the risks
while maximizing the diffusion of the product in the malar and
submalar areas.
Zygomatic protrusion
• At least 2 cm away from the external
corner of the eye
Nasal base
• Draw a line connecting the nostril and the tragus
• Draw a perpendicular line starting from
the pupil
• Locate the injection point at the intersection
of the 2 lines
Tragus
• 1 cm anterior to the bottom of the tragus
Chin
• Draw a vertical line in the center of the chin
• Draw a perpendicular line one third from
the top of the vertical line
• From the point of intersection move 1.5 cm
towards the oral commissures
Mandibular angle
• 1 cm above the mandibular angle
Daily home care
VISCODERM® Patch, VISCODERM® Cream, VISCODERM® Pearls.
CASE
REPORT 2 Nadezhda Pavlova
Dermatologist, Russian Federation
nadejda12@list.ru

Hypotrophic scar treated

with PROFHILO®
Patient’s history and needs
Russian female, 42 years old, Caucasoid, satisfactory health status.
In January 2017 the patient underwent liposuction in the anterior
region of the right knee (similar operation conducted on the left).
During healing, a hypertrophic scar appeared (3 x 15 mm) at the
cannula site of the liposuction medication on the right. The plastic
surgeon injected betamethasone (1:5 sodium chloride) into the scar.
In the 3 weeks following the procedure there were significant changes
BEFORE to the skin at the injection site, and at the end of March 2017 a
AFTER 10 MONTHS hypotrophic scar appeared.
• Localization: skin deformation in the medial anterior region of the
right knee.
• Form: irregular, in the shape of a star with one extended ray.
• Dimension: 60 mm max height, width from 20 mm to 85 mm.
• Relief: congeneric, smooth, apparent depression of the abnormal focus
with maximum recess in the center measuring 50 mm (height) x 40 mm
(width); punctiform region of deeper depression in the lower part.
• Color: pale bluish with areas of peripheral hyperpigmentation.
• Peripheral outlines: uneven, obscure, ascending from depression to
the level of the normal skin, partly hyperpigmented.
• Displaceability: displaceable.
• Compliance: reduced elasticity.
• Firmness: reduced.
• Skinfold thickness: reduced compared to surrounding normal skin.

Product and technique

PROFHILO®: 3 treatment sessions, 20 papules of 0.1 ml
per injection, deep dermis technique, 4-week intervals.

Epidermis

Dermis

Subcutaneous
tissue

Muscle
Periosteum
Bone
• Skin markings: normal anatomy, apart from the punctiform depression in the lower part of the
scar.
• Painfulness: not painful.
• Moisture: significantly reduced (there was fine scaling of skin).
• Imaging of underlying anatomical organization: while stretching subcutaneous veins can be
seen well.
Diagnosis: Iatrogenic hypotrophic scar on the anterior region of the right knee.
The scar looks unaesthetic, causing psycho-emotional discomfort of the patient who would like
to improve the appearance of the abnormal focus, making it less visible/more aesthetic.

The doctor’s opinion

Use of PROFHILO® to correct the hypotrophic scar (4th stage of scar

shaping) was able to improve the defect significantly after the
2nd session, to correct it almost completely in 3 months, after the
3rd session, and to achieve full correction of the defect in 8 months,
after the 3rd session.

Treatment protocol
1st treatment (T0)

Local anaesthetic:
lidocaine 2.5% / prilocaine
2.5% cream.
PROFHILO®: 20 bolus
injections of 0.1 ml in the deep
dermis of the scar area and of
the intact skin around the edge
of the scar.
Total product: 1 syringe, 2 ml.

Daily home care

Do not use topical therapy.
Avoid injury.
Do not apply irritating agents.
Avoid ultraviolet exposure.
CASE
REPORT 2
2nd treatment (1 month after T0) T0
Changes: Significant decrease in
scar’s dimensions and intensity of skin
depression; decrease in bluish color with
increased hyperpigmented area; increase
in shadow softness from abnormal
changed skin to normal skin; increased
strength, compliance and thickness of skin
fold; while stretching subcutaneous veins
cannot be seen; moisture is restored to
normal.
Local anaesthetic: lidocaine 2.5% /
prilocaine 2.5% cream.
PROFHILO®: 20 bolus injections of 0.1 ml
in the deep dermis of the scar area and of
the intact skin around the edge of the scar.
Total product: 1 syringe, 2 ml.

3rd treatment (2 months after T0)

Changes: Significant decrease in

scar’s dimensions and intensity of skin
depression, the area of the lowest point
of depression in the skin is 20 mm x 20
mm in the lower part of the scar, almost
oval in shape; decrease in bluish color,
hyperpigmentation of the whole area
of the pre-existing depression, whitish
coloring in the lowest point of depression;
edges of abnormal focus almost
completely smooth; increased strength,
compliance and thickness of skin fold.
Local anaesthetic: lidocaine 2.5% /
prilocaine 2.5% cream.
PROFHILO®: 20 bolus injections of 0.1 ml
in the deep dermis of the scar area and
of the intact skin around the edge of the
scar.
10 months after T0
Total product: 1 syringe, 2 ml.
 Control 1 (3 months after T0)

Changes: Decrease in
dimensions of abnormal
focus to 15 mm x 15 mm
with slight depression and
whitish coloring remaining in
this area; decreased intensity
of hyperpigmentation on the
pre-existing scar and increased
hyperpigmentation around
residual part of the depression;
consequent increased strength,
compliance and thickness of
skin fold.
A hypertrophic scar appeared
in the rougher “dotted” area
of the initial defect, without
preservation of the skin pattern.

Control 2 (5 months after T0)

Changes: Skin almost fully

recovered; slight depression in
the center of the pre-existing
scar; significant decrease
in area and intensity of
hyperpigmentation. PROFHILO® was able to completely
A hypertrophic scar 3 mm correct the defect in 8 months.
in diameter appeared in the
rougher “dotted” area of the
initial defect.

Control 3 (10 months after T0)

Changes: Full recovery of skin

in the area of pre-existing scar;
slight hyperpigmentation in the
center of pre-existing scar.
A hypertrophic scar 3 mm
in diameter appeared in the
rougher “dotted” area of the
initial defect.
CASE
REPORT 3 Lada Novotná
Dermatologist, Czech Republic
novotnalada@centrum.cz

Aliaxin for upper lip asymmetry

®

BEFORE AFTER 30 DAYS

Patient’s history and needs

46 yrs old, Czech Caucasian woman.
Normal skin type, good elasticity.
The patient had a problem with upper lip symmetry: her lips looked oblique on her face.
She did not like the asymmetry of the chin with depression.
She sought correction of the lip symmetry and an opinion on what could be done with the chin.

The doctor’s opinion

The choice of Aliaxin® to correct the lip asymmetry brought the
expected results. Patient was very satisfied: lips look beautifully
symmetrical, chin unexpectedly, too.

Product and technique

Aliaxin® FL 0.4 ml bolus, on the left part of upper lip
Aliaxin® GP 1 ml bolus, (chin depression)
Aliaxin® EV 0.8 ml bolus, (left edge of the chin)
FL GP EV

Epidermis

Dermis

FL 0.4 ml
Subcutaneous
tissue

Muscle
Periosteum GP 1 ml
Bone

EV 0.8 ml
 Treatment protocol

1st and only treatment (T0)

Aliaxin® FL 0.4 ml bolus

FL 0,4 ml
using a 30G TW needle, one
session, in the left part of
upper lip.
Aliaxin® GP 1 ml bolus
using a 27G TW needle,
GP 1 ml
one session to treat the left
edge of the chin.
Aliaxin® EV 0.8 ml bolus
using a 27G TW needle,
one session to fill the chin EV 0,8 ml

depression.
Total product: 3 syringes, 2.2 ml.

Control (1 month after T0)

Aliaxin® treatment
brought the expected
results.
I tried to solve the chin
asymmetry and depression
with two types of fillers for the
first time.
Patient was very satisfied
with results, lips looking
beautifully symmetrical, chin
unexpectedly, too.

Daily home care

VISCODERM® Patch, VISCODERM® Cream, VISCODERM® Pearls.
CASE
REPORT 4 Naomi Sharon
Family medicine specialist, Israel
naomi.sharon@clariter.com

Facial wrinkles treated

with PROFHILO®
Patient’s history and needs
47 yrs old, Israeli Caucasian woman.
Dry skin type, elastosis on cheeks and crow’s feet accentuated by
contraction of the orbicularis muscle, and upon dynamic movement
and mimics all the way down to the cheeks, including formation of
the zygomatic and cheek smile wrinkles.
Static and dynamic wrinkles.
• Medications: SSRI
BEFORE • Non-smoking, no allergies
• Nephrectomy at childhood
AFTER • No aesthetic procedures in the past
• Not pregnant, no ongoing dental procedures
Patient complains about increased number of wrinkles, expression
wrinkles around the eyes and cheeks, sagging eyes and tired facial
appearance.

The doctor’s opinion

After the treatment the face appeared rejuvenated,
refreshed and without the appearance of dynamic
wrinkles upon mimic.
The correction of aging without increasing facial
volume created natural results.

Product and technique

PROFHILO® 0.2 ml retrograde injection, cannula 25G
(lateral suborbicularis oculi fat, lateral temporal cheek fat,
mandibular angle, zygomatic arch).

0.2
Epidermis
0.2

Dermis

0.2
Subcutaneous
tissue

Muscle 0.2
Periosteum
0.2
Bone
 Treatment protocol
1st treatment (T0)

• PROFHILO® 0.2 ml
retrograde injection, cannula
25G: lateral suborbicularis
oculi fat.
• PROFHILO® 0.2 ml
retrograde injection, cannula
25G: lateral temporal
cheek fat, from 2 cm above
mandibular angle up to 2 cm
next to tragus.
• PROFHILO® 0.2 ml
retrograde injection, cannula
25G: nasolabial folds.
Total product: 1 syringe, 2 ml.

2nd treatment (2 weeks after T0)

Botox: forehead (glabella “omega”).
• 2 units x 5 + 4 units x 2: frown.
• 2 units x 3: crow’s feet.
3rd treatment (1 month after T0)
Botox 2 units x 2: forehead.
4th treatment (2 months after T0)
• PROFHILO® 0.2 ml retrograde
injection, cannula 25G: lateral
suborbicularis oculi fat.
• PROFHILO® 0.2 ml retrograde
injection, cannula 25G: lateral
temporal cheek fat, from 2 cm
above mandibular angle up to
2 cm next to tragus.
• PROFHILO® 0.2 ml retrograde
injection, cannula 25G:
nasolabial folds.
Total product: 1 syringe, 2 ml.
With cannula 25G, approach under the dermis to the
superficial fat up the lines marked on the scheme and inject
retrograde 0.2 ml into the fat compartment and the dermis.
Patient’s goal was achieved: after the last
treatment the face appeared rejuvenated,
refreshed and without the appearance of dynamic
wrinkles upon mimic. Forehead wrinkles and skin
texture were improved; the position of eyebrow
was enhanced and the expression kept natural
as well. Note disappearance of elastosis upon
dynamic mimic. Moreover, the correction of aging
vector without increasing facial volume created
natural results.
Safety points
Slowly inject into subdermal fat compartment, gently, using a
cannula to avoid hematoma, posterior to parotid gland, where
buccal nerve and parotid duct passes.
Daily home care
Ointment containing pro-vitamin B5; serum and sunscreen.
CASE
REPORT 5 Gabriel Siquier-Dameto
Aesthetic Physician
Dameto Clinics International, Spain and the Netherlands
Research Group of Clinical Anatomy, Embryology and Neuroscience (NEOMA),
Department of Medical Sciences, Universitat de Girona (UdG), Girona, Spain
info@dametoclinics.com

VISCODERM® Hydrobooster for the

treatment of male scalp wrinkles
Patient’s history and needs
47 yrs old, male Caucasian from the Netherlands
No relevant medical data for the case
No apparent scars, with wrinkles and mild erythema with
photo-aging in exposed areas.
Aging of the skin and the process of wrinkle formation are
highly documented. Male scalp wrinkles, as a specific gender
and skin area, have, however, received little attention.
BEFORE Conventional chemical peels and dermabrasion are the most
1 MONTH AFTER common approaches to rejuvenating the scalp, but they don’t
THE TREATMENT provide effective rejuvenation if wrinkles are present.
Based on this background we examined the efficacy and
safety of a scalp rejuvenation procedure with hyaluronic acid
to improve wrinkle severity, skin hydration and elasticity on
the scalp area.

The doctor’s opinion

VISCODERM® Hydrobooster led to a
significant aesthetic improvement in scalp
rejuvenation and wrinkle severity compared to
baseline, together with an amelioration in skin
hydration, elasticity and structure.

Product and technology

VISCODERM® Hydrobooster 1.1 ml, 33G needle,
one session, “blanching evolution’ technique.

Epidermis

Dermis

Subcutaneous
tissue

Muscle
Periosteum
Bone
 Treatment protocol
1st and only treatment

• VISCODERM® Hydrobooster
1.1 ml, 33G needle, one
session, “blanching evolution’
technique, an effective
injection technique for
biorevitalization.
Total product: 1 syringe, 1.1 ml.

IMMEDIATELY AFTER THE TREATMENT

Patient was injected in a single session with 1.1 ml VISCODERM®

Hydrobooster using a 33G needle with the ‘blanching evolution’
technique: the needle was supported above the skin at an angle
of 45 degrees and a vertical pressure was applied to enable the
needle to bend slightly; it was then moved forward slightly and a
small amount of the product was injected (while applying constant
pressure without putting excessive force on the plunger, and
stopping when the skin was saturated). With this technique the
“blanching effect” (whitening of the skin) is immediate. The smaller
gauge used led to virtually no product waste. Once the procedure
was completed, the injection site was carefully massaged by hand
to enable the product to spread evenly.

We observed a significant aesthetic improvement in

scalp rejuvenation and wrinkle severity compared
to baseline. This improvement was coupled with an
amelioration in skin hydration, elasticity and structure.
These preliminary results suggest that VISCODERM®
Hydrobooster is a safe product and the ‘blanching
evolution’ is an easy technique which enables a
significant correction of scalp wrinkles.

This case report has been accepted by the scientific committee

and presented as an E-Publication during IMCAS World Daily home care
Congress in Paris 2019 with the title: “Male scalp wrinkles After the injection, apply no make-up for 12 hours.
treatment with HA skinbooster - Case report” Avoid sunbathing or high temperatures for one week.
CASE
REPORT 6 Sergey Blokh
Specialist in Aesthetic Medicine, Israel
s0547591980@gmail.com

Periorbital wrinkles:
benefits of PROFHILO®

Patient’s history and needs

49 yrs old, Israeli Caucasian woman.
Usually healthy.
Bright skin, flexible with some pigmentation spots,
upper eyelid ptosis, periorbital and forehead wrinkles.
BEFORE • Not receiving any medications
AFTER • No aesthetic procedures in the past
• Not pregnant, no ongoing dental procedures
• Non-smoking
• No allergies
Patient complains of periorbital wrinkles and upper
eyelid ptosis with sagging and tired look.

The doctor’s opinion

PROFHILO® combined with PlasmaJet
produced an improvement both in
wrinkles and upper eyelid ptosis.

Product and technology

Blepharoplasty with PlasmaJet; after two weeks PROFHILO®
first session; after 5 weeks PROFHILO® second session.

Epidermis

Dermis

Subcutaneous
tissue

Muscle
Periosteum
Bone
 Treatment protocol
1st treatment (T0)

Blepharoplasty treatment by
PlasmaJet (intensity 6).

2nd treatment (2 weeks after T0)

The technique used was

40 subdermal microbolus
injections of 0.05 ml of
PROFHILO® with 29G needle.
Total product: 1 syringe, 2 ml.

3rd treatment (5 weeks after T0)

The technique used was

40 subdermal microbolus
injections of 0.05 ml of
PROFHILO® with 29G needle.
Total product: 1 syringe, 2 ml.

The treatment chosen for this patient –

PROFHILO® combined with PlasmaJet –
produced an obvious improvement thanks to
the combination of both technologies.

Daily home care

UV broad-spectrum spectrum protective compact foundation + trolamine cream.
CASE
REPORT 7 Elena Rossi
Dermatologist, Italy
dr.elenarossi@gmail.com

Neck skin laxity: efficacy of

PROFHILO® injections
Patient’s history and needs
65 yrs old, Italian caucasian woman.
• No medications
• Non-smoking, no allergies
• No aesthetic procedures in the past on the neck
• Not pregnant
• No active infection
Dry and photodamaged skin, elastosis and laxity on the
BEFORE neck accentuated by dynamic movement.
AFTER Static and dynamic wrinkles.
Patient complains about the wrinkles and the skin texture on
the neck area. She asked for the area to be improved using
a minimally invasive technique.

The doctor’s opinion

After the treatment the neck appeared
rejuvenated, refreshed. The horizontal
neck lines were less visible; the skin was
smoother and more hydrated. The global
result was a very natural improvement of the
area to the patient’s great satisfaction.

Product and technique

- Plasma exeresis
- PROFHILO® 0.2 ml

Epidermis

Dermis

Subcutaneous
tissue

Muscle
Periosteum
Bone
 Treatment protocol
1st treatment (T0)

Both plasma exeresis and

PROFHILO® injection were
performed.
• Anesthetic cream was
applied 30 minutes before
the treatment.
• Plasma exeresis was
performed on the areas
of skin laxity on the neck:
sublimation of punctiform
areas with no overlaps, with
spots never lasting more than
2 seconds.
• 15 minutes after PROFHILO®,
0.2 ml injected with 29G
needle using retrograde
technique on the horizontal Combined strategies are emerging as the standard of care for
fold of the neck in the dermis. patients with neck skin laxity.

Total product: 1 syringe, 2 ml. Plasma exeresis is a simplified non-ablative technique

performed with a medical device that sublimates the treated
area without damaging the surrounding tissues.

2nd treatment (1 month after T0)
PROFHILO® injection in the neck
wrinkles was repeated.
• PROFHILO®, 0.2 ml injected
with 29G needle using
retrograde technique on the
horizontal fold of the neck in
the dermis.
Total product: 1 syringe, 2 ml.
Non-crosslinked hyaluronic acid (PROFHILO®) can help to:
increase skin firmness and elasticity, tighten and lift skin,
improve skin tone and texture, rehydrate skin and restore
radiance.
In this patient, plasma exeresis was able to tighten
the skin resulting in less tissue redundancy, while
the bioremodeling effect of PROFHILO® improved
the folds and the hydration of the skin. The final
effect was very good.

Control (2 month after T0)

A follow-up visit was performed

to assess global efficacy of the
two-step combined treatment.
Safety points
During the procedures injection into Erb’s point was avoided.
After the 1st treatment sun exposure was avoided for one month.
CASE
REPORT 8 2
Ofir Artzi1, Or Friedman2
1
Dermatologist, Israel
Plastic and reconstructive surgeon, Israel
or.friedman@gmail.com

Correction of atrophic acne scars

with PROFHILO®
Patient’s history and needs
• Acne is a common inflammatory condition that affects up to 80 percent of the
adolescent population to varying degrees and can result in permanent scars.
• Atrophic acne scars are the most common subtype.
• Many types of treatment are available to reduce the appearance of these scars,
but the treatment of acne scars needs to be individually tailored for each patient
depending on the types of scars present.

Atrophic acne scars were treated with PROFHILO®, using a dual-plane technique for
2 treatment sessions at a 4-week interval.
The dual-plane technique consists of filling the atrophic dermal component of the scar
and then addressing the subdermal element by subcision and placement of a small
amount of HA for regenerative stimulation.
In the patient treated here, each marked scar was filled in the dermis with 0.02-0.1 ml
(PROFHILO®), using a 29G syringe.
The second injection pass was done immediately afterwards using a 25G cannula
inserted into the superficial hypodermis using the blunt cannula to disrupt the
subcutaneous fat under the superficially injected scars.
Areas were massaged as required to flatten the product and ensure correct placement.

The doctor’s opinion

Dual-plane atrophic acne scar treatment led to an impressive improvement in

the depth of the scars, suggesting that this technique can result in safe and
rapid amelioration of atrophic acne scars in only two sessions.
 DUAL-PLANE INJECTION TECHNIQUE

The dual-plane technique consists of seven steps:

1. mark each appropriate scar, outlining where it is to be injected.
2. assess the total volume likely to be required.
3. evaluate what structures may lie beneath the scar to avoid injury.
4. inject each scar intradermally using a 29G needle.
5. manually mold small overfilled scars into position at the end of the injection if necessary.
6. make an entry point adjacent to the scar or scarred area, insert a 25G cannula into the
superficial hypodermis. Subcise the area below the scar and leave a small deposit of material.
7. repeat at 4 weeks in a supplemental procedure usually requiring about 70% of the initial
corrective volume.

First pass filling the scars in the dermis,
using a 29G syringe.
The second injection pass was done using
a 25G cannula immediately under the
dermis using the blunt cannula to disrupt
the subcutaneous fat under the superficially
injected scars.

Dual-plane atrophic acne scar treatment appears to be a safe and efficient

way to treat facial atrophic acne scars. The benefits of HCC HA-based
formulations (PROFHILO®) may be related to their pro-collagenogenic and
pro-adipogenic effects.

Daily home care

Application of antibiotic cream twice daily for a week and a broad-spectrum sunscreen
with a sun protection factor of at least 30 SPF.
CASE
REPORT 9 Carlo Peramezza
Plastic surgeon, Italy
carloprn@libero.it

Combo treatment (Aliaxin® and PROFHILO®) to

correct long-term volumetric changes in the face
Patient’s history and needs
46 yrs old, Italian Caucasian woman.
Good skin tissue.
Static wrinkles in the upper third of the face on the forehead, glabella and periocular region,
with an early lowering of the eyebrows.
Overall emptying of the face, made worse by recent weight loss, resulting in an overall
appearance of laxity, with pseudo eyelid bags and deep nasolabial folds.
Slight prognathism
contributes to the
impression of lack of
prominence of the
upper lip and nose.
The patient complains
of looking old and tired
in the face. She would
like to have a fresher
and overall younger
look to the face.

BEFORE AFTER

The doctor’s opinion

Volume restoration with filler associated with bioremodeling with PROFHILO®
and treatment with botulinum toxin has cancelled out the tired, lax
appearance of the face.
The result is extremely natural-looking and the patient is very satisfied.
 Treatment protocol
Volume restoration – 1st treatment (T0)

Volume restoration in malar/zygomatic region

via supraperiosteal injection of 3 ml of Aliaxin®
EV using 27G needle.
During the same session, 1 ml of Aliaxin® EV is
injected into the nasolabial folds.
Total product: 4 syringes, 4 ml.

Bioremodeling (6 months after T0)

3 sessions at 30-day intervals and a recall visit

every 3 months, using 2 ml of PROFHILO®
(BAP technique) at each session injected in
deep dermis using a 29G needle. T0
Total product: 1 syringe, 2 ml.

Volume restoration – 2nd treatment

(14 months after T0)

Following partial reabsorption of previously

implanted filler, it is decided to restore the
volume of the malar/zygomatic region via
supraperiosteal injection of 2 ml of Aliaxin® EV
using a 27G needle. During the same session,
the upper lip is treated with 1 ml of Aliaxin® FL
injected using a 25G cannula, and the temples
and the zygomatic arch are treated with deep
supraperiosteal injection of 2 ml of Aliaxin® EV
using a 27G needle.
Total product: 5 syringes, 5 ml.
After 2nd volume restoration After 3rd volume restoration
using a 29G syringe.
Volume restoration – 3rd treatment
(18 months after T0) Volume restoration associated with
bioremodeling with PROFHILO® and treatment
Botulinum toxin treatment is repeated in the with botulinum toxin has eliminated the tired,
upper 1/3 and the lacrimal groove is treated lax appearance of the face. Overall, the face
with 1 ml of Aliaxin® FL injected using a 27G
cannula. During the same session, 1 ml of looks younger: static and dynamic wrinkles
Aliaxin® EV is injected into the nasolabial folds are reduced and the texture of the skin is
and the nasal spine to fill the depressions and improved.
give greater prominence to the nose. Lastly,
the lower third of the face is treated with 2 ml
of Aliaxin® EV injected subcutaneously using
a 25G cannula into the chin depression and
marionette lines. Safety points
Inject very slowly to reduce pain.
Total product: 4 syringes, 4 ml.
Daily home care
Gently massage the area treated.
Apply a gentamicin-betamethasone cream on the day of treatment and the following day.
CASE
REPORT 10 Sharon Davidson
DMD, aesthetic physician, Israel
sharondavidsohn@gmail.com

Barcode wrinkles treated with Aliaxin®

and PROFHILO®
Patient’s history and needs
54-yr-old female patient
Bright and untreated thin skin
Dry type skin
Elastosis on cheeks and perioral area highly demonstrated by contraction of the orbicularis oris muscle
Superficial fat pads of the cheek area seem empty
Barcode and side cheek seams on smiling
Previous botulinum toxin injections
• Non-smoking
• No ongoing dental procedures
Patient complained about aging of the perioral area: barcode wrinkles and marionette lines were
demonstrated well.

The doctor’s opinion

The combo use of Aliaxin® and PROFHILO® allowed to improve skin texture,
with natural and vital results.
Patient was very satisfied; both the barcode area and the mouth angles
seemed to give younger appearance and the marionette line almost
disappeared. Under contraction the dynamic wrinkles seemed less evident.

Product and technique

Aliaxin® SR, 25G cannula, for the buccal fat pad area (fanning technique) including
marionette line.
Aliaxin® SR bolus, 30G needle, for the barcode area (linear retrograde technique).
PROFHILO®, 29G needle, for the perioral area.

Epidermis

Dermis

Subcutaneous
tissue

Muscle
Periosteum
Bone
 Treatment protocol
Session 1 (T0)

Aliaxin® SR using a 25G

cannula was injected into
the buccal fat pad and in
the marionette line with the
fanning technique.
Aliaxin® SR using a 30G
needle was injected into
the barcode area with linear
retrograde technique both
horizontally and vertically.
Total product: 2 syringes,
2 ml.

Session 2 (2 weeks after T0)

Dysport®, 30 units, injected

into the vermilion border.

Session 3 (4 weeks after T0)

PROFHILO® 0.2 ml, 10

boluses, using a 29G needle
in the perioral area.
Total product: 1 syringe, 2 ml.

BEFORE BEFORE SESSION 2 BEFORE SESSION 3 1 MONTH AFTER SESSION 3

The Company
IBSA is a privately owned pharmaceutical company,
founded in Lugano in 1945 by a group of Swiss
biologists.
After its first steps on the domestic market, IBSA quickly
strengthened its position internationally thanks to a
consolidated global expansion strategy.

Today, IBSA is present on 5 continents and over 80

countries, including the USA.
The company experienced a key moment in 1985, when the
current management acquired its ownership, completely
redefining its vision and strategy and bringing it for
the first time on the international scene. Since then, an
extraordinary and intense development program has been
launched to expand the company’s assets and create a
competitive product portfolio.
As a result, IBSA today has achieved a leading position in
the global markets in specific therapeutic areas.
Following this extensive expansion, IBSA today counts on
10 companies, between affiliates and representative offices
in Europe, China and United States, and boasts a product
portfolio covering 9 major therapeutic areas.
Over the years, the Group has grown considerably, also
beyond Swiss borders and today employs more than 1400
people.
Today IBSA is the largest privately owned
pharmaceutical company in Switzerland, the fourth
largest operator in the Fertility sector, after the major
multinationals, and one of the world leaders in products
based on hyaluronic acid.

MISSION
IBSA is strongly committed to enhancing the life quality of
patients from a physical, emotional, psychological and
relational point of view.
IBSA is a caring employer and delivers superior value to all
stakeholders in a responsible, ethical and sustainable way.

VISION
IBSA strives to shape drugs into their best form, to make
them more patient-friendly and provide treatments that
better patients’ quality of life.
IBSA develops special technologies that qualitatively
improve existing therapeutic molecules and solutions.
The company aims to stand out as the creator of innovative
pharmaceuticals and administering systems of proven and
superior efficacy.
Dermoaesthetic

The dermoaesthetic area offers a full range of

products and brands such as Viscoderm®,
Profhilo® and Aliaxin® based on the Hydrolift®
Action concept. Hydrolift® Action is an
innovative approach aimed at counteracting
the physiological reduction of hyaluronic acid
in the skin, restoring hydration, elasticity and
skin tone. Hydrolift® Action is an expression
of the synergistic action derived from the use
of selected hyaluronic acid produced using
patented IBSA technology, which when used in
concert create optimal conditions for preventing
and fighting the aging process.

Aliaxin® is IBSA’s filler line for volume restoration

produced according to an innovative technology
that assures high tissue integration.
All formulations are developed specifically for
each indication by using a combination of
hyaluronic acid at different molecular weights,
thereby creating distinct visco-elastic properties.

Profhilo®, stabilized hybrid cooperative

complexes, is the first product developed with
NAHYCO® technology, a unique and innovative
production process patented by IBSA, aimed
at counteracting skin laxity through tissue
remodeling.

Viscoderm®, ultrapure natural hyaluronic

acid, is a complete line for bio restructuration
procedures, aimed at restoring the physiological
conditions of healthy skin: Hydration, firmness
and brightness.
 IBSA IS ONE OF THE
LEADING PHARMACEUTICAL
COMPANIES
IN HYALURONIC
ACID PRODUCTION
&
PRODUCTS
CONTAINING
HA

• Scientific knowledge

• Technological developments

• Full production process control

HA raw material finished product

• State of the art production plants

• Continuous R&D investments

IBSA’s hyaluronic acid is an ultrapure grade HA,

produced through a patented biofermentation p  rocess,
of Streptococcus Zooepidemicus.
 Materiale destinato esclusivamente agli operatori sanitari
Cod. IST-CRB-001-2019-E

IBSA Farmaceutici Italia S.r.l

Via Martiri di Cefalonia 2 - 26900 Lodi - Italy
www.ibsaderma.com