JIMMA UNIVERSITY

COLLEGE OF NATURAL SCIENCES

DEPARTMENT OF CHEMISTRY

WORKSHEET OF ORGANIC CHEMISTRY

Answer the Following Questions Accordingly

1. Erythronolide B is the biological precursor of erythromycin, a broad-spectrum antibiotic.
How many chirality centers does erythronolide B have? Identify them.

2. Eight alcohols have the formula C5H12O. Draw them. Draw their structure and identify
whether they are chiral or achiral?
3. Which of the following are chiral and, therefore, capable of existing as enantiomers?
(a) 1,3-Dichlorobutane (c) 1,5-Dichloropentane
(b) 1,2-Dibromopropane (d) 3-Ethylpentane

4. Assign R or S configuration to each chirality center in the following molecules:

5. What are the stereochemical relations (identical, enantiomers, diastereoisomers) of the

following four molecules (I–IV)? Assign absolute configurations at each stereogenic centre.
 I. II.

III. IV.

6. The product of the following substitution reaction is ______________

7. Write the product of the following substitution reaction.

8. Which one of the following alkyl halide undergoes SN1 reaction?

A. B. C.