12/12/2023

Regression II
Non-linear regression using curve fitting

Linear regression shows a relationships where an

increase in one variable is associated with a
predictable increase in another variable.

1
 12/12/2023

What is a non-linear regression?

• Nonlinear regression refers to a regression analysis where the
regression model portrays a nonlinear relationship between a
dependent variable and independent variables.
• In other words, the relationship between predictor and response
variable follows a nonlinear pattern.
• It is more accurate and flexible than a linear model.
• The model can accommodate diverse curves deriving complex
relations between two or more variables.

Example 1: Quadratic equation

2
 12/12/2023

Example 2: Cosine Relationships

Curve Fitting of Non-Linear Data using Solver

in Excel

3
 12/12/2023

Michaelis-Menten Enzyme Kinetics

(can be used for Monod fitting)
[S] Vo
30 17.31
37.5 20.45
46.88 23.94

𝑉 = 𝑉𝐾𝑚𝑎𝑥 𝑆
58.59 27.71
73.24 31.71 +𝑆
91.55 35.85
𝑚
114.44 40.03
143.05 44.14
178.81 48.1
223.52 51.82
279.4 55.23
349.25 58.31
436.56 61.02
545.7 61.38

Sigmoidal
curve

4
 12/12/2023

PR