Professional Documents
Culture Documents
ANVISA Normative Instruction N.° 116 - 2021
ANVISA Normative Instruction N.° 116 - 2021
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 422
012302434537805 9 9900140 43409 9900140
9:;<=>=>?@A@ABA>?C<@<DEFGHIJ<EJEHKLGHIJ<EMNGOPEQK<@<RILK<A@AB<RILKGHNJIL<LEMNGLEPEQKS<TUL<KVE
WISGH<SITEKX<IQF<ESSEQKGIJ<OELTULPIQHE<UT<VGYV<TLEMNEQHX<SNLYGHIJ<EMNGOPEQK<IQF<VGYV<TLEMNEQHX<SNLYGHIJ
IHHESSULGES
Z[\]<\[^<9:;<=>=>?@A@_BA>?`<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@_B
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FE<EMNGOIPEQKUS<FE<KELIOGI<OUL
UQFIS<HNLKIS
Z[\]<\[^<9:;<=>=>?@A@`BA>?`<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@`B<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FE<FESfWLGJIFULES<HILFgIHUS
Z[\]<\[^<9:;<=>=>?@A@hBA>?A<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@hB<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FUS<EMNGOIPEQKUS<FE<fSGUKELIOGI<OUL
NJKLISSUP
Z[\]<\[^<9:;<=>=>?@A@=BA>?`<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@=B
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FUS<EMNGOIPEQKUS<FE<KELIOGI<OUL
PGHLU@UQFIS
Z[\]<\[^<9:;<=>=>?@A@?>BA>?`<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@?>B
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FE<ESKGPNJIFULES<FE<QELiUS<E
PjSHNJUS
9kl<m>=>?@A@?ABA>A><@<DEFGHIJ<EJEHKLGHIJ<EMNGOPEQK<@<RILK<A@?AB<RILKGHNJIL<LEMNGLEPEQKS<TUL
WISGH<SITEKX<IQF<ESSEQKGIJ<OELTULPIQHE<UT<HLGKGHIJ<HILE<iEQKGJIKULS
Z[\]<\[^<9kl<m>=>?@A@?_BA>?C<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@?_B<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FE<ESKIdnU<FE<KLIWIJVU<FE<IQESKESGI
Z[\]<\[^<9:;<=>=>?@A@?=BA>?h<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@?=B<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FUS<EMNGOIPEQKUS<FE<VEPUFGeJGSEo
VEPUFGIfJKLIdnU<E<VEPUfJKLIdnU
Z[\]<\[^<9:;<=>=>?@A@?mBA>?`<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@?mB<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FUS<EMNGOIPEQKUS<EQFUSHpOGHUS
Z[\]<\[^<9:;<=>=>?@A@?bBA>?`<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@?bB
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FIS<GQHNWIFULIS<OILI<LEHcP@
QISHGFUS
Z[\]<\[^<9:;<=>=>?@A@A>BA>?A<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@A>B
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FIS<GQHNWIFULIS<FE<KLIQSOULKE
OILI<LEHcP@QISHGFUS
Z[\]<\[^<9:;<=>=>?@A@A?BA>?_<a<:PEQFI<?BA>?b<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@A?B
^EMNGSGKUS<OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FE<IMNEHEFULES<LIFGIQKES<OILI
LEHcP@QISHGFUS
Z[\]<\[^<9:;<=>=>?@A@AABA>?A<a<:PEQFI<?<BA>?`<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@AAB
^EMNGSGKUS<OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FE<EMNGOIPEQKU<I<JISEL<OILI
HGLNLYGISo<NSU<HUSPcKGHUo<KELIOqNKGHU<E<FGIYQpSKGHU
Z[\]<\[^<9:;<=>=>?@A@A_BA>?A<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@A_B<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FE<EMNGOIPEQKUS<FE<PUQGKULIdnU<FI
OLESSnU<OILHGIJ<KLIQSHNKrQEI
Z[\]<\[^<9:;<=>=>?@A@A`BA>?h<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@A`B<^EMNGSGKUS
OILKGHNJILES<OILI<I<SEYNLIQdI<WeSGHI<E<U<FESEPOEQVU<ESSEQHGIJ<FE<WUPWIS<FE<GQTNSnU<E<FE<HUQKLUJIFULES
FE<GQTNSnU
Z[\]<\[^<9:;<=>=>?@A@AhBA>?`<@<:MNGOIPEQKU<EJEKLUPcFGHUS<@<RILKE<A@AhB<^EMNGSGKUS
OILKGHNJILES<OILI<SEYNLIQdI<WeSGHI<E<FESEPOEQVU<ESSEQHGIJ<FE<EJEKLUHILFGpYLITU
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 522
012302434537805 9 9900140 43409 9900140
9:;<=;:>=?@A=BCBCDEFEFBGFCDH=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEFBG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VO=OSOQTROPWO_MS̀ZTM_RX
9:;<=;:>=?@A=BCBCDEFEFaGFCDb=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEFaG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=VO=NRPKQRTM[cR
OSOQTRWMTVKRZT]dWM
9:;<=;:>=?@A=BCBCDEFEFeGFCDf=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEFeG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=WRPgJPQRX=ONKXXRTOX=VO=TMVKM[cR=h
LMTM=VKMZP`XQKWR=NUVKWR
9:;<=;:>=?@A=eCBCDEFEbCGFCDF=i=@NOPVM=DGFCDH=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbCG
>OIJKXKQRX=LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=OXdZNRNMPjNOQTRX
MJQRN]QKWRX=PcREKPkMXKkRX
9:;<=;:>=?@A=BCBCDEFEbDGFCDb=i=@NOPVM=DGFCDH=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbDG
>OIJKXKQRX=LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=NMTWMELMXXRX=WMTVlMWRX
OmQOTPRX=WRN=MSKNOPQM[cR=OSUQTKWM=KPQOTPM
9:;<=;:>=?@A=BCBCDEFEbHGFCDH=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbHG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=KPkMXKkRX=VO
NRPKQRTM[cR=VM=LTOXXcR=XMPZJlPOM
9:;<=;:>=?@A=eCBCDEFEbnGFCDb=i=@NOPVM=DGFCDf=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbnG
>OIJKXKQRX=LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=VKXLRXKQKkRX=LMTM
MIJOWKNOPQR=IJO=JQKSKoMN=WR\OTQRTOXp=MSNR_MVMX=RJ=WRSW^qOX=O=XcR=VOXQKPMVRX=LMTM=MIJOWKNOPQR=PM
LT]QKWM=NUVKWM
?@A=BCBCDEFEbBGFCDH=rOVKWMS=OSOWQTKWMS=OIJKLNOPQ=E=YMTQ=FEbBG=YMTQKWJSMT=TOIJKTONOPQX=_RT=Q^O
\MXKW=XM_OQs=MPV=OXXOPQKMS=LOT_RTNMPWO=R_=OIJKLNOPQ=_RT=OmQTMWRTLRTOMSSs=KPVJWOV=SKQ^RQTKLXs
9:;<=;:>=?@A=BCBCDEFEbaGFCDB=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbaG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=NUVKWRX=VO
NRPKQRTMNOPQR=O=VKMZP`XQKWR=LRT=JSQTMXXRN
9:;<=;:>=?@A=BCBCDEFEbfGFCDC=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEbfG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=XOZJTMP[M=\]XKWM=O=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=VO=VK]SKXO=LOTKQRPOMS
9:;<=;:>=?@A=BCBCDEFEHCGFCDf=E=@IJKLMNOPQRX=OSOQTRNUVKWRX=E=YMTQO=FEHCG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VO=OSOQTRNK̀ZTM_RX=O=OIJKLMNOPQRX=VO
LRQOPWKMS=OkRWMVR
9:;<=;:>=?@A=BCBCDEFEHDGFCDF=i=@NOPVM=DGFCDH=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEHDG
>OIJKXKQRX=LMTQKWJSMTOX=LMTM=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VMX=SJNKP]TKMX=WKTtTZKWMX=O=VMX
SJNKP]TKMX=LMTM=VKMZP`XQKWR
9:;<=;:>=?@A=BCBCDEFEHbGFCDF=i=@NOPVM=DGFCDf=i=@NOPVM=FGFCFD=E=@IJKLMNOPQR
OSOQTRNUVKWRX=E=YMTQO=FEHbG=>OIJKXKQRX=LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=VOXONLOP^R=OXXOPWKMS=VRX
OIJKLMNOPQRX=VO=TMKRX=h=LMTM=LTRWOVKNOPQRX=KPQOTkOPWKRPKXQMX
9:;<=;:>=?@A=BCBCDEFEHHGFCDa=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEHHG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=VO=TMKRX=h=LMTM
QRNRZTMdM=WRNLJQMVRTKoMVM
9:;<=;:>=?@A=BCBCDEFEHnGFCDb=i=@NOPVM=DGFCDa=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEHnG
>OIJKXKQRX=LMTQKWJSMTOX=LMTM=M=XOZJTMP[M=\]XKWM=O=R=VOXONLOP^R=OXXOPWKMS=VRX=OIJKLMNOPQRX=VO=TMKRX=h
LMTM=NMNRZTMdM=O=VRX=VKXLRXKQKkRX=VO=OXQOTORQMmKM=NMNRZT]dWM
9:;<=;:>=?@A=BCBCDEFEHBGFCFC=E=@IJKLMNOPQR=OSOQTRNUVKWRX=E=YMTQO=FEHBG=>OIJKXKQRX
LMTQKWJSMTOX=LMTM=XOZJTMP[M=\]XKWM=O=VOXONLOP^R=OXXOPWKMS=VO=NOXMX=VO=RLOTM[cR
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 722
012302434537805 9 9900140 43409 9900140
9:;<=;:>=?@A=BCBCDEFEGHIFCDG=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEGHI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=YLYRPONY=PTPRUSXNUWLS[U^`XSY
NO]KTNRSULNLY
9:;<=;:>=?@A=BCBCDEFEGaIFCDG=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEGaI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=OKTRLbKQXLSQNLY=WP
OSQLRSUN\cS=WP=MNXLPQRPY
9:;<=;:>=?@A=BCBCDEFEdCIFCDC=e=@OPQWN=DIFCDa=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEdCI
>PJKLYLRSY=MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WS=PJKLMNOPQRS=WP=bSRSRPUNMLN
MNUN=UPXVOEQNYXLWS
9:;<=;:>=?@A=BCBCDEFEdFIFCDf=e=@OPQWN=DIFCFC=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEdFI
>PJKLYLRSY=MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WNY=XNONY=_SYMLRNTNUPY
?@A=BCBCDEFEdGIFCCa=e=9OWg=DIFCDd=e=9OWgFIFCDh=E=iPWLXNT=PTPXRULXNT=PJKLMOPQR=E=ZNUR=FEdGI
ZNURLXKTNU=UPJKLUPOPQRY=bSU=R_P=]NYLX=YNbPRj=NQW=PYYPQRLNT=MPUbSUONQXP=Sb=kEUNj=PJKLMOPQR=bSU=UNWLS[UNM_j
NQW=UNWLSYXSMj
9:;<=;:>=?lm=hCBCDEFEddIFCFC=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEddI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=OSQLRSUPY=WP=[^Y=UPYMLUNRnULS
9:;<=;:>=?lmo?@A=hCBCDEFEdBIFCDf=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEdBI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=RPUOpOPRUSY=XTqQLXSY=MNUN=OPWL\cS=WN
RPOMPUNRKUN=XSUMSUNT
9:;<=;:>=?@A=BCBCDEFEdHIFCDd=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEdHI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=bSQRP=TKOLQSYN=QcS=TNYPU=WPYRLQNWN=r
KRLTLsN\cS=RPUNMtKRLXNu=WLN[QnYRLXNu=XSYOVRLXNoPYRVRLXN=P=WP=OSQLRSUN\cSoYKMPUvLYcS
9:;<=;:>=?lmo?@A=hCBCDEFEdhIFCDH=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEdhI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WSY=WLYMSYLRLvSY=MNUN=UPOS\cS=WS
XULYRNTLQS=P=WLYMSYLRLvSY=MNUN=vLRUPXRSOLN=MNUN=XLUKU[LN=SbRNTOSTn[LXN
9:;<=;:>=?@A=hCBCDEFEBCIFCDd=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBCI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=SWSQRSTn[LXSY
9:;<=;:>=?lm=hCBCDEFEBDIFCDd=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBDI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=MNUN=SwLOPRULN=WP=MKTYS
9:;<=;:>=?@A=BCBCDEFEBFIFCDd=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBFI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=WP=KTRUNYYSO
RPUNMtKRLXS=WP=NTRN=LQRPQYLWNWP=xy?<z{
9:;<=;:>=?@A=BCBCDEFEBfIFCDd=e=@OPQWN=DIFCFC=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBfI
>PJKLYLRSY=MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=WP=UNLSY=k
SWSQRSTn[LXSY=PwRUNSUNLY
9:;<=;:>=?@A=BCBCDEFEBdIFCDG=e=@OPQWN=DIFCFC=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBdI
>PJKLYLRSY=MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=WP=UNLSY=k
SWSQRSTn[LXSY=LQRUNSUNLY
9:;<=;:>=?@A=BCBCDEFEBBIFCFC=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEBBI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WSY=NMNUPT_SY=WP=NOMTL̀XN\cS=YSQSUN
LQWLvLWKNT=P=WSY=YLYRPONY=WP=NMNUPT_SY=WP=NOMTL̀XN\cS=YSQSUN=LQWLvLWKNTg
9:;<=;:>=?lm=hCBCDEFEHCIFCDH=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEHCI=>PJKLYLRSY
MNURLXKTNUPY=MNUN=N=YP[KUNQ\N=]^YLXN=P=S=WPYPOMPQ_S=PYYPQXLNT=WP=PJKLMNOPQRSY=WP=RPUNMLN=UPYMLUNRnULN
MNUN=NMQPLN=WS=YSQS
9:;<=;:>=?lm=hCBCDEFEHFIFCDh=E=@JKLMNOPQRS=PTPRUSOVWLXSY=E=ZNURP=FEHFI=>PJKLYLRSY
PYMPXq̀XSY=MNUN=YP[KUNQ\N=]^YLXN=P=WPYPOMPQ_S=PYYPQXLNT=WP=vPQRLTNWSUPY=WP=XKLWNWS=OVWLXS=WSOLXLTLNU
MNUN=MNXLPQRPY=WPMPQWPQRPY=WP=vPQRLTNWSUPY
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 122
012302434537805 9 9900140 43409 9900140
9:;<=;:>=?@A=BCDCEFGFHIJGCGC=F=KLMNOPQRSTU=RVRTWUQXYNZU[=F=\PWTR=GFHIJ=>RLMN[NTU[
OPWTNZMVPWR[=OPWP=[R]MWPS^P=_`[NZP=R=YR[RQORSaU=R[[RSZNPV=YR=RLMNOPQRSTU[=YR=MQNYNbZP^cU=WR[ONWPTdWNP
?@A=BCDCEFGFBIJGCGC=F=eRYNZPV=RVRZTWNZPV=RLMNOQRST=f=\PWT=GFBIJ=\PWTNZMVPW=WRLMNWRQRST[=gUW
TaR=_P[NZ=[PgRTh=PSY=R[[RSTNPV=ORWgUWQPSZR=Ug=iRSTNVPTUW[=gUW=TaR=RQRW]RSZh=QRYNZPV=[RWiNZR[=RSiNWUSQRST
Ij=9[=SUWQP[=TXZSNZP[=VN[TPYP[=P=[R]MNWk=[RWcU=ZUQOMV[dWNP[=P=TUYU[=U[=RLMNOPQRSTU[=[U_=WR]NQR
YR=lN]NVmSZNP=@PSNT`WNP=LMR=R[TRnPQ=YRSTWU=YU[=[RM[=WR[ORZTNiU[=ZPQOU[=YR=POVNZP^cUJ
?@A=EIIoHJGCEH=F=pRSTN[TWh=F=qPSYONRZR[=PSY=QUTUW[
?@A=HIrIFEJGCEB=F=pRSTN[TWh=F@TPTNUSPWh=YRSTPV=MSNT[=PSY=YRSTPV=OPTNRST=ZaPNW[=F=\PWT=EJ=sRSRWPV
WRLMNWRQRST[
?@A=HIrIFGJGCEo=F=pRSTN[TWh=F=pRSTPV=MSNT[F=\PWT=GJ=9NWk=tPTRWk=[MZTNUS=PSY=tP[TRtPTRW=[h[TRQ[
9:;<=;:>=?@A=DBHoJGCEI=F=AYUSTUVU]NP=F=uPYRNWP=UYUSTUVd]NZP=OPWP=OPZNRSTR
?@A=rDBCJGCEI=F=pRSTN[TWh=AORWPTNS]=VN]aT[
9:;<=;:>=?@A=EEEroJ=GCGE=F=eN[TMWPYUW=YR=]`[=OPWP=M[U=QXYNZU=F=eN[TMWPYUWR[=YR=]`[
PMTvSUQU[
9:;<=;:>=?@A=ECDoEFwJGCEI=F=lRSTNVPYUWR[=OMVQUSPWR[=OPWP=M[U=QXYNZU=F=\PWTR=wJ=>RLMN[NTU[
OPWTNZMVPWR[=OPWP=iRSTNVPYUWR[=YR=TWPS[OUWTR=R=RQRW]xSZNP
9:;<=;:>=?@A=HEHDFEJGCEB=F=uPYRNWP=YR=>UYP[=F=\PWTR=EJ=pRTRWQNSP^cU=YP=R[TP_NVNYPYR=R[T`TNZP
9:;<=;:>=?@A=HEHDFwJGCEo=F=uPYRNWP=YR=WUYP[=F=\PWTR=wJ=pRTRWQNSP^cU=YP=RbZ`ZNP=YU[=gWRNU[
9:;<=;:>=?@A=HEHDFHJGCCr=F=uPYRNWP=YR=>UYP[=F=\PWTR=HJ=eRYN^cU=YR=YNQRS[yR[=YR=P[[RSTU[=R
WUYP[
9:;<=;:>=?@A=HEHDFBJGCEB=F=uPYRNWP=YR=>UYP[=F=\PWTR=BJ=>RLMN[NTU[=R=QXTUYU[=YR=RS[PNU=OPWP
gUW^P=R[T`TNZPk=YR=NQOPZTU=R=gPYN]P
?@A=HEHDFEIJGCCB=F=zaRRVZaPNW[=F=\PWT=EIJ=\UtRW=PSY=ZUSTWUV=[h[TRQ[=gUW=RVRZTWNZPVVh=OUtRWRY
taRRVZaPNW[=PSY=[ZUUTRW[=F=>RLMNWRQRST[=PSY=TR[T=QRTaUY[
9:;<=;:>=?@A=HEHDFEoJGCCr=F=uPYRNWP=YR=>UYP[=F=\PWTR=EoJ=>RLMN[NTU[=YR=YNiMV]P^cU=YR
NSgUWQP^cUk=YUZMQRSTP^cU=R=NYRSTNbZP^cU
9:;<=;:>=?@A=HEHDFGEJGCEr=F=uPYRNWP[=YR=WUYP[=F=\PWTR=GEJ=>RLMN[NTU[=R=QXTUYU[=YR=RS[PNU
OPWP=ZUQOPTN_NVNYPYR=RVRTWUQP]SXTNZP=YR=ZPYRNWP[=YR=WUYP[=QUTUWN{PYP[=R=[ZUUTRW[=R=ZPWWR]PYUWR[=YR
_PTRWNP[
?@A=HEHDFGoJGCEw=F=zaRRVZaPNW[=F=\PWT=GoJ=:PTTRWNR[=PSY=ZaPW]RW[=gUW=OUtRWRY=taRRVZaPNW[
?@A=ECowoJGCCD=F=qUN[T[=gUW=TaR=TWPS[gRW=Ug=YN[P_VRY=ORW[US[=f=>RLMNWRQRST[=PSY=TR[T=QRTaUY[
9;K|A=??
;UWQP=sRWPV K}N]N_NVNYPYR=ZUQOMV[dWNP
E9:;<=;:>=?Ku=DCDCEFEJGCEC=~=KQRSYP=EJGCED iN]RSTR
;UWQP[=uUVPTRWPN[=YP=[XWNR=?Ku=DCDCE K}N]N_NVNYPYR=ZUQOMV[dWNP
E 9:;<=;:>=?Ku=DCDCEFEFGJGCEH iN]RSTR
G 9:;<=;:>=?Ku=DCDCEFEFwJGCEE=~=KQRSYP=EJGCED iN]RSTR
w 9:;<=;:>=?Ku=DCDCEFEFDJGCEE iN]RSTR
wjE9:;<=;:>=?Ku=DCDCEFEFDJGCEE=~=KQRSYP=EJGCGC wEYR{GCGG
I 9:;<=;:>=?Ku=DCDCEFEFBJGCEC=~=KQRSYP=EJGCEI iN]RSTR
o 9:;<=;:>=?Ku=DCDCEFEFrJGCEC=~=KQRSYP=EJGCEI iN]RSTR
D 9:;<=;:>=?Ku=DCDCEFEFECJGCEC=~=KQRSYP=EJGCEH iN]RSTR
H 9:;<=;:>=?Ku=DCDCEFEFEEJGCEG iN]RSTR
HjE 9:;<=;:>=?Ku=DCDCEFEFEEJGCGE wEnMVGCGI
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 122
012302434537805 9 9900140 43409 9900140
9 :;<=><;?>@AB>CDCDEFEFEGHGDGD IJKLMNL
OPQRLMNL>STUT>QV>ULWXJVJNQV>YZE[>YZ\ZG>L>YZ\Z]>^T>UL_LUJ^T>MQURT
<QURTV>`TUNJaXbTULV>^T>VcUJL>@AB>CDCDEd9DCDE AeJKJfJbJ^T^L>aQRSXbVgUJT
E @AB>CDCDEFGFGHGDEh IJKLMNL
G :;<=><;?>@AB>CDCDEFGF]HGDEY IJKLMNL
GZE :;<=><;?>@AB>CDCDEFGF]HGDEY>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
] :;<=><;?>@AB>CDCDEFGFYHGDEY IJKLMNL
Y :;<=><;?>@AB>CDCDEFGF\HGDEG IJKLMNL
\ :;<=><;?>@AB>CDCDEFGFCHGDEY IJKLMNL
\ZE :;<=><;?>@AB>CDCDEFGFCHGDEY>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
C :;<=><;?>@AB>CDCDEFGFEDHGDEY IJKLMNL
CZE :;<=><;?>@AB>CDCDEFGFEDHGDEY>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
h :;<=><;?>@Pl>9DCDEFGFEGHGDEY IJKLMNL
hZE @Pl>9DCDEFGFEGHGDGD ]Ed^LkdGDG]
9 :;<=><;?>@Pl>9DCDEFGFE]HGDEh IJKLMNL
j :;<=><;?>@AB>CDCDEFGFECHGDE\ IJKLMNL
ED :;<=><;?>@AB>CDCDEFGFE9HGDEY IJKLMNL
EE :;<=><;?>@AB>CDCDEFGFEjHGDEY IJKLMNL
EEZE :;<=><;?>@AB>CDCDEFGFEjHGDEY>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
EG :;<=><;?>@AB>CDCDEFGFGDHGDEG IJKLMNL
EGZE :;<=><;?>@AB>CDCDEFGFGDHGDEG>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
E] :;<=><;?>@AB>CDCDEFGFGEHGDE] IJKLMNL
E]ZE :;<=><;?>@AB>CDCDEFGFGEHGDE]>i>ARLM^T>EHGDEj ]Ed^LkdGDGG
EY :;<=><;?>@AB>CDCDEFGFGGHGDEG>i>ARLM^T>E>HGDEY IJKLMNL
E\ :;<=><;?>@AB>CDCDEFGFG]HGDEG IJKLMNL
EC :;<=><;?>@AB>CDCDEFGFGYHGDE\ IJKLMNL
Eh :;<=><;?>@AB>CDCDEFGFG\HGDEY IJKLMNL
E9 :;<=><;?>@AB>CDCDEFGFGCHGDEY IJKLMNL
Ej :;<=><;?>@AB>CDCDEFGFGhHGDE] IJKLMNL
GD :;<=><;?>@AB>CDCDEFGFG9HGDEj IJKLMNL
GE :;<=><;?>@AB>9DCDEFGF]DHGDEG>i>ARLM^T>EHGDEY IJKLMNL
GG :;<=><;?>@AB>CDCDEFGF]EHGDE]>i>ARLM^T>EHGDEY IJKLMNL
G] :;<=><;?>@AB>CDCDEFGF]YHGDEY IJKLMNL
GY :;<=><;?>@AB>CDCDEFGF]\HGDDC IJKLMNL
GYZE:;<=><;?>@AB>9DCDEFGF]\HGDE]>i>ARLM^T>EHGDEj ]Ed^LkdGDG]
G\ @AB>CDCDEFGF]CHGDEY IJKLMNL
GC :;<=><;?>@AB>CDCDEFGF]hHGDEC IJKLMNL
Gh :;<=><;?>@AB>CDCDEFGF]jHGDED IJKLMNL
G9 :;<=><;?>@AB>CDCDEFGFYDHGDEj IJKLMNL
Gj :;<=><;?>@AB>CDCDEFGFYEHGDEG>i>ARLM^T>EHGDEY IJKLMNL
]D :;<=><;?>@AB>CDCDEFGFY]HGDEG IJKLMNL
]DZE:;<=><;?>@AB>CDCDEFGFY]HGDEG>i>ARLM^T>EHGDEj>i>ARLM^T>GHGDGE]Ed^LkdGDG]
]E :;<=><;?>@AB>CDCDEFGFYYHGDEh IJKLMNL
]G :;<=><;?>@AB>CDCDEFGFY\HGDE]>i>ARLM^T>EHGDEh IJKLMNL
]] :;<=><;?>@AB>CDCDEFGFYCHGDEG IJKLMNL
]]ZE:;<=><;?>@AB>CDCDEFGFYCHGDGD ]Ed^LkdGDG]
]Y :;<=><;?>@AB>CDCDEFGFYhHGDEY IJKLMNL
]\ :;<=><;?>@AB>CDCDEFGFYjHGDEY IJKLMNL
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 722
012302434537805 9 9900140 43409 9900140
9: ;<=>?=<@?ABC?:D:DEFGFHDIGDED JKLMNOM
9:PE;<=>?=<@?ABC?:D:DEFGFHDIGDED?Q?BRMNST?EIGDEU 9EVSMWVGDGG
9X ;<=>?=<@?ABC?:D:DEFGFHGIGDE9 JKLMNOM
9XPE ;<=>?=<@?ABC?:D:DEFGFHGIGDE9?Q?BRMNST?EIGDGD 9EVSMWVGDGG
9Y ABC?:D:DEFGFHZIGDDU?Q?;RSP?EIGDEH?Q?;RSPGIGDEY JKLMNOM
9U ;<=>?=<@?A[\?YD:DEFGFHHIGDEZ JKLMNOM
9UPE;<=>?=<@?A[\?YD:DEFGFHHIGDGD 9EVSMWVGDG9
ZD ;<=>?=<@?A[\VABC?YD:DEFGFH:IGDE9 JKLMNOM
ZE ;<=>?=<@?ABC?:D:DEFGFHXIGDEH JKLMNOM
ZG ;<=>?=<@?A[\VABC?YD:DEFGFHYIGDE9 JKLMNOM
ZGPE;<=>?=<@?A[\VABC?YD:DEFGFHYIGDEX 9EV]^_VGDGZ
Z9 ;<=>?=<@?ABC?YD:DEFGF:DIGDEH JKLMNOM
ZZ ;<=>?=<@?A[\?YD:DEFGF:EIGDEH JKLMNOM
ZH ;<=>?=<@?ABC?:D:DEFGF:GIGDEH JKLMNOM
Z: ;<=>?=<@?ABC?:D:DEFGF:9IGDEH JKLMNOM
Z:PE;<=>?=<@?ABC?:D:DEFGF:9IGDEH?Q?BRMNST?EIGDGD 9EVSMWVGDGG
ZX ;<=>?=<@?ABC?:D:DEFGF:HIGDEZ JKLMNOM
ZXPE ;<=>?=<@?ABC?:D:DEFGF:HIGDEZ?Q?BRMNST?EIGDGD 9EVSMWVGDGG
ZY ;<=>?=<@?ABC?:D:DEFGF::IGDEX JKLMNOM
ZYPE;<=>?=<@?ABC?:D:DEFGF::IGDGD 9EVSMWVGDG9
ZU ;<=>?=<@?A[\?YD:DEFGFXDIGDEX 9EVSMWVGDG9
HD ;<=>?=<@?A[\?YD:DEFGFXGIGDEY 9EVSMWVGDG9
HE ;<=>?=<@?A[\?YD:DEFGFXZIGDGD 9EVSMWVGDG9
HG A[\?YD:DEFGFYZIGDGD 9EVSMWVGDG9
`MRTKa?=bcRTa BdKLKeK_KSTSM?fbRg^_ahcKT
E A[\?EZZHXIGDEG JKLMNOM
EPE A[\?EZZHXIGDEX 9EVSMWVGDG9
G A[\?XZUZFEIGDEE JKLMNOM
GPE A[\?XZUZFEIGDEY 9EVSMWVGDG9
9 A[\?XZUZFGIGDEH JKLMNOM
Z ;<=>?=<@?A[\?:YXHIGDEZ JKLMNOM
H A[\?U:YDIGDEZ JKLMNOM
: ;<=>?=<@?A[\?EEEUHI?GDDD JKLMNOM
:PE ;<=>?=<@?A[\?EEEUHI?GDGE 9EVSMWVGDG9
X ;<=>?=<@?A[\?ED:HEF9IGDEZ JKLMNOM
Y ;<=>?=<@?A[\?XEX:FEIGDEY JKLMNOM
U ;<=>?=<@?A[\?XEX:F9IGDEH JKLMNOM
ED ;<=>?=<@?A[\?XEX:FXIGDDU JKLMNOM
EE ;<=>?=<@?A[\?XEX:FYIGDDU JKLMNOM
EEPE;<=>?=<@?A[\?XEX:FYIGDEY 9EVSMWVGDG9
EG A[\?XEX:FEZIGDDY JKLMNOM
E9 ;<=>?=<@?A[\?XEX:FEHIGDDU JKLMNOM
EZ ;<=>?=<@?A[\?XEX:FGEIGDEU JKLMNOM
EH A[\?XEX:FGHIGDE9 JKLMNOM
E: A[\?EDH9HIGDD: 9EVSMWVGDG9
BaOM?fbNOMiSb?Njb?a^eaOKO^K?b?g^e_KfTSb?NT?JMcajb?fMcOKkfTSTP
822!!!"#$"%&'"()2*$2!*(2+&,22#$),-.&$&)/.#'.#$$001+*40+*+*0*/()&+*43405731415213848*56037")"7+*8.$*#)&+*4344" 222