Professional Documents
Culture Documents
Full Download pdf of Paller and Mancini - Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood & Adolescence 6th Edition Amy S. Paller - eBook PDF all chapter
Full Download pdf of Paller and Mancini - Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood & Adolescence 6th Edition Amy S. Paller - eBook PDF all chapter
Full Download pdf of Paller and Mancini - Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood & Adolescence 6th Edition Amy S. Paller - eBook PDF all chapter
http://ebooksecure.com/product/andrews-diseases-of-the-skin-
clinical-dermatology-13th-edition-ebook-pdf/
https://ebooksecure.com/download/weinbergs-color-atlas-of-
pediatric-dermatology-ebook-pdf/
http://ebooksecure.com/product/ebook-pdf-disorders-of-childhood-
development-psychopathology/
http://ebooksecure.com/product/original-pdf-childhood-and-
adolescence-voyages-in-development-6th-edition/
(eBook PDF) Disorders of Childhood: Development and
Psychopathology 3rd Edition
http://ebooksecure.com/product/ebook-pdf-disorders-of-childhood-
development-and-psychopathology-3rd-edition/
http://ebooksecure.com/product/ebook-pdf-pediatric-dentistry-
infancy-through-adolescence-6th-edition/
https://ebooksecure.com/download/taylor-and-kellys-dermatology-
for-skin-of-color-ebook-pdf/
https://ebooksecure.com/download/movement-disorders-in-childhood-
ebook-pdf/
https://ebooksecure.com/download/pediatric-dermatology-ebook-pdf/
Any screen.
Any time.
Anywhere.
Activate the eBook version
of this title at no additional charge.
Elsevier eBooks for Practicing Clinicians gives you the power to browse and search
content, view enhanced images, highlight and take notes—both online and offline.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Paller and Mancini -
Hurwitz Clinical
Pediatric Dermatology
A Textbook of Skin Disorders
of Childhood and Adolescence
SIXTH EDITION
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Elsevier
3251 Riverport Lane
St. Louis, Missouri 63043
No part of this publication may be reproduced or transmitted in any form or by any means, electronic
or mechanical, including photocopying, recording, or any information storage and retrieval system, without
permission in writing from the publisher. Details on how to seek permission, further information about the
Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance
Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our understanding, changes in research methods, professional practices, or medical treatment
may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating
and using any information, methods, compounds or experiments described herein. Because of rapid
advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages
should be made. To the fullest extent of the law, no responsibility is assumed by Elsevier, authors, editors
or contributors for any injury and/or damage to persons or property as a matter of products liability,
negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas
contained in the material herein.
Printed in China
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Dedication
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Preface
We were truly honored when initially asked to consider updating expanded discussions of mycoplasma-associated disorders and up-
Hurwitz Clinical Pediatric Dermatology. Dr. Hurwitz was a true icon dated sections on congenital syphilis, toxoplasmosis, and pediatric
of our specialty and one of its founding fathers. We have advanced melanoma. A discussion of congenital Zika virus infections has been
this text to be evidence based but full of our tips for the diagnosis added, as have expanded discussions of therapy for infantile heman-
and treatment of pediatric skin diseases in the four editions since giomas, newer approaches for other vascular tumors and malforma-
Dr. Hurwitz “passed the baton” after writing the first and second edi- tions, and the expanding spectrum of genetic mutations and clinical
tions. In this Paller/Mancini text, we have maintained the focus on presentations of vascular disorders and syndromes. We have expanded
educating and enlightening pediatricians, dermatologists, family the discussions of pediatric vasculitides, as well as factitial disorders
practitioners, medical students, residents, fellows, nurses, and other and delusional infestation in children.
allied pediatric care providers with a book that is practical, relevant, Several new tables have been added or updated in this edition, in-
and user friendly in both its online and paper formats. cluding the evaluation of suspected neonatal infection with herpes
What lies between these covers will be familiar but with many addi- simplex virus, a discussion of monitoring for comorbidities in psoriasis,
tions. The field of pediatric dermatology has continued to expand new classifications for ectodermal dysplasias and epidermolysis bullosa
since our last edition. The molecular bases for many established skin that focus on a molecular basis, fixed-dose combination therapies
diseases continue to be elucidated, and several new disease and syn- for acne vulgaris, contraindications to combined oral contraceptives,
drome associations have been described. The therapeutic armamen- clinical features of polycystic ovary syndrome, the RASopathies, gene
tarium for cutaneous disease has broadened, with many new forms of polymorphisms and pigmentation, the epidermal necrolysis classifica-
pathogenesis-based therapy available for patients, including through tion, diagnostic criteria for hemophagocytic lymphohistiocytosis, an
new classes of drugs. We have strived to maintain a book that repre- update on the contemporary classification of pediatric histiocytoses,
sents a balance between narrative text, useful tables, and vivid clinical consensus-derived PHACES syndrome criteria, the updated ISSVA clas-
photographs. sification of vascular anomalies, updated treatment recommendations
Several new features have been added to this sixth edition, includ- for herpes simplex virus infections, revised Jones criteria for acute
ing a downloadable e-book with the printed edition and more than rheumatic fever, and features of juvenile dermatomyositis.
350 new clinical images. We have updated the sections on atopic As with our last edition, the references have again been extensively
dermatitis, psoriasis, connective tissue diseases, and autoinflamma- updated in our companion online edition, leaving only some excellent
tory disorders to reflect our growing armamentarium of new medica- reviews and landmark articles to allow for more complete textual
tions. Our sections on the ichthyoses, hair and ectodermal dysplasias, content for our readers of the print version.
genetic blistering disorders, and mosaic gene disorders have grown We continue to be indebted to several individuals, without whom
based on so many new discoveries of underlying causes. New direc- this work would not have been possible. First and foremost, we thank
tions, such as the use of stem cell and cell therapy, as well as recombi- Dr. Sidney Hurwitz, whose vision, dedication, and enthusiasm for the
nant protein, for treating epidermolysis bullosa are also mentioned. specialty of pediatric dermatology lives on as a legacy in this text, ini-
Our discussion of treatment for pediatric head lice reflects the mul- tially published in 1981. We are indebted to Teddy Hurwitz, his wife,
titude of new therapy options, and we have expanded the discussion who entrusted to us the ongoing tradition of this awesome project; to
of viral exanthematous diseases, including the resurgence in measles Dr. Alvin Jacobs, a “father” of pediatric dermatology, who kindled the
infections and the broadened scope of manifestations related to flame of the specialty in both of us through his teaching at Stanford; to
infection with human herpesviruses and enteroviruses. There are Dr. Nancy B. Esterly, the “mother” of pediatric dermatology, whose
vi
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Preface vii
superb clinical acumen and patient care made her the perfect role a daily basis and place their trust in us to provide them care; to the
model for another female physician who yearned to follow in her foot- clinicians who referred many of the patients seen in these pages; to
steps; and to Dr. Alfred T. Lane, who believed in a young pediatric intern our pediatric dermatology fellows (especially Dr. Ayelet Ollech),
and mentored him through the process of becoming a mentor himself. nurses, and office staff (especially Melissa Jones and Giuliana Wells),
We are also indebted to the staff at Elsevier, most notably Charlotta who contributed enormously through assistance with literature
Kryhl, Melissa Rawe, Kathleen Nahm, and Janish Paul, who worked searches and the taking and archiving of our many clinical photo-
tirelessly through this edition to again meet the many demands of two graphs; and to our families, whose understanding, sacrifice, support,
finicky academicians; to our patients, who continue to educate us on and unconditional love made this entire endeavor possible.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Contents
viii
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 An Overview of Dermatologic
Diagnosis and Procedures
CHAPTER OUTLINE Configuration of Lesions Racial Variations in the Skin and Hair
Distribution and Morphologic Patterns of Procedures to Aid in Diagnosis
Common Skin Disorders Therapeutic Procedures
Changes in Skin Color
Accurate diagnosis of cutaneous disease in infants and children is a Lesions that tend to merge are said to be confluent. Confluence of
systematic process that requires careful inspection, evaluation, and lesions is seen, for example, in childhood exanthems, Rhus dermatitis,
some knowledge of dermatologic terminology and morphology to erythema multiforme, tinea versicolor, and urticaria.
develop a prioritized differential diagnosis. The manifestations of Lesions localized to a dermatome supplied by one or more dorsal
skin disorders in infants and young children often vary from those ganglia are referred to as dermatomal. Herpes zoster classically occurs
of the same diseases in older children and adults. The diagnosis may in a dermatomal distribution.
be obscured, for example, by different reaction patterns or a ten- Discoid is used to describe lesions that are solid, moderately raised,
dency toward easier blister formation. In addition, therapeutic and disc shaped. The term has largely been applied to discoid lupus
dosages and regimens often differ from those of adults, with medi- erythematosus, in which the discoid lesions usually show atrophy and
cations prescribed on a “per kilogram” (/kg) basis and with liquid dyspigmentation.
formulations. Discrete lesions are individual lesions that tend to remain separated
Nevertheless, the same basic principles that are used to detect disor- and distinct. Eczematoid and eczematous are adjectives relating to in-
ders affecting viscera apply to the detection of skin disorders. An ade- flamed, dry skin with a tendency to thickening, oozing, vesiculation,
quate history should be obtained, a thorough physical examination and/or crusting; although atopic dermatitis is a classic eczematous
performed, and, whenever possible, the clinical impression verified by disorder, other examples of eczema are contact, nummular, and dys-
appropriate laboratory studies. The easy visibility of skin lesions all too hidrotic forms.
often results in a cursory examination and hasty diagnosis. Instead, Grouping and clustering are characteristic of vesicles of herpes
the entire skin should be examined routinely and carefully, including simplex or herpes zoster, insect bites, lymphangioma circumscriptum,
the hair, scalp, nails, oral mucosa, anogenital regions, palms, and soles, contact dermatitis, and bullous dermatosis of childhood.
because visible findings often hold clues to the final diagnosis. Guttate or drop-like lesions are characteristic of flares of psoriasis in
The examination should be conducted in a well-lit room. Initial children and adolescents that follow an acute upper respiratory tract
viewing of the patient at a distance establishes the overall status of the infection, usually streptococcal.
patient and allows recognition of distribution patterns and clues to Gyrate refers to twisted, coiled, or spiral-like lesions, as may be seen
the appropriate final diagnosis. This initial evaluation is followed by in patients with urticaria and erythema annulare centrifugum.
careful scrutiny of primary and subsequent secondary lesions in an Iris or target-like lesions are concentric ringed lesions characteristic
effort to discern the characteristic features of the disorder. of erythema multiforme. The classic “targets” in this condition are
Although not always diagnostic, the morphology and configuration composed of a central dusky erythematous papule or vesicle, a periph-
of cutaneous lesions are of considerable importance to the classifica- eral ring of pallor, and then an outer bright red ring.
tion and diagnosis of cutaneous disease. A lack of understanding of Keratosis refers to circumscribed patches of horny thickening, as
dermatologic terminology commonly poses a barrier to the description seen in seborrheic or actinic keratoses, keratosis pilaris, and keratosis
of cutaneous disorders by clinicians who are not dermatologists. Ac- follicularis (Darier disease). Keratotic is an adjective pertaining to kera-
cordingly, a review of dermatologic terms is included here (Table 1.1). tosis and commonly refers to the epidermal thickening seen in chronic
The many examples to show primary and secondary skin lesions refer dermatitis and callus formation.
to specific figures in the text that follows. The Koebner phenomenon or isomorphic response refers to the appear-
ance of lesions along a site of injury. The linear lesions of warts and
molluscum contagiosum, for example, occur from autoinoculation of
Configuration of Lesions virus from scratching; those of Rhus dermatitis (poison ivy) result from
the spread of the plant’s oleoresin. Other examples of disorders that
A number of dermatologic entities assume annular, circinate, or ring show a Koebner phenomenon are psoriasis, lichen planus, lichen niti-
shapes and are interpreted as ringworm or superficial fungal infections. dus, pityriasis rubra pilaris, and keratosis follicularis (Darier disease).
Although tinea is a common annular dermatosis of childhood, there Lesions in a linear or band-like configuration appear in the form of
are multiple other disorders that must be included in the differential a line or stripe and may be seen in epidermal nevi, Conradi syndrome,
diagnosis of ringed lesions, including pityriasis rosea, seborrheic der- linear morphea, lichen striatus, striae, Rhus dermatitis, deep mycoses
matitis, nummular eczema, lupus erythematosus, granuloma annu- (sporotrichosis or coccidioidomycosis), incontinentia pigmenti, pig-
lare, annular psoriasis, erythema multiforme, erythema annulare ment mosaicism, porokeratosis of Mibelli, or factitial dermatitis. In
centrifugum, erythema migrans, secondary syphilis, sarcoidosis, urti- certain genetic and inflammatory disorders, such linear configura-
caria, pityriasis alba, tinea versicolor, lupus vulgaris, drug eruptions, tions represent the lines of Blaschko, which trace clones of embryonic
and cutaneous T-cell lymphoma. epidermal cells and, as such, represent a form of cutaneous mosa-
The terms arciform and arcuate refer to lesions that assume arc-like icism. This configuration presents as a linear pattern on the extremi-
configurations. Arciform lesions may be seen in erythema multiforme, ties, wavy or S-shaped on the lateral trunk, V-shaped on the central
urticaria, pityriasis rosea, bullous dermatosis of childhood, and some- trunk, and varied patterns on the face and scalp.
times epidermolysis bullosa simplex. Text continued on p. 7
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 1 • An Overview of Dermatologic Diagnosis and Procedures
Plaque Broad, elevated, disk-shaped lesion that Psoriasis (see Fig. 4.6); lichen
occupies an area of .1 cm. It is commonly simplex chronicus
formed by a confluence of papules. (neurodermatitis, see Fig. 3.43);
granuloma annulare (see Fig. 9.62);
nevus sebaceus (see 9.43–9.46);
and lesions of lichen planus
(see Fig. 4.55)
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 • An Overview of Dermatologic Diagnosis and Procedures 3
Tumor Deeper circumscribed solid lesion of Deep hemangioma (see Fig. 12.8)
the skin or subcutaneous tissue that and plexiform neurofibroma
measures .2 cm in diameter. It may be (see Fig. 11.56)
benign or malignant.
Vesicle Sharply circumscribed, elevated, fluid- Herpes simplex (see Figs. 15.8
containing lesion that measures #1 cm and 15.12); hand-foot-and-
in diameter. mouth disease (see Fig. 16.32);
pompholyx (see Fig. 3.47);
varicella (see Fig. 16.1);
and contact dermatitis
(see Fig. 3.65, B)
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
4 1 • An Overview of Dermatologic Diagnosis and Procedures
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 • An Overview of Dermatologic Diagnosis and Procedures 5
SECONDARY LESIONS
Secondary lesions represent evolutionary changes that occur later in the course of the cutaneous disorder. Although helpful in dermatologic
diagnosis, they do not offer the same degree of diagnostic aid as that afforded by primary lesions of a cutaneous disorder.
Crust Dried remains of serum, blood, pus, or Herpes simplex (see Fig. 15.5);
exudate overlying areas of lost or weeping eczematous dermatitis
damaged epidermis. Crust is yellow (see Fig. 3.1); and dried
when formed by dried serum, green honey-colored lesions of
or yellowish-green when formed by impetigo (see Fig. 14.1)
purulent exudate, and dark red or
brown when formed by bloody
exudative serum.
Fissure Dry or moist, linear, often painful Angular cheilitis (see Fig. 17.46)
cleavage in the cutaneous surface that and dermatitis on the palmar
results from marked drying and long- aspect of the fingers (see
standing inflammation, thickening, and Fig. 3.58) or the plantar aspect
loss of elasticity of the integument. of the foot (see Fig. 3.69)
Erosion Moist, slightly depressed vesicular or Herpes simplex (see Figs. 3.31
bullous lesions in which part or all of and 15.3); epidermolytic
the epidermis has been lost. Because ichthyosis in a neonate (see
erosions do not extend into the Fig. 5.6); and superficial forms of
underlying dermis or subcutaneous epidermolysis bullosa (see
tissue, healing occurs without Fig. 13.5)
subsequent scar formation.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
6 1 • An Overview of Dermatologic Diagnosis and Procedures
Ulcer Necrosis of the epidermis and part or all Pyoderma gangrenosum (see
of the dermis and/or the underlying Fig. 25.18) and ulcerated
subcutaneous tissue. hemangioma of infancy (see
Figs. 12.15 and 12.26)
Lichenification Thickening of the epidermis with Atopic dermatitis (see Fig. 3.8);
associated exaggeration of skin chronic contact dermatitis (see
markings. Lichenification results Fig. 3.61, B); and lichen simplex
from chronic scratching or rubbing chronicus (see Fig. 3.43)
of a pruritic lesion.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 • An Overview of Dermatologic Diagnosis and Procedures 7
Moniliform refers to a banded or necklace-like appearance. This is vertebrae. The fifth cranial nerve commonly is involved, and only
seen in monilethrix, a hair deformity characterized by beaded nodu- rarely are lesions seen below the elbows or knees.
larities along the hair shaft. Lichen planus often affects the limbs (see Figs. 4.54, 4.55, and
Multiform refers to disorders in which more than one variety or shape 4.58). Favorite sites include the lower extremities, the flexor surface of
of cutaneous lesions occurs. This configuration is seen in patients with the wrists, the buccal mucosa, the trunk, and the genitalia.
erythema multiforme, urticaria multiforme, early Henoch–Schönlein The lesions of lupus erythematosus most commonly localize to the
purpura, and polymorphous light eruption. bridge of the nose, malar eminences, scalp, and ears, although they
Nummular means coin shaped and is usually used to describe num- may be widespread (see Figs. 22.3 and 22.4). Patches tend to spread
mular dermatitis. at the border and clear in the center with atrophy, scarring, dyspig-
Polycyclic refers to oval lesions containing more than one ring, as mentation, and telangiectases. The malar or butterfly rash is neither
commonly is seen in patients with urticaria. specific for nor the most common sign of lupus erythematosus; telan-
A reticulated or net-like pattern may be seen in erythema ab igne, giectasia without the accompanying features of erythema, scaling,
livedo reticularis, cutis marmorata, cutis marmorata telangiectatica or atrophy is never a marker of this disorder other than in neonatal
congenita, and lesions of confluent and reticulated papillomatosis. lupus.
Serpiginous describes the shape or spread of lesions in a serpentine Molluscum contagiosum is a common viral disorder characterized
or snake-like configuration, particularly those of cutaneous larva by dome-shaped, skin-colored to erythematous papules, often with a
migrans (creeping eruption) and elastosis perforans serpiginosa. central white core or umbilication (see Figs. 15.41 through 15.47).
Umbilicated lesions are centrally depressed or shaped like an umbi- These papules most often localize to the trunk and axillary areas. Al-
licus or navel. Examples include lesions of molluscum contagiosum, though molluscum lesions can be found anywhere, the scalp, palms,
varicella, vaccinia, variola, herpes zoster, and Kaposi varicelliform and soles are rare sites of involvement.
eruption. Photodermatoses are cutaneous disorders caused or precipitated by
Universal (universalis) implies widespread disorders affecting the exposure to light. Areas of predilection include the face, ears, anterior
entire skin, as in alopecia universalis. V of the neck and upper chest, dorsal aspect of the forearms and
Zosteriform describes a linear arrangement along a nerve, as typified hands, and exposed areas of the legs. The shaded regions of the upper
by lesions of herpes zoster, although herpes simplex infection can also eyelids, subnasal, and submental regions tend to be spared. The major
manifest in a zosteriform distribution. photosensitivity disorders are lupus erythematosus, dermatomyositis,
polymorphous light eruption, drug photosensitization, phototoxic
reactions, and porphyria (see Chapter 19).
Distribution and Morphologic Patterns Photosensitive reactions cannot be distinguished on a clinical basis
of Common Skin Disorders from lesions of photocontact allergic conditions. They may reflect in-
ternal as well as external photoallergens and may simulate contact
The regional distribution and morphologic configuration of cutane- dermatitis from airborne sensitizers. Lupus erythematosus can be dif-
ous lesions are often helpful in dermatologic diagnosis. ferentiated by the presence of atrophy, scarring, hyperpigmentation or
Acneiform lesions are those having the form of acne, and an acne- hypopigmentation, and periungual telangiectases. Dermatomyositis
iform distribution refers to lesions primarily seen on the face, neck, with swelling and erythema of the cheeks and eyelids should be dif-
chest, upper arms, shoulders, and back (see Figs. 8.3 through 8.8). ferentiated from allergic contact dermatitis by the heliotrope hue and
Sites of predilection of atopic dermatitis include the face, trunk, and ex- other associated changes, particularly those of the fingers (periungual
tremities in young children; the antecubital and popliteal fossae are the most telangiectases and Gottron papules).
common sites in older children and adolescents (see Figs. 3.1 through 3.11). Pityriasis rosea begins as a solitary round or oval scaling lesion known
The lesions of erythema multiforme may be widespread but have a as the herald patch in 70% to 80% of cases, which may be annular and is
distinct predilection for the hands and feet (particularly the palms and often misdiagnosed as tinea corporis (see Fig. 4.49). After an interval of
soles) (see Figs. 20.35 through 20.37). days to 2 weeks, affected individuals develop a generalized symmetric
Lesions of herpes simplex may appear anywhere on the body but eruption that involves mainly the trunk and proximal limbs. The clue to
have a distinct predisposition for the areas about the lips, face, and diagnosis is the distribution of lesions, with the long axis of these oval le-
genitalia (see Figs. 15.1 through 15.14). Herpes zoster generally has sions parallel to the lines of cleavage in what has been termed a Christmas-
a dermatomal or nerve-like distribution and is usually but not neces- tree pattern (see Figs. 4.50, 4.51, and 4.53). A common variant, inverse
sarily unilateral (see Figs. 15.15 through 15.17). More than 75% pityriasis rosea, often localizes in the inguinal region (see Fig. 4.52), but
of cases occur between the second thoracic and second lumbar the parallel nature of the long axis of lesions remains characteristic.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
8 1 • An Overview of Dermatologic Diagnosis and Procedures
Psoriasis classically consists of round, erythematous, well-marginated more typical of postinflammatory hypopigmentation, pityriasis alba,
plaques with a rich red hue covered by a characteristic grayish or tinea versicolor, leprosy, nevus achromicus, tuberous sclerosis, and
silvery-white mica-like (micaceous) scale that on removal may result the hypopigmented streaks of pigment mosaicism. A generalized de-
in pinpoint bleeding (Auspitz sign) (see Figs. 4.1 through 4.16). crease in pigmentation can be seen in patients with albinism, un-
Although exceptions occur, lesions generally are seen in a bilaterally treated phenylketonuria, and Menkes syndrome. The skin of patients
symmetric pattern with a predilection for the elbows, knees, scalp, and with Chédiak–Higashi and Griscelli syndromes takes on a dull silvery
lumbosacral, perianal, and genital regions. Nail involvement, a valu- sheen and may show decreased pigmentation.
able diagnostic sign, is characterized by pitting of the nail plate, discol-
oration, separation of the nail from the nailbed (onycholysis), and an
accumulation of subungual scale (subungual hyperkeratosis). A Racial Variations in the Skin and Hair
characteristic feature of this disorder is the Koebner or isomorphic
response in which new lesions appear at sites of local injury. The skin of Black and other darker-skinned children varies in several
Scabies is an itchy disorder in which lesions are characteristically ways from that of lighter-skinned children based on genetic back-
distributed on the wrists and hands (particularly the interdigital ground and customs (see Chapter 11). The erythema of inflamed
webs), forearms, genitalia, areolae, and buttocks in older children and black skin may be difficult to see and likely accounts for the purport-
adolescents (see Figs. 18.1 through 18.12). Other family members edly decreased incidence of macular viral exanthems such as ery-
may be similarly affected or complain of itching. In infants and young thema infectiosum. Erythema in Black children commonly has a
children, the diagnosis is often overlooked because the distribution purplish tinge that can be confusing to unwary observers. The skin
typically involves the palms, soles, and often the head and neck. Oblit- lesions in several inflammatory disorders such as in atopic dermatitis,
eration of demonstrable primary lesions (burrows) because of vigor- pityriasis rosea, and syphilis commonly show a follicular pattern in
ous hygienic measures, excoriation, crusting, eczematization, and Black children.
secondary infection is particularly common in infants. Postinflammatory hypopigmentation and hyperpigmentation oc-
Seborrheic dermatitis is an erythematous, scaly or crusting erup- cur readily and are more obvious in darker-skinned persons, regard-
tion that characteristically occurs on the scalp, face, and postauricu- less of racial origin. Pityriasis alba and tinea versicolor are more
lar, presternal, and intertriginous areas (see Figs. 3.3, 3.44, and commonly reported in darker skin types, perhaps because of the easy
3.45). The classic lesions are dull, pinkish-yellow, or salmon colored visibility of the hypopigmented lesions in marked contrast to unin-
with fairly sharp borders and overlying yellowish greasy scale. Mor- volved surrounding skin. Lichen nitidus is more apparent and report-
phologic and topographic variants occur in many combinations and edly more common in Black individuals; lichen planus is reported to
with varying degrees of severity from mild involvement of the scalp be more severe, leaving dark postinflammatory hyperpigmentation.
with occasional blepharitis to generalized, occasionally severe ery- Vitiligo is particularly distressing to patients with darker skin types,
thematous scaling eruptions. The differential diagnosis may include whether Black or Asian, because of the easy visibility in contrast with
atopic dermatitis, psoriasis, various forms of diaper dermatitis, Lang- surrounding skin.
erhans cell histiocytosis, scabies, tinea corporis or capitis, pityriasis Although darker skin may burn, sunburn and chronic sun-induced
alba, contact dermatitis, Darier disease, and lupus erythematosus. diseases of adults such as actinic keratosis and carcinomas of the skin
Warts are common viral cutaneous lesions characterized by the ap- induced by ultraviolet light exposure (e.g., squamous cell carcinoma,
pearance of skin-colored small papules of several morphologic types keratoacanthoma, basal cell carcinoma, and melanoma) generally
(see Figs. 15.19 through 15.37). They may be elevated or flat lesions have an extremely low incidence in Blacks and Hispanics. Congenital
and tend to appear in areas of trauma, particularly the dorsal surface melanocytic nevi also tend to have a lower tendency to transform to
of the face, hands, periungual areas, elbows, knees, feet, and genital malignancy in darker-skinned individuals. Café-au-lait spots are more
or perianal areas. Close examination may reveal capillaries appearing numerous and seen more often in Blacks, although the presence of six
as punctate dots scattered on the surface. or more should still raise suspicion about neurofibromatosis. Derma-
tosis papulosa nigra commonly develop in adolescents, especially
those who are female, of African descent. Mongolian spots occur more
Changes in Skin Color often in persons of African or Asian descent. Physiologic variants in
children with darker skin include increased pigmentation of the gums
The color of skin lesions commonly assists in making the diagnosis and tongue, pigmented streaks in the nails, and Voigt–Futcher lines,
(see Chapter 11). Common disorders of brown hyperpigmentation lines of pigmentary demarcation between the posterolateral and
include postinflammatory hyperpigmentation, pigmented and epi- lighter anteromedial skin on the extremities.
dermal nevi, café-au-lait spots, lentigines, incontinentia pigmenti, Qualities of hair may also differ among individuals of different
fixed drug eruption, photodermatitis and phytophotodermatitis, me- races. Black hair tends to tangle when dry and becomes matted when
lasma, acanthosis nigricans, and Addison disease. Blue coloration is wet. As a result of its naturally curly or spiral nature, pseudofolliculi-
seen in congenital dermal melanocytosis, blue nevi, nevus of Ito and tis barbae is more common in Blacks than in other groups. Tinea ca-
nevus of Ota, and cutaneous neuroblastomas. Cysts, deep hemangio- pitis is particularly common in prepubertal Blacks; the tendency to
mas, and pilomatricomas often show a subtle blue color, whereas the use oils because of hair dryness and poor manageability may obscure
blue of venous malformations and glomuvenous malformations is the scaling of tinea capitis. Pediculosis capitis, in contrast, is rela-
often a more intense, dark blue. Yellowish discoloration of the skin tively uncommon in this population, possibly related to the diameter
is common in infants, related to the presence of carotene derived and shape of the hair shaft. Prolonged continuous traction on hairs
from excessive ingestion of foods, particularly yellow vegetables con- may result in traction alopecia, particularly with the common prac-
taining carotenoid pigments. Jaundice may be distinguished from tice of making tight cornrow braids. The use of other hair grooming
carotenemia by scleral icterus. Localized yellow lesions may repre- techniques such as chemical straighteners, application of hot oils,
sent juvenile xanthogranulomas, nevus sebaceous, xanthomas, or and hot combs increases the risk of hair breakage and permanent
mastocytomas. Red lesions are usually vascular in origin, such as alopecia. Frequent and liberal use of greasy lubricants and pomades
superficial hemangiomas, spider telangiectases, and nevus flammeus produces a comedonal and sometimes papulopustular form of acne
(capillary malformations), or inflammatory, such as the scaling (pomade acne).
lesions of atopic dermatitis or psoriasis. Keloids form more often in individuals of African descent, often as
Localized lesions with decreased pigmentation may be hypopig- a complication of a form of inflammatory acne, including nodulocys-
mented (decreased pigmentation) or depigmented (totally devoid of tic acne and acne keloidalis nuchae. Other skin disorders reportedly
pigmentation); Wood lamp examination may help to differentiate seen more commonly are transient neonatal pustular melanosis, in-
depigmented lesions, which fluoresce a bright white, from hypopig- fantile acropustulosis, impetigo, papular urticaria, sickle cell ulcers,
mented lesions. Localized depigmented lesions may be seen in vitiligo, sarcoidosis, and dissecting cellulitis of the scalp. Atopic dermatitis
Vogt–Koyanagi syndrome, halo nevi, chemical depigmentation, pie- and Kawasaki disease have both been reported most often in children
baldism, and Waardenburg syndrome. Hypopigmented lesions are of Asian descent.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 • An Overview of Dermatologic Diagnosis and Procedures 9
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
10 1 • An Overview of Dermatologic Diagnosis and Procedures
cantharidin. In addition, lesions should not be occluded. Blistering Light amplifications by stimulated emission of radiation (lasers)
occurs in 24 to 48 hours, and crusting clears within about a week. produce intense light energy at a specific wavelength that can be emit-
Associated discomfort is variable, but application is painless. ted as a pulse or continuous wave to target tissue components for de-
Curettage is a scraping technique used most commonly after topical struction. After absorption of the light, heat is generated and the target
anesthetic application for physical removal of molluscum contagio- tissue is selectively destroyed. This process of selective destruction has
sum, especially for larger lesions for which cantharidin is less effective. been called selective photothermolysis and carries the benefit of destruc-
Curettage can also be used after electrodesiccation (with a hyfrecator) tion of the target chromophores (substances that absorb specific wave-
to remove the desiccated tissue, most commonly for removal of a pyo- lengths of light) with minimal damage to surrounding tissues.13
genic granuloma (see Chapter 12). Many pediatric dermatologists By far the most common laser used in children is the pulsed-dye laser
avoid the use of curettage in younger patients, given the associated (PDL; wavelength 585 to 595 nm), which targets hemoglobin and is used
discomfort. for a variety of vascular lesions, including capillary malformations (port
Biopsies and excisions are performed in pediatric patients as inter- wine stains, salmon patches), macular (flat) infantile hemangiomas, ul-
vention, not just for diagnosis. The decision to remove a lesion thera- cerated hemangiomas (in which case it helps speed reepithelialization),
peutically should be based on the indication and urgency for removal, spider telangiectasias, and even small pyogenic granulomas. PDL has also
the age and maturity of the pediatric patient, the location, and the been used (with more variable response) for inflammatory linear verru-
expected cosmetic result. Careful explanation of the procedure to the cous epidermal nevus, erythematous striae, warts14,15, acne,16 and even
parents and child is important to allay concerns and manage expecta- some inflammatory dermatoses such as psoriasis and eczema.
tions. If possible, the area to be biopsied, excised, or injected with an- The response of a port wine stain to PDL therapy is variable and
esthesia can be treated initially with a topical anesthetic cream (e.g., may depend on the depth of the dermal capillaries, location of the
4% lidocaine or 2.5% lidocaine/2.5% prilocaine) under a clear occlu- stain (e.g., central facial stains classically respond less to PDL therapy
sive film (e.g., waterproof transparent dressing [Tegaderm] or Glad than lesions on the forehead or peripheral face, in part likely related to
Press’n Seal wrap, which adheres more effectively than traditional the more superficial depth of laterally located dilated capillaries),17
plastic cling wrap). Buffering the lidocaine with sodium bicarbonate size of the stain, and age at the time treatment is initiated. Sequential
and use of a 30-gauge needle also help to decrease the pain of injec- treatment sessions are often necessary (generally at 4- to 8-week in-
tion; once buffered, lidocaine with epinephrine must either be kept tervals), and multiple treatments may be necessary to achieve signifi-
refrigerated or discarded after a week because of accelerated epineph- cant improvement.18 Port wine stains located on the extremities tend
rine degradation. Regional nerve blocks can be used selectively for to require more treatments than those located elsewhere, and those
larger excisions or cryotherapy. Distraction techniques such as con- associated with early-onset hypertrophy have a poorer response and
versation, listening to music, watching a video, or applying vibrations higher complication rate after PDL treatment.19 Recent studies in
to a contiguous area can also allay fear at almost any age. Punch bi- adults with facial port wine stains suggest that the effect of the
opsy is most useful for removing lesions smaller than 6 mm in diam- combination of topical rapamycin and PDL may be greater and more
eter. For larger lesions and in cosmetically sensitive areas, an elliptical persistent than PDL alone.20
excision is preferred. Elliptical excisions ideally have their long axis Other lasers used in pediatric patients include neodymium:yttrium-
following skin lines to minimize tension on the wound and to optimize aluminum-garnet (Nd:YAG; 1064 nm),21 alexandrite (755 nm),22 di-
the ultimate cosmetic appearance of the scar. Shave biopsies are ap- ode (810 nm), Q-switched ruby (694 nm), and intense pulsed light
propriate for the superficial removal of skin tags (acrochordons) and (555 to 950 nm) lasers, which have shown variable benefit in port
more protuberant small nevi that are cosmetically problematic; how- wine stains, venous malformations, deeper hemangiomas, and pig-
ever, shave removal can be followed by lesional regrowth and should mented lesions (mongolian spots, nevus of Ota, Becker melanosis).13,23
not be performed if there is any concern about lesional atypia or ma- The xenon-chloride excimer laser (308 nm) provides a wavelength
lignancy. Surgical wounds of 4 mm or larger in diameter should be similar to narrow-band UVB therapy, with the advantage of being able
closed with suture; wounds that are 3 mm or less can be left to heal via to selectively treat a more targeted area of the skin. It has been
secondary intention after hemostasis (including with insertion of demonstrated to be useful in psoriasis, vitiligo, nevus depigmentosus,
Gelfoam), although suturing of any lesion often gives a better cos- pityriasis alba, and postinflammatory hypopigmentation.24–28
metic result. Although octylcyanoacrylates such as Dermabond are
appropriate for closure of lacerations, the cosmetic result of their use The complete list of 28 references for this chapter is available
in elective procedures may be suboptimal and they are generally not online at http://expertconsult.inkling.com.
recommended. Deep sutures are often required to close the deeper
space of larger or deeper wounds (e.g., .6 mm in diameter) using
buried absorbable suture materials. Although a variety of methods Key References
are available for closing at the surface, interrupted or running subcu-
ticular suturing with nonabsorbable suture material is most often Haliasos EC, Kerner M, Jaimes-Lopez N, et al. Dermoscopy for the pediatric derma-
tologist. Part I. Dermoscopy of pediatric infectious and inflammatory skin lesions
used. Adhesive wound closure strips such as Steri-Strips are often used and hair disorders. Pediatr Dermatol 2013;30:163–71.
to further protect the wound from dehiscence. Haliasos EC, Kerner M, Jaimes N, et al. Dermoscopy for the pediatric dermatologist. Part
The most common complications of biopsies and surgical excisions II. Dermoscopy of genetic syndromes with cutaneous manifestations and pediatric
are wound infection, dehiscence, postoperative bleeding, and hema- vascular lesions. Pediatr Dermatol 2013;30:172–81.
toma (especially on the scalp). Contact dermatitis may also occur, es- Haliasos EC, Kerner M, Jaimes N, et al. Dermoscopy for the pediatric dermatologist.
Part III. Dermoscopy of melanocytic lesions. Pediatr Dermatol 2013;30:281–93.
pecially in reaction to adhesives or topical antibiotics; many surgeons Rudnicka L, Olszewska M, Waskiel A, et al. Trichoscopy in hair shaft disorders.
use petrolatum alone after skin surgery to avoid the risk of contact Dermatol Clin 2018;36(4):421–30.
dermatitis. Parents should be given clear, written postoperative in- Bonifaz A, Isa-Isa R, Araiza J, et al. Cytobrush-culture method to diagnose tinea
structions about keeping dressings in place (and the wound com- capitis. Mycopathologia 2007;163(6):309–13.
pletely dry) for the first 48 hours, appropriate wound care thereafter, Cordisco MR. An update on lasers in children. Curr Opin Pediatr 2009;21:499–504.
Craig LM, Alster TS. Vascular skin lesions in children: a review of laser surgical and
limitation in physical activity (generally 4 weeks without sports or medical treatments. Dermatol Surg 2013;39:1137–46.
gym if an excision), managing potential complications, and when to Dinulos JGH. Cosmetic procedures in children. Curr Opin Pediatr 2011;23:395–8.
have sutures removed (typically 7 days for the face and 10 to 14 days Franca K, Chacon A, Ledon J, et al. Lasers for cutaneous congenital vascular lesions:
on the body and extremities). a comprehensive overview and update. Lasers Med Sci 2013;28:1197–204.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
1 • An Overview of Dermatologic Diagnosis and Procedures 10e.1
References 15. Shin YS, Cho EB, Park EJ, et al. A comparative study of pulsed dye laser versus
long pulsed Nd:YAG laser treatment in recalcitrant viral warts. J Dermatolog
1. Piotto DP, Sekiyama J, Kayser C, et al. Nailfold videocapillaroscopy in healthy Treat 2017;28(5):411–16.
children and adolescents: description of normal patterns. Clin Exp Rheumatol 16. Voravutinon N, Rojanamatin J, Sadhwani D, et al. A comparative split-face
2016;34 Suppl. 100(5):193–9. study using different mild purpuric and subpurpuric fluence level of 595-nm
2. Barth Z, Schwartz T, Flato B, et al. Association between nailfold pulsed-dye laser for treatment of moderate to severe acne vulgaris. Dermatol
capillary density and pulmonary and cardiac involvement in medium to long- Surg 2016;42(3):403–9.
standing juvenile dermatomyositis. Arthritis Care Res (Hoboken) 2019;71(4): 17. Yu W, Ma G, Qiu Y, et al. Why do port-wine stains (PWS) on the lateral face
492–7. respond better to pulsed dye laser (PDL) than those located on the central face?
3. Guitera P, Menzies SW, Argenziano G, et al. Dermoscopy and in vivo confocal J Am Acad Dermatol 2016;74(3):527–35.
microscopy are complementary techniques for diagnosis of difficult amelanotic 18. Craig LM, Alster TS. Vascular skin lesions in children: a review of laser surgical
and light-coloured skin lesions. Br J Dermatol 2016;175(6):1311–19. and medical treatments. Dermatol Surg 2013;39:1137–46.
4. Haliasos EC, Kerner M, Jaimes-Lopez N, et al. Dermoscopy for the pediatric 19. Passeron T, Salhi A, Mazer JM, et al. Prognosis and response to laser treatment of early-
dermatologist. Part I. Dermoscopy of pediatric infectious and inflammatory skin onset hypertrophic port-wine stains (PWS). J Am Acad Dermatol 2016;75(1):64–8.
lesions and hair disorders. Pediatr Dermatol 2013;30:163–71. 20. Marques L, Nunez-Cordoba JM, Aguado L, et al. Topical rapamycin combined
5. Haliasos EC, Kerner M, Jaimes N, et al. Dermoscopy for the pediatric dermatolo- with pulsed dye laser in the treatment of capillary vascular malformations in
gist. Part II. Dermoscopy of genetic syndromes with cutaneous manifestations Sturge-Weber syndrome: phase II, randomized, double-blind, intraindividual
and pediatric vascular lesions. Pediatr Dermatol 2013;30:172–81. placebo-controlled clinical trial. J Am Acad Dermatol 2015;72(1):151–8.e1.
6. Haliasos EC, Kerner M, Jaimes N, et al. Dermoscopy for the pediatric dermatologist. 21. Murthy AS, Dawson A, Gupta D, et al. Utility and tolerability of the long-pulsed
Part III. Dermoscopy of melanocytic lesions. Pediatr Dermatol 2013;30:281–93. 1064-nm neodymium:yttrium-aluminum-garnet (LP Nd:YAG) laser for treat-
7. Lencastre A, Tosti A. Role of trichoscopy in children’s scalp and hair disorders. ment of symptomatic or disfiguring vascular malformations in children and
Pediatr Dermatol 2013;30:674–82. adolescents. J Am Acad Dermatol 2017;77(3):473–9.
8. Rudnicka L, Olszewska M, Waskiel A, et al. Trichoscopy in hair shaft disorders. 22. Carlsen BC, Wenande E, Erlendsson AM, et al. A randomized side-by-side study
Dermatol Clin 2018;36(4):421–30. comparing alexandrite laser at different pulse durations for port wine stains.
9. Chiaverini C, Le Duff F, Deville A, et al. Reflectance confocal microscopy Lasers Surg Med 2017;49(1):97–103.
for the diagnosis of Langerhans cell histiocytosis. Br J Dermatol 2018;179(1): 23. Dinulos JGH. Cosmetic procedures in children. Curr Opin Pediatr 2011;23:395–8.
186–7. 24. Franca K, Chacon A, Ledon J, et al. Lasers for cutaneous congenital vascular le-
10. Iriarte C, Rao B, Haroon A, et al. Acral pigmented Spitz nevus in a child with sions: a comprehensive overview and update. Lasers Med Sci 2013;28:1197–204.
transepidermal migration of melanocytes: dermoscopic and reflectance confo- 25. Mudigonda T, Dabade TS, Feldman SR. A review of protocols for 308 nm ex-
cal microscopic features. Pediatr Dermatol 2018;35(2):e99–102. cimer laser phototherapy in psoriasis. J Drugs Dermatol 2012;11(1):92–7.
11. Levine A, Markowitz O. Introduction to reflectance confocal microscopy and its 26. Cho S, Zheng Z, Park YK, Roh MR. The 308-nm excimer laser: a promising de-
use in clinical practice. JAAD Case Rep 2018;4(10):1014–23. vice for the treatment of childhood vitiligo. Photodermatol Photoimmunol
12. Chiaverini C, Kang HY, Sillard L, et al. In vivo reflectance confocal microscopy Photomed 2011;27(1):24–9.
of the skin: a noninvasive means of assessing body cystine accumulation in 27. Bae JM, Jung HM, Chang HS, et al. Treatment of nevus depigmentosus using the
infantile cystinosis. J Am Acad Dermatol 2013;68(4):e111–6. 308-nm excimer laser: a retrospective study of 14 patients. J Am Acad Derma-
13. Bonifaz A, Isa-Isa R, Araiza J, et al. Cytobrush-culture method to diagnose tinea tol 2016;75(3):626–7.
capitis. Mycopathologia 2007;163(6):309–13. 28. Bae JM, Choo JY, Chang HS, et al. Effectiveness of the 308-nm excimer laser
14. Veitch D, Kravvas G, Al-Niaimi F. Pulsed dye laser therapy in the treatment of on hypopigmentation after lichen striatus: a retrospective study of 12 patients.
warts: a review of the literature. Dermatol Surg 2017;43(4):485–93. J Am Acad Dermatol 2016;75(3):637–9.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 Cutaneous Disorders
of the Newborn
Neonatal Skin by itself with successive changes of clothing (generally within the first
few weeks of life). It has been suggested that vernix-based topical
The skin of the infant differs from that of an adult in that it is thinner creams may be effective in augmenting stratum corneum repair and
(40% to 60%), is less hairy, and has a weaker attachment between the maturation in infants and could play a role in the treatment of epider-
epidermis and dermis.1 In addition, the body surface area–to–weight mal wounds.12
ratio of an infant is up to five times that of an adult. The infant is The skin acts as a protective organ. Any break in its integrity there-
therefore at a significantly increased risk for skin injury, percutaneous fore affords an opportunity for initiation of infection. The importance
absorption, and skin-associated infection. Premature infants born of skin care in the newborn is compounded by several factors:
before 32 to 34 weeks’ estimated gestational age may have problems
associated with an immature stratum corneum (the most superficial 1. The infant does not have protective skin flora at birth.
cell layer in the epidermis), including an increase in transepidermal 2. The infant has at least one and possibly two open surgical wounds
water loss (TEWL). This increased TEWL may result in morbidity be- (the umbilicus and circumcision site).
cause of dehydration, electrolyte imbalance, and thermal instability. 3. The infant is exposed to fomites and personnel that potentially
Interestingly, in the majority of premature infants an acceleration of harbor a variety of infectious agents.
skin maturation occurs after birth such that most develop intact bar-
rier function by 2 to 3 weeks of life.2 However, in extremely low- Skin care should involve gentle cleansing with a nontoxic, nonabra-
birthweight infants, this process may take up to 4 to 8 weeks.3 In light sive neutral material. During the 1950s, the use of hexachlorophene-
of the elevated TEWL levels seen in premature infants, a variety of containing compounds became routine for the skin care of newborns
studies have evaluated the use of occlusive dressings or topical emol- as prophylaxis against Staphylococcus aureus infection. In 1971 and
lients in an effort to improve compromised barrier function.4–7 1972, however, the use of hexachlorophene preparations as skin
The risk of percutaneous toxicity from topically applied substances cleansers for newborns was restricted because of studies demonstrat-
is increased in infants, especially those born prematurely.8,9 Percuta- ing vacuolization in the central nervous system (CNS) of infants and
neous absorption is known to occur through two major pathways: laboratory animals after prolonged application of these prepara-
(1) through the cells of the stratum corneum and the epidermal mal- tions.13 At the minimum, neonatal skin care should include gentle
pighian layer (the transepidermal route) and (2) through the hair removal of blood from the face and head, and meconium from the
follicle–sebaceous gland component (the transappendageal route). perianal area, by gentle rinsing with water. Ideally, vernix caseosa
Increased neonatal percutaneous absorption may be the result of the should be removed from the face only, allowing the remaining vernix
increased skin surface area–to–weight ratio as well as the stratum to come off by itself. However, the common standard of care is for
corneum immaturity seen in premature neonates. Although trans- gentle drying and wiping of the newborn’s entire skin surface, which
dermal delivery methods may be distinctly advantageous in certain is most desirable from a thermoregulatory standpoint. Recommenda-
settings, extreme caution must be exercised in the application of topi- tions for “first bathing” of the newborn suggest timing it according to
cal substances to the skin of infants, given the risk of systemic absorp- local culture, performing it only after the newborn is physiologically
tion and potential toxicity. Table 2.1 lists some compounds reported in stable and able to appropriately thermoregulate, considering the use
association with percutaneous toxicity in infants and children. of water alone or water and an appropriately formulated pH neutral
(or acidic) liquid cleanser such as a synthetic detergent (syndet) or
liquid baby cleanser, and considering the use of gloves by healthcare
SKIN CARE OF THE NEWBORN workers if performing the initial bath.14–16
The skin of the newborn is covered with a grayish-white, greasy mate- There is no single method of umbilical-cord care that has been
rial termed vernix caseosa. The vernix represents a physiologic protec- proven to limit bacterial colonization and disease, and cord care prac-
tive covering derived partially from secretions of the sebaceous glands tices are quite variable in relation to cultural beliefs and healthcare
and in part as a decomposition product of the infant’s epidermis. Ver- disparities. Several methods have been reported, including local
nix contains protein, lipids, and water and provides water-binding free application of isopropyl alcohol, triple dye (an aqueous solution of
amino acids that facilitate the adaptation from amniotic fluid immer- brilliant green, proflavine, and gentian violet), and antimicrobial
sion in utero to the dry ambient postnatal state.10 Although its func- agents such as bacitracin or silver sulfadiazine cream. The routine use
tion is not completely understood, it may act as a natural protectant of povidone-iodine should be discouraged, given the risk of iodine ab-
cream to “waterproof ” the fetus in utero, where it is submerged in the sorption and transient hypothyroxinemia or hypothyroidism. A safer
amniotic fluid.11 Some studies suggest that vernix be left on as a pro- alternative is a chlorhexidine-containing product.17 A recent clinical
tective coating for the newborn skin and that it be allowed to come off review suggests consideration of application of antimicrobial agents
11
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
12 2 • Cutaneous Disorders of the Newborn
Reprinted with permission from Bree AF, Siegfried EC. Neonatal skin care and toxicology. In: Eichenfield LF, Frieden IJ, Esterly NB, editors. Textbook of neonatal
dermatology. 2nd ed. London: Saunders Elsevier; 2008:59–72.
for infants born at home or otherwise outside of birthing centers or during periods of crying, breath holding, or chilling. This normal
hospitals in resource-limited settings but highlights that their use in phenomenon, termed acrocyanosis, appears to be associated with an
high-resource countries or the setting of in-hospital delivery has not increased tone of peripheral arterioles, which in turn creates vaso-
been found to provide clear benefit.18 spasm, secondary dilation, and pooling of blood in the venous plex-
uses, resulting in a cyanotic appearance to the involved areas of the
skin. The intensity of cyanosis depends on the degree of oxygen loss
Physiologic Phenomena of and the depth, size, and fullness of the involved venous plexus. Acro-
the Newborn cyanosis, a normal physiologic phenomenon, should not be confused
with true cyanosis.
Neonatal dermatology, by definition, encompasses the spectrum of cu-
taneous disorders that arise during the first 4 weeks of life. Many such
conditions are transient, appearing in the first few days to weeks of life CUTIS MARMORATA
only to disappear shortly thereafter. The appreciation of normal phe- Cutis marmorata is a normal reticulated bluish mottling of the skin
nomena and their differentiation from the more significant cutaneous seen on the trunk and extremities of infants and young children
disorders of the newborn is critical for the general physician, obstetri- (Fig. 2.1). This phenomenon, a physiologic response to chilling with
cian, and pediatrician, as well as for the pediatric dermatologist. resultant dilation of capillaries and small venules, usually disappears
At birth, the skin of the full-term infant is normally soft, smooth, as the infant is rewarmed. Although a tendency for cutis marmorata
and velvety. Desquamation of neonatal skin generally takes place may persist for several weeks or months, this disorder bears no medi-
24 to 36 hours after delivery and may not be complete until the third cal significance and treatment generally is unnecessary. In some chil-
week of life. Desquamation at birth is an abnormal phenomenon dren cutis marmorata may tend to recur until early childhood, and in
and is indicative of postmaturity, intrauterine anoxia, or congenital patients with Down syndrome, trisomy 18, and Cornelia de Lange
ichthyosis. syndrome, this reticulated marbling pattern may be persistent. When
The skin at birth has a purplish-red color that is most pronounced the changes are persistent (even with rewarming) and are deep
over the extremities. Except for the hands, feet, and lips, where the violaceous in color, cutis marmorata telangiectatica congenita
transition is gradual, this quickly changes to a pink hue. In many (Fig. 2.2; see also Chapter 12) should be considered. In some infants a
infants, a purplish discoloration of the hands, feet, and lips occurs white negative pattern of cutis marmorata (cutis marmorata alba)
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 13
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
14 2 • Cutaneous Disorders of the Newborn
Caput Succedaneum
Caput succedaneum is a localized edema of the newborn scalp related
to the mechanical forces involved in parturition. It is probably related
to venous congestion and edema secondary to cervical and uterine
pressure and as such is more common with prolonged parturition and
seen most often in primigravidas. Caput succedaneum presents as a
boggy scalp mass and may result in varying degrees of bruising and
necrosis in addition to the edema, at times with tissue loss. In distinc-
tion to cephalohematoma, caput succedaneum lesions often cross the
midline. These lesions tend to resolve spontaneously over 48 hours,
and treatment is generally unnecessary. One possible complication in
cases of severe caput succedaneum is permanent alopecia. Halo scalp
ring refers to an annular alopecia that presents in a circumferential Fig. 2.5 Staphylococcal scalp abscess. Fluctuant, erythematous nodule
ring around the scalp in infants with a history of caput.33 It represents on the scalp of this 9-day-old infant as a complication of intrauterine
a pressure necrosis phenomenon, and the hair loss may be transient fetal monitoring.
or occasionally permanent.
Complications from Fetal and Neonatal fetal scalp electrodes are the cause of aplasia cutis congenita (ACC; see
Diagnostic Procedures later in this chapter).
Scalp injuries sustained during the birth process tend to be minor
Fetal complications associated with invasive prenatal diagnostic procedures and include lacerations, erosions, and ecchymoses. Injuries of the
include cutaneous puncture marks, scars or lacerations, exsanguina- scalp and face occur in approximately 16% of vacuum-assisted deliv-
tion, ocular trauma, blindness, subdural hemorrhage, pneumothorax, eries and in 17% of forceps-assisted deliveries (Fig. 2.6).40 In a large
cardiac tamponade, splenic laceration, porencephalic cysts, arteriove- series of vacuum-assisted deliveries, occurrence of head injury did not
nous or ileocutaneous fistulas, digital loss (in 1.7% of newborns whose correlate with duration of vacuum application or the number of pop-
mothers had undergone early chorionic villus sampling), musculoskel- offs or pulls.41
etal trauma, disruption of tendons or ligaments, and occasionally Transcutaneous oxygen monitoring (application of heated elec-
gangrene. Cutaneous puncture marks, which occur in 1% to 3% of trodes to the skin for continuous detection of tissue oxygenation) and
newborns whose mothers have undergone amniocentesis, may be seen pulse oximetry may also result in erythema, tissue necrosis, and first-
as single or multiple 1- to 6-mm pits, dimples, or round depressed scars or second-degree burns. Although lesions associated with transcuta-
on any cutaneous surface of the newborn (Fig. 2.4).34–36 neous oxygen monitoring generally resolve within 48 to 60 hours,
Fetal scalp monitoring can result in infection, bleeding, or fontanel persistent atrophic hyperpigmented craters may at times be seen as a
puncture, and prenatal vacuum extraction can produce a localized area complication. Frequent (every 2 to 4 hours) changing of electrode
of edema, ecchymosis, or localized alopecia. The incidence of scalp sites and reduction of the temperature of the electrodes to 43° C,
electrode infection varies from 0.3% to 5%, and although local sterile however, can lessen the likelihood of this complication.42,43
abscesses account for the majority of adverse sequelae, S. aureus or Anetoderma of prematurity refers to macular depressions or out-
Gram-negative infections, cellulitis, tissue necrosis, subgaleal abscess, pouchings of skin associated with loss of dermal elastic tissue seen in
osteomyelitis, necrotizing fasciitis, and neonatal herpes simplex infec- premature infants. Reports suggest that these cutaneous lesions may
tions may also occur as complications of this procedure (Fig. 2.5).37–39 correlate with placement of electrocardiographic or other monitoring
It is not unusual for new parents to be under the false impression that electrodes or leads.44,45
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 15
A B
Fig. 2.7 Heel-stick calcinosis. (A) Firm, yellow-white papule on the lateral plantar heel of an infant who had multiple heel sticks as a newborn.
(B) Hyperkeratotic firm papule on the heel of another infant, with early transepidermal elimination before resolution.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
16 2 • Cutaneous Disorders of the Newborn
Table 2.2 Features of Sclerema Neonatorum and remains unknown but appears to be related to perinatal trauma,
Subcutaneous Fat Necrosis asphyxia, hypothermia, and, in some instances, hypercalcemia.53,54
Although the mechanism of hypercalcemia in SCFN is not known, it
Sclerema Neonatorum Subcutaneous Fat Necrosis has been attributed to aberrations in vitamin D or parathyroid ho-
meostasis. Birth asphyxia and meconium aspiration seem to be com-
Premature infants Full-term or postmature infants monly associated. In one large series, 10 of 11 infants with SCFN
Serious underlying disease Healthy newborns; may have had been delivered via emergency cesarean section for fetal distress,
(sepsis, cardiopulmonary dis- history of perinatal asphyxia or and 9 of the 11 had meconium staining of the amniotic fluid.55 The
ease, diarrhea, or dehydration) difficult delivery relationship among SCFN, maternal diabetes, and cesarean section,
Also seen in infants with history if any, is unclear. SCFN after ice-bag application for treatment of
of therapeutic cooling for HIE supraventricular tachycardia has been reported,56 and it has
Wax-like hardening of skin and Circumscribed, indurated, ery- also been observed after selective head or generalized cooling for
subcutaneous tissue thematous nodules and plaques hypoxic-ischemic encephalopathy.57,58 In a review of neonates with
hypoxic-ischemic encephalopathy in Switzerland, 2.8% of all cooled
Whole body except palms and Buttocks, thighs, arms, face,
soles shoulders
neonates developed SCFN, which occurred independently of the
cooling method used and the number of temperature measurements
Poor prognosis; high mortality Excellent prognosis; treat associ- outside the target temperature range.59
ated hypercalcemia if present The onset of SCFN is generally during the first few days to weeks
of life. Lesions appear as single or multiple localized, sharply circum-
HIE, Hypoxic-ischemic encephalopathy. scribed, usually painless areas of induration. Occasionally the af-
fected areas may be tender, and infants may be uncomfortable and
cry vigorously when they are handled. Lesions vary from small ery-
disease. Infants with this disorder are characteristically small or pre- thematous, indurated nodules to large plaques, and sites of predilec-
mature, debilitated, weak, cyanotic, and lethargic. In 25% of cases the tion include the cheeks, back, buttocks, arms, and thighs (Fig. 2.9).
mothers are ill at the time of delivery. Exposure to cold, hypothermia, Many lesions have an uneven lobulated surface with an elevated
peripheral chilling with vascular collapse, and an increase in the ratio margin separating it from the surrounding normal tissue. Histologic
of saturated to unsaturated fatty acids in the triglyceride fraction of examination of skin biopsy tissue reveals larger-than-usual fat lob-
the subcutaneous tissue (because of a defect in fatty acid mobilization) ules and an extensive inflammatory infiltrate, needle-shaped clefts
have been hypothesized as possible causes for this disorder but lack within fat cells, necrosis, and calcification. Fine-needle aspiration
confirmation.51 biopsy has been reported as a useful and less invasive method for
The histopathologic findings of sclerema neonatorum consist of diagnosis.60 Magnetic resonance imaging (MRI), although rarely
edema and thickening of the connective tissue bands around the fat performed, reveals decreased T1 and increased T2 signal intensity in
lobules. Although necrosis and crystallization of the subcutaneous affected areas.61
tissue have been described, these findings are more characteristically The prognosis for SCFN is excellent. Although lesions may develop
seen in lesions of SCFN. extensive deposits of calcium, which may liquefy, drain, and heal with
The prognosis of infants with sclerema neonatorum is poor, and scarring, most areas undergo spontaneous resolution within several
mortality occurs in 50% to 75% of affected infants. In a series of 51 weeks to months. Hypercalcemia is an association observed in up to
infants with sclerema neonatorum in a special-care nursery within a 56% to 63% of infants in larger series,62,63 and infants with this find-
Bangladeshi hospital, the fatality rate was 98%.52 In infants who sur- ing may require low calcium intake, restriction of vitamin D, and/or
vive, the cutaneous findings resolve without residual sequelae. There systemic corticosteroid therapy. Etidronate therapy has been reported
is no specific therapy, although steroids and exchange transfusion for treatment of recalcitrant SCFN-associated hypercalcemia.64,65 In-
have been used.50 fants should be monitored for several months after delivery, because
the onset of hypercalcemia can be delayed.55,66 Other rare systemic
complications may include thrombocytopenia, hypoglycemia, and
SUBCUTANEOUS FAT NECROSIS hypertriglyceridemia, all of which tend to be mild or self-limited.
Subcutaneous fat necrosis (SCFN) is a benign, self-limited disease
that affects apparently healthy, full-term newborns and young in-
fants. It is characterized by sharply circumscribed, indurated, and
nodular areas of fat necrosis (Fig. 2.8). The cause of this disorder
Fig. 2.9 Subcutaneous fat necrosis. This 20-day-old girl presented with
firm, indurated erythematous plaques and nodules on the thighs and
had been delivered via emergency cesarean section with a history of
meconium aspiration, respiratory distress, and hypoglycemia. Her se-
Fig. 2.8 Subcutaneous fat necrosis. Indurated, erythematous plaques rum ionized calcium was found to be markedly elevated and required
on the shoulders and back of this 1-week-old boy. therapy with pamidronate.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 17
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
18 2 • Cutaneous Disorders of the Newborn
ACNE NEONATORUM
Occasionally infants develop a facial eruption that resembles acne vul-
garis as seen in adolescents (Fig. 2.15). Clinical examination typically Fig. 2.15 Acne neonatorum. Erythematous papules and papulopus-
reveals erythematous papules, pustules, and occasionally comedones tules on the cheek.
(although the latter are more common in infantile acne; see Chapter 8).
Although the cause of this disorder is not clearly defined, it appears to
develop as a result of hormonal stimulation of sebaceous glands that
have not yet involuted to their childhood state of immaturity. In mild
cases of acne neonatorum, therapy is often unnecessary; daily cleans-
ing with soap and water may be all that is required. Occasionally, ben-
zoyl peroxide, a topical retinoid, or topical antibiotics may be helpful (see
Chapter 8). Unusually severe or recalcitrant cases of acne neonatorum
warrant investigation for underlying androgen excess.
A facial acneiform eruption in infants has been associated with the sap-
rophytic Malassezia species and has been termed neonatal cephalic pustulosis
(see Chapter 8). Lesions consist of pinpoint papules, papulopustules, or
larger pustules, and they are located on the cheeks, chin, and forehead
(Fig. 2.16). A correlation may exist between the clinical severity of lesions
and the colonization with this fungal saprophyte.69,70 In these infants, topi-
cal antifungal agents may lead to more rapid resolution of lesions.
Fig. 2.14 Sebaceous gland hyperplasia. Yellow-white, pinpoint pap- Fig. 2.17 Erythema toxicum neonatorum. Blotchy, erythematous mac-
ules on the nasal tip of this 2-day-old boy. ules and edematous papules.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 19
of these, and may occur anywhere on the body, especially the fore- a prospective 1-year multicenter study of more than 2800 neonates in
head, face, trunk, and extremities. The fact that these lesions (which Brazil, the prevalence of ETN was 21.3%, and it was primarily noted
histologically reveal follicular-centered eosinophils) often tend to in term infants.76 The incidence of ETN clearly appears to increase
spare the palms and soles may be explained by the absence of pilose- with increasing gestational age and birthweight of the infant.77,76 No
baceous follicles in these areas. sexual or racial predisposition has been noted.
ETN often initially appears as a blotchy, macular erythema that ETN is usually diagnosed clinically. Skin biopsy, which is rarely nec-
then develops firm, 1- to 3-mm, pale yellow or white papules and pus- essary, reveals a characteristic accumulation of eosinophils within the
tules. The erythematous macules are irregular or splotchy in appear- pilosebaceous apparatus. The diagnosis can be rapidly differentiated
ance, varying from a few millimeters to several centimeters in diame- from other newborn pustular conditions by cytologic examination of
ter. They may be seen in sharp contrast to the surrounding unaffected a pustule smear that with Wright or Giemsa staining reveals a pre-
skin, may blend into a surrounding erythema, or may progress to a dominance of eosinophils. Affected infants may have a peripheral eo-
confluent eruption. sinophilia. Although the eosinophilic response has led some observers
Although ETN appears most commonly during the first 3 to 4 days to attribute the cause of this disorder to a hypersensitivity reaction,
of life, it has been seen at birth and may be noted as late as 10 days of specific allergens have never been implicated or confirmed.
age.71 Exacerbations and remissions may occur during the first Because erythema toxicum is a benign, self-limiting, asymptomatic
2 weeks of life, and the duration of individual lesions varies from a few disorder, no therapy is indicated. Occasionally, however, it may be
hours to several days. The cause of ETN remains obscure. One study confused with other pustular eruptions of the neonatal period, includ-
suggested that it represents an immune response to microbial coloni- ing transient neonatal pustular melanosis, milia, miliaria, and con-
zation of the skin at the hair follicle.72 ETN incidence data are variable. genital infections such as candidiasis, herpes simplex, and bacterial
Some authors report an incidence as low as 4.5%; others report inci- processes. Of these, the congenital infections are the most important
dences varying from 31% to 70% of newborns.73 Two large prospec- diagnostic considerations because of the implications for possible sys-
tive series of skin findings in newborns (one in the United States and temic involvement. Table 2.3 lists the differential diagnosis of the
one in Turkey) found incidences of 7% and 13.1%, respectively.74,75 In newborn with vesicles or pustules.
CNS, Central nervous system; LAD, lymphadenopathy; SEM, skin, eyes, and/or mouth; XLD, X-linked dominant.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
20 2 • Cutaneous Disorders of the Newborn
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 21
setting is often sufficient.83 However, a complete blood cell count to leave a collarette of fine, white scale around a small hyperpig-
and blood culture are advisable given the rare association with mented macule. Although the distribution may be diffuse, common
bacteremia. areas of involvement include the inferior chin, forehead, neck, lower
The term pemphigus neonatorum is an archaic misnomer occasion- back, and shins. Rarely, vesicles that do not progress to pigmented
ally applied to superficial bullous lesions of severe impetigo widely macules may be detected on the scalp, palms, and soles.
distributed over the surface of the body. However, a transient neonatal Wright-stained smears of the pustules of TNPM, in contrast to
form of pemphigus vulgaris does exist and is caused by transplacental lesions of ETN, demonstrate variable numbers of neutrophils, few or
passage of antibodies from a mother with the same disease (see no eosinophils, and cellular debris. Histopathologic evaluation is
Chapter 13). usually unnecessary.
TNPM is a benign disorder without associated systemic manifesta-
tions, and therapy is unnecessary. The pustular lesions usually disap-
SUCKING BLISTERS pear within 24 to 48 hours, leaving behind hyperpigmented macules
Sucking blisters, presumed to be induced by vigorous sucking on the that fade gradually, usually over several weeks to months. Occasion-
affected part in utero, are seen in up to 0.5% of normal newborns as ally, newborns may have solely the hyperpigmented macules, in
0.5- to 2-cm oval bullae or erosions on the dorsal aspect of the fingers, which case it is presumed that the pustular phase occurred (and
thumbs, wrists, lips, or radial aspect of the forearms. These lesions, resolved) in utero.
which must be differentiated from bullous impetigo, epidermolysis
bullosa, and herpes neonatorum, resolve rapidly and without
sequelae. ACROPUSTULOSIS OF INFANCY
Acropustulosis of infancy, also known as infantile acropustulosis (IA),
is an idiopathic pustular disorder with onset usually between birth
TRANSIENT NEONATAL PUSTULAR MELANOSIS and 2 years of age. It is characterized by pruritic, vesiculopustular
Transient neonatal pustular melanosis (TNPM) is a benign self-limiting lesions that recur every few weeks to months. The lesions begin as
disorder of unknown cause characterized by superficial vesiculopus- pinpoint erythematous papules and enlarge into well-circumscribed
tular lesions that rupture easily and evolve into hyperpigmented discrete pustules.85 They are concentrated on the palms (Fig. 2.24)
macules (Fig. 2.22). This disorder is seen in fewer than 1% of new- and soles (Fig. 2.25) and appear in lesser numbers on the dorsal aspect
borns84 and occurs most commonly in infants with black skin. Lesions of the hands, feet, wrists, and ankles. Occasional lesions may occur on
begin as superficial sterile pustules (Fig. 2.23) that rupture easily the face and scalp.
The differential diagnosis of IA includes scabies, dyshidrotic ec-
zema, pustular psoriasis, ETN, TNPM, impetigo, and subcorneal pus-
tular dermatosis. However, the characteristic presentation and course
of IA is usually distinctive enough to render a clinical diagnosis. A
smear of pustule contents (or histologic evaluation) reveals large
numbers of neutrophils and occasionally eosinophils.85–88 Although
the etiology of IA remains unclear, several authors have noted a likely
association with preceding scabies infestation.89–91 IA appears to be
common in internationally adopted children.92
Patients with IA experience fewer and less intense flares of their
lesions with time, and the entire process usually subsides within 2 to
3 years. Pruritus, however, may be severe early in the course, mak-
ing therapy desirable. Possible associations include irritability, sleep-
lessness, excoriation, and secondary bacterial infection. Systemic
antihistamines, usually in high doses, may relieve pruritus. High-
potency topical corticosteroids are quite effective for this condi-
tion,89 and given the limited distribution of lesions, the epidermal
thickness at affected (acral) sites, and the periodicity of flares, con-
cerns regarding systemic absorption of these medications should be
minimal. Dapsone has long been a recommended therapy for severe
Fig. 2.22 Transient neonatal pustular melanosis. Papules and papulo- cases, but the risk-to-benefit ratio of this agent is not generally
pustules rupture to leave a collarette of fine scales and eventual hyper-
justified in patients with IA.
pigmentation. (Courtesy Nancy B. Esterly, MD.)
Fig. 2.23 Transient neonatal pustular melanosis. Tense pustules and Fig. 2.24 Acropustulosis of infancy. Multiple tense erythematous pap-
collarettes of scale at sites of older lesions. ules and pustules on the palm of this 4-month-old girl.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
22 2 • Cutaneous Disorders of the Newborn
SEBORRHEIC DERMATITIS
Seborrheic dermatitis is a common, self-limiting condition of the
scalp, face, ears, trunk, and intertriginous areas characterized by
greasy scaling, redness, fissuring, and occasional weeping. It appears
Fig. 2.25 Acropustulosis of infancy. Tense pustules, some of which
to be related to the sebaceous glands and has a predilection for so-
have ruptured, on the plantar and lateral surfaces of the foot of a called “seborrheic” areas where the density of these glands is high. It
14-month-old girl. usually presents in infants with a scaly dermatitis of the scalp termed
cradle cap (Fig. 2.27) and may spread over the face, including the fore-
head, ears, eyebrows, and nose. Other areas of involvement include
the intertriginous zones, umbilicus, and anogenital region (Fig. 2.28).
CONGENITAL EROSIVE AND VESICULAR (For a more detailed discussion of seborrheic dermatitis and its ther-
DERMATOSIS apy, see Chapter 3.)
Congenital erosive and vesicular dermatosis (CEVD) healing with re-
ticulated supple scarring is an uncommon disorder characterized by
erosive and bullous lesions that, as the name implies, are present at LEINER DISEASE
birth and heal with characteristic scarring. Although its cause is un- The term Leiner disease, rarely used in the current era, refers to a
known, it appears to represent a nonhereditary intrauterine event shared phenotype for a number of nutritional and immunologic
such as infection or amniotic adhesions, or perhaps an unusual heal- disorders characterized by severe seborrheic dermatitis with exfo-
ing defect of immature skin. There are several reports of CEVD occur- liation, failure to thrive, and diarrhea. The disorder may occur
ring in association with neonatal herpes simplex virus infection.93,94 during the first week of life but generally starts around 2 to
The disorder generally involves skin of the trunk, extremities, scalp, 4 months of age. Patients are particularly at risk for recurrent
face, and occasionally the tongue, with sparing of the palms and soles. yeast and Gram-negative infections. Among disorders that may
CEVD occurs most often in premature infants and presents with show this phenotype are deficiency or dysfunction of complement,
extensive cutaneous ulcerations (Fig. 2.26, A) and intact vesicles that Bruton agammaglobulinemia, severe combined immunodeficiency,
develop crusting and then heal during the first month of life. and HIES.102–106
A B
Fig. 2.26 Congenital erosive and vesicular dermatosis healing with reticulated supple scarring. (A) Diffuse reticulated erythematous erosions and
atrophic plaques involved most of the skin surface in this female infant at 37 weeks’ gestational age. (B) At age 8 months, prominent generalized
reticulate supple scars were distributed on the trunk, face, scalp, and extremities.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 23
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
24 2 • Cutaneous Disorders of the Newborn
Fig. 2.29 Irritant contact diaper dermatitis. Erythema of the vulva, but-
tocks, and medial thighs. The inguinal creases were relatively spared.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 25
Fig. 2.33 Jacquet dermatitis. Severe diaper area erythema with ulcer-
ated papules and islands of reepithelialization.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
26 2 • Cutaneous Disorders of the Newborn
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 27
Fig. 2.37 Granuloma gluteale infantum. Erythematous to violaceous Fig. 2.39 Prominent sacral dimple. This young girl was found to have
papulonodules on the labia majora of this infant with a history of po- this prominent dimple superior to the gluteal cleft in association with
tent topical corticosteroid use in the diaper region. mild gluteal cleft deviation. Imaging for associated spinal dysraphism
was unremarkable.
most agree that these lesions, when occurring alone, do not predict an
increased risk of underlying malformations. Cervical OSD is signifi-
cantly less common, and in those cases associated with cutaneous
stigmata, more than one lesion is usually present.142 It is important to
remember that an isolated nevus simplex (“stork bite”) of the poste-
rior nuchal or occipital region is not an indicator of underlying OSD.
When OSD is being considered, radiographic imaging must be per-
formed. MRI is the diagnostic modality of choice, especially with
higher-risk cutaneous findings. Ultrasound screening may be consid-
ered in infants younger than 4 months (before ossification of the ver-
tebral bodies is complete), with the advantages being that it is nonin-
vasive and does not require sedation. However, ultrasonography is
limited in that small cord lesions (i.e., lipomas or dermal sinus tracts)
may be missed,137 and the overall sensitivity is quite dependent on the
experience of the ultrasonographer. In a study of 41 infants with
lumbosacral infantile hemangioma, the sensitivity of ultrasound
scanning in detecting spinal anomalies was only 50%, with a specific-
Fig. 2.38 Lumbosacral port wine stain associated with occult spinal ity of 77.8%.140 Ultrasound may occasionally be associated with false-
dysraphism. Note the associated central depression in this boy who positive findings, as reported in a study of 439 newborns in whom the
also had an underlying tethered spinal cord.
study was performed because of cutaneous stigmata. A total of 39 of
439 had abnormal findings, with subsequent MRI revealing unre-
markable findings in 17 of them.143
congenital spinal-cord anomalies.136 Because occult spinal dysra- In infants with low-risk lesions such as simple dimples or gluteal
phism (OSD) can lead to irreversible neurologic complications from cleft deviation and without other high-risk findings (e.g., hypertricho-
tethered cord syndrome, early recognition is desirable. Cutaneous or sis, skin tags, lipoma, or other mass), the need for imaging is unclear.
subcutaneous stigmata may be the presenting sign of OSD, and as If it is performed, however, ultrasound may provide a reliable screen-
such, a working knowledge of potentially associated lesions is vital. ing when interpreted by an experienced pediatric radiologist.144 Early
Lumbosacral skin lesions that may be associated with OSD and spinal neurosurgical referral is indicated if underlying defects are diagnosed.
cord defects include hypertrichosis (the classic “faun tail” or finer, la-
nugo hair), lipomas, vascular lesions (infantile hemangioma, port
wine stain; Fig. 2.38), atypical sacral dimples (Fig. 2.39), sinuses, ap- DRUG-INDUCED FETAL SKIN MALFORMATIONS
pendages (skin tag, tail), ACC, and melanocytic nevi.137 Gluteal cleft There are numerous drugs, including alcohol, hydantoin, valproic
asymmetry or deviation is another useful finding. The presence of acid, warfarin, aminopterin, and isotretinoic acid, that when taken by
multiple findings increases the risk of OSD.138,139 In one study, 11 of pregnant women produce an adverse effect on the fetus and newborn.
18 patients with two or more congenital midline skin lesions had OSD, Exposure to these drugs in utero may result in a variety of organ mal-
and the most common midline cutaneous lesions to be associated with formations, although specific skin malformations are rare. Terato-
OSD were lipomas (either isolated or in combination with other le- genic risks as they relate to skin have most commonly focused on an-
sions).140 In a prospective study of infants with lumbosacral infantile tithyroid drugs, especially methimazole (MMI), and their possible role
hemangiomas, the overall relative risk for spinal anomalies was in causing ACC (see later).
640; importantly, 35% of the infants with an isolated lumbosacral
hemangioma (and no additional cutaneous findings) had spinal
anomalies.141 CONGENITAL HEMIHYPERTROPHY
The majority of simple midline dimples are not associated with Idiopathic congenital hemihypertrophy is a developmental defect in
OSD. Patients with atypical dimples (.5 mm in size, further than which one side of the body is larger than the other. Although differ-
2.5 cm from the anal verge), on the other hand, have a significant risk ences in symmetry are often detectable during the newborn period,
of associated OSD.138 The association of nevus simplex (small, dull- they usually become more striking with growth of the child. The cu-
pink, vascular malformation, most commonly seen on the occipital taneous findings most often associated with hemihypertrophy are hyper-
scalp, glabella, or eyelids) of the sacrum and OSD is unclear, although pigmentation, telangiectasia, abnormal nail growth, and hypertrichosis
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
28 2 • Cutaneous Disorders of the Newborn
(Fig. 2.40). Body temperature and sweating differences have also been
reported in patients with this disorder.145
Of particular significance is the fact that about 50% of persons with
hemihypertrophy may have associated anomalies, including Wilms
tumor, aniridia, cataracts, ear deformities, internal hemangiomas,
genitourinary tract anomalies, adrenocortical neoplasms, and brain Fig. 2.42 Aplasia cutis congenita. Healed scar with alopecia near the
tumors. Therefore patients who exhibit congenital hemihypertrophy hair whorl in this 8-month-old girl.
should be evaluated for potentially associated conditions. Associated
tumors most commonly involve the kidney, adrenal gland, and liver.146
In patients with hemihypertrophy combined with cutaneous vascular
malformations (i.e., port wine stain), the possibility of Klippel– Whereas most scalp defects are small, larger lesions may occur and
Trénaunay syndrome; Proteus syndrome; congenital lipomatous can extend to the dura or the meninges. Although treatment is
overgrowth, vascular malformations, epidermal nevi, and scoliosis/ generally unnecessary, large scalp lesions (i.e., .4 cm2) may require
skeletal and spinal anomalies (CLOVES) syndrome; or another surgery with grafting to prevent the potential complications of
syndrome comprising a vascular anomaly with hypertrophy should hemorrhage, venous (sagittal sinus) thrombosis, and meningitis.
be considered (see Chapter 12). At birth, the skin defect may vary from an ulceration with a granu-
lating base (Fig. 2.41) to a superficial erosion or even a well-formed
scar. As healing of open lesions occurs, the defect is replaced by
APLASIA CUTIS CONGENITA smooth, hairless scar tissue (Fig. 2.42), although sometimes the tissue
Aplasia cutis congenita is a congenital defect of the skin characterized is raised and keloidal. Some lesions may present as a translucent, glis-
by localized absence of the epidermis, dermis, and, at times, subcuta- tening membrane (membranous aplasia cutis) and when surrounded
neous tissues. Although ACC generally occurs on the scalp, it may also by a ring of long, dark hair (the “hair collar sign”; Fig. 2.43) may
involve the skin of the face, trunk, and extremities. The diagnosis of represent a forme fruste of a neural tube defect.150 This membranous
ACC is usually a clinical one, and the histologic picture varies. Al- form of ACC may have a recognizable appearance on prenatal sonog-
though most cases appear to be sporadic, a variety of potential asso- raphy as a round hypoechoic defect.151
ciations, including teratogens, limb abnormalities, epidermal nevi, Although most infants with ACC are otherwise well, defects that
underlying embryologic malformations, epidermolysis bullosa, mal- may occasionally be present include cleft lip and palate, ophthalmo-
formation syndromes, and infections, have been proposed.147 logic defects, limb reduction defects, cardiac anomalies, gastrointesti-
ACC classically presents as solitary or multiple, sharply demarcated, nal tract malformations, spinal dysraphism, hydrocephalus, defects of
weeping or granulating, oval to circular, stellate defects ranging from the underlying skull, congenital midline porencephaly, spastic paraly-
1 to 3 cm in diameter. Some 70% of scalp lesions are isolated and 20% sis, seizures, mental retardation, and vascular anomalies.147 Adams–
are double, and in 8% of patients three or more defects may be present.148 Oliver syndrome (AOS), a malformation syndrome caused by muta-
The most common location for ACC is the scalp, and in those tions in the ARHGAP31, DLL4, RBPJ, or NOTCH1 (autosomal
cases 80% occur in close proximity to the hair whorl.149 Although dominant) genes or DOCK6 or EOGT (autosomal recessive) genes, is
aplasia cutis may also affect the occiput, the postauricular areas, and the association of ACC with transverse terminal limb defects and
the face, involvement of these areas appears to be relatively uncommon. cardiac and CNS abnormalities.152–155 The limb defects may include
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 29
Fig. 2.43 Aplasia cutis congenita, membranous type, with hair collar
sign. Note the hairs surrounding the defect in this infant girl, which are
longer and darker than her other hair. Magnetic resonance imaging
revealed a small tract down to calvarium, without any intracranial or
intradural extension.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
30 2 • Cutaneous Disorders of the Newborn
Fig. 2.46 Dermoid sinus. Small sinus ostium at the superior nasal
bridge. This patient had no intracranial extension.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 31
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
32 2 • Cutaneous Disorders of the Newborn
A Fig. 2.51 Thyroglossal duct cyst. This congenital nodule of the anterior
midline neck was noted to move upward with swallowing.
Fig. 2.50 Accessory tragi. These fleshy papules may present in a soli-
tary or localized fashion (A) or in a multifocal form, occurring along the
embryologic migration line extending from the preauricular cheek to
the mouth angle (B). thyroid descent and occasionally may contain ectopic thyroid tissue.
Although surgical excision is the treatment of choice, care must be
exercised to preserve aberrant thyroid tissue to prevent postoperative
hearing loss, suggesting that audiologic evaluation should be per- hypothyroidism.
formed in these infants.191–194 The data regarding genitourinary mal- Bronchogenic cysts present early, usually at birth, as a nodule
formations are more controversial, with studies both supporting and (Fig. 2.52) or draining pit, usually over the suprasternal notch. These
refuting an association with preauricular pits or tags.190,195 It appears lesions may develop from ectopic elements of the tracheobronchial
that when these preauricular lesions occur in the absence of other tree or may represent ectopic branchial cleft cysts. Surgical excision is
dysmorphic or syndromic features, such associations are less likely. the treatment of choice. Fig. 2.53 shows the locations of several types
Branchial cleft cysts and sinuses, formed along the course of the of congenital neck cysts. Small superficial midline neck cysts that ap-
first and second branchial clefts as a result of improper closure during pear similar to a giant milium near the sternal notch (Fig. 2.54) have
embryonic development, are generally located along the lower third of also been observed and appear to be another type of midline develop-
the lateral aspect of the neck near the anterior border of the sterno- mental anomaly. These lesions have recently been termed midline ante-
cleidomastoid muscle. Lesions may be unilateral or bilateral and may rior neck inclusion cysts (MANICs).196
open onto the cutaneous surface or may drain into the pharynx. Al- Congenital cartilaginous rests of the neck (also known as wattles)
though these lesions may present in childhood, they more commonly occur as small fleshy appendages on the anterior neck or over or near
come to medical attention during adulthood because of recurrent in- the lower half of the sternocleidomastoid muscle. Treatment consists
flammation. Treatment consists of complete surgical removal or mar- of surgical excision with recognition of the fact that these cutaneous
supialization (exteriorization, resection of the anterior wall, and su- appendages may contain cartilage. Pterygium colli, congenital folds
turing of the cut edges of the remaining cyst to the adjacent edges of of skin extending from the mastoid region to the acromion on the
the skin). lateral aspect of the neck, may be seen in individuals with Turner,
Thyroglossal cysts and sinuses are located on or near the midline of Noonan, Down, lentigines, electrocardiographic conduction abnor-
the neck and may open onto the skin surface, extend to the base of the malities, ocular hypertelorism, pulmonic stenosis, abnormal genitalia,
tongue, or drain into the pharynx. Clinically they present as a midline retardation of growth, deafness (LEOPARD), and multiple pterygium
neck cyst that moves with swallowing (Fig. 2.51). These lesions repre- syndromes; trisomy 18; short-limbed dwarfism; and combined immu-
sent persistence of the embryonic structure associated with normal nodeficiency disease.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
2 • Cutaneous Disorders of the Newborn 33
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
34 2 • Cutaneous Disorders of the Newborn
A B
Fig. 2.55 (A) Supernumerary nipple. This papule, inferior and medial to the right breast, was present at birth in this young
girl. (B) Closer inspection reveals an umbilicated, pink papule representing a well-formed nipple and surrounding areola.
Downloaded for Anonymous User (n/a) at Egyptian Knowledge Bank from ClinicalKey.com by Elsevier on July 14,
2021. For personal use only. No other uses without permission. Copyright ©2021. Elsevier Inc. All rights reserved.
Another random document with
no related content on Scribd:
The Project Gutenberg eBook of Por las dos Américas
This ebook is for the use of anyone anywhere in the United States
and most other parts of the world at no cost and with almost no
restrictions whatsoever. You may copy it, give it away or re-use it
under the terms of the Project Gutenberg License included with this
ebook or online at www.gutenberg.org. If you are not located in the
United States, you will have to check the laws of the country where
you are located before using this eBook.
Language: Spanish
ENRIQUE MOLINA
Es Propiedad
DE VALPARAÍSO A COLÓN
Por las costas de Chile.—Mollendo.—El Callao.—Lima.—Espíritu español.
—Atraso político de los peruanos.—Gentileza de la gente culta.—
Problemas internacionales.—Panorama de la naturaleza y de los pasajeros.
—Un atormentado.—Panamá.—El Canal.
El camino más corto para ir desde Chile a los Estados Unidos es a través
del canal de Panamá. Los buenos vapores se demoran ya de Valparaíso a
Nueva York sólo diez y ocho días, y es probable que antes de un año no
necesiten más de quince y aún menos.
La rapidez y la economía que así resultan compensan la falta de otros
atractivos que pudieran deleitar a los viajeros a lo largo de la costa del
Pacífico meridional. Esta costa es monótona, y fuera de Valparaíso y tal vez
de Antofagasta, no ofrece grandes puertos que puedan despertar la
admiración o la curiosidad en algún sentido. Hablar de grandes puertos,
refiriéndose a los lugares chilenos nombrados, debe entenderse dicho con
relación a las ciudades, porque en cuanto puertos, bien sabido es que son
detestables y que difícilmente habrá otros peores en el mundo. Si en
cualquier peñón desierto en medio del océano se levantara un poste con un
letrero que dijera «Puerto», seguramente resultaría más abrigado que
cualquiera de los dos.
La costa occidental no presenta a la vista el regalo de algo semejante a
los panoramas encantados de Río de Janeiro, Santos y otros puntos
tropicales de la costa oriental.
Tampoco centellean de noche en ella los innumerables faros que animan
sin cesar las pobladas orillas del Mar del Norte europeo; ni aguzan la vista
de los pasajeros, como ocurría en este mar antes de la gran guerra, el pasar
continuo de transatlánticos ni el deslizarse en medio de centenares de
barquichuelos pescadores de pintorescas velas.
A bordo no se baila, y apenas se toca. Por lo demás, no es mucho lo que
perdemos con no oir más seguido el piano de nuestro vapor, el Aysen,
porque, por lo viejo, desafinado y chillón, resultan sus sonidos capaces de
hacer temblar de irritación a los nervios más bien puestos. Un maestro se
arrojaría al mar antes de poner las manos sobre ese teclado. Entre los
pasajeros hay sólo tres niñas, que son las que hacen los gastos de nuestros
escasos entretenimientos sociales con algún encanto femenino.
No se divisan más de dos parejas que «flirtean». En la rada de
Coquimbo, primera escala del vapor, contemplaban un joven y su
compañera a las vendedoras que habían subido a vender frutas, dulce de
papaya, confitados, quesos, canarios, objetos adornados de conchas, etc.
—Estas cosas son traídas de La Serena y de los valles vecinos, le dijo él.
Por haber llegado tan tarde el vapor, me ha fallado uno de los primeros
números de mi programa de viaje. Tenía vivo interés en alcanzar a visitar
La Serena, que es mi pueblo natal, ver sus calles coloniales adormecidas en
su estagnación semi-secular; pero ya es de noche. Tengo que contentarme
con divisar sus luces que parpadean cerca de la costa. Es un suplicio
tantálico: anhelaba ir allá; tengo a la vista el lugar de mi anhelo y sé que
será imposible conseguirlo. Es una imagen en pequeño de lo débiles que
suelen ser nuestras fuerzas ante el destino. En estas circunstancias las
lucecitas de la ciudad querida me parecen las miradas de una mujer que se
desea y no se alcanza, aunque ella misma quisiera ser alcanzada.
—Quién sabe si tanto en el caso de la mujer como en el de la ciudad es
lo mejor que pudiera ocurrir para no perder la ilusión, dijo suspirando un
señor maduro, que estaba cerca.
La niña sonreía sin entender tal vez la pena del joven ni el dolor que
palpitaba en la triste reflexión del señor maduro.
Uno de los «flirts» produjo resultados francamente saludables. Para
aliviarlo de una honda neurastenia, llevaba un padre a su hijo a viajar; y el
juego del amor, las dulces coqueterías de una simpática niña, pudieron más
para mejorarlo, sin duda junto con la acción del descanso y del aire del mar,
que todos los médicos que lo habían atendido y drogas que había engullido
antes. He considerado el caso muy digno de ser mencionado, sin que piense
que el remedio haya de ser recomendado siempre.
*
**
Los pasajeros leen, se pasean, juegan a las cartas, al dominó, a los dados
para beber los indispensables aperitivos antes de almuerzo y comida, o
cualquier cosa a toda hora. Los norte-americanos dan pruebas de mayores
aficiones gimnásticas que los demás. Juegan al lanzamiento de pequeños
discos de madera en el puente, y lo hacen con grandes gritos y alboroto y en
mangas de camisa. También gastan más empeño que otros en recorrer el
vapor diariamente de popa a proa con trancos elásticos.
Hay un japonés que no se mete con nadie. Retraído, huraño, fuma, toma
notas, y tiene una marcada fisonomía de bicho mal intencionado.
Viene un joven argentino, que es un pequeño «super-hombre». No muy
alto, delgadito, anguloso, muy metido en sí mismo, de pantalón blanco
irreprochablemente planchado y doblado abajo, de inmaculadas zapatillas
blancas con suave suela de goma; se pasea abstraído en sus hondos
pensamientos, muy derechito, lanzando las piernas como si obedecieran a
resortes muy bien montados! Protesta de que no le preparan el baño a
tiempo, llama a los mozos a grandes voces y habla de una comisión de su
gobierno que lo lleva a los Estados Unidos. Parece que tuviera en sus
manos los destinos de toda la América Española.
La costa de Chile va acompañada de cerros que en las latitudes del norte
acentúan su carácter árido, estéril, monótono. Aquí limitan al desierto o a la
pampa y son de un color café claro. Se presentan formados de una
substancia al parecer blanda, sin una planta, repulsivos, contrarios a la vida,
y como dispuestos a tragarse al hombre que se atreva a aventurarse en
medio de ellos. Y detrás de esta barrera se encuentra el salitre, la inmensa
riqueza que fecunda la tierra y es fuente de vida.
Antofagasta, la principal ciudad chilena del norte, se levanta en las
faldas de estos cerros desolados. Contemplada desde a bordo, se presenta
como un pequeño pueblo ahogado en los brazos de la montaña triste y
aplastante. Mirada de cerca, ya es otra cosa. Pero no siempre es fácil
desembarcar y llegar a ella. Hay días,—y el en que nosotros fondeamos fué
uno de ellos,—en que el mar forma tantas olas aquí como en el lugar más
abrupto de la larga costa chilena. Los vapores fondean lejos y danzan sin
cesar, acompañados de los botes y vaporcitos que se acercan a ellos, y
suben y bajan diez o doce metros en un movimiento continuo.
Los angustiados pasajeros, que desean o tienen que desembarcar, deben
esperar el momento preciso en que el bote se acerca a la base de la escalera
para saltar sin peligro, pero no sin que sea menester dar pruebas de gran
agilidad y acrobacia. Aun así no escapa el pasajero libre de una buena
mojada.
Las calles de Antofagasta son anchas, y en ellas reina la animación de
una ciudad activa y llena de vida. Se hallan pavimentadas de asfalto de
roca, hecho en mejores condiciones que en cualquiera otra ciudad de Chile,
y las recorren automóviles y victorias limpios, nuevos, brillantes. La
población tiene cincuenta años de existencia y cuenta sesenta mil habitantes
más o menos. Hay buen alumbrado eléctrico, buen agua potable, y hasta
jardines, quintas y parques preciosos. Los chilenos han creado un oasis al
borde del desierto.
Iquique, más que una ciudad, es un campamento. Le falta de la
verdadera ciudad el carácter de mansión definitiva, de lugar elegido por el
hombre para establecer su hogar. Es una plaza de tránsito en que los
hombres se congregan para enriquecerse y divertirse. Y en cuanto pueden
se marchan. Es un campamento que no tiene nada de desagradable y donde
se lleva una vida ligera y fácil. Cuenta con algunas calles amplias y
hermosas y con un bello paseo a la orilla del mar. Desgraciadamente, según
informaciones que recibí al pasar, en lo que más importa a la vida no es un
campamento nacional, sino extranjero. Las principales industrias y el gran
comercio se hallan en manos de extranjeros, y hasta el agua que usan y
beben los habitantes la suministra una compañía foránea que cobra por ella
los precios más exorbitantes que es dable encontrar en el mundo.
Después de recorrer la costa desnuda de toda vegetación de Antofagasta
y Tarapacá, Arica se presenta a la vista como un pequeño vergel. Arica es la
puerta de algunos ricos valles de la provincia de Tacna que producen, entre
otras cosas, exquisita fruta. Las naranjas y las chirimoyas del valle de
Azapa son de una dulzura deliciosa e insuperable.
Arica es un pueblo de calles estrechas, tristes, amodorradas,
pavimentadas con piedra de río, y con aceras angostas que se extienden casi
al mismo nivel de la calzada.
¡Qué laxitud se siente en la vida de este pueblo! La gente anda despacio,
no gasta prisa para nada. La gente del pueblo anda sucia, desarrapada; y los
ejemplares de la raza peruana que se encuentran evocan la mísera imagen
de los tipos sud-africanos. Parece que todos vivieran en una comadrería
condescendiente y resignada.
Al alejarnos del último puerto chileno, contemplamos al Morro de Arica,
pelado, macizo, abrupto, teatro de las inmortales hazañas de nuestros
guerreros; lo juntamos en nuestra mente con otro escenario de valor épico,
la rada de Iquique, y sentimos que en estas tierras yérmicas y escuetas, ha
dejado el heroísmo chileno palpitaciones inmortales y vigorizantes, que
sumen el alma en un estado depurador de unción patriótica, casi religiosa.
*
**
Mollendo, el primer lugar peruano en que tocamos, es un puertecito
enclavado en las faldas de los estériles cerros de la costa, que continúa
siempre desolada. El pueblo no tiene hacia donde extenderse abrigado entre
el mar y la montaña. Sus casitas parecen palomares colgados de las paredes
de un barranco. Tampoco existe una bahía propiamente dicha, y el mar se
presenta de ordinario más agitado y terrible que en Antofagasta, con lo que
se dice todo. Los pasajeros, para embarcarse o desembarcarse en el vapor o
en el muelle, tienen que ser izados o bajados amarrados en sillas.
El principal puerto del Perú, El Callao, nos ofrece en una mañana de
Septiembre, ligeramente envuelta en leves brumas, su bahía amplia,
hermosa y tranquila. El puerto, con su desembarcadero propiamente dicho,
es muy bueno y seguro. Pero el pueblo es pequeño, bastante sucio y sin
importancia. Callao sufre con la proximidad de Lima, a la cual está unido
por buenos tranvías eléctricos que hacen el viaje entre la capital y el puerto,
en menos de una hora. Hay además carreteras muy bien tenidas para
automóviles y otros carruajes. Toda la gente de cierta posición social
prefiere no vivir en el puerto sino en Lima o en algunos de los bellos y
graciosos balnearios de los alrededores, como Miraflores, Chorrillos,
Barrancos. Entre Lima y El Callao se encuentran además San Miguel y
Magdalena, lugares de residencia también, compuestos de pintorescos
chalets, que aquí con cierta modestia y dejo de casticismo se llaman
«ranchos».
La vieja Lima es un encanto. Uno se cree en medio de esas seductoras
antiguas ciudades italianas que sugieren misterios, hacen convivir con
siglos pasados y hechizan la imaginación. Las calles son estrechas y no bien
pavimentadas; pero gustan mucho. Los balcones con vidrieras corridas, o
con espesas celosías, las rejas moriscas, los patios andaluces producen una
impresión artística propia, impresión de ensueño y de tranquilidad
sonriente.
De las ciudades importantes de la América Latina, Lima es,—cediéndole
el paso en esto tal vez a Méjico,—la que tiene más carácter genuinamente
español y colonial; y es, por lo mismo, más interesante a los ojos del artista
y del arqueólogo que otras ciudades como Buenos Aires y Santiago, de
muchísimo más valor desde otros puntos de vista.
Los principales monumentos de la época colonial que se señalan en
Lima son la catedral, el convento de San Francisco, el Palacio de Torre-
Tagle, la casa de la Perricholi, y el Palacio del Senado, donde funcionaba la
Inquisición.
La casa de la Perricholi fué hecha por el virrey Amat, en la segunda
mitad del siglo XVIII, en obsequio de su querida, la célebre artista Villegas,
a quien él, en los momentos de discordias semi-conyugales, llamaba en su
mal pronunciado castellano «Perricholi», por decir «perra chola». Es una
casa que se encuentra bastante en ruinas; no fué hecha de material noble y
durable; y aun en su tiempo debe haber sido más pretensiosa que hermosa y
recargada de colores y decoraciones. Hoy hace la impresión de una mujer
que, a pesar de sus muchos años, ha seguido vistiéndose con telas claras un
tanto raídas y conserva sin cesar en sus arrugas restos de afeites.
La catedral es una fábrica perfectamente bien tenida, pero de estilo poco
definido, y tal vez algo pintarrajeada y sobrecargada de dorados. La sillería
del coro tiene tallados admirables que la hacen una valiosa obra de arte.
Entre las reliquias de la catedral se encuentran los restos del conquistador
Pizarro, conservados en una urna de vidrio. En el mismo departamento hay
un riquísimo altar de plata maciza y una madona muy bella, que, según
dicen, fué un obsequio de Carlos V. Es una obra en que se ha combinado la
pintura con el relieve. La virgen está pintada al óleo, y lleva una diadema de
verdadero oro realzado; el conjunto da una impresión de armonía completa.
El palacio de los marqueses de Torre-Tagle data de 1735, y es la mansión
más importante y típica que conserva Lima de la época colonial. Es una
casa de dos pisos, de color obscuro, situada en el centro de la ciudad. Su
patio español, sus maderos ricamente labrados en cuanto se ve de ellos, sus
frisos de azulejos, sus azoteas, su fachada, hacen de este palacio un
monumento único. Ocupa el segundo piso de la fachada un balcón corrido,
sobresaliente a la calle, cerrado con espesas celosías; y al contemplar éstas
desde afuera o mirar a través de ellas desde adentro, vuela la fantasía hacia
el siglo XVIII y se complace en forjar romances de amor. Como todos los
obstáculos que se oponen a los enamorados aumentan el incentivo de la
pasión, las discretas celosías deben haber prestado cierto misterio a los
encantos de las limeñas y enardecido los sentimientos de sus adoradores.
Uno ve a un galán pasando por la calle y renegando de la cortina de madera
que le impide disfrutar de los ojos de su amada; y ella, quizás una
marquesita, que no se atreve a abrir la celosía, sufre también. Y la
imaginación se representa este vulgar episodio de la eterna historia del
corazón, hermoseado con toques artísticos por la mágica pátina del tiempo.
El convento de San Francisco, fundado en el siglo de la conquista, goza
entre los peruanos de la fama de ser una maravilla en todo sentido. Sin
embargo, debo confesar que no me pareció así. No es una obra de arte
arquitectónico ni contiene grandes obras pictóricas o esculturales. La
sillería del coro se halla magníficamente tallada, aunque, según mis
recuerdos, los tallados no son de tanto mérito como los de la catedral.
El convento tiene, sí, la venerabilidad que prestan los siglos a todo lo
inanimado que se mantiene a través del tiempo sin cambiar. Según las
palabras del amable monje que me acompañaba, el convento se halla tal
cual fué en la centuria decimosexta. Y no cuesta creerlo. El siglo de la
conquista fué, sin duda, de fabulosas riquezas en la tierra de los incas, pero
ni el carácter de la época ni los medios disponibles permitían emplear esa
riqueza en hacer la vida confortable. Austeridad, frialdad,
desmantelamiento, son las impresiones que produce esta casa de religiosos.
La iglesia solitaria, el amplio coro, la alta sacristía, envuelven el ánimo en
una sensación de encogimiento triste. El espíritu no se siente invitado a
recogerse en sí mismo a meditar, porque quiere huir de ahí. Los corredores
están adornados de altos frisos de hermosos azulejos; pero se hallan
rodeados de rejas hacia el patio y la idea de encontrarse en una cárcel
oprime el corazón. En el patio, sobre el suelo húmedo, languidece
marchitándose, desplomándose, un pobre jardín.
Sin embargo, mi guía, que pasaba su vida entre esas paredes desoladas y
frías, no denotaba nada de tristeza. No era en verdad el tipo del monje
rechoncho, de carnes opulentas, que se nos suele pintar. Era pequeñito,
delgado, de faz anémica; pero de todo su ser emanaba una conformidad
risueña y se mostraba muy ufano del renombre y antigüedades de su
convento.
Me mostró el buen monje, por último, una capilla muy mona, en que
había una virgencita extremadamente milagrosa. Era el lugar predilecto de
las devotas limeñas de la buena sociedad. Ah! en los días de grandes fiestas,
la capillita parecía un canastillo de flores y un rincón del cielo lleno de
soles y de estrellas. Una vez estalló un incendio que amenazaba devorar la
hermosa nave. La virgencita bajó entonces por sí sola del alto sitial en que
se encontraba, se puso a orar delante del altar y las llamas detuvieron como
por encanto su avance destructor. Los que estaban empeñados en apagar el
incendio, y vieron el prodigio, corrieron a dar cuenta de lo ocurrido a otros
monjes y al superior; pero cuando volvieron, ya la virgen había subido de
nuevo a su lugar, también por sí sola, y estaba ahí tan serena como si nada
hubiera hecho.
Al monje no le asaltaba la menor duda sobre la veracidad de su relato.
Por mi parte, complacido en la contemplación de ese cerebro adulto que se
hallaba en tal estado de fe ingenua, me encontraba muy lejos de querer, con
observaciones inconvenientes, arrojar sombras sobre la limpiedad de su
creencia.
Y para corroborar que tal milagro cuadraba como si dijéramos en el
orden natural de las cosas que podían ocurrir en la capital peruana, el monje
agregó:
«Lima es un lugar de bendición, predilecto del Señor. No ve que ha sido
tierra de santos, como Santa Rosa de Lima, Santo Toribio de Molgrovejo (y
nombró algunos más que no recuerdo). Aquí no hay pestes ni calamidades
de ninguna especie. Esta ciudad es un paraíso».
El viajero que pasa a la ligera por Lima no se resiste a aceptar que el
monje estuviera en lo cierto. Para ello se juntan a los encantos de que ya he
hablado la suavidad y dulzura del clima. Pero los que viven largo tiempo
aquí, saben muy bien que esa blandura es enervante, debilitante y
perjudicial para la salud, y que los habitantes del paraíso limeño se hallan
muy expuestos a ser víctimas del paludismo, fiebre maligna causada por la
picadura de un mosquito que se desarrolla en los pantanos de los
alrededores.
Dicho sea de paso que cultivando mejor los terrenos circunvecinos, se
obtendría la doble ventaja de aumentar la riqueza agrícola y de sanear más
esta parte del país. Uno no puede dejar de hacer tal apuntación al observar
cierto abandono en los campos que se extienden entre El Callao y Lima.
El espíritu español subsiste en el Perú incorporado no sólo en las cosas,
sino en algunas costumbres. Y si no, díganlo las corridas de toros. No me
tocó la suerte de asistir a ninguna, pero es sabido que las de Lima no le
ceden en brillo, en importancia y en rendimiento pecuniario a las más
pintadas de España. Los jóvenes limeños de ambos sexos adoran a los
toreros famosos, y guardan sus retratos como los de héroes y grandes
artistas. Toreros ha habido que han levantado fortunas de millones de soles,
toreando en Lima. Un peruano cultísimo y profesional distinguido me decía
al respecto:
«Yo prefiero una tarde en la Plaza de Toros a cinco noches de ópera en el
Metropolitano de Nueva York; y usted haría lo mismo, agregaba, si hubiera
asistido siquiera una vez en su vida a una buena corrida».
El pueblo peruano encierra en los cuatro millones de almas que lo
forman, tres millones de raza india. Por esta razón tal vez es tan frecuente
en las clases bajas el tipo pequeño, endeble, casi negro, que hace pensar en
tipos sud-africanos. En los gendarmes de Lima se observan generalmente
estas características y no hay mucho que admirar en ellos, por supuesto, en
cuanto a apostura marcial.
Esta circunstancia racial debe ser también uno de los antecedentes que
han obrado para producir el atraso político, la falta de preparación cívica en
que aun se encuentra la nación peruana. El Perú no ha salido todavía del
período de las asonadas militares y de los gobernantes que suben y bajan en
virtud de afortunados golpes de mano y de motines de cuartel, período por
que pasaron en diferentes décadas del último siglo todos los pueblos
hispanoamericanos y que un buen número de ellos ha dejado atrás
afortunadamente para siempre. Al parecer no hay en este país partidos
sólidamente organizados ni opinión pública con fuerza bastante para servir
de freno a los desmanes de los caudillos y del militarismo. El pueblo, en el
más perfecto sentido de la palabra, entendido como concepto comprensivo
de todas las clases sociales, teniendo la conciencia de formar una comparsa
que no puede influir en la suerte de la República, permanece impasible ante
las intrigas de palacio que derriban y elevan mandatarios[1].
¡Qué personas tan finas, amables y de vivaz inteligencia son los
peruanos de las clases cultas! En este viaje no he tratado uno solo que no
me haya dejado tal impresión.
Aun para discurrir sobre las más espinosas y peliagudas cuestiones
internacionales, sobre aquellas que aprietan entre sus mallas el amor propio
nacional, he encontrado en ellos espíritus claros y serenos. Charlando a
bordo sobre tópicos de esta clase, me decía un diputado:
—El desenlace de la Guerra del Pacífico fué desgraciadamente una cosa
natural y lógica. Nosotros teníamos que ser vencidos por un motivo racial.
Como usted sabe, las tres cuartas partes de nuestra población están
formadas de indios y con la indiada no se pueden hacer buenos soldados.
¿Cómo íbamos a combatir con éxito con el pueblo de ustedes, compuestos
de fuertes mestizos o de tipos de raza blanca?
Hablábamos en otra ocasión con otro distinguido peruano a propósito de
la, por parte de sus compatriotas, soñada intervención de los Estados
Unidos para solucionar la cuestión de Tacna y Arica. Y me decía:
—Es un recurso empleado por algunos politicastros para agitar la
opinión pública y mantenerla favorable a ellos, atizar la esperanza de que en
el arreglo de nuestros conflictos vamos a contar con el apoyo de los norte-
americanos. Esta es una pobre ilusión. Tal cosa no ocurrirá. Nosotros
debemos levantarnos en virtud de nuestras propias fuerzas, y resolver
directamente nuestros problemas, con cordura y equidad, sin la intervención
de nadie de fuera de la América Española.
Escuché con hondo regocijo estas palabras que me producían una
sensación de alivio y venían a confirmar y a dar más nitidez a muchos
juicios y sentimientos que yo ya sustentaba de antemano. Han estado en lo
cierto la inmensa mayoría de los chilenos que han considerado insensato el
odio a los peruanos. No revelaría hidalguía odiar a una nación hermana que
es militarmente más débil que nosotros. Es claro que no es posible remontar
el curso de la historia; y que Chile y el Perú no pueden encontrarse de
nuevo en la situación en que se hallaban antes de 1879 o de 1873; pero,
dentro de la aceptación de los hechos consumados y del respeto a los
derechos adquiridos, hay que buscar una pronta solución al conflicto
existente, solución que signifique el principio de una nueva era en la
historia de la América Española. La grandeza futura de las naciones de este
Continente descansa en la unión de la América Latina. De otra suerte, serán
fácil presa de los extranjeros, primeramente en el orden económico, y quién
sabe después en cuántos sentidos más, lo que puede no permitirles llegar a
desarrollar una personalidad vigorosa y acentuada en el concierto de los
pueblos civilizados.
*
**
Para muchos, el viaje se prosigue dentro de la monotonía de una vida
siempre igual. Todos los días los mismos paseos, los mismos juegos, las
mismas comidas, el mismo matar somnoliento de las horas en las cómodas
sillas de cubierta, el mismo esperar lánguido de la próxima distribución.
Sin embargo, la monotonía es en muchos aspectos sólo aparente. Las
bellezas naturales, el mar y el cielo que en su grandeza nos arrastran hacia
las misteriosas vaguedades de lo infinito, sobrepasan el concepto de lo
monótono. El mar es un objeto que invita a la contemplación serena y
plácida, al arrobamiento, no al hastío, ya se presente con la tranquila
magnificencia de un lago sin límites, ya se agite en olas irritadas por la
acción levantisca del viento, ya tomen sus aguas tintes verdosos de algas, o
azules obscuros, tenebrosos, que hacen pensar en algún líquido abetunado,
pegajoso.
Navegamos casi siempre en un mar tranquilo, muy digno de su nombre
de Pacífico. Sólo entre Antofagasta y Mollendo un viento sur fuerte nos
azotó algo de costado, encrespó el mar de manera formidable e hizo bailar
al vapor como un barquichuelo insignificante. Aquí fué el protestar de la
gente mareada. Muchas señoras creían morirse y no pocos señores también,
y clamaban en contra de lo pequeño, de lo inseguro y de lo inestable del
buque. Este resultaba el fracaso más completo de la arquitectura naval. Pero
el mal tiempo fué cuestión de dos o tres días y pasó.
La naturaleza volvió a recobrar su hermosa placidez. En Paita se nos
presentó con todas las galas de una belleza tropical, brillante, nítida,
transparente. Era una noche placentera, tibia, amorosa. La bóveda azulada
parecía una tersa piedra preciosa en que estuvieran engastadas centelleantes
la luna y las estrellas. Se sentía un aire grato que envolvía en laxitud. Las
aguas se mecían balanceando en sus ondas los rayos de la luna:
correspondían con la suavidad del movimiento a la caricia de la luz. El alma
se sentía inclinada a caer en adoración y a divinizar el mar, las estrellas, la
luna, como deidades palpitantes de amor, sonrientes y benévolas.
Paita es famosa por tres capítulos: por la luna, los sombreros de jipijapa
y la chancaca. En esta ocasión sólo de esta última no pudimos dar fe. Ya
hemos visto cuán justificada es la fama de la luna, tomada como
representativa de un cielo tropical esplendoroso. Por lo que respecta a los
sombreros, una nube de vendedores subió al vapor a ofrecerlos. Eran
individuos de tipo indio muy acentuado, aunque no enteramente puro y con
caracteres de mestizos. Traen los sombreros en bolsas de tela y algunos son
tan finos que se pueden doblar como el más delicado tejido de seda o de
hilo. Pero se permiten pedir por éstos de ocho a diez libras esterlinas. Con
el regateo bajan a cinco, a cuatro, y cuando el vapor va ya a levar anclas es
fácil obtener alguno bastante bueno por dos libras.
*
**
Así como el panorama de la naturaleza no resulta monótono para el que
sabe mirarlo con amor e interés, de igual manera el panorama, por decirlo
así, que van presentando las personas de los viajeros ofrece siempre algo de
nuevo si se le observa con atención. Nunca alcanza a conocer uno a todos
sus compañeros de viaje ni siquiera de vista en los primeros días. A lo
mejor, extrañado de una facha que no ha visto antes, se pregunta: ¿Y este
señor de dónde salió? Otros van subiendo y bajando en los puertos en que
se hace escala. Hay contactos de almas que duran el fugaz minuto de una
cortesía, y luego se apartan en diversas trayectorias, tal vez para siempre.
Los hay también un poco más largos, lo suficiente para que se alcancen a
tejer las etéreas fibras de una mutua simpatía; pero también viene luego el
apartamiento, a menudo para siempre. En general el trato con los demás
resulta, con raras excepciones, provechoso. Acercándose a las personas y
penetrándose de lo que son, se desvanecen prejuicios, esquiveces, y se las
juzga con más ecuanimidad y justicia.
¡Cuántas veces bajo un cielo azul bruñido, que es una lluvia de dicha
para los que saben recibirla, y sobre un mar que se mece con suaves ondas
de ensueño, soplan a bordo en los corazones vientos de tormentas
pasionales horrorosas, vientos de tragedia!
A este respecto me interesó hondamente la situación espiritual
desgarradora de un joven médico en quien no había reparado en los
primeros días, el doctor N. Era un hombre de aspecto sereno, pero,
observándolo con cuidado, se veía que un hondo desgano, una displicencia
que le venía de las entrañas le encogían el ánimo y que él luchaba para
mantener por lo menos en apariencia el equilibrio de su alma. Le faltaba la
alegre espontaneidad característica de las personas que gozan de plena
salud corporal y espiritual.
Notando el interés que me inspiraba, empezó a ser franco conmigo, y
una tarde me abrió su pecho en una dolorosa confesión:
—Estoy desesperado, amigo mío, me dijo. La idea del suicidio me
obsesiona, me ahoga el corazón, me tiene seco el cerebro, me impide pensar
en cualquier cosa e interesarme por nada. Cuando me paseo solo, sobre todo
en las tardes y en las noches, las aguas ya obscuras del mar y la estela que
va dejando el vapor, me atraen. Siento que lo mejor, lo mejor que podría
hacer, sería arrojarme a ellas y acabar de una vez. No llevo cuenta de las
veces que he deseado tener un revólver y de las en que me lo he puesto
imaginariamente en las sienes. Mi fantasía se ocupa en combinar las
mejores maneras de terminar instantáneamente con mi vida. Pienso en lo
eficaz que sería sentarme en la barandilla de popa, pegarme un tiro y caer al
mismo tiempo al mar. Pero sería un escándalo, y esto no se aviene con mis
sentimientos. Busco un suicidio que pudiera pasar por un accidente natural.
La idea del escándalo me aterra. Oh! qué golpe significaría esto para mi
pobre madre, mis hermanitos, algunos de mis amigos!
—Veo que usted ha empezado por hacer lo que debe hacer toda persona
que se encuentre en el malhadado caso de usted: luchar con la obsesión y
dejar siempre para el día siguiente la ejecución del nefando proyecto. ¿Pero
su situación tendrá algunos antecedentes?
—Ah! sí, muy fáciles de exponer, pero no de remediar, como es fácil que
se diga porque álguien tiene tuberculosis en último grado y que, con
diagnóstico y todo, no haya salvación para el enfermo.
—Creamos que su mal no sea de último grado.
—En mí han obrado la acción disolvente y morbosa de un mal estado
espiritual general, y el dominio de una pasión que entró en mi corazón con
alborozos y resplandores de celestial aurora; y luego me ha deshecho lo que
me quedaba de voluntad y carácter; ha deshecho mi vida. Sin duda lo
primero que me ocurrió fué que insensible, paulatinamente, fueron
secándose en mí las fuentes vivas de un idealismo sólido y desinteresado. El
mundo sensual y frívolo, la falta de una religiosidad honda, el espectáculo
de una moral hipócrita y de un patriotismo y civismo declamatorios, dieron
los primeros golpes a la contextura de mi alma. Luego la ciencia pura,
imposible de acompañar por sí sola con alguna concepción ética salvadora,
y cierta literatura hicieron tambalear más aún las amarras ideales a que yo
me aferraba. Pocas obras más funestas para el mantenimiento de la voluntad
y de la fuerza moral que las de Eça de Queiroz, de Anatole France y otros
franceses por el estilo, y las de algunos españoles. No niego las grandes
cualidades artísticas y literarias que casi siempre las adornan. Pero el
escepticismo que campea en ellas, la ironía y el sarcasmo que gastan en sus
pinturas de la vida humana, la insistencia con que presentan a sus héroes
dominados por las pasiones sensuales, dejan en el alma una impresión de
vacío, un estado abúlico, un desprecio de los hombres y un menosprecio de
la vida que abisman. La conciencia herida de esta suerte mira con sonrisa de
duda cualquier gesto noble, cualquier esfuerzo levantado, cualquier
sacrificio, se pregunta ante ellos: «¿Para qué sirve eso?» «A quoi bon?» y el
veneno del desánimo y de la apatía que la ha emponzoñado, sugiere la
respuesta de: «Para nada, al fin todo será igual».
—¡Cuánta razón tiene usted! Qué descripción y qué diagnóstico tan bien
hechos! Pero lo que importa es salir de ese estado.
—¿Dónde encontrar una filosofía sólida de la vida, una filosofía que nos
conforte y nos haga avanzar con esperanzas por los senderos del tiempo?
Ah! las religiones! Felices los que creen. Mientras nuestros cuerpos
marchan en la tierra con planta segura, nuestros espíritus andan a tontas y a
locas. La tierra, sólida para los pies, es frágil para el alma, y ésta se debate
desolada entre la insuficiencia de nuestro planeta y los misterios del cielo.
Me imagino a los hombres y a sus obras como insignificantes monigotillos
que se agitan y tejen débiles telarañas en tinieblas y entre dos abismos.
—Todo esto puede ser muy cierto desde un punto de vista cósmico y
eterno, haciendo tabla rasa de toda palpitación de un corazón humano. Pero
el valor de la vida no depende de su comparación con las dimensiones del
cosmos y de la eternidad, sino de nuestros sentimientos. Se puede
defenderla indudablemente con argumentaciones y razonamientos sólidos;
pero cualquiera alegación, por bien fundada que sea, no es lo esencial de
ella. El valor íntimo de la existencia resulta simplemente y siempre de la
afirmación categórica del ser que vive, como se ve en la graciosa
ingenuidad de un niño que hace de todo motivo de juego, en las
abnegaciones inagotables de una madre, en la virtud de una joven que
trabaja alegremente día a día sin preguntarse jamás para qué sirve la vida.
—Es cuestión de sentimiento, quizás de amor.
—Sí, sí; pero distingamos, no se trata del amor sexual.
—Sin embargo, ¡cuántas veces es el amor de una mujer lo que presta su
encanto supremo a la vida!
—En ciertas edades, por supuesto.
—Y si él no es correspondido o no es posible, caemos en un limbo de
tedio y desesperación. Es lo que me ha ocurrido a mí. Hace algunos años
conocí una mujer, una señora, cuya hermosura, gracia, talento y trato, me
atrajeron. Empezó por ser un pasatiempo delicioso. Luego estar con ella,
verla, oirla, eran las mejores horas de mis días. A ella le gustaba también mi
compañía. Con el tiempo mi simpatía se convirtió en una pasión
arrebatadora que me elevó en un sueño de amor y vino a dar nueva luz a mi
existencia. ¿Y cómo no amarla? Había tan grande armonía en su persona: la
viveza de sus palabras, la frescura de su talento y de su ingenio, lo sano y
delicado de sus sentimientos, su capacidad de amar: todo formaba un
conjunto feliz que, cuando hablaba, su voz me deleitaba el alma como las
notas de una cajita de música espiritual. Así solía decirle: «cajita de
música». A menudo la llamaba también «vidita» y cuando hacía esto, se me
iba el alma por los labios. Perdone que entre en estos detalles, tal vez
pueriles, pero ¡qué quiere! me complazco tanto en recordarlos. No ir a verla
a veces me causaba un dolor como si me desgarraran las entrañas. Yo estaba
loco de pasión, pero ella tenía un concepto demasiado claro de sus deberes
para que nuestro cariño pudiera conducir a algo ilícito. Jamás pasé más allá
de besarle la mano. Tomando del sentimental libro «La Sombra Inquieta»,
pensamientos de Fogazzaro, nos decíamos que seríamos «esposos sin
bodas, que nos querríamos como se quieren los astros y los planetas, no con
el cuerpo, sino con la luz, como las palmeras, no con las raíces, sino con las
ramas más altas de sus copas».
Yo tenía que ir a Europa a estudiar los últimos adelantos de la cirugía y
debimos separarnos. Lo hicimos en una despedida dolorosa que ha
significado tal vez un adiós para siempre.
He quedado, como le decía al empezar esta confesión, herido de muerte,
con una congoja que me atenacea sin cesar el corazón, me aprieta la
garganta y hace que mi vida sea como un prolongado sollozo interior. Qué
de lágrimas he vertido hacia adentro que me ahogan el pecho! Y ve usted la
ironía del destino: en tal estado voy a buscar la mejor manera de curar las
heridas corporales de los hombres.