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Immunosuppressants
Immunosuppressants
Immunosuppressants
IMMUNOSUPPRESSANTS
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1.CALCINEURIN INHIBITORS
-Cyc/osporine: Very lipophilic and essentially not soluble
in water
administered orally , i.v. and i.v. infusion
Mechanism of action :
enters in target cells
l
binds to cyclophilin
l
cyclosporine - cyclophili n complex
!
inhibit calcineurin and blocks activation of T cells and decresed
production of IL-2 and other cytokines
1.CALCINEURIN INHIBITORS
Uses:
-prevent and treat rejection episod ~UMAN
oRGAH
organ transplantation
like kidney.bone marrow.liver et.o --,;
-Mechanis1
1
m of ,action1:
ith an immunophilin
It forms comp lex w1 1
!
Inhibits a key·enzyme :in cell cyc:le p,rogressio:n
1
!
l'nhibits the response of interleuk.in-2
!,
That blocks activation ofT-cells and B-.cells
Uses : -To treat and prevent graph rejection reaction
-Thrombocytopenia
4.GLUCOCORTICOI DS
Prednisoloine : !Induce redistribution of lymphocyte·s that
decrease in
peripheral1blood, lymphocyte count.
Mechanism of a.c t1
i o1
n:
Inhibit proliferation 0f T~lymphocytes
1
!
Decrease expressio·n of interleukines
!
B,.l.ocks the activatio·n of r-.ce11s an.,d B,-c.ells
Uses : -~o prevent ,and treat rej ection episodes during
1
1
0rgan
1
tra nspll.antation.
1
-Autoimmu1ne diseases.
Adverse 8'f fects : -Osteoporo,sis
1
-Hyperglycemi;a
...Risk of Infection
-Po0r wound hrealing
1
Mechanism of action :
It forms a relatively stable complex
l
Binds to soluble and membrane bound TNF
i
That blocks activation of T-lymphocytes
Uses : -Rheumatoid arthritis
-Crohn's Disease