12 y .

ET : Secretion of sexhormones

kiss-I neuron
Kisspeptin
nutrition + L

GPR54
[

t
:
Stress &

GURH

GABA-ergic neuron ·::

pituitana
-

CH
&

FSH

Progesterone aktivasiaromatase

Andrigen >

Estrogen

↑ CHESH

Ovulasi

Corpusiuteum

Degenerasi

Progesterone ,

endometriumlumn

menarche
·
epophoresistvani
Fundus uteri

ovarium corpusuteri

- I

↳ endometrium

myometrium

8 O
perimetrium

ostiumintema
plica
Fomix cervix

·
intundibula
&

& portio
--
--
ostium externa

tubaena
isthmua a

Lig Sacrouterina

T1o -Li
.

A iliaca interna
hipogastrik inferior
.

plexusvuterina plexusv Vaginalis

.
N .

A uterina A .

vaginalis Veterina
utems-cerrix
v .
Vaginalis
S2-Su
A spiralis/
N pudendus N
coiledartery .

, .

Pelvikus
V Iliaca externa
.
vagina-genitalia ext.

n
·
r
.&e si c onta i n ↑
-
-
O
him
M-
-A /
&
&
-

-
↑

i
monspubis

praepurium ditoridia

ditoris
ostium paraurethrales

labia majore

baro
HISTO cortex
Xep germinal
.

medulla
go
· 11
tunica
albugine a

-
L

1777
L

O
O O

i,
i:"
!...
&

Of
·
,
--

%
&
M

'

O
-
T

↑
I

& -
S

⑧
& -
&

O g
-
-
G

Sz
2
E ~
-

- -

&
O
O
O
8
O
O

O o
O
O 8

Sekretoristhovulasi menstratifluruh dinding

Proliferasi folikulersth endometrium
mens
sekret =nutriciutkjanin darah roll koagularikarena
vaskularisas : ↑ ada fibrinolisin
Fase-fase
Hypothalamus
GnRH

FSH

"
·

LH FSH
,

① Folikuler awal estrogen inhibisiSH

:
a
Piritan
Face Ovarium

GuRt
⑳HurgekarenestrogenCorals
s GGnRH]
FA

11
Luteal
④ Inhibin inhihisi FSH LH
siFSt
Folikuler Fung
Estrogen ClOhari) Feedback
inhibis: (H
↓ consenpasi-

FSH + estrogent
seady estrogen , FLAN
-

↳ days estrogen

~
Guilt + estrogen = LI
outsi
GnRH
FSH
LH
--
·

-- corpus
Tof
-

cuteum
. plymatic

Estrogen
Progesterone
Inhibin
-
⑧ 28

②
~

g [
↑ 2) estrogenhamya + feedback saatorulasi
beprost
estrogen Estrogen
Inhibin

Progesterone

I
-
⑧
14
88
&

7
333 ↑
28

Folikulerawal Folikuler akhir - ovulasi GHRH

GnRH
-GnRH
GnRH + ↓
perm + feedback
-
L
dari estrogen

FSH CH- ↑ FSH CHe

Est androgen
L ~

-ESH CH- -

M Corpus
w w
~
luteum
estrogen Androgen estrogen progesterone Est
Estrogen Pro
Progesterone Inhv
inhibin
B1Okim

LH
CH
Theca LDL
Granulosa LDL

AC ATP

Cholesterl
camp CYPIIAL

V
I Cholesterl Pregnenolone
CYPlAl 3B HSD
pKa
Pregnenolone
3BHSD
<
Progesterone Progesterone
CYP1) 1) -x
hydroxylase
-
3 BHSD
172-OH
pregnenolone , 17-OH progesterone
CYP17
ase estrogen
,
~

DHEA 17-20 T

M
3 BHSD
VL
CAMPS
aromatase AC
Androstenedione
ATR FSH
17 BHSP
W

Testosterone > Testosterone

HSD = hydroxysteroid dehydrogenase