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Test Bank 2
3. A patient suffering from asthma has difficulty breathing and is treated with albuterol
and ipratropium, drugs that relax bronchiolar smooth muscles. Ipratropium acts as a(n)
Explanation:
The answer is a. Ipratropium is a cholinergic receptor antagonist and interferes with the
binding of acetylcholine, a neurotransmitter, to its receptor sites on the cell membrane,
thus preventing the contraction of bronchiolar smooth muscle. The two drugs are used in
combination agonist-antagonist therapy to have the desired effect of maintaining an open
airway.
4. A 9-month-old female Jewish baby, whose parents were born in Poland, is seen by her
pediatrician because of neurologic problems, including generalized paralysis and
blindness. The pediatrician should suspect that the child is suffering from
a. spina bifida
b. cranial nerve X (vagus nerve) disorder
c. Tay-Sachs disease
d. Fabry’s disease
e. Refsum’s disease
Explanation:
The answer is c. Tay-Sachs disease affects mostly children of Eastern European Jewish
ancestry as well as certain families in Lousiana of Cajun ancestry. Children suffering
from this lysosomal-storage disease cannot catabolize GM2 gangliosides that accumulate
in their lysosomes, and the enlarged lysosomes interfere with cell function. The
interference is most problematic in the neurons of the central nervous system and causes
death by the third year of life. Neither spina bifida nor vagus nerve disorders would cause
generalized paralysis or blindness. Fabry’s disease, although a lysosomal-storage
disorder, is due to an X chromosomal defect and affects only males. Refsum’s disease is
due to the accumulation of phytanic acid, a by-product of chlorophyll metabolism, and
affects older children who already eat fresh fruits and vegetables.
5. Acid hydrolases are synthesized on the rough endoplasmic reticulum and are delivered
to the Golgi complex to be packaged and distributed to their final destination. In patients
whose protooncogenes have mutated to form ras protein–related products known as ADP-
ribosylation factor (ARF), this factor may interfere with
d. clathrin synthesis
e. clathrin assembly
Explanation:
The answer is b. Delivery of proteins manufactured on the rough endoplasmic reticulum
to the Golgi complex is accomplished in COP-II coated vesicles. ARF catalyzes the
assembly of COP-II molecules to form coatomer on the cytoplasmic aspect of these
transfer vesicles. Synthesis of COP-II proteins as well as the disassembly of the coatomer
are not influenced by ARF. Clathrin coats mediate the endocytotic pathway as well as the
pathway that leads away from the trans Golgi network.
6. Patients with sickle cell anemia possess hemoglobin-s, a mutated form of hemoglobin.
Hemoglobin-s is
Explanation:
The answer is a. Hemoglobin, whether normal or mutated, is present freely in the cytosol;
therefore, it is synthesized on free ribosomes. Only proteins that are to be packaged are
synthesized on the rough endoplasmic reticulum. Because hemoglobin is not packaged, it
does not enter the Golgi apparatus.
7. A neonatal baby boy is observed to have malformed hands, feet, and skull. Additional
examination displays jaundice, hepatomegaly, and hypotonic muscles with psychomotor
retardation. The pediatrician diagnoses the disorder as cerebrohepatorenal syndrome
(Zellweger’s syndrome). This condition is due to problems with which of the following
organelles?
a. mitochondria
b. lysosomes
c. early endosomes
d. late endosomes
e. peroxisomes
Explanation:
The answer is e. Children with cerebrohepatorenal syndrome die at an early age due to
mutations in their peroxin genes that code for defective receptors that are unable to
transfer enzymes destined for peroxisomes into these organelles. Mitochondria,
lysosomes, and endosomes are not affected by this mutation.
8. A 20-year-old male seeking help from his ophthalmologist presents with deteriorating
vision in both eyes, especially his central vision. The patient also evidences cardiac
Test Bank 4
a. lysosomes
b. early endosomes
c. late endosomes
d. mitochondria
e. peroxisomes
Explanation:
The answer is d. Leber’s hereditary optic neuropathy is due to a point mutation on the
mitochondrial DNA. Because the spermatozoon does not contribute mitochondria to the
zygote, only the female can transmit this condition to her offspring. Lysosomes,
peroxisomes, and early and late endosomes do not possess DNA.
Explanation:
The answer is b. Cadherins are integral proteins that are designed to assist cells to
maintain contact with one another. Hemidesmosomes, heparin sulfate, and basal lamina
are all associated with cell-to-extracellular matrix contact.
10. Dynein arms are always attached to one of the following. Which one is that structure?
a. central sheet
b. singlets
c. subunit A
d. subunit B
e. radial spoke
Explanation:
The answer is c. Dynein arms are microtubule-associated proteins that function in
bending of the cilium. These molecular motors are attached to the subunit A of the
axoneme. The central sheet and the radial spokes are both composed of an elastic protein
that becomes stretched during the “cocking” of the axoneme and, as they return to their
normal length, they effect ciliary motion.
Test Bank 5
11. The component of the erythrocyte cell membrane that is the most essential in
maintaining its biconcave disc shape is
a. glycophorin
b. spectrin
c. ankyrin
d. actin
e. band 3 protein
Explanation:
The answer is b. Spectrin is a rod-shaped tetramer that, in association with actin and
adducin, forms a hexagonal lattice that underlies the cytoplasmic surface of the red blood
cell plasmalemma. Ankyrin and band 3 protein and band 1 protein anchor the hexagonal
lattice to the cell membrane. Glycophorins and band 3 proteins are transmembrane
proteins.
12. A six-month-old baby boy, when seen by his pediatrician,, exhibits an enlarged
tongue and an enlarged liver. Additionally, the baby has problems with swallowing. The
pediatrician should suspect that the child is suffering from
Explanation:
The answer is b. Pompe’s disease is a lethal glycogen-storage disease that affects infants
and usually causes death by the second or third year of life. The baby is missing
lysosomal acid maltase, and as glycogen accumulates in the lysosomes of the liver, heart,
and some skeletal muscles, these organs enlarge. Although cranial nerve X distributes
through much of the body, its malfunction does not cause any of the symptoms present in
this infant. McArdle’s syndrome has an adult onset, and the symptoms of Tarui’s disease
usually are noted only after vigorous physical exercise. Tay-Sachs disease is not
accompanied by swollen tongue or enlarged liver.
13. A patient with Kartagener’s syndrome has a genetic disorder that is known to
a. affect microfilaments
b. affect intermediate filaments
c. have defective dynein
d. have defective kinesin
e. have defective -tubulin
Explanation:
Test Bank 6
14. A patient who had surgery for ovarian cancer is placed on a combination of cisplatin
and taxol therapy. Taxol is an antimitotic agent that
a. affects microfilaments
b. affects intermediate filaments
c. has defective dynein
d. prevents the polymerization of microtubules
e. stabilizes microtubules
Explanation:
The answer is e. Unlike most antimitotic agents that interfere with polymerization or
depolymerization of microtubules, taxol stabilizes microtubules, so they cannot shorten
or lengthen. In this fashion the mitotic spindle apparatus cannot change its length, thus
preventing the movement of the chromosomes during the mitotic event. Dynein,
microfilaments, and intermediate filaments are unaffected by taxol.
15. A patient with lymphoma that involves his small intestines is treated with a various
chemotherapeutic agents, including vincristine. This antimitotic substance acts on
a. -actinin
b. dynein
c. tubulin
d. myosin I
e. actin
Explanation:
The answer is c. Vincristine interferes with polymerization of microtubules and halts
mitosis, thus killing dividing cells. Vincristine has no effect on -actinin, dynein, myosin
I, or actin.
16. A two-week-old infant was seen by her pediatrician because of blistering of the
fingers and the back of her hands. The blisters were quite large and the results of the
biopsy indicated that blistering occurred in the basal layer of the epidermis. The diagnosis
was epidermolysis bullosa simplex. This disease is caused by mutations in the
a. tubulins
b. neurofilaments
c. G actins
d. keratins
Test Bank 7
e. chondroitins
Explanation:
The answer is d. Blistering in infants that occurs on the regions of the skin that are
exposed to friction and pressure is a result of mutations in types 14 and 5 keratins.
Tubulins, neurofilaments, G actins, and chondroitins are not affected.
17. Early in the morning, a male patient sees his physician because he and his wife have
been trying to start a family. According to the patient, his wife was told that she is able to
become pregnant, and he wants to have the physician check him for sterility. The
physician notices that the patient has a heavy cough. Upon questioning, the patient
reveals that he also coughs in the evening, produces a lot of sputum, and has had
numerous colds and even occasional pneumonia. The doctor asks for a sperm sample but
already is thinking of a possible diagnosis of Kartagener’s syndrome, a genetic disorder
that affects
a. a number of keratins
b. microtubule-associated proteins
c. thin filaments
d. intermediate filaments
c. thick filaments
Explanation:
The answer is b. Kartagener’s syndrome is due to an autosomal recessive disorder that
affects ciliary motion because a microtubule-associated protein, dynein, is either
defective or not present. The tubulins of microtubules are formed normally and
microtubule assembly, per se, is not affected. Thin filaments, thick filaments, and
intermediate filaments are not affected in Kartagener’s syndrome.
18. A 55-year-old patient was placed on tetracycline therapy and a week later returns to
the physician, indicating that the antibiotic did not alleviate his symptoms. During their
conversation the physician determines that the patient took the tetracycline capsules with
milk. Which of the following components of milk interfered with theaction of the drug?
a. calcium
b. lipid
c. sodium
d. rennin
e. potassium
Explanation:
The answer is a. Calcium taken within an hour of oral tetracycline ingestion interferes
with the absorption of the antibiotic through the membranes of the cells lining the
stomach and small intestines. Lipid, sodium, and potassium do not interfere with
tetracycline absorption. Rennin, an enzyme that curdles milk protein, has no effect on the
absorption of tetracycline.
Test Bank 8
19. A 77-year-old female is having problems sleeping, and her physician prescribed
flurazepam, a sleep aid. The patient reports that she feels “groggy” for about 2 days after
having taken the drug. Flurazepam is
Explanation:
The answer is d. Many drugs are inactivated by the P-450 enzyme system of the liver. In
this patient the level of this enzyme system is depressed; therefore, flurazepam is not
inactivated in 18 hours, as in most patients, but has a longer half-life, which accounts for
the groggy feeling even 2 days later. Flurazepam is not affected by HCl, pepsin, or
trypsin, nor does it enter the proteasome system of the cell.
20. In Fig. Img_001, the region at the arrow tip is the place where
Test Bank 9
Explanation:
The answer is a. The arrow tip is in the nucleolus and it is here that the assembly of both
small and large ribosomal subunits occur. rRNA, not mRNA, is transcribed in the
nucleolus, and tRNA is not degraded here. Protein synthesis as well as the coupling of
amino acids to tRNA occur in the cytoplasm, not in the nucleolus.
21. In Fig. Img_002, the collecting tubule of the kidney, water enters the lumen via
a. pinocytosis
b. endocytosis
c. aquaporins
Test Bank 10
d. ion channels
e. carrier proteins
Explanation:
The answer is c. Water leaves the cells of the collecting tubule to enter its lumen by way
of structures known as aquaporins. Pinocytosis and endocytosis both refer to substances
entering the cell. Ion channels are designed to carry ions along a concentration gradient in
or out of a cell, whereas carrier proteins can move ions as well as small molecules along
and/or against a concentration gradient.
22. In Fig. Img_004, the structure at the tip of the arrow is responsible for which of the
following?
a. synthesis of ATP
b. assembly of microtubules
c. assembly of neurofilaments
d. synthesis of lysosomal proteins
e. assembly of neurotubules
Explanation:
Test Bank 11
The answer is d. The large cell in the center of this field is a multipolar neuron in the gray
matter of the spinal cord. The arrow is pointing to a structure known as a Nissl body,
which was noted by electron microscopy to be composed of rough ER, the region where
proteins that are to be packaged, such as lysosomal proteins, are synthesized whereas
microtubules (also known as neurotubules) and neurofilaments are assembled in the
cytoplasm, but not involving the rough ER.
23. A patient who is unable to metabolize long-chain fatty acids has problems involving
her
a. early endosomes
b. late endosomes
c. lysosomes
d. peroxisomes
e. proteasomes
Explanation:
The answer is d. Peroxisomes function in the catabolism of long-chain fatty acids, in
detoxifying noxious agents, and in killing bacteria. Early and late endosomes are
organelles that participate in the endocytic and endolysosomal pathways, whereas
proteasomes function in the catabolism of proteins.
a. zonula occludens
b. zonula adherens
c. fascia occludens
d. desmosomes
e. hemidesmosomes
Explanation:
The answer is e. Integrins are transmembrane proteins that are restricted to interact with
the extracellular matrix. In epithelial cells they are localized in the basal surfaces and
assist hemidesmosomes in adhering to the basal lamina. They do not participate in cell-
to-cell contact, and all the other choices involve intracellular contact.
25. In Fig. Img_019, the core of the structures at the arrow tip is composed of
Test Bank 12
a. thin filaments
b. intermediate filaments
c. thick filaments
d. microtubules
e. actin filaments
Explanation:
The answer is d. The photomicrograph depicts a pseudostratified, ciliated columnar
epithelium and the structures at the arrow tip are cilia. The core of each cilium is consists
of an axoneme. Axonemes are composed of nine doublet microtubules surrounding two
central singlet microtubules. Thin filaments (actin filaments) constitute the core of
microvilli. Intermediate filaments and thick filaments are not associated with cilia.
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The Project Gutenberg eBook of Renaissance
literary theory and practice
This ebook is for the use of anyone anywhere in the United
States and most other parts of the world at no cost and with
almost no restrictions whatsoever. You may copy it, give it away
or re-use it under the terms of the Project Gutenberg License
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are not located in the United States, you will have to check the
laws of the country where you are located before using this
eBook.
Language: English
Renaissance Literary
Theory and Practice
By
CHARLES SEARS BALDWIN
Edited with Introduction by
DONALD LEMEN CLARK
GLOUCESTER, MASS.
PETER SMITH
1959
Copyright, 1939
COLUMBIA UNIVERSITY PRESS
Reprinted, 1959
By Permission of
COLUMBIA UNIVERSITY PRESS
BEATO THOMAE MORO
JVDICI
CVI STILVM ANGLICVM
LATINE REGENTI
PERSTABAT IN REGIA
QVAESTIONE PAX ROMANA
INTRODUCTION
When he died in 1936 Charles Sears Baldwin, Professor of
Rhetoric and English Composition at Columbia University, left the
unpublished manuscript which here appears in print. At the request
of his family, I undertook to prepare the manuscript for publication
and see it through the press. As a devoted student, colleague, and
friend I have been happy to do so.
Baldwin’s Renaissance Literary Theory and Practice takes its
place as the continuation of his previously published studies: Ancient
Rhetoric and Poetic (1924) and Medieval Rhetoric and Poetic
(1928), both published by the Macmillan Company. It takes up the
story where Medieval Rhetoric and Poetic left off in 1400 and carries
it on to 1600.
The first sentences of his preface to the first study suggest that
Baldwin had the present study in mind before 1924. “To interpret
ancient rhetoric and poetic afresh from typical theory and practice is
the first step toward interpreting those traditions of criticism which
were most influential in the Middle Age. Medieval rhetoric and poetic,
in turn, prepare for a clearer comprehension of the Renaissance
renewal of allegiance to antiquity.”
Like the two earlier studies, it is firmly based on the Aristotelian
philosophy of composition embodied in the Rhetoric and the Poetic.
Baldwin adheres to the sound rhetoric which aims at enhancing the
subject and repudiates the sophistic rhetoric which aims at
enhancing the speaker. Rhetoric and poetic are different in aim and
different in their modes of composition. Consequently he considers
poetic deviated when it becomes confused with rhetoric and
perverted when controlled by sophistic.
Had he lived, Baldwin would have written more than here appears.
He had planned a chapter on Renaissance education which would
have demonstrated more fully the channels through which poetical
theory reached poetical practice. In the chapter “Sixteenth Century
Poetics” he had planned sections on Castelvetro and Sibillet which
were never written. Other writers on literary theory he deliberately
omitted as less typical, less significant, or less influential than the
writers he discusses. His method was to go directly to the original
sources, both for theory and for practice, to make his own
translations, and to ignore secondary sources, which he rarely cites.
Although Chapters IV, V, VI, and VIII deal with literary forms: lyric,
pastoral, romance, drama, tales, history, and essay, Baldwin was not
attempting a history of Italian, French, and English literature in the
fifteenth and sixteenth centuries. To have written such a history
would have involved a completeness he never intended. He was
assaying samples of literature for literary values. Especially was he
tracing the influences of sound literary theory on sound literary
practice, and the disastrous results in literature of the misapplication
of rhetorical theory to poetic and the composition of story and drama.
As literary critic and teacher of composition, he saw no good reason
why modern literature, in theory or in practice, should make the
same mistakes that were made in ancient times, the Middle Age, and
the Renaissance. He believed that modern literature, modern
criticism, and modern teaching should learn from the mistakes of
others as well as from their own.
Before Baldwin’s death I had read the manuscript in two states as
I had the two earlier works. Further, the manuscript was read and
criticized by Dr. Caroline Ruutz-Rees of Rosemary Hall and
Professor William G. Crane of The College of the City of New York.
To these friends, and to the others whose aid I have been unable to
discover, the author’s and the editor’s gratitude is due. Professor
Marshall Whithed Baldwin, son of Charles Sears Baldwin, read both
the galley and the page proofs. My colleagues, Professors Harry
Morgan Ayres and Nelson Glenn McCrea, advised on the proofs and
other details. I join with the Baldwin estate in gratitude to the
generous assistance of the officers and editorial staff of the
Columbia University Press.
Donald Lemen Clark
Columbia University
September, 1939
CONTENTS
I. The Renaissance as a Literary Period 3
II. Latin, Greek, and the Vernaculars 17
1. humanistic latin 17
2. greek 19
3. the vernaculars 27
(a) Italian 27
(b) French 31
(c) English 36
III. Imitation of Prose Forms, Ciceronianism,
Rhetorics 39
1. orations, letters, dialogues 39
2. ciceronianism 44
3. rhetorics 53
IV. Imitation in Lyric and Pastoral 65
1. lyric 65
(a) Latin Lyric 65
(b) Italy and England 66
(c) France 68
2. pastoral 78
V. Romance 91
1. the romantic contrast 91
2. separate romances 95
3. the arthurian cycle in malory 98
4. the carolingian cycle on the street 100
5. pulci 100
6. boiardo 102
7. ariosto 111
8. tasso and spencer 123
(a) Tasso 124
(b) Spencer 127
VI. Drama 133
1. sacred plays 134
2. tragedy 137
3. history plays 144
4. pastoral and rustic comedy 146
VII. Sixteenth-Century Poetics 155
1. vida 155
2. trissino 158
3. giraldi cinthio 158
4. muzio 161
5. fracastoro 162
6. peletier 163
7. minturno 164
8. partenio 169
9. scaliger 171
10. ronsard and tasso 175
11. sidney 178
12. english discussion of verse 180
13. patrizzi 184
14. denores 185
15. vauquelin 186
16. summary 187
VIII. Prose Narrative 190
1. tales 190
(a) Bandello 190
(b) Marguerite de Navarre 194
(c) Giraldi Cinthio 195
(d) Belleforest, Painter, and Fenton 198
(e) Pettie, Lyly, and Greene 199
2. rabelais 202
3. history 213
(a) Latin Histories 214
(b) Vernacular Histories: More; Macchiavelli 217
IX. Essays 223
1. discussion on politics and society 223
2. montaigne 232
Index 241
RENAISSANCE
LITERARY THEORY
AND PRACTICE
Chapter I
THE RENAISSANCE AS A LITERARY PERIOD
The best part, I think, we now have in our hands, saved from the deluge of
more than a thousand years; for a deluge indeed, calamitous to life, had
so drained and absorbed literature itself and the kindred arts worthy of the
name, and kept them so dismantled and buried in barbarian mud that it
was a wonder they could still exist (De studio literarum, 1527; Basel ed.
1533).
For who of you is unaware that from the time when the Roman Empire, for
all its power and eminence, began to totter and lean, literature was asleep,
not to say overwhelmed and buried, till the time of Petrarch? From then
on, it has been so steadily regaining the light that now it has been almost
recalled from that [medieval] rude and barbarous teaching to its ancient
cult (De poeta, 1559, p. 14).
I feel the greatest satisfaction, most learned Robert, in the flourishing here
at Paris, where they used to be unknown, of poetic compositions and all
the parts of eloquence. For when in my youth I first left the Baux country to
study at Paris the learning of Aristotle, I used to be much astonished at
finding so rarely in all Paris an orator and a poet. No one was studying
Cicero night and day as many do now. No one knew how to write verse
correctly or to scan the verse of others. For the school of Paris, having lost
the habit of Latinity, had hardly emerged from ignorance in the field of
discourse. But from our days dates a better epoch; for the gods, to speak
poetically, and the goddesses are reviving among us the art of speaking
well.[1]
The Middle Age, then, could not write Latin. Not John of Salisbury,
not Dante, not even Aquinas was really eruditus! Fifty years later the
judicious Bembo reports the restoration as accomplished.
Latin has so far been purged of the rust of the untaught centuries that
today it has regained its ancient splendor and charm.[2]