Gout

Arthritis
 Definition
Gout is a heterogeneous group of diseases
resulting from deposition of monosodium urate
crystals in tissues or from supersaturation of
uric acid in extracellular fluid.
 Etiology
The etiology of gout is usually multifactorial, including genetic risk
factors, medical comorbidities, and dietary factors.

Whatever the cause, the result is an increase in serum uric acid, which
in some patients eventually leads to clinical gout.
 Risk factor
Modifiable: That cannot be
Iron overload modified:
Thyroid disease Tribe/race
Trauma Gender
Pathophysiology
physical examinations
Eritema
Edema
Warm
Tenderness
Deformity
Tofi
physical examinations
Supporting examinations
Routine blood tests, uric acid,
creatinine
24-hour urinary uric acid
excretion
Creatinine clearance
Joint radiology
differential diagnoses
Pseudogout
Artritis Septik
Artritis Reumatoid
 management
Pharmaco: Non-Pharmaco:
Obat anti inflamasi non Low purine diet
steroids (OAINS) Adequate hydration
Kortikosteroid: Weight loss (target ideal
Triamsinolon 5-10mg/20- weight)
40mg.
Kolkisin
complications:
prognosis:
Recurrence rate of acute gout:
First year : 60%
Two years: 80%
Five years: 90%
education and prevention:
 References
Alwi, I, A. (2015). Penatalaksanaan di bidang ilmu penyakit
dalam panduan praktik klinis . Jakarta: PIP Interna.

Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata M, Setiati S.

Buku Ajar Ilmu Penyakit Dalam Jilid III edisi V. Jakarta:
Interna Publishing; 2010.