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Journal of Biomedical Materials Research - Part B Applied Biomaterials Cited by 0 document since 1996
Volume 101, Issue 4, May 2013, Pages 568-575
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Influence of processing parameters on microstructure and
biocompatibility of surface laser sintered hydroxyapatite-SiO2
Related documents
composites (Article)
Silicon substitution in the calcium phosphate
bioceramics
Kivitz, E.a, Georke, R.a, Schilling, A.F.b, Zhang, J.c, Heinrich, J.G.a
Pietak, A.M. , Reid, J.W. , Stott, M.J.
a (2007) Biomaterials
Department of Engineering Ceramics, Clausthal University of Technology, Clausthal-Zellerfeld 38678, Germany
b TU Munchen, Experimentelle Plastische Chirurgie, Klinik und Poliklinik fur Plastische und Hand-Chirurgie, Munchen 81675, Accurate characterization of pure silicon-substituted
hydroxyapatite powders synthesized by a new
Germany
precipitation route
c Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China Marchat, D. , Zymelka, M. , Coelho, C.
(2013) Acta Biomaterialia

View references (31) Si-substituted hydroxyapatite nanopowders:

Abstract Synthesis, thermal stability and sinterability
Bianco, A. , Cacciotti, I. , Lombardi, M.
Silica-doped hydroxyapatite (HA) is a promising material concerning biocompatibility to natural bone, (2009) Materials Research Bulletin
bioactivity and osteoconductive characteristics. HA exhibits phase transformations during sintering which
View all related documents based on references
are attendant to the change in volume and thermal strain. To avoid cracks during sintering, the exact
knowledge of the phase transition temperatures is necessary. The sintering behavior of HA can be Find more related documents in Scopus based on:
improved by adding amorphous silica with a low coefficient of thermal expansion. Therefore, the phase
Authors | Keywords
transformations in the system HA-SiO2 were analyzed by using differential scanning calorimetry followed
by quantitative phase analysis by X-ray diffraction with the Riedveld method. The maximum sintering
temperature without reversible phase transformation was defined as 1265°C. In laser surface sintered
(LSS) samples, amorphous SiO2, HA, and Si-α-TCP (or α-TCP) were detected. By comparison, only
crystalline phases, such as cristobalite, HA, β-TCP, and Si-α-TCP (or α-TCP), were determined after
furnace sintering. Scanning electron microscopy micrographs of furnace sintered and LSS samples show
the differences in the resulting microstructures. Biocompatibility was determined by measuring cell
activity of osteoblasts cultivated on four laser-sintered materials in the HA-SiO2 system in comparison to
normal cell culture plastic. Cell proliferation was similar on all surfaces. The level of the cell activity on
day 8 varied depending on the composition of the material and increased linearly as the amorphous SiO2
content rose. Taken together a laser-based method to develop novel biocompatible HA-SiO2 ceramics
with adjustable properties and possible applications as orthopedic bioceramics are discussed. © 2012
Wiley Periodicals, Inc.

Reaxys Database Information

|

Author keywords
Amorphous SiO2; Biocompatibility; Hydroxyapatite; Laser surface sintering; Phase transition temperature

Indexed keywords
Laser surface; Low coefficient of thermal expansions; Osteoconductive characteristics; Processing
parameters; Quantitative phase analysis; Reversible phase transformations; Sintering behaviors; Sintering
temperatures
Engineering controlled terms: Amorphous silicon; Bioceramics; Biocompatibility; Cell culture; Cell
proliferation; Differential scanning calorimetry; Hydroxyapatite; Intermetallics; Laser heating;
Microstructure; Phase transitions; Scanning electron microscopy; Silica; Silicate minerals; Silicon;
Surfaces; X ray diffraction
Engineering main heading: Sintering
EMTREE drug terms: bioceramics; hydroxyapatite; silicon dioxide
EMTREE medical terms: article; biochemical composition; biocompatibility; biological activity; cell
activity; cell proliferation; controlled study; crystal structure; differential scanning calorimetry; furnace;

http://www.scopus.com/record/display.url?eid=2-s2.0-84879606450&origin=resultslist&sort=plf-f&src=s&st1=influence+of+particle+size+on+bioactivity+of+bio… 1/5
7/22/2014 Scopus - Document details
high temperature procedures; molecular weight; osteoblast; particle size; phase transition; room
temperature; scanning electron microscopy; surface laser sintering; surface property; thermoregulation;
transition temperature; X ray diffraction
MeSH: 3T3 Cells; Animals; Biocompatible Materials; Bone and Bones; Bone Substitutes; Cell
Proliferation; Ceramics; Durapatite; Lasers; Materials Testing; Mice; Microscopy, Electron, Scanning;
Osteoblasts; Powders; Silicon Dioxide; Surface Properties; Temperature; X-Ray Diffraction
Medline is the source for the MeSH terms of this document.

Chemicals and CAS Registry Numbers: hydroxyapatite, 1306-06-5, 51198-94-8; silicon dioxide, 10279-
57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9;Biocompatible Materials; Bone
Substitutes; Ceramics; Durapatite, 91D9GV0Z28; Powders; Silicon Dioxide, 7631-86-9

ISSN: 15524973 CODEN: JBMRG Source Type: Journal Original language: English
DOI: 10.1002/jbm.b.32858 PubMed ID: 23255362 Docum ent Type: Article

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this document.

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