Preventol® CMK for effective disinfection

Product Information

Preventol® CMK (p-chloro-m-cresol) is an active substance
suitable for the formulation of hard surface disinfectants
for animal housing and industrial & institutional areas,
as well as products with antimicrobial claims, such
as hand soap. Disinfectant formulations based on
Preventol® CMK benefit from proven broad-spectrum
efficacy against (myco-) bacteria, fungi, viruses and
endoparasites, including coccidia and round worm eggs.
Besides the broad efficacy spectrum, Preventol® CMK also
performs well under challenging conditions. Preventol®
CMK show strong performance even in the presence of
organic matter, such as dirt, faeces and blood.
Furthermore, the active is highly effective at low temperatures
often found in animal farming, as demonstrated by the
European veterinary test standards performed at 10°C.
This makes Preventol® CMK a suitable active ingredient for
surface disinfectants on farms, but also for boot and wheel
dip applications.
Preventol® CMK is utilized in a wide variety of application,
including:
■ Animal Housing Disinfection
■ Industrial & Institutional Disinfection
■ Healthcare Disinfection
■ Household Disinfection
■ Hand Hygiene

Table 1: Chemical and physical data

Preventol® CMK
Active ingredient: >= 99.8 % 4-chloro-3-methylphenol (common name: p-chloro-m-
cresol, PCMC, chlorocresol)
Product description: Almost white solid flakes

Specification
The specification parameters can be found in the currently valid product specification.

Characteristic data*
Density (20 °C): approx. 1.34 g/cm3
Bulk density (flakes): Pour density: 0.68 g/mL
Tap density: 0.75 g/mL
Melting point: approx. 64.2°C
Boiling point (1013 mbar): approx. 242 ºC
pH (0.1% dilution in water): approx. 6.5
Stability range: pH 1 - 14
Ionic character: Anionic in solution

Solubility (20 °C)

Solvent Solubility (approx. ) Solvent Solubility (approx. ) Solvent Solubility (approx. )
Water 3.6 g/l Isopropanol > 500 g/l Triethylene glycol > 500 g/l
Acetone > 500 g/l Methanol > 500 g/l Xylene 190 g/l
Ethanol > 500 g/l Propylene glycol > 500 g/l 10% NaOH 320 g/l
Ethylene glycol > 500 g/l Toluene 300 g/l Glycerine > 550 g/l
*Characteristic data provide further information about the product and are not subject to constant monitoring. They are therefore not binding.
 Preventol®

Biocidal properties
Efficacy spectrum:
The broad-spectrum efficacy profile of Preventol® CMK
or CMK-based formulations includes a variety of disease-
causing organisms, such as African swine fever virus
(ASFv), Influenza viruses and Coccidia in veterinary
applications. The efficacy against Mycobacterium
tuberculosis and lipophilic, enveloped viruses such as
Herpes simplex virus, Hepatitis B virus, Human
Immunodeficiency virus (HIV) and SARS-CoV-2, makes
disinfectants based on phenolic active ingredients attractive
for HI&I applications. Depending on the formulation,
phenolic-based disinfectants are also effective against non-
enveloped viruses such as ECBO virus or Feline calicivirus.
To achieve the optimum spectrum of activity at the lowest
concentration Preventol® CMK can be combined with
other phenolic active ingredients such as Preventol® O
extra and Preventol® BP. Preventol® CMK can also be
used in combination with ethanol or isopropanol.
For additional virucidal activity Preventol® CMK
can be successfully combined with Klarix™/ Ucarcide™
(glutaraldehyde).
Efficacy data in line with European test norms:
To demonstrate the efficacy of our active substance a
representative formulation “SF-CMK”* containing 10%
Preventol® CMK was developed and tested using the
European standards. The effective concentrations of
Preventol® CMK are given in tables 2 and 3. The results
presented here do not replace the need to evaluate the
efficacy of your own disinfectant formulation. As the
efficacy of a disinfectant is dependent on various
parameters, it is important to evaluate the efficacy of each
formulation individually.

Table 2: Effective concentrations [%] of Preventol® CMK for veterinary applications, according to European
test norms with low level of soiling.

Effective concentration [%]

Test organisms
EN 1656 1
EN 1657 2
EN 143493 EN 164384 EN 142045
Staphylococcus aureus 0.10 0.10
Proteus vulgaris 0.03 0.03
Pseudomonas aeruginosa 0.20 0.15
Enterococcus hirae 0.05 0.05
Candida albicans 0.20 0.08
Aspergillus brasiliensis 0.40 0.40
Mycobacterium avium 0.40
 Preventol®

Table 3: Effective concentrations [%] of Preventol® CMK for household and industrial
& institutional applications, according to European test methods with low level of soiling.

Effective concentration [%]

Test organisms
EN 12766 EN 16507 EN 136978 EN 143489
Staphylococcus aureus 0.08 0.10
Escherichia coli 0.08 0.08
Pseudomonas aeruginosa 0.20 0.15
Enterococcus hirae 0.05 0.03
Candida albicans 0.15 0.10
Aspergillus brasiliensis 0.30 0.25
Mycobacterium avium 0.20
Mycobacterium terrae** 0.20

Table 4: List of microorganisms Preventol® CMK has proven efficacy against using Minimal Inhibitory
Concentration (MIC) test method.

Bacteria
Aeromonas punctata Escherichia coli EHEC Pseudomonas aeruginosa
Bacillus mycoides Leuconostoc mesenteroides Pseudomonas fluorescens
Bacillus subtilis Listeria monocytogenes Salmonella choleraesuis
Desulfovibrio desulfuricans Mycobacterium terrae Staphylococcus aureus MRSA
Enterobacter aerogenes Propionibacterium acnes Staphylococcus aureus MRSA clinical
Escherichia coli Proteus mirabilis isolate

Yeasts
Candida albicans Saccharomyces cerevisiae Torula utilis
Candida krusei Saccharomyces bailii
Rhodotorula mucilaginosa Rhodotorula rubra

Mould fungi
Alternaria tenuis Aspergillus ustus Penicillium brevicaule
Aspergillus flavus Chaetomium globosum Rhizopus stolonifer
Aspergillus niger Microsporium canis Trichophyton metagrophytes
Aspergillus terreus Mucor racemosus Trichophyton rubrum

Formulating an effective disinfectant composition: optimize disinfectant properties. The ideal concentration
The efficacy of a phenolic-based disinfectant depends of the ingredients must be proven for each formulation and
on the concentration of the active ingredients as well intended application by using appropriate test methods.
as the overall composition. In order to readily disolve
Preventol® CMK in a water-based formulation solvents
should be included. For improved stability and lower
surface tension of the formulation anionic surfactants
are commonly used. By including acidic surfactants and
lowering the pH to an acidic or neutral value (pH 2 - 8),
better efficacy performance can be achieved. Further,
suitable formulating auxiliaries such as sequestering
agents, fragrances, corrosion inhibitors etc. can also
 Preventol®

Storage, Safety and Regulatory Information
If correctly stored and kept in the original sealed package, the
product has a shelf life of 2 years. The product may become
slightly discoloured when exposed to air, light, moisture
or heat. This has no adverse effect on the quality of the
product.
and handling. This cannot be overemphasized. Information
is available in several forms, e.g., material safety data
sheets, product information and product labels. Consult
your LANXESS representative in Germany or contact
the Regulatory Affairs and Product Safety Department of
LANXESS Deutschland GmbH or - for business in the USA
- the LANXESS Corporation Product Safety and Regulatory
Affairs Department in Pittsburgh, PA, USA.

Health and Safety Information: Appropriate literature
has been assembled which provides information concerning
the health and safety precautions that must be observed
when handling the LANXESS products mentioned in
this publication. For materials mentioned which are not
LANXESS products, appropriate industrial hygiene
and other safety precautions recommended by their
manufacturers should be followed. Before working with
any of these products, you must read and become familiar
with the available information on their hazards, proper use
Regulatory Compliance Information: Some of the end
uses of the products described in this publication must
comply with applicable regulations, such as the FDA, BfR,
NSF, USDA, and CPSC. If you have any questions on the
regulatory status of these products, contact – for business
in the USA - the LANXESS Corporation Regulatory Affairs
and Product Safety Department in Pittsburgh, PA, USA or
for business outside US the Regulatory Affairs and Product
Safety Department of LANXESS Deutschland GmbH
in Germany.

1
EN 1656: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and
antiseptics used in the veterinary area
2
EN 1657: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of fungicidal or yeasticidal activity of chemical
disinfectants and antiseptics used in the veterinary area
3
EN 14349: Chemical disinfectants and antiseptics - Quantitative surface test for the evaluation of bactericidal activity of chemical disinfectants and
antiseptics used in the veterinary area on non-porous surfaces without mechanical action
4
EN 16438: Chemical disinfectants and antiseptics - Quantitative surface test for the evaluation of fungicidal or yeasticidal activity of chemical disinfectants
and antiseptics used in the veterinary area on non-porous surfaces without mechanical action
5
EN 14204: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants
and antiseptics used in the veterinary area
6
EN 1276: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity of chemical disinfectants and
antiseptics used in food, industrial, domestic and institutional areas
7
EN 1650: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of fungicidal or yeasticidal activity of chemical
disinfectants and antiseptics used in food, industrial, domestic and institutional areas
8
EN 13697: Chemical disinfectants and antiseptics - Quantitative non-porous surface test for the evaluation of bactericidal and/or fungicidal activity of
chemical disinfectants used in food, industrial, domestic and institutional areas
9
EN 14348: Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants
in the medical area including instrument disinfectants
* The representative formulation was only developed to illustrate the efficacy of our active substance and this product is not available in the market.
** Mycobacterium terrae is the surrogate for Mycobacterium tuberculosis in national and international standards on testing of the efficacy of chemical
disinfectants. Both species show similar resistance

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and information (whether verbal, written or by way of production evaluations), including any suggested formulations
and recommendations are beyond our control. Therefore, it is imperative that you test our products, technical
assistance and information to determine to your own satisfaction whether they are suitable for your intended uses and
applications. This application-specific analysis must at least include testing to determine suitability from a technical
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information and technical assistance is given without warranty or guarantee and is subject to change without notice. It
is expressly understood and agreed that you assume and hereby expressly release us from all liability, in tort, contract
or otherwise, incurred in connection with the use of our products, technical assistance, and information.

Any statement or recommendation not contained herein is unauthorized and shall not bind us. Nothing herein shall
LANXESS Deutschland GmbH
be construed as a recommendation to use any product in conflict with patents covering any material or its use. No
Business Unit Material Protection license is implied or in fact granted under the claims of any patent.
Products
@2023 LANXESS. Preventol®, LANXESS and the LANXESS Logo are trademarks of LANXESS Deutschland GmbH
50569 Cologne/Germany
or its affiliates. All trademarks are registered in many countries in the world.

https://microbialcontrol.lanxess.com Preventol® CMK/24.07.23/G