USP Elemental Impurities for Drug Products

Oral Parenteral
Element Daily Dose (µg/day) Element Daily Dose (µg/day)

Cadmium 5 Cadmium 2

Lead 5 Lead 5

Arsenic 15 Arsenic 15

Mercury 30 Mercury 3

Iridium 100 Iridium 10

Osmium 100 Osmium 10

Palladium 100 Palladium 10

Platinum 100 Platinum 10

Rhodium 100 Rhodium 10

Ruthenium 100 Rutheium 10

Chromium 11000 Chromium 1100

Molybdenum 3000 Molybdenum 1500

Nickel 200 Nickel 20

Vanadium 100 Vanadium 10

Copper 3000 Copper 300

Cobalt 50 Cobalt 5

Thallium 8 Thallium 8

Selenium 150 Selenium 80

Silver 150 Silver 10

Gold 100 Gold 100

Lithium 550 Lithium 250

Antimony 1200 Antimony 90

Barium 1400 Barium 700

Tin 11000 Tin 600