c15+

c30+

Reed
EBV stenberg cell
owl eye
hodgkin lymphoma nuclei
starry sky
c-myc from chromosome 8

jaw lesion
EBV

chromosome 14+heavy chain immunoglobulin

B cell lymphoma

affects children and adolescent

burkitt lymphoma
 rapidly enlarging mass Richter transformation
from CLL

diffuse large b cell lymphoma

mutation in BCL2 and
BCL6
 affects B cells

translocation from chromosome 18

follicular lymphoma
translocation to 14(fortune)

Bcl2 expression

inhibits B cell apoptosis

waxing and waning lymphadenopathy

 t(11,14)
B cells
11
14(fortune)

heavy chain immunoglobulin

cyclin D1
common in male

mantle cell lymphoma

CD5+
associated with chronic inflammation
T(11,18)

marginal cell lymphoma

B-cells
 EBV

EBV
ring enhancing lesion
B cell origin
primary CNS
associated with immunodeficiency
lymphoma
 caused by HTLV-1(hot lava)

cutaneous lesion

adult T cell leukemia/lymphoma

 pautrier
originates from microabscesses
CD4+ helper
t-cells
cerebriform nuclei

sézary
skin lesion syndrome
cutaneous invasion of T-cells

mycosis fungoides
dec O2 sat
 risk risk
factor=chemotherapy factor=radiation
down s

leukemia triad:fatigue
,bleeding, risk factor:myeloproliferative
infection disorders

elderly adults

MPO
AML(amulet)
blast cells(exploding)
 auer rods

translocation 15,17

subtype of AML
blast
treat with ATRA(vitamin A derivative)
cells
DIC
APL

MPO positive(moped)
 SVC S

T-cell ALL
B-cell
chemotherapy must reach CNS+scrotum
targets bone
TdT positive better
mediastinal/thymic mass
prognosis
with t(12,21)
better prognosis in
typical leukemic presentation children

worse prognosis in adults(adult was attacked)

ALL(ALLigator)

associated Blast
withdown
syndrome
 smudge cells
richter
transformation

anemia
CLL affects older adults more than
warm type 60

CD 5+ mature B cells
BCR/ABL

CML ELEVATED
philadelphia chromosome NEUTROPHILS

t(9,22)

dasatinib(dash)
ELEVATED BASOPHILS

DECREASED LAP
imatinib(mat)
 bone marrow fibrosis/dry marrow tap

Cladribine

hairy cell leukemia

splenomegaly

affects B-cells
associated with BRAF mutation(bamboo raft)

pancytopenia
TRAP+
 Waldenstrom
Macroglobulinemia
M-spike in urine

anemia

bence-Jones protein in urine overproduction of IgM

peripheral neuropathy

hyperviscosity syndrome
leads to thrombois
 multiple myeloma
plasma cell cancer

older adults
AL amyloidosis
overproduction og IgA

overproduction of IgG

lytic lesion of bones

hypercalcemia
bence-jones
protein in
renal failure urine
rouleaux formation
immunosupression
anemia M-spike
in serum

gamma gap more than 4