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Pingsheng, Liu

Title
Principal Investigator - National Laboratory of Biomacromolecules, IBP

Email
pliu@sun5.ibp.ac.cn

Phone
010-6488-8517(o)-8521(L)

Address

Pingsheng, Liu, Ph.D, Prof.

Principal Investigator
National Laboratory of Biomacromolecules, IBP
Lipid droplet biology
E-mail：pliu@sun5.ibp.ac.cn，
Tel：010-6488-8517(o)-8521(L)

SEC: Huina Zhang, Ph.D., Tel: 010-6488-8516
Fax：8610-64888517，Zip code：100101
Biography & Introduction
EXPERIENCE AND EDUCATION
2009-present Visiting Professor, Nanjing University, China
2008-present Professor/Principal Investigator, Institute of Biophysics, Chinese Academy of Sciences,
Beijing, China
2002-present Visiting Professor, Guizhou University, Guiyang, Guizhou, China
1999-2008 Research Assistant Professor, UT Southwestern Medical Center, Dallas, TX 75235-9039, USA
1998-1999 Instructor, UT Southwestern Medical Center, Dallas, TX 75235-9039, USA
1997-1998 Assistant Instructor, UT Southwestern Medical Center, Dallas, TX 75235-9039, USA
1994-1997 Postdoctoral Fellow, UT Southwestern Medical Center, Dallas, TX 75235-9039, USA
1987-1994 Ph.D., Clarkson University, Potsdam, NY 13699, USA
1985-1987 Lecturer, Guizhou University, Guiyang, Guizhou, China
1982-1985 MS, National Academy of Light Industrial Science, Beijing, China
1978-1982 BS, Guizhou University, Guiyang, Guizhou, China

Lipid droplets, a cellular organelle that is involved synthesis, storage, and metabolism of neutral lipids,
have recently been linked to metabolic syndromes and biofuel development. Our lab focuses on lipid
droplet biology. We established a method to isolate lipid droplets and have conducted proteomic
studies of the organelle from animal cells, skeletal muscle tissue, bacteria, and C. elegans. We identified
a structure-like protein, MLDS from bacteria and a marker protein from C. elegans. In addition, we also
carried out a lipidomic analysis for animal lipid droplets. Recently, we conducted a comprehensive
study including genome sequencing, comparative transcritomes, and proteomic analysis for an
oleaginous bacterium, and established a bacterial model system to study lipid droplets. Our current
projects include:
1) Molecular mechanisms of lipid droplet formation and dynamics
We try to identify the common property of lipid droplet structure-like proteins and study how they
regulate lipid droplet formation and dynamic changes.
2) Cellular energy homeostasis and metabolic syndromes
We focus on the effects of saturated and unsaturated fatty acids on insulin signaling. We also determine
the changes of lipid droplets in metabolic syndromes.
3) Biofuel storage in microorganisms
We study how lipid droplet formed and its regulation mechanism, and try to build a photosynthetic
bacterium to produce bio-oil.
Selected Publications
Su W., Wang Y., Jia X., Wu W., Li L., Tian X., Li S., Wang C., Xu H., Cao J., Han Q., Xu S., Chen Y., Zhong Y.,
Zhang X., Liu P*., Gustafsson J*., and Guan Y*. (2014) “Comparative proteomic study reveals 17β-HSD13 as
a pathogenic protein in non-alcoholic fatty liver disease” PNAS 111, 11437-11442.
Chen Y., Ding Y., Yang L., Yu J., Liu G., Wang X., Zhang S., Yu D., Song L., Zhang H., Zhang C., Huo L., Huo C.,
Wang Y., Du Y., Zhang H., Zhang P., Na H., Xu S., Zhu Y., Xie Z., Liu H., Wang X., Zhang X., Zhang M., Li Y.,
Steinbuchel A., Fujimoto T., Cichello S., Yu J., and Liu P.* (2014) “Integrated omics study delineates the
dynamics of lipid droplets in Rhodococcus opacus PD630” Nucleic Acids Res. 42, 1052-1064.
Ding Y., Zhang S., Yang L., Na H., Zhang P., Zhang H., Wang Y., Chen Y., Yu J., Huo C., Xu S., Garaiova M.,
Cong Y., and Liu P.* (2013) “Isolating lipid droplets from multiple species” Nature Protocols 8, 43-51.


Zhang P., Na H., Liu Z., Zhang S, Chen Y., Pu J., Peng G., Huang X., Yang F., Xie Z., Xue P., Xu T, Xu P, Ou G,
Zhang S., and Liu P.* (2012) “Proteomic Study and Marker Protein Identification of Caenorhabditis
elegans Lipid Droplets” Mol Cell Proteomics 11, 317-328.
Zhang H., Wang Y., Li J., Yu J., Pu J., Li L., Zhang H., Zhang S., Peng G., Yang F.,* and Liu P.* (2011)
“Proteome of Skeletal Muscle Lipid Droplet Reveals Association with Mitochondria and Apolipoprotein
A-I” J. Proteo Res. 10, 4757-4768.

International College of UCAS

subordinate to University of Chinese Academy of Sciences.

 No.80, Zhongguancun East St., Haidian Dist., Beijing, China

 ic-ucas@ucas.ac.cn